scholarly journals ANTI-CANCER ACTIVITY OF CUMINUM CYMINUM: A REVIEW.

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
NIKHIL ARUN CHAUDHARI ◽  
NINAD SATHE
Keyword(s):  
Biologically Active ◽  
Research Papers ◽  
Cuminum Cyminum ◽  
Current Review ◽  
Therapeutic Value ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Constituents ◽  
Herbal Plant ◽  
Cancer Activity

Jeeraka, commonly known as cumin (Cuminum cyminum Linn.) (Family: Umbelliferae), is a popular herbal plant in traditional ayurvedic medicine, which has since long used as antioxidant, gastric stimulant, anti-flatulence, anti-diarrheal, sprue, anthelmintic, galactagogue, diuretic, astringent, carminative. This plant is pharmacologically and clinically evaluated for various activities like antioxidant, aphrodisiac, antimicrobial, hepato-protective, and anti-inflammatory. It is promulgated to possess a wide range of many phytochemical constituents. The current review is presented to give a comprehensive account of all anti-cancer activities of cumin. It will be helpful to create interest towards cumin and may be useful in developing new and economical anti-cancer formulations with more therapeutic value. The part used of the selected plant is seed. As per retrospective review cumin seed, its essential oil, ethanoic extract and 1­(2­Ethyl, 6­Heptyl) Phenol (EHP), a biologically active compound formerly extracted by benzene are found having anti-cancer activity against 13 different cell lines of various origins and 6 animal models. Also, it can be used as chemopreventive ingredient in the herbal anti-cancer formulation. Total 8 research articles, peer viewed research papers, abstracts and classical texts were reviewed.

scholarly journals New Insights into Molecular Mechanism behind Anti-Cancer Activities of Lycopene

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3888
Author(s):  
Boon-Peng Puah ◽  
Juriyati Jalil ◽  
Ali Attiq ◽  
Yusof Kamisah
Keyword(s):  
Immune Cells ◽  
Scientific Evidence ◽  
Special Role ◽  
Real Potential ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
The Relationship ◽  
Cancer Activity ◽  
Reduced Risk

Lycopene is a well-known compound found commonly in tomatoes which brings wide range of health benefits against cardiovascular diseases and cancers. From an anti-cancer perspective, lycopene is often associated with reduced risk of prostate cancer and people often look for it as a dietary supplement which may help to prevent cancer. Previous scientific evidence exhibited that the anti-cancer activity of lycopene relies on its ability to suppress oncogene expressions and induce proapoptotic pathways. To further explore the real potential of lycopene in cancer prevention, this review discusses the new insights and perspectives on the anti-cancer activities of lycopene which could help to drive new direction for research. The relationship between inflammation and cancer is being highlighted, whereby lycopene suppresses cancer via resolution of inflammation are also discussed herein. The immune system was found to be a part of the anti-cancer system of lycopene as it modulates immune cells to suppress tumor growth and progression. Lycopene, which is under the family of carotenoids, was found to play special role in suppressing lung cancer.

Anti-cancer activity of the HIV accessory molecule viral protein R (Vpr): Delivery as a DNA expression plasmid or biologically active peptides

Vaccine ◽  
2010 ◽  
Vol 28 (8) ◽  
pp. 2005-2010 ◽  
Author(s):  
Karrupiah Muthumani ◽  
Vance M. Lambert ◽  
Omkar Kawalekar ◽  
Richard Heller ◽  
J. Joseph Kim ◽  
...  
Keyword(s):  
Viral Protein ◽  
Biologically Active ◽  
Expression Plasmid ◽  
Active Peptides ◽  
Viral Protein R ◽  
Anti Cancer ◽  
Biologically Active Peptides ◽  
Accessory Molecule ◽  
Cancer Activity

scholarly journals Phytoecdysteroids: Chemical Structure And Biological Activity

2021 ◽  
Author(s):  
Zh.S. Akhmetkarimova ◽  
B.S. Temirgaziev
Keyword(s):  
Herbal Remedy ◽  
Biological Effects ◽  
Food Additives ◽  
Biologically Active ◽  
Biochemical Processes ◽  
Wide Range ◽  
Anti Cancer ◽  
Therapeutic Properties ◽  
Polyhydroxylated Sterols ◽  
The Brain

Owing to the need to develop new medicines and biologically active food additives with adaptogenic effects, phytoecdysteroids – polyhydroxylated sterols-are of great interest. Different types of drugs, extracts and individual compounds, have a wide range of pharmacological effects on several organs, such as the brain, blood, cardiovascular and nervous systems, as well as on various biochemical processes and physiological functions. Extracts and preparations from plants are safe and exhibit additional biological effects (antioxidant, immunomodulatory, anti-cancer, antimicrobial, antiparasitic and antifidant). Data on the chemical, pharmacological, and toxicological characteristics of R. carthamoides demonstrate that this species has beneficial therapeutic properties, and indicate its potential as an effective adaptogenic herbal remedy.

scholarly journals Myristica fragrans (Jaiphal): A Significant Medicinal Herbal Plant

2021 ◽  
Vol 8 (2) ◽  
pp. 213-224
Author(s):  
Isha Kumari ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Herbal Remedies ◽  
Herbal Drugs ◽  
Myristica Fragrans ◽  
Therapeutic Uses ◽  
Wide Range ◽  
Anti Cancer ◽  
The World ◽  
Anti Oxidant ◽  
Myristica Fragrans Houtt ◽  
Herbal Plant

The tradition of using herbal drugs and herbal remedies for treating human ailments is very old. From last few years, the demand of herbal remedies has been increased. Myristica fragrans Houtt, commonly known as nutmeg, is a very common spice, which is used around the world. It is described in almost each medicine system such as Ayurveda, Siddha, Unani and folk system. It has wide range of fixed oils and essential oils in it for example myristicin, safrole, myristic acid, trimyristicin, eugenol, elimicin and meso-dihydroguaiaretic acid. Myristica fragrans Houttis well considered medicinal plant for its extraordinary properties like aphrodisiac, hepatoprotective, antimicrobial, anti-diabetic, anti-oxidant, anti-cancer etc. The review aim is to provide data/information related to medicinal herbal plant called Myristica fragrans such as its phytomedicinal value in traditional medicine systems like Ayurveda and folk system, its therapeutic uses and associated toxicity.

scholarly journals Effect of Sodium Fluoride (NaF) Exposure on Heart: Protective Effect of Eugenol with Reference to the Lipid Metabolic Profiles

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Srinivas K ◽  
Shanmugam K. R. ◽  
Shanmugam B. ◽  
Venkatasubbaiah G. ◽  
Ravi S. ◽  
...  
Keyword(s):  
Protective Effect ◽  
Effective Treatment ◽  
Sodium Fluoride ◽  
Review Article ◽  
Metabolic Profiles ◽  
Wide Range ◽  
Anti Cancer ◽  
Phytochemical Compounds ◽  
Anti Oxidant ◽  
Cancer Activity

Flavonoids are phytochemical compounds found in a variety of plants, fruits, vegetables, leaves, and barks, it offers a wide range of health benefits. Quercetin is a polyphenolic flavonoid that is found in onions, apples, berries, broccoli, grapes, nuts, cherries and many other food products. Pharmacologically, quercetin has been examined for various disorders and is reported to possess the ability to prevent as well as treat them. It possesses anti-oxidant, anti-allergic, anti-inflammatory, anti-viral and anti-cancer activity as well. Developing suitable formulation for the delivery of quercetin to specific site leads to better compliance and effective treatment of the disease. This review article highlights the beneficiary activities exhibited by quercetin along with the mechanism behind its activity, followed by reporting the different quercetin formulations developed in last few years.

scholarly journals Evaluation of Hemidesmus indicus Plant Compounds for Anti-Cancer Studies – An In silico Approach

2021 ◽  
pp. 64-69
Author(s):  
Pavan Kumar Tummala ◽  
Sreeja Nannapaneni ◽  
Sumana Pratyusha Durvasula ◽  
Supriya Chadalavada ◽  
Sunandini Venigandla ◽  
...  
Keyword(s):  
Conventional Medicine ◽  
Hemidesmus Indicus ◽  
Alternative Medicines ◽  
Medicinal Plant Extracts ◽  
Wide Range ◽  
Anti Cancer ◽  
Ethanolic Extracts ◽  
Cyclohexane Carboxylate ◽  
Cancer Studies ◽  
Cancer Activity

Background: Phytocompounds in medicinal plants have a wide range of properties and are alternative medicines for those who cannot be helped by conventional medicine. Objective: In this work we have selected bioactive compounds from Hemidesmus indicus medicinal plant extracts. Methods: Gas chromatography and Mass spectrum studies were studied to identify the compounds present in the ethanolic extracts based on the retention time and area. Results: The identified compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Conclusion: Out of twenty selected compounds, docking results showedMethyl-1-Cyclohexane carboxylate and 1,2-diacetoxy-5-idohexane as best docked to the BCL-2.

Design, Synthesis and Biological Activity Evaluation of Novel N-Acylation Substituted Isatin Derivatives

2013 ◽  
Vol 683 ◽  
pp. 34-37
Author(s):  
Bin Zeng ◽  
Xiao Hua Zhu
Keyword(s):  
Human Cancer ◽  
Biological Activities ◽  
Human Cancer Cell ◽  
Design Synthesis ◽  
Design And Synthesis ◽  
Wide Range ◽  
Anti Cancer ◽  
Endogenous Compound ◽  
Isatin Derivatives ◽  
Cancer Activity

Isatin, an endogenous compound existent in many organisms, shows a wide range of biological activities. In this paper, we like to report the design and synthesis of several isatin derivatives through the acetalization and N-Acylation. Six newly synthesized compounds were characterized on the basis of 1H NMR, and those compounds were determined using two different human cancer cell . Anti-cancer activity showed those compounds IC50＜50 μm.

scholarly journals Genistein: A Potent Anti-Breast Cancer Agent

2021 ◽  
Vol 43 (3) ◽  
pp. 1502-1517
Author(s):  
Smitha S. Bhat ◽  
Shashanka K. Prasad ◽  
Chandan Shivamallu ◽  
Kollur Shiva Prasad ◽  
Asad Syed ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tyrosine Kinases ◽  
Cancer Cell Proliferation ◽  
Wide Range ◽  
Anti Cancer ◽  
Cancer Agent ◽  
Post Menopausal ◽  
Dose Dependent ◽  
Proliferation Suppression ◽  
Cancer Activity

Genistein is an isoflavonoid present in high quantities in soybeans. Possessing a wide range of bioactives, it is being studied extensively for its tumoricidal effects. Investigations into mechanisms of the anti-cancer activity have revealed many pathways including induction of cell proliferation, suppression of tyrosine kinases, regulation of Hedgehog-Gli1 signaling, modulation of epigenetic activities, seizing of cell cycle and Akt and MEK signaling pathways, among others via which the cancer cell proliferation can be controlled. Notwithstanding, the observed activities have been time- and dose-dependent. In addition, genistein has also shown varying results in women depending on the physiological parameters, such as the early or post-menopausal states.

scholarly journals Study of antioxidant activity of selected monocarbohydrazone derivatives

2021 ◽  
Vol 62 (1) ◽  
pp. 5-8
Author(s):  
Gorana Mrđan ◽  
Borko Matijević ◽  
Sanja Vlaisavljević ◽  
Đenđi Vaštag ◽  
Suzana Apostolov
Keyword(s):  
Sulfonic Acid ◽  
Biological Activities ◽  
Biologically Active ◽  
Radical Scavengers ◽  
Antioxidant Power ◽  
Antioxidant Agents ◽  
Wide Range ◽  
Anti Cancer ◽  
Ferric Reducing Antioxidant Power ◽  
Active Substances

Many of carbohydrazone derivatives have shown a wide range of biological activities. In previous studies, these compounds have proven to be excellent anti-cancer, antitumor, antibacterial, antimicrobial and antioxidant agents. Monocarbohydrazones, as one of the carbohydrazone derivatives, have been slightly explored. Due to that reason, in this study, eight newly synthesized monocarbohydrazones were subjected to examinations by the use of three antioxidant tests. To determine the effectiveness of monocarbohydrazone as potential radical scavengers, DPPH (2,2-Diphenyl-1-picrylhydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) and FRAP (Ferric Reducing Antioxidant Power) assays were used. The obtained results could open the door for further studies of these compounds as biologically active substances.

scholarly journals Identification and Quantification, Metabolism and Pharmacokinetics, Pharmacological Activities, and Botanical Preparations of Protopine: A Review

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 215
Author(s):  
Wangli Huang ◽  
Lingbo Kong ◽  
Yang Cao ◽  
Liang Yan
Keyword(s):  
Pharmacological Activity ◽  
Metabolic Pathways ◽  
Clinical Applications ◽  
Pharmacological Activities ◽  
Therapeutic Value ◽  
Pubmed Database ◽  
Wide Range ◽  
Anti Cancer ◽  
Identification And Quantification

Through pharmacological activity research, an increasing number of natural products and their derivatives are being recognized for their therapeutic value. In recent years, studies have been conducted on Corydalis yanhusuo W.T. Wang, a valuable medicinal herb listed in the Chinese Pharmacopoeia. Protopine, one of its components, has also become a research hotspot. To illustrate the identification, metabolism, and broad pharmacological activity of protopine and the botanical preparations containing it for further scientific studies and clinical applications, an in-depth and detailed review of protopine is required. We collected data on the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine from 1986 to 2021 from the PubMed database using “protopine” as a keyword. It has been shown that protopine as an active ingredient of many botanical preparations can be rapidly screened and quantified by a large number of methods (such as the LC-ESI-MS/MS and the TLC/GC-MS), and the possible metabolic pathways of protopine in vivo have been proposed. In addition, protopine possesses a wide range of pharmacological activities such as anti-inflammatory, anti-platelet aggregation, anti-cancer, analgesic, vasodilatory, anticholinesterase, anti-addictive, anticonvulsant, antipathogenic, antioxidant, hepatoprotective, neuroprotective, and cytotoxic and anti-proliferative activities. In this paper, the identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine are reviewed in detail to lay a foundation for further scientific research and clinical applications of protopine.

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