Anticancer Properties of Strobilanthes crispus: A Review

Cancer is a major cause of death worldwide, as exemplified by millions of cancer diagnoses every year. The use of chemotherapy in treating cancer has many disadvantages which include recurrence of cancer, associated with drug resistance, and severe side effects that are harmful to the patients. A better source of anticancer drugs can come from nature. Strobilanthes crispus (S. crispus) is a herbal medicinal plant that is indigenous in Madagascar and the Malay Archipelago. The plant possesses high vitamin and mineral content as well as phytochemicals—like phenols, catechins, tannins, and flavonoids—that are known to have therapeutic effects. Numerous preclinical studies have reported very versatile pharmacological effects of this plant, such as anticancer, antimicrobial, antioxidant, anti-angiogenesis, anti-diabetes, anti-ulcerogenic, and wound healing. Herein, this paper reviews the anticancer properties of S. crispus, providing information for future research and further exploration.

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Phytotherapeutic mechanism of medicinal plants with wound-healing potential: a mini-review

10.14293/s2199-1006.1.sor-.ppc8pll.v1 ◽

2021 ◽

Author(s):

Stephen EMMANUEL ◽

Ademidun Adeola ADESIBIKAN ◽

Oluwole Solomon OLADEJI

Keyword(s):

Wound Healing ◽

Medicinal Plants ◽

Therapeutic Potential ◽

Higher Plants ◽

Current Knowledge ◽

Biologically Active ◽

Future Research ◽

Therapeutic Effects ◽

Active Metabolites ◽

Closure Rate

The applications of medicinal plant species for diverse therapeutic effects are well documented throughout the world. In recent times, the screening of higher plants for unique biologically active compounds, particularly those with pronounced therapeutic potency, has received the interest of the science community. A wound is a loss or break in the anatomic stability of active tissue. It not only poses a physical and mental threat to zillions of people but could cause the failure of multiple organs, amputation, and even death. Therefore, thousands of plants have been screened to obtain active metabolites or compounds that can accelerate the process of restoring the damaged tissue structure and inhibit the probability of infections. Due to the severity of wounds to the human body, it is essential to explore safe, economical, and environmentally friendly therapeutics from nature. This review aims to conduct a comprehensive search of medicinal herbs to uncover their therapeutic potential, identify gaping holes, and assess future research prospects that could lead to the discovery of novel pharmacophores. Thus, the review is tailored towards the appraisals of phytotherapeutic mechanism and wound healing efficacy of medicinal plants, which will help spur future research and improve our current knowledge leading to the unearthing of novel and potent pharmacophores with pronounced wound healing potentials. Several medicinal plants with scientifically proven wound-healing activities are reported and discussed alongside phytochemicals present their various extracts and isolates. The achievable wound-healing closure rate of each plant was also reported with a focus on what is responsible for the healing rate.

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Yogic Intervention in Sexual Dysfunction - A Review

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v2i4.9360 ◽

2017 ◽

Vol 2 (4) ◽

Author(s):

Rakshith K. R. ◽

Shivakumar . ◽

Kaushal Sinha ◽

Vijeth Kumar L. A.

Keyword(s):

Psychological Functioning ◽

Empirical Studies ◽

Empirical Literature ◽

Future Research ◽

Therapeutic Effects ◽

Yoga Therapy ◽

Cognitive Component ◽

Beneficial Effects ◽

Breathing Exercises ◽

The Mind

Yoga is an ancient practice with Eastern roots that involves both physical postures (Asanas) and breathing techniques (Pranayamas). Yoga therapy for male sexual problems can effectively be treated through Yoga therapy, particularly with the help of Yoga poses and breathing exercises, Yoga has proven itself highly very effective in the treatment of a number of incurable and sometimes terminable diseases. Then again, Yoga's therapeutic effects are just a spin-off and supplementary. Yoga which has proved to be very effective in the treatment of many impossible and incurable diseases, the therapeutic effect of Yoga is only a by product and incidental. Problems related to sex can very well be handled with Yoga as most often these problems are more related to the mind than body. Either they are caused by lack of confidence or stress or fatigue or fear and very few times some physical cause is there. There is also a cognitive component focusing on meditation and concentration, which aids in achieving the goal of union between the self and the spiritual. Although numerous empirical studies have found a beneficial effect of Yoga on different aspects of physical and psychological functioning, claims of Yoga's beneficial effects on sexuality derive from a rich but no empirical literature. The goal of this article is to review the philosophy and forms of Yoga, to review the no empirical and (limited) empirical literatures linking Yoga with enhanced sexuality, and to propose some future research avenues focusing on Yoga as a treatment for sexual disorder.

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Therapeutic effects of EGF-modified curcumin/chitosan nano-spray on wound healing

Regenerative Biomaterials ◽

10.1093/rb/rbab009 ◽

2021 ◽

Vol 8 (2) ◽

Author(s):

Yue Li ◽

QingQing Leng ◽

XianLun Pang ◽

Huan Shi ◽

YanLin Liu ◽

...

Keyword(s):

Drug Delivery ◽

Wound Healing ◽

Chitosan Nanoparticles ◽

Skin Lesions ◽

In Vitro Assays ◽

Therapeutic Effects ◽

Skin Defects ◽

Post Operation

Abstract Dermal injury, including trauma, surgical incisions, and burns, remain the most prevalent socio-economical health care issue in the clinic. Nanomedicine represents a reliable administration strategy that can promote the healing of skin lesions, but the lack of effective drug delivery methods can limit its effectiveness. In this study, we developed a novel nano-drug delivery system to treat skin defects through spraying. We prepared curcumin-loaded chitosan nanoparticles modified with epidermal growth factor (EGF) to develop an aqueous EGF-modified spray (EGF@CCN) for the treatment of dermal wounds. In vitro assays showed that the EGF@CCN displayed low cytotoxicity, and that curcumin was continuously and slowly released from the EGF@CCN. In vivo efficacy on wound healing was then evaluated using full-thickness dermal defect models in Wistar rats, showing that the EGF@CCN had significant advantages in promoting wound healing. On day 12 post-operation, skin defects in the rats of the EGF@CCN group were almost completely restored. These effects were related to the activity of curcumin and EGF on skin healing, and the high compatibility of the nano formulation. We therefore conclude that the prepared nano-scaled EGF@CCN spray represents a promising strategy for the treatment of dermal wounds.

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Strong Antimicrobial and Healing Effects of Beta-Acids from Hops in Methicillin-Resistant Staphylococcus aureus-Infected External Wounds In Vivo

Antibiotics ◽

10.3390/antibiotics10060708 ◽

2021 ◽

Vol 10 (6) ◽

pp. 708

Author(s):

Radek Sleha ◽

Vera Radochova ◽

Jiri Malis ◽

Alexander Mikyska ◽

Milan Houska ◽

...

Keyword(s):

Wound Healing ◽

Porcine Model ◽

Therapeutic Effects ◽

Methicillin Resistant ◽

Antimicrobial Effects ◽

Therapeutic Modalities ◽

Positive Effects ◽

Inflammatory Parameters

Staphylococcus (S.) aureus is an important causative agent of wound infections with increasing incidence in the past decades. Specifically, the emergence of methicillin-resistant S. aureus (MRSA) causes serious problems, especially in nosocomial infections. Therefore, there is an urgent need to develop of alternative or supportive antimicrobial therapeutic modalities to meet these challenges. Purified compounds from hops have previously shown promising antimicrobial effects against MRSA isolates in vitro. In this study, purified beta-acids from hops were tested for their potential antimicrobial and healing properties using a porcine model of wounds infected by MRSA. The results show highly significant antimicrobial effects of the active substance in both the powder and Ambiderman-based application forms compared to both no-treatment control and treatment with Framycoin. Moreover, the macroscopic evaluation of the wounds during the treatment using the standardized Wound Healing Continuum indicated positive effects of the beta-acids on the overall wound healing. This is further supported by the microscopic data, which showed a clear improvement of the inflammatory parameters in the wounds treated by beta-acids. Thus, using the porcine model, we demonstrate significant therapeutic effects of hops compounds in the management of wounds infected by MRSA. Beta-acids from hops, therefore, represent a suitable candidate for the treatment of non-responsive nosocomial tissue infections by MRSA.

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The Effect of Plantago major on Wound Healing in Preclinical Studies: A Systematic Review

Wound Management & Prevention ◽

10.25270/wmp.2021.1.2734 ◽

2021 ◽

Vol 67 (1) ◽

pp. 27-34

Author(s):

Fernanda Cardoso ◽

Jéssica Breder ◽

Priscila Apolinário ◽

Henrique Oliveia ◽

Maria Saidel ◽

...

Keyword(s):

Systematic Review ◽

Wound Healing ◽

Meta Analysis ◽

Experimental Studies ◽

Risk Of Bias ◽

Preclinical Studies ◽

Plantago Major ◽

Best Response ◽

Meta Analyses

BACKGROUND: Plantago major is a medicinal plant that has been used for centuries to treat various health conditions including wounds. PURPOSE: To investigate the effectiveness of the topical use of P major in healing skin wounds in animal models. METHODS: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review was conducted. Seven (7) electronic databases (Virtual Health Library, Public/Publisher MEDLINE, Scopus, Web of Science, Embase, Cumulative Index of Nursing and Allied Health Literature, and CAB Direct) were searched for controlled studies published in English from January 2006 to March 2020. The Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Studies tools guided the evaluation of the studies and determined their quality. The Systematic Review Center for Laboratory Animal Experimentation was used to assess the risk of bias. RESULTS: Of the 176 publications identified, 4 met the inclusion criteria. Studies included 20 to 100 animals and varying concentrations of P major. There were no reports of losses during research. Wound healing was assessed between 17 and 21 days following wounding. The best response in terms of wound contraction rate occurred with 10%, 20%, and 50% concentrations when compared with control groups. One (1) study did not have an animal ethics committee review. All studies had a high risk of bias and a lack of methodological rigor. CONCLUSION: The results of this review did not find evidence about the in vivo effectiveness of P major for wound healing. More rigorous preclinical studies with adequate sample sizes are required to identify the best concentrations and formulations as well as increase understanding about the mechanisms of action of P major in wound healing.

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Effects of Electrical Stimulation in Tinnitus Patients: Conventional Versus High-Definition tDCS

Neurorehabilitation and Neural Repair ◽

10.1177/1545968318787916 ◽

2018 ◽

Vol 32 (8) ◽

pp. 714-723 ◽

Cited By ~ 12

Author(s):

Laure Jacquemin ◽

Giriraj Singh Shekhawat ◽

Paul Van de Heyning ◽

Griet Mertens ◽

Erik Fransen ◽

...

Keyword(s):

Electrical Stimulation ◽

Depression Scale ◽

Future Research ◽

Therapeutic Effects ◽

Long Term Effects ◽

High Definition ◽

Tinnitus Questionnaire ◽

Temporal Area ◽

Clinically Significant ◽

The Right

Background. Contradictory results have been reported for transcranial direct current stimulation (tDCS) as treatment for tinnitus. The recently developed high-definition tDCS (HD tDCS) uses smaller electrodes to limit the excitation to the desired brain areas. Objective. The current study consisted of a retrospective part and a prospective part, aiming to compare 2 tDCS electrode placements and to explore effects of HD tDCS by matched pairs analyses. Methods. Two groups of 39 patients received tDCS of the dorsolateral prefrontal cortex (DLPFC) or tDCS of the right supraorbital–left temporal area (RSO-LTA). Therapeutic effects were assessed with the tinnitus functional index (TFI), a visual analogue scale (VAS) for tinnitus loudness, and the hyperacusis questionnaire (HQ) filled out at 3 visits: pretherapy, posttherapy, and follow-up. With a new group of patients and in a similar way, the effects of HD tDCS of the right DLPFC were assessed, with the tinnitus questionnaire (TQ) and the hospital anxiety and depression scale (HADS) added. Results. TFI total scores improved significantly after both tDCS and HD tDCS (DLPFC: P < .01; RSO-LTA: P < .01; HD tDCS: P = .05). In 32% of the patients, we observed a clinically significant improvement in TFI. The 2 tDCS groups and the HD tDCS group showed no differences on the evolution of outcomes over time (TFI: P = .16; HQ: P = .85; VAS: P = .20). Conclusions. TDCS and HD tDCS resulted in a clinically significant improvement in TFI in 32% of the patients, with the 3 stimulation positions having similar results. Future research should focus on long-term effects of electrical stimulation.

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Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review

Membranes ◽

10.3390/membranes11090702 ◽

2021 ◽

Vol 11 (9) ◽

pp. 702

Author(s):

Seyyed-Mojtaba Mousavi ◽

Zohre Mousavi Nejad ◽

Seyyed Alireza Hashemi ◽

Marjan Salari ◽

Ahmad Gholami ◽

...

Keyword(s):

Wound Healing ◽

Chronic Wounds ◽

Therapeutic Potential ◽

Healing Process ◽

Wound Dressings ◽

Future Research ◽

Wound Healing Process ◽

Nanofiber Membranes ◽

Bioactive Agents ◽

Bioactive Agent

Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.

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Investigation on phytochemical composition, anti-oxidant and anticancer properties of methanolic extract of Phyllanthus niruri schumach & thonn. And protein modelling and drug docking

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i4.4704 ◽

2020 ◽

Vol 11 (4) ◽

pp. 7937-7943

Author(s):

Sugumar R ◽

Saravana D ◽

Pavithra N ◽

Suresh Raj V ◽

Sekar Babu M ◽

...

Keyword(s):

Methanolic Extract ◽

Docking Studies ◽

Future Research ◽

Total Phenolic ◽

Human Beings ◽

Protein Modelling ◽

Phyllanthus Niruri ◽

Anticancer Properties ◽

Phytochemical Composition ◽

Anti Oxidant

The study aims to investigate the Phytochemical Composition, Anti-oxidant and Anticancer properties of methanolic extract of Phyllanthus niruri Schumach & Thonn And the Protein Modelling and drug docking. The research deals with the methanolic extraction and phytochemical screening, determination of total phenolic and flavonoids contents and anti-oxidant assay. By performing GC-MS characterisation, various active metabolites are analysed. Thin-layer chromatography profiling of the Phyllanthus niruri methanolic extract was performed. The IC50 of the Phyllanthus niruri methanolic extract against PA-1 Cell lines(Ovarian cancer) was calculated. Docking studies also performed for antitumor activity by using Bioinformatics and Cheminformatics software on corilagin and cisplatin. The results suggested that the methanolic extract of Phyllanthus niruri leaves has the anticancer cancer effect on the ovarian cell line. The docking studies also performed that Corilagin interaction with T.F. receptor shows a high binding score when compared to cisplatin. Our future research can be done in this area to optimise anticancer activity efficacy. Our results can be further tested Clinico-pharmacologically to prove its efficiency in human beings.

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Adipose Stem Cells from Type 2 Diabetic Mice Exhibit Therapeutic Potential in Wound Healing

10.21203/rs.3.rs-16134/v1 ◽

2020 ◽

Author(s):

Yongfa Sun ◽

Lili Song ◽

Yong Zhang ◽

Hongjun Wang ◽

Xiao Dong

Keyword(s):

Wound Healing ◽

Growth Factor ◽

Transforming Growth Factor ◽

Therapeutic Potential ◽

Diabetic Patients ◽

Therapeutic Effects ◽

Skin Damage ◽

Impaired Wound Healing ◽

Collagen Iii

Abstract BACKGROUND: Diabetic patients suffer from impaired wound healing. Mesenchymal stem cell (MSC) therapy represents a promising approach toward improving skin wound healing through release of soluble growth factors and cytokines that stimulate new vessel formation and modulate inflammation. Whether adipose-derived MSCs (ASCs) from type 2 diabetes donors are suitable for skin damage repair remains largely unknown. METHODS: In this study, we compared the phenotype and functionality of ASCs harvested from high fat diet (HFD) and streptozotocin (STZ)-induced T2D or control mice, and assessed their abilities to promote wound healing in an excisional wound splinting mouse model with T2D. RESULTS: T2D ASCs expressed similar cellular markers as control ASCs, but secreted less hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and transforming growth factor β (TGF-β). T2D ASCs were somewhat less effective in promoting healing of the wound, as manifested by slightly reduced re-epithelialization, cutaneous appendage regeneration, and collagen III deposition in wound tissues. In vitro, T2D ASCs promoted proliferation and migration of skin fibroblasts to a comparable extent as control ASCs via suppression of inflammation and macrophage infiltration. CONCLUSIONS: From these findings, we conclude that, although ASCs from T2D mice are marginally inferior to control ASCs, they possess comparable therapeutic effects in wound healing.

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Review: Aktivitas Farmakologi Dan Perkembangan Produk Dari Lidah Buaya (Aloe vera L.)

Jurnal Pharmascience ◽

10.20527/jps.v6i1.6073 ◽

2019 ◽

Vol 6 (1) ◽

pp. 38

Author(s):

Dian Kurnia ◽

Prima Happy Ratnapuri

Keyword(s):

Amino Acids ◽

Wound Healing ◽

Aloe Vera ◽

Chemical Compounds ◽

Pharmaceutical Products ◽

Therapeutic Effects ◽

Pharmacological Activities

ABSTRAK Lidah buaya (Aloe vera L.) diketahui mengandung banyak senyawa kimia alami, seperti antrakuinon, asam amino, acemannan, aloesin, glukomanan yang bertanggungjawab memberikan efek teraupetik yang bermanfaat dalam dunia farmasi. Review ini bertujuan untuk memberikan informasi terkait aktivitas farmakologi dan perkembangan produk dari lidah buaya dalam bidang farmasi. Pada Review artikel ini data yang disajikan diperoleh dari literatur online berupa jurnal dan artikel ilmiah publikasi lokal maupun internasional dan literatur offline berupa buku dan e-book. Diketahui bahwa lidah buaya memiliki berbagai aktivitas farmakologi yaitu sebagai antiinflamasi, berperan dalam penyembuhan luka, antibakteri, antifungi, antivirus, antioksidan, antikanker, antitumor, antikolesterol, dan antiulcer. Penggunaan lidah buaya dalam produk farmasi juga telah mengalami perkembangan diantaranya yaitu sediaan nano partikel, tablet, suppositoria, gel dan krim. Kata Kunci— Aloe vera L., Aktivitas farmakologi, Perkembangan produk ABSTRACT Aloe vera L. contains many natural chemical compounds, such as anthraquinone, amino acids, acemannan, aloesin, glucomannan which are responsible for providing therapeutic effects that are useful in pharmaceutical. The aims of this review is to provide information about pharmacological activities and products development of Aloe vera. In this article review, online and offline literatures were used. Online literature such us journals and articles obtained from local and international, while the offline literature such us books and e-books. It is known that aloe vera has a variety of pharmacological activities, that act as antiinflammatory, wound healing, antibacterial, antifungal, antiviral, antioxidant, anticancer, antitumor, anticholesterol, and antiulcer. Pharmaceutical products of Aloe vera also have been developed such us nanoparticles products, tablets, suppositories, gels and creams. Keywords— Aloe vera L., Pharmacological activities, Products development

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