scholarly journals Review of Hybrid Materials Based on Polyhydroxyalkanoates for Tissue Engineering Applications

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1738
Author(s):  
Artyom Pryadko ◽  
Maria A. Surmeneva ◽  
Roman A. Surmenev
Keyword(s):  
Tissue Engineering ◽  
Hybrid Materials ◽  
Biomedical Applications ◽  
Hybrid Composites ◽  
Inorganic Materials ◽  
Research Strategies ◽  
Engineering Applications ◽  
Ongoing Research ◽  
Structural And Functional Properties ◽  
Wide Range

This review is focused on hybrid polyhydroxyalkanoate-based (PHA) biomaterials with improved physico-mechanical, chemical, and piezoelectric properties and controlled biodegradation rate for applications in bone, cartilage, nerve and skin tissue engineering. PHAs are polyesters produced by a wide range of bacteria under unbalanced growth conditions. They are biodegradable, biocompatible, and piezoelectric polymers, which make them very attractive biomaterials for various biomedical applications. As naturally derived materials, PHAs have been used for multiple cell and tissue engineering applications; however, their widespread biomedical applications are limited due to their lack of toughness, elasticity, hydrophilicity and bioactivity. The chemical structure of PHAs allows them to combine with other polymers or inorganic materials to form hybrid composites with improved structural and functional properties. Their type (films, fibers, and 3D printed scaffolds) and properties can be tailored with fabrication methods and materials used as fillers. Here, we are aiming to fill in a gap in literature, revealing an up-to-date overview of ongoing research strategies that make use of PHAs as versatile and prospective biomaterials. In this work, a systematic and detailed review of works investigating PHA-based hybrid materials with tailored properties and performance for use in tissue engineering applications is carried out. A literature survey revealed that PHA-based composites have better performance for use in tissue regeneration applications than pure PHA.

Recent advances in the design of inorganic and nano-clay particles for the treatment of brain disorders

2021 ◽  
Author(s):  
Francesca Persano ◽  
Svetlana Batasheva ◽  
Gölnur Fakhrullina ◽  
Giuseppe Gigli ◽  
Stefano Leporatti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Brain Disorders ◽  
Clay Particles ◽  
Recent Advances ◽  
Wide Range ◽  
Nano Clay

Inorganic materials, in particular nanoclays and silica nanoparticles, have attracted enormous attention due to their versatile and tuneable properties, making them ideal candidates for a wide range of biomedical applications, such as drug delivery.

Nano Hydroxyapatite (Nano-Hap): A Potential Bioceramic For Biomedical Applications

2021 ◽  
Vol 06 ◽  
Author(s):  
Varun Saxena ◽  
Lalit Pandey ◽  
T. S. Srivatsan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Biological Properties ◽  
Engineering Applications ◽  
Biological Responses ◽  
Size And Morphology

Background: Hydroxyapatite (HAp) is one of the most studied biomimic for biomedical applications. Specially, nano-HAp has been utilized for bone tissue engineering various orthopedic applications. HAp possesses various suitable properties such as bioactivity, biodegradability and cell proliferation efficiency for bone tissue engineering applications. Yet, lacks in self-antibacterial activity, high surface area and target efficiency. Results: In this directioon, researchers have focused on exploring the required surface as well as the inherent properties of HAp at the nanoscale. These properties are largely dependent on the composition, size and morphology of the nano-HAp. Hence, nano-HAp has been found to be an excellent candidate with an attractive combination of properties for selection and use in biomedical applications, those required to enhanced biological responses. Further, depending on the type of application, these factors can be tuned to optimize the performance. Conclusion: In this review article, we focus on the chemical structure of HAp and the routes chosen and used for the synthesis of the nano-HAp. The role of various parameters in controlling synthesis at the nanoscale are presented and briefly discussed. In addition, we provide an overview of the various applications for the pristine and doped nano-HAp with recent examples in areas spanning the following: (i) bone tissue engineering applications, (ii) drug delivery applications, (iii) surface coatings, and (iv) scaffolds. The effect of chemical composition on the mechanical properties, surface properties and biological properties are also highlighted. Nano-HAp is found to be highly proficient for its biomedical applications, especially for bone tissue engineering applications. The nano-sized properties enhances the biological responses. The dopant ions that replaces the Ca ion into the hydroxyapatite (HAp) lattice plays a crucial role in its biomedical applications

scholarly journals Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

Marine Drugs ◽  
2019 ◽  
Vol 17 (12) ◽  
pp. 654 ◽  
Author(s):  
Ana Isabel Barbosa ◽  
Ana Joyce Coutinho ◽  
Sofia A. Costa Lima ◽  
Salette Reis
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Chemical Structure ◽  
Final Section ◽  
Biological Properties ◽  
Production Methods ◽  
Bioactive Properties ◽  
Wide Range ◽  
Per Se

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

scholarly journals Carbon nanotubes and their polymeric composites: the applications in tissue engineering

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Boyang Huang
Keyword(s):  
Carbon Nanotubes ◽  
Electrical Conductivity ◽  
Tissue Engineering ◽  
Bone Tissue ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Polymeric Composites ◽  
Biological Properties ◽  
Engineering Applications ◽  
Toxicity Effects

Abstract Carbon nanotubes (CNTs), with unique graphitic structure, superior mechanical, electrical, optical and biological properties, has attracted more and more interests in biomedical applications, including gene/drug delivery, bioimaging, biosensor and tissue engineering. In this review, we focus on the role of CNTs and their polymeric composites in tissue engineering applications, with emphasis on their usages in the nerve, cardiac and bone tissue regenerations. The intrinsic natures of CNTs including their physical and chemical properties are first introduced, explaining the structure effects on CNTs electrical conductivity and various functionalization of CNTs to improve their hydrophobic characteristics. Biosafety issues of CNTs are also discussed in detail including the potential reasons to induce the toxicity and their potential strategies to minimise the toxicity effects. Several processing strategies including solution-based processing, polymerization, melt-based processing and grafting methods are presented to show the 2D/3D construct formations using the polymeric composite containing CNTs. For the sake of improving mechanical, electrical and biological properties and minimising the potential toxicity effects, recent advances using polymer/CNT composite the tissue engineering applications are displayed and they are mainly used in the neural tissue (to improve electrical conductivity and biological properties), cardiac tissue (to improve electrical, elastic properties and biological properties) and bone tissue (to improve mechanical properties and biological properties). Current limitations of CNTs in the tissue engineering are discussed and the corresponded future prospective are also provided. Overall, this review indicates that CNTs are promising “next-generation” materials for future biomedical applications.

scholarly journals Advancement of Nanobiomaterials to Deliver Natural Compounds for Tissue Engineering Applications

2020 ◽  
Vol 21 (18) ◽  
pp. 6752
Author(s):  
Sathish Sundar Dhilip Kumar ◽  
Heidi Abrahamse
Keyword(s):  
Tissue Engineering ◽  
Engineering Application ◽  
Natural Compounds ◽  
Treatment Modalities ◽  
Tissue Engineering Application ◽  
Engineering Applications ◽  
Synthetic Drugs ◽  
Medicinal Compounds ◽  
Wide Range ◽  
Clinical Benefits

Recent advancement in nanotechnology has provided a wide range of benefits in the biological sciences, especially in the field of tissue engineering and wound healing. Nanotechnology provides an easy process for designing nanocarrier-based biomaterials for the purpose and specific needs of tissue engineering applications. Naturally available medicinal compounds have unique clinical benefits, which can be incorporated into nanobiomaterials and enhance their applications in tissue engineering. The choice of using natural compounds in tissue engineering improves treatment modalities and can deal with side effects associated with synthetic drugs. In this review article, we focus on advances in the use of nanobiomaterials to deliver naturally available medicinal compounds for tissue engineering application, including the types of biomaterials, the potential role of nanocarriers, and the various effects of naturally available medicinal compounds incorporated scaffolds in tissue engineering.

scholarly journals Review on the Impact of Polyols on the Properties of Bio-Based Polyesters

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2969
Author(s):  
Kening Lang ◽  
Regina J. Sánchez-Leija ◽  
Richard A. Gross ◽  
Robert J. Linhardt
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Molecular Level ◽  
Potential Utility ◽  
Reaction Conditions ◽  
Wide Range ◽  
Soft Tissue Engineering ◽  
The Impact ◽  
Optimal Reaction

Bio-based polyol polyesters are biodegradable elastomers having potential utility in soft tissue engineering. This class of polymers can serve a wide range of biomedical applications. Materials based on these polymers are inherently susceptible to degradation during the period of implantation. Factors that influence the physicochemical properties of polyol polyesters might be useful in achieving a balance between durability and biodegradability. The characterization of these polyol polyesters, together with recent comparative studies involving creative synthesis, mechanical testing, and degradation, have revealed many of their molecular-level differences. The impact of the polyol component on the properties of these bio-based polyesters and the optimal reaction conditions for their synthesis are only now beginning to be resolved. This review describes our current understanding of polyol polyester structural properties as well as a discussion of the more commonly used polyol monomers.

Nano-caged shikimate as a multi-site cross-linker of collagen for biomedical applications

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22106-22116 ◽  
Author(s):  
Kunnavakkam Vinjimur Srivatsan ◽  
Natarajan Duraipandy ◽  
Rachita Lakra ◽  
Sandhiya K ◽  
Usha Ramamurthy ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Silver Nanoparticles ◽  
Biomedical Applications ◽  
Shikimic Acid ◽  
Engineering Applications ◽  
Cross Linker

Shikimic acid caged silver nanoparticles as multi-site cross-linkers of collagen for tissue engineering applications.

Poly(glycerol sebacate) biomaterial: synthesis and biomedical applications

2015 ◽  
Vol 3 (39) ◽  
pp. 7641-7652 ◽  
Author(s):  
Xian Jun Loh ◽  
Anis Abdul Karim ◽  
Cally Owh
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Engineering Applications

The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

Nanofibrous Substrate For Tissue Engineering Applications—A Review

2021 ◽  
Vol 8 (6) ◽  
pp. 13-21
Author(s):  
Odia Osemwegie ◽  
Lihua Lou ◽  
Ernest Smith ◽  
Seshadri Ramkumar
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Cell Culture ◽  
Tissue Regeneration ◽  
Biomedical Applications ◽  
High Volume ◽  
Clinical Applications ◽  
Critical Factors ◽  
Engineering Applications

Nanofiber substrates have been used for various biomedical applications, including tissue regeneration, drug delivery, and in-vitro cell culture. However, despite the high volume of studies in this field, current clinical applications remain minimal. Innovations for their applications continuously generate exciting prospects. In this review, we discuss some of these novel innovations and identify critical factors to consider before their adoption for biomedical applications.

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