scholarly journals Multidisciplinary Investigations on Galphimia glauca: A Mexican Medicinal Plant with Pharmacological Potential

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2985 ◽  
Author(s):  
Ashutosh Sharma ◽  
Paola Angulo-Bejarano ◽  
Alfredo Madariaga-Navarrete ◽  
Goldie Oza ◽  
Hafiz Iqbal ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Cytotoxic Activities ◽  
Endemic Plant ◽  
Traditional Use ◽  
Commercial Exploitation ◽  
Knowledge Based ◽  
Comprehensive Information ◽  
Comprehensive Knowledge ◽  
Pharmacological Potential

Galphimia glauca (Cav.) Kuntze is an important endemic plant species, which possesses many medicinal properties and has been used in the Mexican traditional medicine for its sedative, anxiolytic, anticonvulsant, antiasthmatic and antiallergic properties. The therapeutic properties of this plant are mainly due to the presence of diverse bioactive compounds such as flavonoids, triterpenoids, and phenolics. Several triterpenoids and flavonoids compounds have been isolated and identified. Modern studies have demonstrated many biological activities such as anti-inflammatory, antidiarrheal, gastroenteritis, antimalarial and cytotoxic activities. Nevertheless, many studies are restricted to the crude extract, and many bioactive compounds are yet to be identified and validated according to its traditional use. However, its commercial exploitation and use are highly limited due to the non-availability of enough plant material and lack of knowledge about its agronomical practices. Moreover, the misinterpretation and mislabeling of closely related species of the genus Galphimia Cav. as G. glauca or G. gracilis is a common problem for its rigorous scientific study and commercial exploitation. The present review provides comprehensive knowledge based on the available scientific literature. To the best of our knowledge, this is the first review on G. glauca. This comprehensive information will certainly provide a guide for the better understanding and utilization of G. glauca for its scientific and industrial exploitation.

scholarly journals Ethnomedicinal Use, Phytochemistry, Pharmacology, and Toxicology of Salvia verbenaca L. : A Review

2021 ◽  
Vol 12 (2) ◽  
pp. 1437-1469
Keyword(s):  
Essential Oils ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Traditional Use ◽  
Toxicological Effects ◽  
Stomach Pain ◽  
Toxicological Investigation ◽  
Phytochemical Compounds

Salvia verbenaca L. is a Mediterranean medicinal plant used traditionally to treat several diseases such as burns, ocular wounds, contusion, stomach pain, eye diseases, dermal inflammation. This review highlighted previous reports, including the botanical, taxonomical, geographical distribution, traditional use, phytochemical, biological, and toxicological effects of S. verbenaca. The data were gathered from scientific databases PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, SpringerLink. The presented data on S. verbenaca were organized according to ethnomedicinal use, bioactive compounds, pharmacology, and toxicological investigation. Ethnobotanical studies reported that many folk medicines use S. verbenaca, especially against wounds, burns, and cicatrization. The phytochemical compounds in different parts of S. verbenaca belonged to different classes of chemical compounds, including terpenoids, flavonoids, phenolic acids, phenolic diterpenoids, and fatty acids. The extracts and essential oils from S. verbenaca have a wide variety of in vitro and in vivo pharmacological activities, i.e., antioxidant, antifungal, antidiabetic, anti-inflammatory, antitumor, antihemolytic, antihypertensive, antileishmanial, and immunomodulatory activities. This research suggests that the biological activities of S. verbenaca prove its traditional uses. However, in-depth investigations are required, such as pharmacokinetic, pharmacodynamic, and toxicological experiments, to prove the efficacy and safety of S. verbenaca extracts and essential oils and their bioactive compounds.

scholarly journals Phytochemicals Derived from Catharanthus roseus and Their Health Benefits

Technologies ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 80
Author(s):  
Hong Ngoc Thuy Pham ◽  
Quan Van Vuong ◽  
Michael C. Bowyer ◽  
Christopher J. Scarlett
Keyword(s):  
Bioactive Compounds ◽  
Catharanthus Roseus ◽  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Health Benefits ◽  
Traditional Use ◽  
Human Cancer Cell Lines ◽  
Promising Source

Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Remarkably, vinblastine and vincristine isolated from this plant were the first plant-derived anticancer agents deployed for clinical use. Recently, new isolated indole alkaloids from this plant including catharoseumine, 14′,15′-didehydrocyclovinblastine, 17-deacetoxycyclovinblastine and 17-deacetoxyvinamidine effectively inhibited human cancer cell lines in vitro. Moreover, vindoline, vindolidine, vindolicine and vindolinine isolated from C. roseus leaf exhibited in vitro antidiabetic property. These findings strongly indicate that this plant is still a promising source of bioactive compounds, which should be further investigated. This paper provides an overview of the traditional use and phytochemical profiles of C. roseus, and summarises updated techniques of the preparation of dried material, extraction and isolation of bioactive compounds from this plant. In addition, purported health benefits of the extracts and bioactive compounds derived from this plant were also addressed to support their potential as therapeutic agents.

scholarly journals Biological Activities and GCMS Analysis of the Methanolic Extract of Christia vespertilionis (L.F.) Bakh. F. Leaves

2020 ◽  
Vol 4 (1) ◽  
pp. 78-88
Author(s):  
Zahidah Nasuha Mohd Yasin ◽  
Muhammad Asyaari Zakaria ◽  
Nik Nor Imam Nik Mat Zin ◽  
Nadiah Ibrahim ◽  
Fatin Sofia Mohamad ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Bioactive Compounds ◽  
Methanolic Extract ◽  
Antimalarial Activity ◽  
Biological Activities ◽  
Cytotoxic Activities ◽  
Chemical Compositions ◽  
Ic50 Value ◽  
Nih 3T3 ◽  
Mcf 7

Christia vespertilionis (L.F) Bakh. F. (red butterfly wing) is commonly used as a herbal medicine to treat symptoms of many diseases. The present study aimed to determine the in vitro antimalarial and cytotoxic activities as well as investigate the chemical compositions of the methanolic extract of C. vespertilionis leaves (CVME). The antimalarial activity of CVME against a chloroquine-sensitive (3D7) strain of Plasmodium falciparum was assessed by using a malarial SYBR Green I fluorescence-based (MSF) assay. The cytotoxic effect of CVME on cancerous (MDA-MB-231 and MCF-7) and noncancerous (NIH/3T3) cell lines were evaluated by using methyl tetrazolium (MTT) assay. Chemical constituents of CVME were analysed by using a gas chromatography/mass spectrometry (GCMS). CVME exhibited a moderate antimalarial activity with an IC50 value of 43.87 ± 2.04 µg/mL. CVME is considered as weak cytotoxic and significantly inhibited proliferation of MDA-MB-231 cells with an IC50 value of 37.45 ± 1.05 µg/mL (p<0.05) as compared to standard MCF-7 (IC50>100 μg/mL) and NIH/3T3 cells (IC50>100 μg/mL). This effect is selectively cytotoxic towards certain cancerous cells only. GCMS analysis suggests that CVME potentially contains several pharmacologically bioactive compounds such as tetrahydro-2-methyl- thiophene (61.77%), phytol (8.59%), 10-undecenoic acid (5.00%), 6-methyl heptyl-2-propanoate  (4.96%) and 2-(2-benzothiazolylthio)-1-(3,5-dimethylpyrazolyl)-ethanone  (2.70%) that might possess antimalarial and cytotoxic activities. It implies that CVME has selective cytotoxic activity against the breast cancer cell line (MDA-MB-231) and possesses an antimalarial activity against the 3D7 malaria parasite, suggesting the presence of bioactive compounds in C. vespertilionis leaves that could be a potential source of phytochemicals with high medicinal value to be used in cancer and malaria treatment.     Keywords: Christia vespertilionis, antimalarial activity, anticancer activity, cytotoxic activity, bioactive compounds.

scholarly journals Medicinal Uses, Phytochemistry, and Pharmacological Activities of Quercus Species

2020 ◽  
Vol 2020 ◽  
pp. 1-20 ◽  
Author(s):  
Mehdi Taib ◽  
Yassine Rezzak ◽  
Lahboub Bouyazza ◽  
Badiaa Lyoussi
Keyword(s):  
Bioactive Compounds ◽  
Biological Activities ◽  
Gastric Ulcers ◽  
Cytotoxic Activities ◽  
Medicinal Uses ◽  
Quercus Species ◽  
Human Disorders ◽  
Available Information ◽  
Potential Use

Quercus species, also known as oak, represent an important genus of the Fagaceae family. It is widely distributed in temperate forests of the northern hemisphere and tropical climatic areas. Many of its members have been used in traditional medicine to treat and prevent various human disorders such as asthma, hemorrhoid, diarrhea, gastric ulcers, and wound healing. The multiple biological activities including anti-inflammatory, antibacterial, hepatoprotective, antidiabetic, anticancer, gastroprotective, antioxidant, and cytotoxic activities have been ascribed to the presence of bioactive compounds such as triterpenoids, phenolic acids, and flavonoids. This paper aimed to provide available information on the medicinal uses, phytochemicals, and pharmacology of species from Quercus. However, further investigation is needed to fully clarify the mode of action of its bioactive compounds and to evaluate in vivo chronic toxicity, before exploring their potential use as a supplement in functional foods and natural pharmaceutics.

scholarly journals Conventional Medicinal Uses, Phytoconstituents, and Biological Activities of Euphorbia officinarum L.: A Systematic Review

2022 ◽  
Vol 2022 ◽  
pp. 1-9
Author(s):  
Imane Chamkhi ◽  
Mohamed Hnini ◽  
Jamal Aurag
Keyword(s):  
Bioactive Compounds ◽  
Therapeutic Potential ◽  
Conventional Medicine ◽  
Intestinal Parasites ◽  
Biological Activities ◽  
Research Question ◽  
Chemical Diversity ◽  
Human Pathogens ◽  
Endemic Plant ◽  
Medicinal Uses

The Moroccan endemic plant Euphorbia officinarum is a traditional medicinal plant, known locally as “Daghmus.” Plants in the genus Euphorbia are well known for the chemical diversity of their diterpenoids and isoprenoid constituents, which perform many activities such as cytotoxic, antimicrobial, and anti-inflammatory activities, as well as different biological properties, that cannot be overlooked. The effect of bioactive compounds (antiviral, antidiabetic, anticancer, and antioxidant). Euphorbia officinarum is an important conventional medicine for the treatment of various conditions, including skin and ophthalmological diseases. It is also used against human pathogens (intestinal parasites). E. officinarum latex is the major part of the plant used for conventional medicine and synthesizing new bioactive compounds. The characterization and isolation of its components are necessary to exploiting and enhancing its therapeutic potential. However, to the best of our knowledge, no review is available to date. In order to have and define a research question, we adopt a strategy by considering the items of the PRISMA checklist. Therefore, this review aims to cover E. officinarum taxonomy, botanical description, distribution, conventional uses, and phytochemical compounds of this plant, including the biological activities of compounds isolated and of these semisynthesized compounds. This article provides a foundation for any further studies from this plant.

Pharmacologically potentials of different substituted coumarin derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Benzene Ring ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Pharmacological Properties ◽  
Coumarin Derivatives ◽  
Wide Range ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Coumarin Compounds

Coumarin and its derivatives are widely spread in nature. Coumarin goes to agroup as benzopyrones, which consists of a benzene ring connected to a pyronemoiety. Coumarins displayed a broad range of pharmacologically useful profile.Coumarins are considered as a promising group of bioactive compounds thatexhibited a wide range of biological activities like anti-microbial, anti-viral,antiparasitic, anti-helmintic, analgesic, anti-inflammatory, anti-diabetic, anticancer,anti-oxidant, anti-proliferative, anti-convulsant, and antihypertensiveactivities etc. The coumarin compounds have immense interest due to theirdiverse pharmacological properties. In particular, these biological activities makecoumarin compounds more attractive and testing as novel therapeuticcompounds.

Naphthoquinone-based hydrazone hybrids: synthesis and potent activity against cancer cell lines

2020 ◽  
Vol 16 ◽  
Author(s):  
Délis Galvão Guimarães ◽  
Arlan de Assis Gonsalves ◽  
Larissa Araújo Rolim ◽  
Edigênia Cavalcante Araújo ◽  
Victória Laysna dos Anjos Santos ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Biological Activities ◽  
Supporting Electrolyte ◽  
Cancer Cell Lines ◽  
Molecular Structures ◽  
Cytotoxic Activities ◽  
Electrochemical Studies ◽  
Ic50 Values

Background: Natural naphthoquinones have shown diversified biological activities including antibacterial, antifungal, antimalarial, and cytotoxic activities. However, they are also compounds with acute cytotoxicity, immunotoxicity, carcinogenesis, and cardio- and hepatotoxicity, then the modification at their redox center is an interesting strategy to overcome such harmful activity. Objective: In this study, four novel semisynthetic hydrazones, derived from the isomers α- and β-lapachones (α and β, respectively) and coupled with the drugs hydralazine (HDZ) and isoniazid (ACIL), were prepared, evaluated by electrochemical methods and assayed for anticancer activity. Method: The semisynthetic hydrazones were obtained and had their molecular structures established by NMR, IR, and MS. Anticancer activity was evaluated by cell viability determined by reduction of 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide (MTT). The electrochemical studies, mainly cyclic voltammetry, were performed, in aprotic and protic media. Result: The study showed that the compounds 2, 3, and 4 were active against at least one of the cancer cell lines evaluated, being compounds 3 and 4 the most cytotoxic. Toward HL-60 cells, compound 3 was 20x more active than β-lapachone, and 3x more cytotoxic than doxorubicin. Furthermore, 3 showed an SI value of 39.62 for HL-60 cells. Compound 4 was active against all cancer cells tested, with IC50 values in the range 2.90–12.40 μM. Electrochemical studies revealed a profile typical of self-protonation and reductive cleavage, dependent on the supporting electrolyte. Conclusion: These results therefore indicate that compounds 3 and 4 are strong candidates as prototypes of new antineoplastic drugs.

Design, Synthesis, Anti-Proliferative Evaluation and Cell Cycle Analysis of Hybrid 2-Quinolones

2019 ◽  
Vol 19 (9) ◽  
pp. 1132-1140
Author(s):  
Heba A.E. Mohamed ◽  
Hossa F. Al-Shareef
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Flow Cytometric Analysis ◽  
Annexin V ◽  
Cytotoxic Activities ◽  
Significant Group ◽  
Design Synthesis ◽  
Standard Drug ◽  
Wide Range

Background: Quinolones are a significant group of nitrogen heterocyclic compounds that exist in therapeutic agents, alkaloids, and synthetic small molecules that have important biological activities. A wide range of quinolones have been used as antituberculosis, antibacterial, anti-malarial, antifungal, anticonvulsant, anticancer agents and urease inhibitors. Methods: Ethyl 3,3-disubstituted-2-cyano propionates containing hybride quinolones derivatives were synthesized by the reaction of 1-amino-7-hydroxy-4-methylquinolin-2(1H)-one and its dibromo derivative with α, β-unsaturated carbonyl in ethanol. Results: A novel series of hybrid 2-quinolone derivatives was designed and synthesized. The compounds structures were confirmed using different spectroscopic methods and elemental analysis. The cytotoxic activities of all the compounds were assessed against HepG2 cell line in comparison with doxorubicin as a standard drug. Conclusion: Most compounds revealed superior anti-proliferative activity than the standard. Compound 4b, is the most active compound (IC50 = 0.39mM) compared with doxorubicin (IC50 = 9.23mM). DNA flow cytometric analysis of compound 4b showed cell cycle arrest at G2/M phase with a concomitant increase of cells in apoptotic phase. Dual annexin-V/ propidium iodide staining assay of compound 4b revealed that the selected candidate increased the apoptosis of HepG-2 cells more than control.

A Prospective Review on Phyto-pharmacological Aspects of Vitex negundo Linn.

2019 ◽  
Vol 05 ◽  
Author(s):  
Mohd Faisal Khan ◽  
Poonam Arora ◽  
Mahaveer Dhobi
Keyword(s):  
Chlorogenic Acid ◽  
Biological Activities ◽  
Volatile Oil ◽  
Vitex Negundo ◽  
Bioactive Constituents ◽  
Traditional System ◽  
Comprehensive Information ◽  
Medicinal Properties ◽  
Main Components ◽  
Important Drug

Background: Vitex negundo Linn. commonly known as five leave chase tree is an ethnobotanically important drug in traditional system of medicine. The plant is widely distributed in India, China and other Asian and American countries. Objective: The review aims at presenting comprehensive information with respect to ethnopharmacological rele-vance and recent findings on phytochemical and biological activities of Vitex negundo. Method: Literature was collected from various sources such as pubmed, scopus, science direct, and others. Results: Extracts and secondary metabolites of this plant, particularly those from roots and leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant, antimicrobial, galactagogue, antigas-tric, antiflatulant, antiparasitic, analgesic, hepatoprotective and antihypertensive, some of which have been vali-dated scientifically. All parts of plant especially leave and roots contain a large number of bioactive phytoconstitu-ents including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal compounds which impart it multiple medicinal properties. Vitexin, isovitexin, viridifol, caffeic acid, chlorogenic acid and iso-chlorogenic acid are the main components. Conclusion: The review emphasises the medicinal importance of Vitex negundo and its bioactive constituents in traditional system of medicine.

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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