scholarly journals Nutritional Status, Selected Nutrients Intake and Their Relationship with the Concentration of Ghrelin and Adiponectin in Patients with Diabetic Nephropathy

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4416
Author(s):  
Iwona Boniecka ◽  
Anna Jeznach-Steinhagen ◽  
Weronika Michalska ◽  
Aleksandra Rymarz ◽  
Dorota Szostak-Węgierek ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nutritional Status ◽  
Plasma Concentrations ◽  
Negative Relationship ◽  
Composition Analysis ◽  
Food Record ◽  
Ghrelin Concentration ◽  
Positive Correlation ◽  
Protein Energy ◽  
Nutrients Intake

Background: Overnutrition is one of the risk factors of chronic kidney disease (CKD). The factors related to both obesity and CKD are adiponectin and ghrelin. The aim of the study was to assess if there is a link of nutritional status and selected nutrients intake with adiponectin and ghrelin in patients with diabetic nephropathy (DN). Methods: The study involved 55 patients diagnosed with DN in the pre-dialysis period (two groups: GFR < 30 and >30 mL/min/1.73 m2). In all participants standard blood tests, total ghrelin and total adiponectin plasma concentrations and anthropometric measurements (BMI, WHR- waist–hip ratio, body composition analysis) were performed. The evaluation of energy and nutrient intakes was made using the three-day food record method. Results: Excessive body weight was found in 92.80% patients. The average daily energy intake was 1979.67 kcal/day (14.45% protein energy, 28.86% fat, and carbohydrates 56.89%). In the group with eGFR < 30 mL/min/1.73 m2 the analysis showed a negative relationship between ghrelin and WHR value, and the creatine and albumin concentrations. There was a positive correlation between ghrelin concentration and the consumption of carbohydrates and sucrose. In the group of patients with eGFR > 30 mL/min/1.73 m2, a positive correlation was found between the concentration of ghrelin and the consumption of vegetable protein, carbohydrates, and glucose. Conclusions: The study confirms the high prevalence of obesity in patients with DN-Excessive supply of protein was found in the patients’ diets, which may contribute to the deterioration of the course of the disease and its prognosis. In patients with eGFR < 30 there was a negative correlation between ghrelin concentration and nutritional status, and in patents with eGFR > 30 between ghrelin concentration and some nutrients intake.

scholarly journals DISORDERS OF THE NUTRITIONAL STATUS AND THEIR CORRECTION IN CEREBRAL PALSY CHILDREN

2019 ◽  
Vol 22 (1) ◽  
pp. 23-27
Author(s):  
L. A. Pak ◽  
S. G. Makarova ◽  
T. R. Chumbadze ◽  
A. P. Fisenko
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Cerebral Palsy ◽  
Chemical Composition ◽  
Nutritional Status ◽  
Composition Analysis ◽  
Bioimpedance Analysis ◽  
Z Score ◽  
Energy Deficiency ◽  
Protein Energy

The authors present the results of their own clinical study of the nutritional status of cerebral palsy (CP) children. The chemical composition of the diet of the observed patients and the body composition of patients were analyzed with bioimpedance analysis. The results of the dynamic control of the analyzed indices after the nutritive correction are presented. Aim of the study. To study the nutritional status of CP patients and evaluation of its dynamic changes with the help of bioimpendancemetry after carrying out remedial measures. Material and methods. We observed 27 CP children aged from 5 to 11 years, who were diagnosed with a protein-energy deficiency. Examination of patients included physical examination, the assessment of anthropometric indices using the “WHO Anthro+” and a body composition analysis using bioimpendancemetry. Evaluation of the actual nutrition included the study of the diet, the calculation of the chemical composition of the diet, the state of appetite and the nature of the feces. All studies were conducted in CP children twice: at the time of admission to the hospital and in the following-up period after the correction of the diet and the appointment of treatment with metabolic and vitamin preparations for 2 months. Results and conclusion. The protein-energy deficiency in CP children being associated with a disorder of the diet, decreased appetite, lack of basic macronutrients, needs the nutritive correction, including the introduction of the supplemental nutrition in their diet. The study showed that against the background of the basic drug therapy and nutritional correction there is a positive dynamics in the form of increasing Z-score body weight, Z-score ratio of body weight to age, normalization of appetite, which correlates with the normalization of the main study using bioimpedance analysis of body composition.

scholarly journals Nutritional Habits According to Human Chronotype and Nutritional Status of Morningness and Eveningness

2018 ◽  
Vol 6 (3a) ◽  
pp. 61 ◽  
Author(s):  
Neşe Toktaş ◽  
K. Alparslan Erman ◽  
Zekai Mert
Keyword(s):  
Nutritional Status ◽  
Dietary Habits ◽  
Food Record ◽  
Turkish Version ◽  
Nutritional Habits ◽  
Low Protein ◽  
Protein Energy ◽  
Daily Energy ◽  
Nutrition Habits ◽  
Daily Total

Sixty one female and eighty one male volunteers participated in the study that aims to assess the nutrition habits according to human chronotype and nutritional status of morningness and eveningness. Chronotype was assessed by Turkish version of the Morningness-Eveningness Questionnaire and the other questionnaire prepared to assess of nutritional habits of participants were used. Furthermore a three-day food record for assessment of nutritional status was completed by twelve male who were definite morning/moderate morning types and eleven male who were definite evening/moderate evening types. According to a three-day food record intake of daily total energy (kkal), fat (g) and carbohydrates (g) were higher and intake of protein (% energy) was lower in the evening types (p<0,05). In conclusion, evening chronotype was associated with inadequate dietary habits and status such as high daily energy (kkal), fat (g) and carbohydrates (g) intakes and low protein intake (% energy) and skipped meal.

Plasma Thrombospondin as an Indicator of Intravascular Platelet Activation in Patients with Vasculitis

1987 ◽  
Vol 58 (03) ◽  
pp. 850-852 ◽  
Author(s):  
M B McCrohan ◽  
S W Huang ◽  
J W Sleasman ◽  
P A Klein ◽  
K J Kao
Keyword(s):  
Platelet Activation ◽  
Plasma Levels ◽  
Half Life ◽  
Degradation Products ◽  
Plasma Concentrations ◽  
Primary Source ◽  
Positive Correlation ◽  
Activation Marker ◽  
Fibrin Degradation Products ◽  
The Mean

SummaryThe use of plasma thrombospondin (TSP) concentration was investigated as an indicator of intravascular platelet activation. Patients (n = 20) with diseases that have known vasculitis were included in the study. The range and the mean of plasma TSP concentrations of patients with vasculitis were 117 ng/ml to 6500 ng/ml and 791±1412 ng/ml (mean ± SD); the range and the mean of plasma TSP concentrations of control individuals (n = 33) were 13 ng/ml to 137 ng/ml and 59±29 ng/ml. When plasma TSP concentrations were correlated with plasma concentrations of another platelet activation marker, β-thromboglobulin (P-TG), it was found that the TSP concentration inei eased exponentially as the plasma β-TG level rose. A positive correlation between plasma levels of plasma TSP and serum fibrin degradation products was also observed. The results suggest that platelets are the primary source of plasma TSP in patients with various vasculitis and that plasma TSP can be a better indicator than β-TG to assess intravascular platelet activation due to its longer circulation half life.

Plasma D Dimer: A Useful Marker of Fibrin Breakdown in Renal Failure

1989 ◽  
Vol 61 (03) ◽  
pp. 522-525 ◽  
Author(s):  
M P Gordge ◽  
R W Faint ◽  
P B Rylance ◽  
H Ireland ◽  
D A Lane ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Monoclonal Antibodies ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Plasma Concentrations ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
D Dimer

SummaryD dimer and other large fragments produced during the breakdown of crosslinked fibrin may be measured by enzyme immunoassay using monoclonal antibodies. In 91 patients with renal disease and varying degrees of renal dysfunction, plasma D dimer showed no correlation with renal function, whereas FgE antigen, a fibrinogen derivative which is known to be cleared in part by the kidney, showed a significant negative correlation with creatinine clearance. Plasma concentrations of D dimer were, however, increased in patients with chronic renal failure (244 ± 3l ng/ml) (mean ± SEM) and diabetic nephropathy (308 ± 74 ng/ml), when compared with healthy controls (96 ± 13 ng/ml), and grossly elevated in patients with acute renal failure (2,451 ± 1,007 ng/ml). The results indicate an increase in fibrin formation and lysis, and not simply reduced elimination of D dimer by the kidneys, and are further evidence of activated coagulation in renal disease. D dimer appears to be a useful marker of fibrin breakdown in renal failure.

scholarly journals Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity

2018 ◽  
Vol 315 (1) ◽  
pp. E91-E98 ◽  
Author(s):  
S. R. Coutinho ◽  
J. F. Rehfeld ◽  
J. J. Holst ◽  
B. Kulseng ◽  
C. Martins
Keyword(s):  
Weight Loss ◽  
Severe Obesity ◽  
Peptide Yy ◽  
Plasma Concentrations ◽  
Cardiovascular Fitness ◽  
Ghrelin Concentration ◽  
Time Points ◽  
Diet And Exercise ◽  
The Impact

The impact of lifestyle-induced weight loss (WL) on appetite in patients with obesity remains controversial. This study aimed to assess the short- and long-term impact of WL achieved by diet and exercise on appetite in patients with obesity. Thirty-five (22 females) adults with severe obesity (body mass index: 42.5 ± 5.0 kg/m2) underwent a 2-yr WL program focusing on diet and exercise. Body weight (BW), cardiovascular fitness (V̇o2max), appetite feelings, and plasma concentrations of insulin, active ghrelin (AG), glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and cholecystokinin (CCK), in the fasting and postprandial states, were measured at baseline (B), week 4 (W4), and 1 and 2 yr (and average values for all fasting and postprandial time points computed). BW was significantly reduced and V̇o2max(ml·kg−1·min−1) increased at all time points compared with B (3.5, 8.1, and 8.4% WL and 7, 11, and 8% increase at W4 and 1 and 2 yr, respectively). Basal hunger and average hunger and desire to eat were significantly increased at 1 and 2 yr. Basal fullness was significantly increased at W4, and average ratings were reduced at 1 yr. Average AG and PYY were significantly increased, and insulin was reduced, at all time points compared with B. Average GLP-1 was reduced at W4, and CCK was increased at 2 yr. After lifestyle-induced WL, patients with severe obesity will, therefore, have to deal with increased hunger in the long term. In conclusion, sustained WL at 2 yr achieved with diet and exercise is associated with increased hunger feelings and ghrelin concentration but also increased postprandial concentrations of satiety hormones.

scholarly journals Comparison of Simplified Creatinine Index and Systemic Inflammatory Markers for Nutritional Evaluation of Hemodialysis Patients

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1870
Author(s):  
Ming-Tsun Tsai ◽  
Wei-Cheng Tseng ◽  
Shuo-Ming Ou ◽  
Kuo-Hua Lee ◽  
Chih-Yu Yang ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Body Mass ◽  
Inflammatory Markers ◽  
Risk Index ◽  
Hemodialysis Patients ◽  
Adverse Outcomes ◽  
Fat Free Mass ◽  
Screening Tools ◽  
Composition Analysis ◽  
Nutritional Risk Index

Protein-energy wasting (PEW) is associated with adverse outcomes in hemodialysis patients. This study compares the simplified creatinine index (SCI) and circulating inflammatory markers as nutritional screening tools for hemodialysis patients. Maintenance hemodialysis patients (230 total patients, 34.8% women, 64.0 ± 14.3 years old) from a tertiary medical center were assessed for demographic data, body composition analysis, biochemistry tests, and circulating inflammatory biomarkers. The SCI was calculated using Canaud’s formula. Reduced fat-free mass index (FFMI), a surrogate of lean body mass, was identified according to the European Society for Clinical Nutrition and Metabolism guidelines. Nutritional status was assessed by the geriatric nutritional risk index (GNRI) and International Society of Renal Nutrition and Metabolism (ISRNM) criteria. Multivariate logistic regression revealed independent risk factors for low FFMI and malnutrition. Of the patients, 47.4% had low FFMI. Patients with a reduction in FFMI tended to be older females with lower body mass index, SCI, and GNRI scores but significantly higher levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and IL-8. SCI was found to be an independent predictor for reduced FFMI (OR 0.57, 95% CI 0.40–0.81) and presence of PEW according to ISRNM criteria (OR 0.38, 95% CI 0.21–0.68). Although a positive association between systemic inflammatory markers and low FFMI was observed, this association disappeared in multivariate analysis. Moreover, the inflammatory markers examined in this study were not associated with malnutrition after adjusting for potential confounders. Compared with markers of systemic inflammation, SCI achieved better performance in assessing the nutritional status of hemodialysis patients.

Techniques For Assessment Of Body Composition In Health

2018 ◽  
Author(s):  
Carla M Prado ◽  
Camila LP Oliveira ◽  
M Cristina Gonzalez ◽  
Steven B Heymsfield
Keyword(s):  
Body Composition ◽  
Nutritional Status ◽  
Bioelectrical Impedance Analysis ◽  
Bioelectrical Impedance ◽  
Impedance Analysis ◽  
Dual Energy ◽  
Composition Analysis ◽  
Body Composition Assessment ◽  
Air Displacement Plethysmography ◽  
X Ray

Body composition assessment is an important tool in both clinical and research settings able to characterize the nutritional status of individuals in various physiologic and pathologic conditions. Health care professionals can use the information acquired by body composition analysis for the prevention and treatment of diseases, ultimately improving health status. Here we describe commonly used techniques to assess body composition in healthy individuals, including dual-energy x-ray absorptiometry, bioelectrical impedance analysis, air displacement plethysmography, and ultrasonography. Understanding the key underlying concept(s) of each assessment method, as well as its advantages and limitations, facilitates selection of the method of choice and the method of the compartment of interest. This review contains 5 figures, 3 tables and 52 references Key words: air displacement plethysmography, bioelectrical impedance analysis, body composition, disease, dual-energy x-ray absorptiometry, health, muscle mass, nutritional status, obesity, sarcopenia, ultrasound fat mass

MO847PREVALENCE OF FATIGUE REPORTED BY PATIENTS ON HEMODIALYSIS THERAPY

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Mauricio Sanabria ◽  
Cesar Mauricio Doria ◽  
Edward Martinez ◽  
Carlos Simon ◽  
Jasmin Vesga ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Chronic Hemodialysis ◽  
Multicenter Cohort Study ◽  
Care Services ◽  
Protein Energy ◽  
Confounding Variables ◽  
Patient Reported ◽  
High Prevalence ◽  
One Year

Abstract Background and Aims Fatigue is a symptom with a high prevalence in patients on hemodialysis therapy due to uremic toxins, anemia, associated comorbidity, and hemodialysis treatment per se. Our objective is to evaluate the prevalence of fatigue reported by patients and their association with the nutritional status. Method This was a prospective observational, multicenter cohort study. Prevalent patients on HD therapy for at least 90 days, older than 18, at the Baxter Renal Care Services were included between September 1, 2017, to November 30, 2017 with one-year follow-up. Socio-demographic and clinical characteristics of all patients were summarized descriptively, the nutritional status was evaluated by protein Energy waste (PEW). Patient reported fatigue was measured with high flux membrane and medium cut-off membrane (Theranova). A generalized linear binomial multivariable model was conducted to assess the effect of PEW on fatigue symptom controlling for some confounding variables. Results We found that the fatigue reported by the patients has a prevalence of 55% [95% CI: 52.2 to 57.7] in our population, there are no statistical differences due to the use of different types of membranes p= 0.911, and neither did we find that the nutritional status is an independent factor that explains this symptom. If we find that women and diabetics have a higher risk of fatigue; RR=1.17 [95% CI: 1.06 to 1.29] and RR= 1.19 [95% CI: 1.00 to 1.42] respectively. Conclusion The fatigue is a prevalent symptom in the chronic hemodialysis population; being a woman and the diagnosis of diabetes are risk factors associated with this outcome. PEW and the type of dialysis membrane used were not associated with this symptom. Studies evaluating the recovery time from post-dialysis symptoms and its relationship with the type of membrane are necessary.

scholarly journals Nutritional Status of Participating and Non-participating Pupils in the Ghana School Feeding Programme

2012 ◽  
Vol 1 (3) ◽  
pp. 263 ◽  
Author(s):  
A. O. Danquah ◽  
A. N. Amoah ◽  
M. Steiner-Asiedu ◽  
C. Opare-Obisaw
Keyword(s):  
Nutritional Status ◽  
School Children ◽  
Protein Energy Malnutrition ◽  
School Lunch ◽  
Nutrient Deficiencies ◽  
Demographic Health Survey ◽  
School Feeding ◽  
Protein Energy ◽  
Significant Difference ◽  
Better Than

The Ghana Demographic Health Survey indicates that the major nutritional challenges in Ghana among school children are protein-energy malnutrition and micro-nutrient deficiencies. School Feeding Programmes are one of the main interventions addressing malnutrition and its related effects on children’s health and education. The purpose of this study was to assess the influence of Ghana School Feeding Programme on nutritional status of school children in Atwima-Nwabiagya District of Ashanti Region, Ghana. A total of 234 pupils between 9 and 17 years of age, comprising 114 participants and 120 non-participants from three participating and three non-participating schools, respectively, with similar characteristics, took part in the study. It was hypothesized that the nutritional status of participants was better than that of non-participants. Results did not indicate any association between the school lunch and nutritional status. There was no statistically significant difference in the nutritional status of participants and non-participants. The programme did not impact the nutritional status of participants.

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