scholarly journals Whether or Not the Effects of Curcuma longa Supplementation Are Associated with Physical Exercises in T1DM and T2DM: A Systematic Review

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 124
Author(s):  
Ailton Santos Sena-Júnior ◽  
Felipe José Aidar ◽  
Ana Mara de Oliveira e Silva ◽  
Charles dos Santos Estevam ◽  
Carla Roberta de Oliveira Carvalho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Latin American ◽  
Curcuma Longa ◽  
Relevant Information ◽  
Caribbean Literature ◽  
Diabetic Patients ◽  
Scientific Publications ◽  
Chronic Hyperglycemia ◽  
Type 1 Dm

Diabetes mellitus is one of the most prevalent chronic diseases in the world; one of its main characteristics is chronic hyperglycemia. Pharmacotherapy and other alternatives such as regular exercise are among the therapeutic methods used to control this pathology and participate in glycemic control, as well as the ingestion of plant extracts with antioxidant effects. Among the different plants used for this purpose, curcumin has potential to be used to attenuate the hyperglycemic condition triggered by diabetes mellitus (DM). Some prior studies suggest that this plant has antioxidant and hypoglycemic potential. This review aims to evaluate the antioxidant and hypoglycemic potential of curcumin supplementation in Type 1 DM (T1DM) and Type 2 DM (T2DM). The search considered articles published between 2010 and 2019 in English and Portuguese, and a theoretical survey of relevant information was conducted in the main databases of scientific publications, including the Virtual Health Library and its indexed databases, PubMed, LILACS (Latin American and Caribbean Literature on Health Sciences—Health Information for Latin America and the Caribbean—BIREME/PAHO/WHO), and Scientific Electronic Library Online (SciELO). The associated use of turmeric and physical exercise has demonstrated antioxidant, anti-inflammatory, and hypoglycemic effects, suggesting that these could be used as potential therapeutic methods to improve the quality of life and survival of diabetic patients.

scholarly journals Analysis of the Effects of Curcuma Longa Supplementation and Physical Exercise in Patients With Diabetes: Systematic Review

2020 ◽  
Author(s):  
Ailton Santos Sena Júnior ◽  
Felipe José Aidar ◽  
Ana Mara de Oliveira e Silva ◽  
Fábio Bessa Lima ◽  
Jymmys Lopes dos Santos ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Physical Exercise ◽  
Curcuma Longa ◽  
Relevant Information ◽  
The Body ◽  
Diabetic Patients ◽  
Electronic Library ◽  
Scientific Publications ◽  
Chronic Hyperglycemia ◽  
Patients With Diabetes

Diabetes Mellitus is one of the most prevalent chronic diseases in the world and one of its main features is chronic hyperglycemia. Among the therapeutic forms used to control the pathology are pharmacotherapy and the use of other alternatives such as regular exercise, which participates in glycemic control and the ingestion of plant extracts with antioxidant effects in the body. Among the different plants used, curcumin is a possible plant to be used to attenuate the hyperglycemic picture triggered by Diabetes Mellitus. Some studies suggest that this plant is antioxidant and hypoglycemic. The review aimed to know the antioxidant and hypoglycemic potential of curcumin supplementation in DM. The search was performed considering articles published between 2010 to 2019, in English and Portuguese, and a theoretical survey of relevant information was conducted in the main databases of scientific publications: Virtual Health Library and its indexed databases as Pubmed, LILACS, Scielo and Scientific Electronic Library Online. The associated use Turmeric and Physical Exercise demonstrated antioxidant, anti-inflammatory and hypoglycemic activity caused by Diabetes Mellitus. We may suggest that these are potential therapeutic ways to improve the quality and survival of diabetic patients.

Effectiveness of mobile applications on healthy lifestyles aimed at diabetic patients: review of systematic reviews. (Preprint)

2019 ◽  
Author(s):  
Francisco Jesús Represas Carrera Sr ◽  
Ángel Alfredo Martínez Ques Sr ◽  
Ana Clavería Fontán Sr
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Systematic Reviews ◽  
Mobile Applications ◽  
Control Group ◽  
Diabetic Patients ◽  
Healthy Lifestyles ◽  
Major Public Health Problem

BACKGROUND Diabetes mellitus is currently a major public health problem worldwide. It is traditionally approached in a clinical inpatient relationship between the patient and the healthcare professional. However, the rise of new technologies, particularly mobile applications, is revolutionizing the traditional healthcare model through the introduction of telehealthcare. OBJECTIVE (1) To assess the effects of mobile applications for improving healthy lifestyles on the quality of life and metabolic control of diabetes mellitus in adult patients. (2) To describe the characteristics of the mobile applications used, identify the healthy lifestyles they target, and describe any adverse effects their use may have. METHODS Review of systematic reviews and meta-analysis, following the guidelines of the Cochrane Collaboration and the Joanna Briggs Institute. We included studies that used any mobile application aimed at helping patients improve self-management of diabetes mellitus by focusing on healthy lifestyles. Studies needed to include a control group receiving regular care without the use of mobile devices. In May 2018, a search was conducted in Medline, Embase, Cochrane, LILACS, PsychINFO, Cinahl and Science Direct, updated in May 2019. The methodological quality of the studies was assessed using the Amstar-2 tool. RESULTS Seven systematic reviews of 798 articles were initially selected for analysis. The interventions had a duration of between 1 and 12 months. Mobile applications focused singly or simultaneously on different lifestyles aspects (diet, physical exercise, motivation, blood glucose levels, etc.). There are significant changes in HbA1c values, body weight and BMI, although in others, such as lipid profile, quality of life, or blood pressure, there is no clear improvement. CONCLUSIONS There is clear evidence that the use of mobile applications improves glycemic control in diabetic patients in the short term. There is a lack of evidence in its long-term benefits. It is thus necessary to carry out further studies to learn about the long-term effectiveness of mobile applications aimed at promoting the healthy lifestyles of diabetic patients. CLINICALTRIAL PROSPERO Register: CRD42019133685

scholarly journals Glycaemic Regulation with Zinc Combination in Type 2 Diabetes Mellitus

2021 ◽  
pp. 33-37
Author(s):  
Gangaram Bhadarge ◽  
Pratibha Dawande ◽  
Nandkishor Bankar ◽  
Raunak Kotecha
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Zn Deficiency ◽  
Diabetic Patients ◽  
Chronic Hyperglycemia ◽  
Low Levels

Introduction: Zn supplementation improved glutathione peroxidase enzyme activity and decreased malondialdehyde and nitric oxide levels in diabetic rats, revealing Zn's defensive effect against oxidative stress in type 2 diabetes. The investigators have discovered that consuming Zn increased liver function and protected pancreatic tissue from damage caused by diabetes. Since Zn also prevents chronic hyperglycemia, it helps to minimize oxidative stress caused by type 2 diabetes. Diabetes mellitus (DM) is a global health problem that affects more than 3 million people worldwide (16% of population). Chronic hyperglycemia causes oxidative stress in diabetic patients by the development of free radicals (oxidants) and lowering the antioxidant protection mechanism. Aim: Glycaemic Regulation with Zinc Combination in Type 2 Diabetes Mellitus. Materials and Methods: Faculty of Medicine and Diabetic Opd, Datta Meghe Mediсаl Соllege and Shаlinitаi Meghe Hоsрitаl аnd Reseаrсh Сenter, Nаgрur in соllаbоrаtion with Dаttа Meghe Institute оf Mediсаl Sсienсes Deemed to be University, Sаwаngi, Wаrdhа, Mаhаrаshtrа. Results: The mean Zn level was 12.213±2.342in all participants and 9.121±1.782 in the control group, whereas it was significantly low (9.121±1.782) in the diabetic group, and there was statistically significant difference in Zn levels between the controls and the diabetic group (P < 0.001).FBS, HbA1C, serum Zinc mean effects between control and patients showed statistically significant differences in type 2 diabetes mellitus (P <0.0001). Conclusion: Our findings show that people with diabetes have lower levels of Zn than healthy people. The cause and effect of the association between very low levels of Zn and the progression of diabetes, or diabetes that causes Zn deficiency, is still unknown. Low levels of Zn are associated with poor glycemic control, and poor glycemic control is a good indication of Zn deficiency, as there was a negative association between serum Zn and FBS and HBA1C. If diabetic patients have low glycemic regulation, a long history of diabetes, obesity, or are over the age of 50, we look to assess their levels in Zn so that Zn alternative treatment can begin to release oxidative stress in this high-risk group.

scholarly journals Impact of diabetes mellitus on bladder uroepithelial cells

2013 ◽  
Vol 304 (2) ◽  
pp. R84-R93 ◽  
Author(s):  
Ann T. Hanna-Mitchell ◽  
Giovanni W. Ruiz ◽  
Firouz Daneshgari ◽  
Guiming Liu ◽  
Gerard Apodaca ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Barrier Function ◽  
Transient Receptor Potential ◽  
Quantitative Polymerase Chain Reaction ◽  
Diabetic Patients ◽  
Transient Receptor Potential Vanilloid ◽  
Sprague Dawley ◽  
Bladder Smooth Muscle ◽  
Chronic Hyperglycemia ◽  
The Impact

Diabetic bladder dysfunction (DBD), a prevalent complication of diabetes mellitus (DM), is characterized by a broad spectrum of symptoms including urinary urgency, frequency, and incontinence. As DBD is commonly diagnosed late, it is important to understand the chronic impact of DM on bladder tissues. While changes in bladder smooth muscle and innervation have been reported in diabetic patients, the impact of DM on the specialized epithelial lining of the urinary bladder, the urothelium (UT), is largely unknown. Quantitative polymerase chain reaction analysis and electron microscopy were used to evaluate UT gene expression and cell morphology 3, 9, and 20 wk following streptozotocin (STZ) induction of DM in female Sprague-Dawley rats compared with age-matched control tissue. Desquamation of superficial (umbrella) cells was noted at 9 wk DM, indicating a possible breach in barrier function. One causative factor may be metabolic burden due to chronic hyperglycemia, suggested by upregulation of the polyol pathway and glucose transport genes in DM UT. While superficial UT repopulation occurred by 20 wk DM, the phenotype was different, with significant upregulation of receptors associated with UT mechanosensation (transient receptor potential vanilloid subfamily member 1; TRPV1) and UT autocrine/paracrine signaling (acetylcholine receptors AChR-M2 and -M3, purinergic receptors P2X2 and P2X3). Compromised barrier function and alterations in UT mechanosensitivity and cell signaling could contribute to bladder instability, hyperactivity, and altered bladder sensation by modulating activity of afferent nerve endings, which appose the urothelium. Our results show that DM impacts urothelial homeostasis and may contribute to the underlying mechanisms of DBD.

Quality of Life of Parents of Children with Type I Diabetes Mellitus, Baghdad 2017

2021 ◽  
Vol 17 (2) ◽  
pp. 107-114
Author(s):  
Sadik Jaafar Shukur ◽  
Wijdan Akram Hussein ◽  
Nazik L. Kadhum
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
World Health Organization ◽  
World Health ◽  
Type I ◽  
Healthy Children ◽  
Social Domain ◽  
Chronic Hyperglycemia ◽  
Health Organization

Background: Diabetes is defined by the World Health Organization as a metabolic disorder characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. Families are co-regulating systems in which the stresses and strains of one family member affect the well-being of another member of the family. Caregivers of children with chronic illness report experiencing more parental stress than parents of healthy children. Objective: A descriptive cross-sectional study had been conducted in four centers of endocrine diseases in Baghdad city and data was collected by using self-administered questionnaire regarding quality of life adapted from World Health Organization. The study was conducted on six hundred participants. Data analysis was done by using frequency, percentage and mean and analytical statistics using Chi Square test.  P value less than 0.05 was considered statistically significant. Results: The study showed that social domain had the highest mean score of (51.1) and that environmental domain had the lowest mean score of (38.9). The physical domain’s mean score was (40.2), while mean score of psychological domain was (46.2). The study reported that mothers of children with type 1 diabetes mellitus were more affected than fathers in physical, psychological and environmental domains. There was no difference between mothers and fathers in social domain of quality of life. Conclusion: It was concluded from the study that parents of diabetic children had generally poor quality of life that merits further investigations.

scholarly journals Quality of Life in Type 2 Diabetic Patients

2014 ◽  
Vol 31 (3) ◽  
pp. 193-200 ◽  
Author(s):  
Ana Spasić ◽  
Radmila Veličković Radovanović ◽  
Aleksandra Catić Đorđević ◽  
Nikola Stefanović ◽  
Tatjana Cvetković
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Short Form ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Cross Sectional ◽  
Significant Difference ◽  
Type 2 Diabetic

Summary The presence of diabetes mellitus leads to a decrease in life quality in all domains. The aim of our study was to evaluate the quality of life (QOL) in diabetic patients and the factors affecting it in type 2 diabetic mellitus patients. We conducted a cross-sectional study that included 86 patients with type 2 diabetes mellitus, in the territory of the City of Niš. Health-related QOL of patients was measured using the short form survey (SF-36) that produces an 8-scale health profile. The average duration of diabetes was 12.76±8.08 years. The best QOL in all areas was observed in patients diagnosed with diabetes less than 10 years ago p<0.05) and younger than 65 years. Male respondents perceived a better QOL compared to women, especially in the vitality and pain domains. The patients with comorbidity (93.64%) had lower QOL score in all domains. There was no significant difference in the QOL of patients with diabetes compared to the level of education. High QOL represents an ultimate goal and an important outcome of all medical interventions in diabetic patients. Factors related to lower QOL included: older age, female gender, and existence of comorbidities. Uncontrolled diabetic patients had a lower QOL than controlled diabetics.

Pesquisa sobre a Intolerância, Diagnóstico e Alternativas para os Pacientes com Intolerância ao Glúten

2019 ◽  
Vol 23 (1) ◽  
pp. 40 ◽  
Author(s):  
Erick De Oliveira Lemes ◽  
Amanda Ferreira Lucena ◽  
Kátia Merces Moreira ◽  
Larissa Soares Geremias ◽  
Nathalia Assis Alves
Keyword(s):  
Latin American ◽  
Well Being ◽  
Caribbean Literature ◽  
Health Sciences ◽  
The Body ◽  
Good Relationship ◽  
Gluten Intolerance ◽  
De Medicina ◽  
Latin American And Caribbean

A intolerância ao glúten é uma incapacidade do organismo em absorver os nutrientes do glúten, que é a principal proteína encontrada em alguns cereais. A incapacidade de absorver partes do glúten pode ser devida a um componente genético ou pode ser adquirida em qualquer fase da vida. A intolerância pode ainda se manifestar após a ingestão de alimentos que contém este elemento, ou em casos assintomáticos, em que mesmo com a ausência dos sintomas, o intestino sofre agressões pela ingestão ao glúten. O estudo teve como objetivo pesquisar sobre o diagnóstico, intolerância ao glúten e alternativas de alimentos para os pacientes. O estudo foi composto por um conjunto de publicações contidas em periódicos, livros-textos, monografias, dissertações e teses. A coleta foi realizada nas bases eletrônicas Scielo (Scientific Eletronic Library Online), Bireme (Biblioteca Regional de Medicina), BVS (Biblioteca Virtual em Saúde), Pubmed e Lilacs (Literatura Latino Americana e do Caribe em Ciências Sócias e da Saúde) e publicações como: monografias, dissertações e teses disponíveis eletronicamente, bem como livros-textos no período de 1989 a 2016. Através da realização deste estudo, foi possível perceber que o glúten está presente na maioria dos alimentos disponíveis, sendo encontrado no trigo, na cevada, no centeio, na aveia e derivados, e se faz necessário que existam companhas informativas aos portadores, especialmente, os quais buscam informações quanto a sua deficiência e formas de conviver com ela, sempre prezando pelo seu bem-estar e qualidade de vida. Palavras-chave: Intolerância. Ingestão. Glúten. AbstractThe gluten intolerance is an inability of the body to absorb nutrients, which is one of the main nutrients of some cereals. The inability to absorb the parts can be a genetic component or can be acquired at any stage of life. Intolerance may continue to manifest itself after a process of awareness, that is, in asymptomatic cases, when with the absence of bowel symptoms, in the aggression to the use. The study had a good relationship with diagnosis, gluten intolerance and food alternatives for patients. The study was composed of a set of publications contained in periodicals, textbooks, monographs, dissertations and theses. The collection was carried out in the electronic databases of Scielo, the Regional Library of Medicine, the Virtual Health Library, Pubmed and Lilacs and the publication in English of Latin American and Caribbean Literature in Social and Health Sciences. The monographs, dissertations and theses available electronically, as well as textbooks from 1989 to 2016, are not found in wheat, in barley, rye, oats and derivatives. It is necessary to have information about the patients, especially those who seek information about their disability and ways of living with them, always esteemed by their well-being and quality of life. Keywords: Intolerance. Ingestion. Gluten.

scholarly journals Interleukin-1-Beta and Dyslipidemic Syndrome as Major Risk Factors for Thrombotic Complications in Type 2 Diabetes Mellitus

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Oana Bădulescu ◽  
Codruţa Bădescu ◽  
Manuela Ciocoiu ◽  
Magda Bădescu
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Complex Disease ◽  
Interleukin 1 ◽  
Hdl Cholesterol ◽  
Plasminogen Activator Inhibitor ◽  
Diabetic Patients ◽  
Interleukin 1 Beta ◽  
Thrombotic Risk ◽  
Chronic Hyperglycemia

Diabetes mellitus (DM) is a complex disease characterized by chronic hyperglycemia, a known risk factor for accelerated atherosclerosis and vascular disease. The aim of this study was to show that the connection between DM and other risk factors, such as dyslipidemia, inflammatory phenomena, or the development of certain vascular injuries, leads to a high frequency of thrombotic events in diabetic patients compared to the nondiabetic population. The study included one hundred eighty patients divided in the following groups: diabetic without ischemic cardiopathy-related disorders (DM), diabetic with clinical or off-clinical (electrocardiogram, cardiac ultrasound) ischemic cardiopathy-related disorders (DM + IC), and nondiabetic with ischemic cardiopathy-related disorders (IC). We investigated the following parameters: von Willebrand Factor, HDL-cholesterol, LDL-cholesterol, interleukin-1-beta, protein C, and plasminogen activator inhibitor type 1. The results achieved in our study have revealed the highest thrombotic risk among the groups of diabetic patients, which is in direct correlation with the high values of interleukin-1-beta and the modifications of lipid parameters, acknowledging the data in the literature, according to which hyperglycemia alters endothelial functions directly and indirectly by synthesis of growth factors and cytokines and generates metabolic disorders which would explain the high risk for thrombotic events.

scholarly journals Pathogenesis of Type 1 Diabetes Mellitus: A Brief Overview

2012 ◽  
Vol 19 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Adrian Vlad ◽  
Romulus Timar
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Insulin Therapy ◽  
Type 1 Diabetes Mellitus ◽  
Chronic Complications ◽  
Type 1 Dm ◽  
Preventive Methods

Pathogenesis of Type 1 Diabetes Mellitus: A Brief OverviewBefore the discovery of insulin, type 1 diabetes mellitus (DM) was a disease with acute evolution, leading to death shortly after diagnosis. During the first years of insulin therapy, the medical world was optimistic, even enthusiastic, considering that the therapeutic solution for the malady was found. Unfortunately this was only an illusion, because the patients started to develop chronic complications that shortened their lifespan and impaired their quality of life. In other words, insulin therapy transformed type 1 DM into a chronic disease. The prevention or the delay of the onset of hyperglycemia emerged as a new solution for the patients and, consequently, the understanding of the pathogenesis of the disease (a prerequisite for developing efficient preventive methods) became a priority for all the diabetologists involved in research. Almost 40 years have passed since the autoimmune theory regarding the pathogenesis of type 1 DM was imagined but, despite the tremendous research performed in this field since then, the prevention could not be obtained. The aim of this paper is to present the most important theoretic notions regarding the mechanisms that underlie the development of type 1 DM, in the way they are understood today.

scholarly journals CENTER BASED VERSES TELE-REHABILITATION FOR DIABETES MELLITUS

2021 ◽  
Vol 5 (1) ◽  
pp. 190-191
Author(s):  
Saira Waqar ◽  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Health Care ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Rehabilitation Center ◽  
Rehabilitation Programs ◽  
Practice Models ◽  
At Home

Globally, new trends of practices are incorporating in health care sector, academics as well as in our daily lives to cope with the current population need. It is much needed to develop and implement new sophisticated practice models in rehabilitation to treat the different clinical conditions. Diabetes mellitus is one among the top 10 causes of death, with significant increase of 80% since year 20001. As estimated by International Diabetes Federation worldwide, 425 million people are suffering with diabetes mellitus.2 Diabetic neuropathy is one of highly prevalent condition which substantially affects patients by increasing frequency of falls, neuropathic pain and low quality of life (QOL).Diabetic patients suffer with following complaints i.e. Foot ulcers that develops due to peripheral vascular ischemia and poor pressure distribution on plantar surface of foot which increases the risk of fall due to loss of balance and disturbance in gait patterns.3 Total 20% of foot ulcers need an amputation wherein patients further suffer with secondary complications which in turn builds massive economic burden on health care system.4 The rehabilitation combined with diet and medications has proven as an effective method to treat diabetes and its neuropathy symptoms. Supervised conventional center based physical activity training programs are generally in practice to treat this metabolic condition. Though clinical effectiveness of these programs is established on clinical outcomes, with reduction in mortality rate, despite all the benefits of rehabilitation programs, very low patient attendance is observed in hospital based supervised rehabilitation programs. The regularity in exercise along with dietary intervention and fixed medication monitoring is the key component to manage diabetes. But high drop-out levels negatively affects the proven effectiveness of rehabilitation. There are different aspects for this low level of participation i.e. lack of time, approachability of a program, home bound work or obligations and psychological barriers etc. Therefore, new practice models are essential to improve the rate of participation on regular basis in these exercise program.5 Computer based technological incorporation in the field of health is evolving dramatically as a promising tool in improving quality of life cost effectively. It can also help us to achieve WHO goal “to improve access to health care services and professionals”. Tele-rehabilitation may prove effective as part of the rehabilitation program, especially for diabetic patients who fail to participate in conventional rehabilitation center-based programs due to domestic issues. The factors associated with suboptimal participation in rehabilitation at home are less prevalent. In tele-rehabilitation, patients are not bound to visit rehabilitation center or hospital; hence they have the freedom to perform exercise at home. But the limitations in utilization of this approach are: patient assessment and evaluation in a structured manner, monitoring the effect of program on regular basis, suitability of approach for all type of morbidities & severity levels of diabetes and suitable equipment having required features for patients as well as practitioners.6 Tele-rehabilitation is a prospective opportunity to treat the diabetic patients through regular monitoring with less drop outs rather than center based approach. However, there is a need to identify the types and severity of diabetic patients for whom this approach is safe and effective. Secondly, it is required to define clinical assessment outcomes which can be monitored and assessed. Incorporation of advanced equipment and relevant operational training is indispensable. Development of Standardized documentation for patient evaluation, intervention and outcomes monitoring is imperative to long term sustainability and improvement of practice. It is equally important to ensure the security and confidentiality of Patient’s personal data and privacy.7

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