Assessment of Sclerostin and Interleukin 6 Levels and Selected Anthropometric Parameters in Patients Receiving Hemodialysis Replacement Therapy—Pilot Study

Background and Objectives: Chronic kidney disease (CKD) is an important public health problem associated with, e.g., progressive renal insufficiency, bone mineral disorders, and increased inflammatory marker levels. The objective of this study was to compare selected biochemical parameters and to evaluate potential correlations between selected anthropometric parameters and levels of sclerostin and interleukin 6 (IL-6) in blood plasma. Materials and Methods: The study group consisted of 34 patients aged 59.8 ± 9.8 years, receiving hemodialysis therapy. The control group consisted of 31 individuals aged 55.4 ± 9.37 years, presenting with GFR (glomerular filtration rate) of more than 60 mL/min/1.73 m2. Selected anthropometric and biochemical parameters were assessed at baseline, as well as 3 and 6 months into the study. Statistical analyses were performed using the Statistica 2014 software package (StatSoft, Inc.Tulsa, OK, USA). Analyses included descriptive statistics, intergroup comparisons using the Mann-Whitney U-test or the Kruskal-Wallis test, and Spearman’s correlation analysis. The significance level was set at p ≤ 0.005. Results: At all measurement time points, i.e., at baseline, at month 3, and at month 6, the IL-6 levels in the study group were significantly higher than those in the control group. No correlations were observed in the study group between SCL or IL-6 levels and anthropometric parameters such as body weight, body mass index (BMI), or waist circumference. Conclusions: Patients receiving hemodialysis replacement therapy present with significantly higher levels of IL-6 in their blood. Anthropometric parameters (body weight, BMI, and waist circumference) have no impact on sclerostin and IL-6 levels in patients undergoing hemodialysis therapy. The results obtained are satisfactory, and the research will be continued.

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Prevalence of overweight and obesity in professional soldiers of the Czech army over a 11-year period

Vojnosanitetski pregled ◽

10.2298/vsp141120112f ◽

2016 ◽

Vol 73 (5) ◽

pp. 422-428 ◽

Cited By ~ 10

Author(s):

Jana Fajfrová ◽

Vladimír Pavlík ◽

Jan Psutka ◽

Michaela Husarová ◽

Pavla Krutisová ◽

...

Keyword(s):

Body Weight ◽

Waist Circumference ◽

Biochemical Parameters ◽

Armed Forces ◽

Communicable Diseases ◽

Overweight And Obesity ◽

Anthropometric Parameters ◽

Non Communicable Diseases ◽

Normal Body ◽

Normal Body Weight

Background/Aim. Obesity is currently considered to be the most frequent metabolic disease worldwide, not only in developed but also in developing countries. The aim of this work was to describe the development of health status in soldiers of the Armed Forces of the Czech Republic (ACR) and to emphasize the markers of non-communicable diseases. Our study describes the anthropometric and biochemical parameters of a large group of Czech Army professional soldiers. Data were obtained over a period of 11 years. Methods. During the monitored period, from 1999 to 2009, military physicians carried out on the average 6,360 examinations on professional soldiers per year and monitored their health and nutritional status with the aim of preventing the risk factors of non-communicable diseases. These examinations are compulsory for all professional soldiers at the age of 25, 30, 33, and 36 years. From the age of 39, these examinations are carried out every year till the end of their career. Besides taking personal histories and carrying out standard physical examinations, blood was taken for biochemical examination. The following anthropometric parameters were monitored: body constitution using body mass index (BMI) and waist circumference. Our study describes only part of the data concerning anthropometric and biochemical parameters of professional soldiers which were obtained over a period of 11 years. Results. Average BMI values in men were in the overweight range (26.5-27 kg/m2). Average values of waist circumference, however, ranged from 91.9 cm to 93.4 cm. Between the first and the last year of monitoring a statistically significant decrease in these values ranging from 93.4 ? 9.8 cm to 92.7 ? 9.5 cm (p < 0.001) was observed. All monitored anthropometric parameters in female professional soldiers were within normal limits. During the monitored period the proportion of overweight men gradually increased from 52% to 57.1% (p < 0.001). There were no statistically significant changes in the prevalence of obesity in men (12-15%). Average glycaemia levels were within normal range in both men and women. A statistically significant decrease in these levels, however, was observed in men (from 5.1 ? 0.9 mmol/L to 4.8 ? 0.7 mmol/L (p < 0.001) and in women (from 4.9 ? 0.6 mmol/L to 4.6 ? 0.6 mmol/L (p < 0.001). Concerning the lipid profile in men, a significant decrease in average values of total cholesterol, triglycerides and LDL cholesterol was observed; from 5.5 ? 1.1 mmol/L to 5.1 ? 1.0 mmol/L (p < 0.001), from 2.0 ? 1.6 mmol/L to 1.6 ? 1.2 mmol/L (p < 0.001) and from 3.4 ? 1.1 mmol/L to 3.2 ? 0.9 mmol/L (p < 0.001), respectively. Conclusion. During the monitored period only one-third of military professionals had normal body weight. More favorable situation was in female professional soldiers, two-thirds of them had normal body weight during the monitored period. Additionally, the increase in the number of individuals with BMI values in the overweight range was observed. Although the number of overweight soldiers was overestimated as a result of the inclusion of individuals with increased body weight due to well-developed musculature, the number of overweight and obese soldiers is still high.

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Detection and Assessment of Interleukin 6 in Irreversible Pulp Inflamation

Revista de Chimie ◽

10.37358/rc.17.2.5445 ◽

2017 ◽

Vol 68 (2) ◽

pp. 323-327

Author(s):

Cristian Levente Giuroiu ◽

Maria Vataman ◽

Gabriel Melian ◽

Dragos Bularda ◽

Ludmila Lozneanu ◽

...

Keyword(s):

Dental Caries ◽

Interleukin 6 ◽

Dental Pulp ◽

The Other ◽

Control Group ◽

Study Group ◽

Pulp Tissue ◽

Immunohistochemical Technique ◽

Systemic Distribution ◽

Cell Zone

The study aimed to assess the number, localization and distribution of interleukin 6 (IL-6) positive cells in healthy pulp, acute and chronic pulpitis. The study group included 48 patients aged between 18-72, treated in University of Medicine and Pharmacy Grigore T. Popa Iasi, Romania. The pulpectomy was performed on 42 patients diagnosed with acute and chronic pulpitis. The other 6 patients, without signs of dental caries or periodontal disease, were submitted to extractions of teeth for orthodontic purposes, with pulpectomy performed before extraction. The pulp samples were examined with optic microscope. The detection and assessment of IL-6 were performed using immunohistochemical technique. Data were statistically analysed using non-parametric tests. According to morphopathological criteria, 42.85% were classified as acute pulpitis and 57.14% as chronic pulpitis. The pulp samples in control group were not associated with IL-6 positive cells. The analysis of all samples with acute and chronic pulpitis identified 73.80% samples with IL-6 and 26.20% associated with the absence of IL-6. The highest frequency of IL-6 positive cells was recorded in rich-cell zone of crown dental pulp. The systemic distribution of IL-6 positive cells was mostly diffused without well-defined orientation. IL-6 release in acute and chronic pulpitis is significantly higher comparing with healthy pulp tissue.

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The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

Journal of Medical Biochemistry ◽

10.2478/v10011-012-0024-z ◽

2013 ◽

Vol 32 (1) ◽

pp. 26-31 ◽

Cited By ~ 1

Author(s):

Emina Čolak ◽

Dragana Pap ◽

Nada Majkić-Singh ◽

Ivana Obradović

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Liver Enzyme ◽

Body Mass ◽

Statistical Processing ◽

The Body ◽

Control Group ◽

Anthropometric Parameters ◽

Nonalcoholic Fatty Liver ◽

Increased Risk

Summary Background: It has been reported that obesity is associated with metabolic syndrome, insulin resistance, cardiovascular risk but also with nonalcoholic fatty liver disease (NAFLD). The prevalence of obesity in children and adolescents is increasing rapidly all over the world. The aim of this study was to analyze the value of liver enzymes: AST, ALT and γGT in a group of obese students in order to establish their correlation to anthropometric parameters such as: BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist-to-hip ratio) compared to non-obese students who comprised the control group (CG). Methods: In this study, 238 students from the University of Novi Sad of both sexes (126 men and 112 women) with a mean age of 22.32 ± 1.85 years were included. According to the body mass index (BMI) lower and higher than 25 kg/m2 and waist circumference (WC) lower and higher than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the obese group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). AST, ALT and γGT activities were determined in fasting blood samples. Results: Statistical processing data revealed significantly higher values of AST, ALT and γGT in the group of students with BMI>25 kg/m2, WC>94 cm for males and WC>80 cm for females, HC>108 cm for males and HC>111 cm for females, and WHR>0.90 for males and WHR>0.80 for females (P<0.001). Significant association was established between anthropometric parameters and liver enzyme levels (P<0.0001). Conclusions: Obese students with higher BMI, WC, HC and WHR values have higher liver enzyme activites and a higher chance to develop NAFLD in the future.

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Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

Journal of Evidence-Based Integrative Medicine ◽

10.1177/2515690x211011038 ◽

2021 ◽

Vol 26 ◽

pp. 2515690X2110110

Author(s):

Wiraphol Phimarn ◽

Bunleu Sungthong ◽

Hiroyuki Itabe

Keyword(s):

Body Mass Index ◽

Body Weight ◽

Blood Glucose ◽

Waist Circumference ◽

Lipid Profile ◽

Body Mass ◽

The Body ◽

Current Evidence ◽

Diabetic Patients ◽

Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

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Influence of Pesticide on Biochemical and Hematological Parameters in Beninese Vegetable Farmers

Journal of Biology and Life Science ◽

10.5296/jbls.v9i1.12461 ◽

2018 ◽

Vol 9 (1) ◽

pp. 65

Author(s):

Lucie AYI-FANOU

Keyword(s):

Blood Cell ◽

Biochemical Parameters ◽

Mean Corpuscular Volume ◽

Hematological Parameters ◽

Control Group ◽

Study Group ◽

Blood Samples ◽

Vegetable Farmers ◽

Insignificant Difference ◽

Hematological And Biochemical Parameters

In several countries, a lot of researches have shown the toxicity of pesticides on farmers. Meanwhile, few of them have dealt with vegetable farmers in Benin. Therefore, this study has been carried out to assess the effects of pesticides on vegetable farmers’ health. This study is conducted on 30 vegetable farmers who used pesticides and 20 subjects as control group. Pesticides used by vegetable farmers and their risky behavior were investigated. Their blood samples were collected and some tests were performed for hematological and biochemical parameters. For the statistical analysis of the results, Student’s test was used. Our investigations revealed that vegetable farmers of Benin were exposed to different active ingredients of pesticides such as (Abamectin, Acetamiprid, Chlorpyriphos ethyl, Cyfluthrin, Cypermethrin, Emamectin benzoat, Flubendiamid, Lambdacyhalothrin, Mancozeb, Profenofos, Spinosad and Spirotétramate). The hematological parameters showed significant decrease in White blood cell (WBC), Red blood cell (RBC), Hemoglobin (HGB), Hematocrit (HTC), Mean Corpuscular Volume (MCV), Platelet (PLT) count among study group. The enzymatic activities of Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) have significantly raised between vegetable farmers and the control group, while the serum concentration in urea and creatinine showed insignificant difference in the study group. These results suggest that pesticides have adverse effects on vegetable farmers of South of Benin.

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The Association of Circulating MiR-29b and Interleukin-6 with Subclinical Atherosclerosis

Cellular Physiology and Biochemistry ◽

10.1159/000485649 ◽

2017 ◽

Vol 44 (4) ◽

pp. 1537-1544 ◽

Cited By ~ 13

Author(s):

Yu-qing Huang ◽

Jie Li ◽

Ji-yan Chen ◽

Ying-ling Zhou ◽

An-ping Cai ◽

...

Keyword(s):

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Interleukin 6 ◽

Subclinical Atherosclerosis ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Control Group ◽

Study Group ◽

Circulating Levels

Background/Aims: Although it is widely acknowledged that atherosclerosis is mainly a chronic inflammatory process, in which both miR-29b and interleukin-6 (IL-6) play multifaceted roles, the association between miR-29b and IL-6 remains unknown. The aim of the present study was to explore the relationship between miR-29b and IL-6 and to test whether circulating levels of miR-29b and IL-6 could predict atherosclerosis. Methods: A total of 170 participants were divided into two groups according to carotid intima-media thickness (CIMT): study group (CIMT ≥ 0.9mm) and control group (CIMT < 0.9mm). Levels of circulating miR-29b and IL-6 were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The association of miR-29b and IL-6 levels with CIMT was assessed using Spearman correlation analysis and multiple linear regression analysis. Results: The study group showed higher miR-29b levels (31.61 ± 3.05 vs. 27.91 ± 1.71 Ct, p < 0.001) and IL-6 levels (3.40 ± 0.67 vs. 2.99 ± 0.37 pg/ml, p < 0.001), compared with the control group. CIMT was positively correlated with miR-29b (r = 0.587, p < 0.001) and IL-6 (r = 0.410, p < 0.001), and miR-29b levels were also correlated with IL-6 (r = 0.242, p = 0.001). Multiple linear regression analysis also showed that CIMT was positively correlated with miR-29b and IL-6. After adjustment for age, body mass index, systolic blood pressure, total cholesterol and C-reactive protein, CIMT was still closely correlated with miR-29b and IL-6. The combination of miR-29b and IL-6 (AUC = 0.901, p < 0.001) offered a better predictive index for atherosclerosis than either miR-29b (AUC = 0.867, p < 0.001) or IL-6 (AUC = 0.747, p < 0.001) alone. Conclusion: Circulating levels of miR-29b and IL-6 may be independently correlated with subclinical atherosclerosis, and may serve as novel biomarkers for the identification of atherosclerosis.

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A 90-Day Oral Toxicity of Hydroethanolic Root Extract of Carissa spinarum in Wistar Rats

Journal of Toxicology ◽

10.1155/2021/5570206 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Komlan M. Dossou-Yovo ◽

Aboudoulatif Diallo ◽

Povi Lawson-Evi ◽

Yendubé T. Kantati ◽

Tchin Darré ◽

...

Keyword(s):

Body Weight ◽

Biochemical Parameters ◽

Wistar Rats ◽

Hematological Parameters ◽

Relative Weight ◽

Control Group ◽

Root Extract ◽

Weight Changes ◽

Oral Toxicity ◽

Significant Difference

Background. Herbal medication is a worldwide and ancient practice, mostly in developing countries, where a large part of the population is involved in this practice. Hence, studies must be conducted to evaluate their safety and efficiency to avoid or prevent toxicological risks due to their usage. In Togo, Carissa spinarum is a medicinal plant belonging to Apocynaceae family, used as an aphrodisiac or to heal some ailments including malaria, sickle cell anemia, hypertension, pain, and asthma. Notwithstanding its several ethnomedicinal benefits, just a few toxicological data associated with its chronic use are available. Objective. Therefore, this study aims to assess the toxicity of an ethanolic root extract of Carissa spinarum in Wistar rats. Methods. The 90-day oral toxicity process following OECD TG 408 guidelines is used. Male Wistar rats received Carissa spinarum root hydroethanolic extract at 500 and 1000 mg/kg for 90 days by oral gavage. Body weight changes, hematological and blood biochemical parameters, organ weight changes, malondialdehyde as a lipoperoxidation marker expressed according to tissue proteins, and histopathology of vital organs were assessed. Results. No signs of toxicity or mortality were observed during the 90 days experiment. Hematological parameters have not shown any treatment-related abnormalities. According to biochemical parameters, an increase in the chloride ion level was observed at 1000 mg/kg p < 0.01 . There was no significant difference between the treated groups and the control group concerning the malondialdehyde concentration, body weight, and organ relative weight. No changes in necropsy and histopathology of vital organs associated with extract treatment were observed. Conclusion. The results indicated that an ethanolic root extract of Carissa spinarum does not cause adverse effects, which can lead to Wistar rats’ death after 90-day oral administration at 500 and 1000 mg.

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PHYSICAL DEVELOPMENT OF CHILDREN OF PRESCHOOL AGE

Trakia Journal of Sciences ◽

10.15547//tjs.2020.s.01.148 ◽

2020 ◽

Vol 18 (Suppl.1) ◽

pp. 903-907

Author(s):

T. Traykova

Keyword(s):

Body Weight ◽

Physical Development ◽

Preschool Age ◽

Chest Circumference ◽

Control Group ◽

Physical Culture ◽

Educational Content ◽

Anthropometric Parameters ◽

Basic Parameters ◽

Experimental Group

Purpose of the study: To register the dynamics of the basic parameters of the physical development of children from the fourth preparatory group, as a result of the implementation of an enriched educational content in physical culture pedagogical situations. 54 girls and 67 boys were investigated and measured twice – at the beginning and at the end of the pedagogical experiment. Anthropometric parameters assessed: height, body weight, chest circumference. Methods: Theoretical analysis, pedagogical experiment, anthropometry, statistical methods. Results: Height: the highest increase in that parameter was found in the Experimental Group of boys and the smallest one – in girls of the Control group. Body weight: boys from the EG showed the highest increase, while the lowest one was found in boys from CG. Chest circumference: the greatest increase was measured in CG of, while the smallest one in the EG of girls. In conclusion, we can underline that the changes in the anthropometric parameters are due both to the laws of biological developments of children at that age, as well as to the applied enriched educational content.

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Wpływ nadwagi i otyłości na stan zdrowia jamy ustnej dzieci i młodzieży

Nowa Stomatologia ◽

10.25121/ns.2019.24.3.108 ◽

2019 ◽

Vol 24 (3) ◽

Author(s):

Katarzyna Deszczyńska ◽

Paweł Piątkiewicz ◽

Renata Górska

Keyword(s):

Risk Factors ◽

Body Mass Index ◽

Body Weight ◽

Oral Cavity ◽

Oral Hygiene ◽

Overweight And Obesity ◽

Control Group ◽

Study Group ◽

Obese Children ◽

Periodontal Health

Introduction. Improper eating habits among children and adolescents often lead to overweight and obesity. Research indicates that these are risk factors for many diseases, including diseases in the oral cavity. Aim. To analyse the correlations of selected parameters of dental and periodontal health as well as oral hygiene status in overweight and obese children and adolescents versus control group. Material and methods. The study included 120 patients aged 11-18 years, who were classified into a study group with 60 overweight/obese individuals and a control group of 60 individuals with normal body weight based on BMI (Body Mass Index). Each patient underwent anthropometric measurements, such as height (cm), body weight (kg), which were used to calculate BMI (Body Mass Index). Additional measurements were taken of waist circumference (WC) and hip circumference (HC), to obtain the waist-hip ratio (WHR). Clinical examination of the oral cavity included an assessment of dentition (DMF), oral hygiene API (Approximal Plaque Index) and periodontal tissue (PD – Pocket Depth, CAL – Clinical Attachment Level, %BOP – % Bleeding On Probing) and CPITN (The Community Periodontal Index for Treatment Needs). Results. Statistically significant differences were found between patient groups with BMI ≥ 25 and BMI < 25 in the values of the following parameters: DMF p = 0.005, API p < 0.001, %BOP p < 0.001, PD p < 0.001, CPI p < 0.001. Conclusions. Overweight and obese children were found to have have worse parameters of dental and periodontal health as well as oral hygiene status compared to the group with normal weight. Our observations indicate that overweight and obesity may be potential risk factors for periodontal diseases in the study group.

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Amisulpride - An Athypical Antipsychotic?

Acta Medica Marisiensis ◽

10.1515/amma-2015-0072 ◽

2015 ◽

Vol 61 (4) ◽

pp. 337-341

Author(s):

Echim George ◽

Sorina Cucuiet ◽

Bianca Osz ◽

Alexandra Grosan ◽

Gal Zsolt ◽

...

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Biochemical Parameters ◽

Low Dose ◽

Body Weight Gain ◽

Control Group ◽

Initial Weight ◽

Glucose Levels ◽

Blood Glucose Concentrations ◽

Different Doses

AbstractAim: the purpose of the present study was to determine the effects of amisulpride at different doses on body weight, glucidic and lipidic metabolism.Material and method: Thirty-six white Wistar rats were treated daily for 9 weeks with amisulpride 1mg/kg and 10mg/kg body weight. Another group received distilled water and served as control group. At the end of the treatment period blood samples were collected and the follow biochemical parameters were determined: serum cholesterol, triglycerides, blood glucose, GOT, GPT. Body weight gain was also assessed weekly.Results: After treatment with amisulpride in doses of 1mg/kg and 10 mg/kg for a period of nine weeks, weight gains were recorded for both groups compared with the initial weight and the control group. Blood glucose concentrations in the group treated with 1 mg amisulpride/kg body weight were significantly increased (p<0.05 vs control group), but in the group treated with 10 mg/kg body weight glucose levels were not statistically significant increased compared to controls. Other biochemical parameters (cholesterol, triglycerides, GOT, GPT) showed no statistically significant differences compared to control group.Conclusions: amisulpride administered over a period of 9 weeks, in doses of 1mg/kg and 10mg/kg showed a slight increase of body weight regardless of gender, increased blood glucose only when was administered in the low dose, and does not affect lipid metabolism, even though decreased cholesterol and triglycerides levels. This results highlight a real benefit of treatment with amisulpride, comparatively with other athypical antipsychotics.

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