scholarly journals Chemical Composition and Biological Activities of Tunisian Ziziphus lotus Extracts: Evaluation of Drying Effect, Solvent Extraction, and Extracted Plant Parts

Plants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 2651
Author(s):  
Touka Letaief ◽  
Stefania Garzoli ◽  
Valentina Laghezza Masci ◽  
Jamel Mejri ◽  
Manef Abderrabba ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Methanolic Extract ◽  
Biological Activities ◽  
Cytotoxic Activities ◽  
Plant Parts ◽  
Cytotoxic Compound ◽  
A Value ◽  
Total Antioxidant ◽  
Quantitative Properties ◽  
Layer Chromatography

The Tunisian Ziziphus lotus plant was investigated to determine its phytoconstituents and evaluate its biological activities. In particular, the GC/MS technique was used to describe the chemical composition of Z. lotus active extracts and fractions. Among the obtained extracts, the yields of the dried root methanolic extract (29.80%) and the fruit aqueous extract (48.00%) were the highest ones. The dried root methanolic extract exhibited the highest amount in the total phenolics (186.44 ± 0.26 mg GAE/g DW), total flavonoids (102.50 ± 3.53 mg QE/g DW), and tannins (60.714 ± 2.2 mg catechin/g DW). The root aqueous extracts revealed the highest antioxidant activity with an IC50 of 8.96 ± 0.38 mg/L and 16.46 ± 0.60 mg/L for the ABTS•+ and DPPH• assays, respectively. The total antioxidant capacity was accorded to the methanolic extract of the dried roots with a value of 304.07 ± 1.11 µg AAE/mg. The drying process was found to improve the qualitative and quantitative properties of the Z. lotus extracts. The evaluation of the cytotoxic activity against the SH-SY5Y cell line was carried out using MTT assay. The petroleum ether and dichloromethane extracts of the dried roots showed relevant cytotoxic activities. The thin layer chromatography and the GC-MS/GC-FID analysis led to the identification of the 13-epimanool as a potent cytotoxic compound.

scholarly journals Chemical Composition, Enantiomeric Distribution, and Biological Activities of Rhododendron anthopogon Leaf Essential Oil from Nepal

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Noura S. Dosoky ◽  
Prabodh Satyal ◽  
Suraj Pokharel ◽  
William N. Setzer
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Components ◽  
Cytotoxic Activities ◽  
Blood Disorders ◽  
Leaf Essential Oil ◽  
Microbroth Dilution

Rhododendron anthopogon D. Don., a small compact Himalayan shrub growing in Nepal, is a known medicinal plant used to treat sore throat, colds, blood disorders, bone disease, potato allergies, and vomiting, and to relieve liver disorders, headaches and back pain. The present study investigated the chemical composition and bioactivities of the leaf essential oil from R. anthopogon from Dhankuta, Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography – mass spectrometry (GC-MS). The enantiomeric distribution of monoterpenoid components was determined using chiral gas chromatography and represents the first chiral examination of R. anthopogon essential oil. The essential oil was screened for antimicrobial activity using the microbroth dilution test, and for cytotoxic activity against MCF-7, MDA-MB-231, and 5637 using the MTT assay. A total of 70 volatile components were identified from the essential oil. The major components were α-pinene (21.5%), δ-cadinene (13.8%), β-pinene (9.5%), limonene (5.9%), δ-amorphene (4.6%), α-muurolene (4.5%), and ( E)-caryophyllene (3.2%) with other minor constituents (< 3%). The essential oil showed marginal antibacterial and cytotoxic activities, but no antifungal effects.

Chemical Composition of Essential Oil, Antioxidant, Antidiabetic, Anti-obesity, and Neuroprotective Properties of Prangos gaubae

2017 ◽  
Vol 12 (12) ◽  
pp. 1934578X1701201 ◽  
Author(s):  
Mir Babak Bahadori ◽  
Gokhan Zengin ◽  
Shahram Bahadori ◽  
Filippo Maggi ◽  
Leila Dinparast
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Skin Diseases ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Volatile Components ◽  
Total Antioxidant ◽  
Pharmaceutical Industries

Chemical composition of essential oil and the potential of Prangos gaubae for the management of public health problems such as Alzheimer's disease, obesity, Diabetes mellitus, and skin diseases were evaluated for the first time. In this direction, enzyme inhibitory effects, antioxidant activity, and total bioactive contents of the plant were determined. EO showed high acetylcholinesterase (2.97 mg GEs/g oil), α-amylase (1.35 mmol ACEs/g oil), α-glucosidase (38.84 mmol ACEs/g oil), and lipase (1.59 mmol OEs/g oil) inhibitory activities. Moreover, strong antioxidant effects were observed in antiradical (DPPH and ABTS), reducing power (CUPRAC and FRAP), total antioxidant, and metal chelating assays. Methanol extract exhibited promising DPPH radical scavenging activity (0.47 mmol TEs/g extract) and also high reducing power in CUPRAC (0.89 mmol TEs/g extract) and FRAP (0.52 mmol TEs/g extract) assays. All extracts showed low total flavonoid but high total phenolics content. Furthermore, they exhibited strong skin-care effect in tyrosinase inhibition assay. EO analysis showed the presence of germacrene D (26.7%), caryophyllene oxide (14.3%), ( E)-caryophyllene (13.8%), and spathulenol (11.3%) as the major volatile components. Results indicated that P. gaubae has promising potential for possible uses in food, cosmetic, and pharmaceutical industries due to its valuable phytoconstituents and biological activities.

scholarly journals In VitroAntibacterial, Antioxidant, and Cytotoxic Activities ofParthenium hysterophorusand Characterization of Extracts by LC-MS Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Shashank Kumar ◽  
Sanjay Pandey ◽  
Abhay K. Pandey
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Biological Activities ◽  
Beta Carotene ◽  
Cancer Cell Lines ◽  
Salmonella Typhi ◽  
Cytotoxic Activities ◽  
Plant Parts ◽  
Colon Cancer Cell Lines

Present work reports the biological activities ofP. hysterophorusleaf, stem, flower, and root. Dried samples were sequentially extracted with many solvents. Hexane (HX), benzene (BZ), and chloroform (CH) extracts of leaf showed considerable antibacterial activity againstStreptococcus mutans(MTCC 497),Proteus vulgaris(MTCC 7299), andSalmonella typhi(MTCC 3917). Flower extracts exhibited presence of higher amount of flavonoids (13.9–59.6 μgQE/mg) followed by leaf, stem, and root. Stem (HX, BZ, and CH), leaf ethanol (ET), and root (HX, BZ, and CH) fractions showed noticeable antioxidant capacity in phosphomolybdate assay. Most of the extracts demonstrated beta carotene bleaching inhibition capability. BZ, ethyl acetate (EA), and ET fractions of leaves, stem aqueous (AQ), and flower EA extracts showed membrane protective activities (40–55%). Middle fractions of the plant parts displayed moderate antihemolytic potential. Most of the flower extracts exhibited cytotoxic activity (80–100%) against lung and colon cancer cell lines. Root (HX and ET) and leaf ET extracts showed considerable inhibition (90–99%) of colon and ovary cancer cell lines. The LC-MS scan demonstrated presence of different compounds showing 3–20 min retention time. The study revealed considerable antibacterial, antioxidant, lipo-protective, antihemolytic, and anticancer potential in all parts ofP. hysterophorus.

scholarly journals Actinidia macrospermaC. F. Liang (a Wild Kiwi): Preliminary Study of Its Antioxidant and Cytotoxic Activities

2012 ◽  
Vol 2012 ◽  
pp. 1-7
Author(s):  
Yin Lu ◽  
Xiangtao Du ◽  
Lidan Lai ◽  
Hao Jin
Keyword(s):  
Antioxidant Activity ◽  
Cytotoxic Activity ◽  
Biological Activities ◽  
Positive Control ◽  
Total Phenolic ◽  
Cytotoxic Activities ◽  
Dependent Manner ◽  
Etoac Extract ◽  
Total Antioxidant

The antioxidant potential ofActinidia macrospermaC. F. Liang (Actinidiaceae) was investigated in vitro for total phenolic content, along with total antioxidant activity (TAA), 1,1-diphenyl 2-picryl hydrazyl (DPPH), and lipid peroxidation (LP). The results indicated that different polarity extracts ofA. macrospermaexhibit different biological activities, which depends mainly on the presence of phenolic compounds. The antioxidant activity was in the following decreasing order: MeOH extract > EtOAc extract > aqueous extract > CHCl3extract > Hexane extract. Moreover, the cytotoxic activity of this plant by MTT dye assay using SMMC-7721 has been determined also. The hexane, EtOAc, and CHCl3extracts showed cytotoxicity in a dose-dependent manner. Methanol and aqueous extracts, however, showed weak activities in this test. And a very significant cytotoxic activity, not significantly different from the positive control of quercetin, was observed in CHCl3extract.

Antimicrobial activity of seven Piper species from Colombian coffee-growing Eco-region against multidrug resistant bacteria

2020 ◽  
Vol 3 (3) ◽  
pp. 33-37
Author(s):  
Oscar M Mosquera ◽  
◽  
Roman Y. Ramirez-Rueda ◽  
Aura M. Blandon ◽  
◽  
...  
Keyword(s):  
Methicillin Resistant Staphylococcus Aureus ◽  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Biological Activities ◽  
Multidrug Resistant ◽  
Inhibitory Effect ◽  
Biological Evaluation ◽  
Resistant Bacteria ◽  
Antibacterial Compounds ◽  
Layer Chromatography

Species of Piper genus are known for their numerous biological activities and their diverse phytochemical composition. The object of this work was to evaluate the antibacterial activity of extracts obtained from seven Piperaceae species. Broth microdilution technique was used for biological evaluation and some phytochemical nuclei present in the bioactive extracts were identified by thin layer chromatography and characterization reactions. Among the most important results, it is highlighted the inhibitory effect of the methanolic extract from Piper pesaresanum against Methicillin-resistant Staphylococcus aureus ATTC 43300, with minimum inhibitory concentration of 62.5 μg/mL. Additionally, secondary metabolites such as alkaloids, phenols and flavonoids were detected in this extract. In conclussion, the species P. pesaresanum showed high potential for bioguided search of antibacterial compounds against multidrug resistant S. aureus.

scholarly journals Phytotoxicity of Schiekia timida Seed Extracts, a Mixture of Phenylphenalenones

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4197
Author(s):  
Fernanda Maria Marins Ocampos ◽  
Ana Julia Borim de Souza ◽  
Guilherme Medeiros Antar ◽  
Felipe Christoff Wouters ◽  
Luiz Alberto Colnago
Keyword(s):  
Chemical Composition ◽  
Methanolic Extract ◽  
Biological Activities ◽  
Germination Rate ◽  
Seed Extract ◽  
Hypocotyl Growth ◽  
Specialized Metabolites ◽  
Phytotoxic Effect ◽  
First Time ◽  
Seed Extracts

Phenylphenalenones, metabolites found in Schiekia timida (Haemodoraceae), are a class of specialized metabolites with many biological activities, being phytoalexins in banana plants. In the constant search to solve the problem of glyphosate and to avoid resistance to commercial herbicides, this work aimed to investigate the phytotoxic effect of the methanolic extract of S. timida seeds. The chemical composition of the seed extract was directly investigated by NMR and UPLC-QToF MS and the pre- and post-emergence phytotoxic effect on a eudicotyledonous model (Lactuca sativa) and a monocotyledonous model (Allium cepa) was evaluated through germination and seedling growth tests. Three concentrations of the extract (0.25, 0.50, and 1.00 mg/mL) were prepared, and four replicates for each of them were analyzed. Three major phenylphenalenones were identified by NMR spectroscopy: 4-hydroxy-anigorufone, methoxyanigorufone, and anigorufone, two of those reported for the first time in S. timida. The presence of seven other phenylphenalenones was suggested by the LC-MS analyses. The phenylphenalenone mixture did not affect the germination rate, but impaired radicle and hypocotyl growth on both models. The effect in the monocotyledonous model was statistically similar to glyphosate in the lowest concentration (0.25 mg/mL). Therefore, although more research on this topic is required to probe this first report, this investigation suggests for the first time that phenylphenalenone compounds may be post-emergence herbicides.

scholarly journals Chemistry, biological activities and toxic effects of alkaloidal constituents of genus Delphinium - A mini review

2021 ◽  
Vol 10 (4) ◽  
pp. 486-499
Author(s):  
Mohammadreza Lotfaliani ◽  
Seyed Abdulmajid Ayatollahi ◽  
Farzad Kobarfard ◽  
Mustafa ghanadian ◽  
Pardis Mohammadi Pour
Keyword(s):  
Chemical Composition ◽  
North America ◽  
Biological Activities ◽  
Toxic Effects ◽  
Cytotoxic Activities ◽  
Diterpenoid Alkaloids ◽  
Medicinal Uses ◽  
Therapeutic Benefits ◽  
The Family ◽  
Alkaloidal Constituents

The genus Delphinium is one of the essential members of the family Ranunculaceae. These species grow wild in North America, Europe, and Asia. They have demonstrated antioxidant, antimicrobial, and cytotoxic activities. Diterpenoid alkaloids are their main constituents and seem to be responsible for medicinal and toxic properties. The primary purpose of this paper is to review the therapeutic benefits of Delphinium species, chemical composition, and its medicinal uses, in addition to the reported toxic effects of these plants influencing different animals and humans.

Bioactive Compounds and Biological Activity of Croton Species (Euphorbiaceae): An Overview

2020 ◽  
Vol 16 (4) ◽  
pp. 383-393
Author(s):  
Fernanda W.F. Bezerra ◽  
Priscila do N. Bezerra ◽  
Mozaniel S. de Oliveira ◽  
Wanessa A. da Costa ◽  
Gracialda C. Ferreira ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Supercritical Fluids ◽  
Biological Activities ◽  
Biological Effects ◽  
Extraction Methods ◽  
Plant Parts ◽  
The World ◽  
Varied Chemical

Background: Croton species are widely spread around the world, and present a varied chemical composition distributed in many classes of secondary metabolites, such as terpenoides, alkaloids, phenolic compounds and phenylpropanoids. These compounds can be obtained by different extraction methods, and more recently, with supercritical fluids. The crude and isolated extracts may have applications due to their biological activities in animals and humans. Methods: The text was written based on literature data from 1996 onwards. Results: The research showed in a concise way the botanical and taxonomic aspects of Croton and the success of its application is in studies related to the biological activities of the plant parts. It was also related to the chemical composition of its extracts and isolated compounds, obtained by many methods. Conclusion: In summary, the review feature studies reported the use of extracts and isolated Croton compounds due to their biological effects with antioxidant, antimicrobial, anti-inflammatory, neuroprotective, antitumor, anticancer, cytotoxic, insecticidal and allelopathic activities, with potential application in food, cosmetics, pharmaceuticals, and agrochemicals products.

Chemical Composition and Biological Activities from Croton delpyi Croton decalvatus and Croton caudatus

2020 ◽  
Vol 10 ◽  
Author(s):  
Sakchai Chaibun ◽  
Wilart Pompimon ◽  
Chanika Tidchai ◽  
Noraset Chalaemwongwan ◽  
Jutarut Wongping ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Antibacterial Activities ◽  
Cytotoxic Activities ◽  
Separation And Purification ◽  
Pure Compounds ◽  
Cytotoxicity Activities ◽  
Anti Hiv ◽  
Hiv 1

Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts; twigs, leaves and barks of these plants were used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decalvatus, and C. caudatus 2) to test their antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed under chromatographic method. The biological activities including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi was founded a new clerodanes diterpenoids; crotondelpyitin A (1). The five known compounds, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4- dimethoxyflavone (3), and pilloin (4) were founded in C. decalvatus and 3α-benzoyloxy-D:A-friedo-oleanan-27,16αlactone (5), and bergenin (6) were founded in C. caudatus. The compound 3 show the most effective antibacterial activities with MIC in range <0.16 -1.25 mg/mL, and MBC in range 0.6 - >5.0 mg/mL. The six compounds were inactive with antiHIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and significant guide for further research of the chemical constituents from these plants as potential medicines.

Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)

2017 ◽  
Vol 28 (3) ◽  
Author(s):  
Ramiz Ahmed Sultan ◽  
Mohammad Shah Hafez Kabir ◽  
Mir Muhammad Nasir Uddin ◽  
Mohi Uddin ◽  
Zobaer Al Mahmud ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Sleep Latency ◽  
Biological Activities ◽  
Glucose Load ◽  
Mice Model ◽  
Plant Parts ◽  
Cns Depressant ◽  
Phragmites Karka ◽  
Time Test ◽  
Cns Depressant Activity

AbstractBackground:In this ethnopharmacological study, methanolic extract of the aerial plant parts ofMethods:The cold methanolic extract of the aerial plant parts ofResults:In the mice model, the MEPK, PEFMEPK, and CTFMEPK fractions showed significant peripheral analgesic activity at a dose of 400 mg/kg body weight with percentage of inhibition of acetic acid-induced writhing 77.67 (p<0.001), 33.50 (p<0.001), and 40.29 (p<0.001), respectively, compared to the standard dichlofenac (60.68%, p<0.001) group. The hypoglycemic properties of MEPK, PEFMEPK, and CTFMEPK extracts were evaluated in normoglycemic mice where the reduction of blood glucose level after 30 min of glucose load were 69.85%, 78.91%, and 72.73%, respectively, and for standard glibenclamide, the reduction was 72.85%. All results were significant (p<0.05). In the case of the CNS depressant activity by phenobarbitone-induced sleeping time test, the crude ME significantly reduced sleep latency by 57.14% and increased the duration of sleep by 63.29% compared to the control, which were comparable to that of standard diazepam (65.71% and 77.62%, respectively). Among all the extract and fractions, methanolic extract showed the maximum antidiarrheal effect. The methanolic extract at 200 mg/kg dose induced a significant decrease in the total number of defecation in 4 h (69.05% of inhibition, p<0.001) and at 400 mg/kg dose showed 76.19% of inhibition (p<0.001).Conclusions:In light of the available literature, these findings represent the first experimental investigation of biological activities of

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