scholarly journals PENGARUH PEMBERIAN AIR PERASAN JERUK NIPIS (CITRUS AURANTIFOLIA SWINGLE) TERHADAP KADAR KOLESTEROL PADA MENCIT HIPERKOLESTEROLEMIA

2019 ◽  
Vol 4 (1) ◽  
pp. 42
Author(s):  
Dewi Pangestuti

Lime (Citrus Aurantifolia) contains of main flavonoid in limes, that is herperidin. Hesperidin can help reducing total Cholesterol level and has the property of hypercholesterolemic. Hypercholesterolemia is the main factor independent risk factor of coronary heart disease (CHD). This study intend to determine whether or not the effect od water lime extract orally with cholesterol level in the hypercholesterolemia mice. This isi an experimental study designed following randomize control design and post test only control group design by using 24 mice (Mus musculus) adult male strain DD Webster divided into 4 groups: control group (P0) that Given adlibitum, (P1) that given hypercholesterolemia 0,2 cc, (P3) that given hypercholesterolemia 0,2 cc and water lime extract 0,3 cc by gastric sonde once a day for 15 days. In the day46 mice are done neck dislocation. Data result was analyzed by One Way- Anova test and continuous and continued with post-hoc test. Result of this study showed that giving of water lime extract 0,3 cc orally per mice could reduced cholesterol level of mice hypercholesterolemia than giving water lime extract 0,1 cc orraly per mice. 

2012 ◽  
Vol 1 (1) ◽  
pp. 258-264
Author(s):  
Widitha Gustining Asmariani ◽  
Enny Probosari

Background: Increased LDL cholesterol concentrations and low plasma HDL cholesterol concentrations are well-established risk factors for cardiovascular disease. Diet modification is one of recommended theraphy to decrease LDL cholesterol level by increasing fiber intake from fruit. Papaya contains niacin, fiber, and antioxidant which can decrease LDL cholesterol level. It also contains quercetin to increase HDL cholesterol level. The aim of this study was to prove the effect of papaya of different dosages on LDL and HDL cholesterol of hypercholesterolemic rats. Methods: This research was true-experimental using pre-post test with control group design. Subjects were male Sprague Dowley rats, 7-8 weeks old, 100-200 grams weight, inducted hypercholesterolemia, given papaya diet using 5,4 gr, 7,2 gr, and 9,0 gr dosage for 4 weeks. LDL cholesterol and HDL cholesterol were measured by direct method using LDL-C Select (DiaSys) reagent and CHOP-PAP methods respectively. Normality of the data was tested by Shapiro Wilks test. Data were analyzed by paired t test continued with One Way Anova.and post-hoc LSD. Result: The study revealed that papaya of dosage 5,4 gr/day decreased LDL cholesterol (p<0,05) significantly from 45,29±9,05 mg/dl to 30,29±5,31 mg/dl but nonsignificantly decrease HDL cholesterol level (p=0,930) from 25,71 ± 5,09 to 25,57 ± 3,59 mg/dl at the same dosage. Other dosage of 7,2 mg/day and 9,0 gr/day neither significantly decrease LDL cholesterol level nor increase HDL cholesterol level. Conclusion: Papaya couldn’t decreased LDL cholesterol and increased HDL cholesterol in hypercholesterolemic rats.


2017 ◽  
Vol 1 (1) ◽  
pp. 28
Author(s):  
Eviana Budiartanti Sutanto ◽  
Taufiq R Nasihun ◽  
Israhnanto Isradji ◽  
Luciana Budiati Sutanto

Introduction: Cigarette smoke causes oxidative stress which results in reduced sperm concentration, motility and morphology, also increased levels of 8-OHdG as a marker of DNA damage. Vitamin C and E have potential role in repairing spermatozoa damages. The aim of this study was to determine the effect of vitamin C and E combination on sperm quality and cement 8-OHdG level of smoke exposed rats.Methods: This study used a post test only control group design among 18 male Wistar rats subject, aged 8 week, 150-200 grams body weight (BW). The subject was randomly divided into 3 groups, K1: control, K2: cigarettes smoke exposed, K3: cigarettes smoke exposed and given a combination of 0.045 mg/gBW vitamin C and 0.036 IU/gBW vitamin E per oral. Analysis was done on day 21 using one-way ANOVA and post-hoc LSD for sperm concentration, motility and morphology; using Kruskal-Wallis and Mann-Whitney tests for cement 8- OHdG levels.Results: The lowest sperm concentration was found in   K2 (K2  32.59  million/mL,  K1 47.91 million/mL, K 339.43 million/mL); the lowest normal sperm motility was found in K2 (K 238.97%, K 164.57%, K3 51.43%); the lowest normal sperm morphology was found in K2 (K2 27.56%, K 138.36%, K 331.18%); and the highest cement 8- OHdG level was found in K2 (K2 20.18ng/mL, K1 3.43ng/mL, K3 5.28ng/mL).Conclusion: Combination of vitamin C and E can improve sperm concentration, motility and morphology and decrease cement 8-OHdG levels of smoke exposed rats.


2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.


e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans


2020 ◽  
Vol 3 (2) ◽  
pp. 62-69
Author(s):  
Alvio Arisia Safitri ◽  
Dwi Sloria Suharti ◽  
Asep Suhendar

In learning English, the students often make some problems while building a recount text. One of the problems causing it is that the teacher might use the old teaching method. This research aimed to observe the effect of grammar-focused writing instruction on the tenth-grade students' writing recount text at one of the Senior High School State at Kabupaten Tangerang. The research method used in this research was a quantitative method with a quasi-experimental design by using a non-equivalent control group design. The population of this research was 460 tenth grade students. The sample of this research was taken from two classes that were chosen by using Simple Random Sampling. There were X IPS 4 as the controlled class and X IPS 5 as the experimental class. The normality test result showed that the data is normally distributed, and the homogeneity test result showed that the variants belong to a homogeneous population. The analysis results of post-test by using t-test (The Pooled Variance Model T-test) were obtained data that t-count = 4,37 and t-table = 1,99 with significant level ɑ = 5% or 0,05. From the post-test calculation result, H0 is rejected, and H1 is accepted. It can be concluded that there is a significant effect of students’ writing recount text between students in the experimental class who were taught by using grammar-focused writing instruction and students in the controlled class who were taught by using the conventional method.


2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Diva Palguna ◽  
Agus Adiarta ◽  
Gede Indrawan

The aim of this study was to know about the effect of Prezi media to the learning result off class x students about a Craft and Entrepreneurship at SMA N 4 Singaraja. The research method used quasi experiment with Post-test only control group design. The research object were a class experiment and a class control. The research object selection used random sampling. The sample class of this research were X MIA 3 class as experiment class and X MIA 6 as the control class. To examine the hypothesis, one sided t-test used. The one sided t-test result showed that the study result of experiment class which used the media of Prezi higher than the class control which used the conventional media. It could be seen from one sided t-test result with tsum = 7,015 bigger than ttable = 1,672. So, the Prezi media gave the positive effect to the study result of a Craft and Entrepreneurship subject.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Niken Yuliwati ◽  
Riezky Faisal Nugroho

Strawberries (Fragaria x ananassa) and Rome beauty apples (Malus sylvestris) contain high antioxidants to reduce oxidative stress and improve the glycemic response with diabetes mellitus (DM) type II. This study aimed to analyze the effect of strawberries, Rome beauty apples, and their combination to decrease fasting blood glucose levels of type II DM patients. This experimental research used a randomized pre-post-test with a control group design. Subjects were 44 patients divided into four groups: K (control, not given the fruit), P1 (strawberries 200 g/day), P2 (apples 300 g/day), and P3 (the combination strawberries 100 g/day, apples 150 g/day) for 14 days in February–March 2019 in Surakarta. The inclusion criteria were DM patients aged 40–55 years who received oral antidiabetic drug therapy. Exclusion criteria were type II DM patients who, based on the doctor's diagnosis, had complications such as gastritis, hypertension, chronic renal failure, heart disease, liver disease, stroke, cancer, patients with consumption of antioxidant supplements. Mean of blood glucose level on K (149.82±39.125), P1 (141.00±38.079), P2 (128.73±31.841), and P3 (177.73±50.176). Analysis paired t test results showed a significant difference between before and after treatment (p=0.045). To find out which group was the most meaningful, the Bonferroni post hoc test. Decrease of fasting blood glucose levels with group K (−10.55, p>0.05), P1 (−30.18, p<0.05), P2 (40.27, p<0.05), and P3 (−32.91, p<0.05). ANOVA test was used to analyze, and the post hoc Bonferroni test with a control comparison was performed, resulting in p=0.028, in P2 and p>0.05 in P1 and P3. In conclusion, strawberries, Rome beauty apples, and their combination significantly decreased fasting blood glucose levels of type II DM patients, with the highest and most significant decrease in Rome beauty apples. POTENSI STROBERI, APEL ROME BEAUTY, DAN KOMBINASI BARU TERHADAP GULA DARAH PUASA SEBAGAI PENUNJANG TERAPI DIET PADA PASIEN DIABETES MELITUS TIPE IIStroberi (Fragaria x ananassa) dan apel Rome beauty (Malus sylvestris) mengandung antioksidan tinggi untuk mengurangi stres oksidatif dan memperbaiki respons glikemik pada diabetes melitus (DM) tipe II. Tujuan penelitian adalah menganalisis pengaruh buah stroberi, apel Rome beauty, dan kombinasinya terhadap penurunan kadar glukosa darah puasa pasien DM tipe II. Jenis penelitian eksperimen dengan rancangan randomized pre-post-test dengan control group design. Subjek penelitian 44 pasien yang dibagi empat kelompok, yaitu K (kontrol tidak diberi buah), P1 (stroberi 200 g/hari), P2 (apel Rome beauty 300 g/hari) dan P3 (kombinasi stroberi 100 g/hari dan apel 150 g/hari) selama 14 hari pada bulan Februari–Maret 2020 di Surakarta. Kriteria inklusi adalah pasien DM usia 40–55 tahun yang mendapat terapi obat antidiabetik oral. Kriteria eksklusi adalah pasien DM tipe II yang berdasar atas diagnosis dokter mengalami komplikasi seperti mag, hipertensi, gagal ginjal kronik, penyakit jantung, penyakit hati, strok, kanker, dan pasien dengan konsumsi suplemen antioksidan. Kadar glukosa darah rerata pada K (149,82±39,125), P1 (141,00±38,079), P2 (128,73±31,841), dan P3 (177,73±50,176). Hasil analisis paired t test menunjukkan terdapat perbedaan yang signifikan antara sebelum dan sesudah perlakuan (p=0,045). Untuk mengetahui kelompok mana yang paling bermakna, dilakukan Uji Post Hoc Bonferroni. Penurunan kadar glukosa darah puasa pada K (−10,55; p>0,05), P1 (−30,18; p<0,05), P2 (−40,27; p<0,05), dan P3 (−32,91; p<0,05). Analisis dilakukan dengan uji ANOVA dan Uji Post Hoc Bonferroni dengan perbandingan kontrol menghasilkan p=0,028 pada P2 serta p>0,05 pada P1 dan P3. Simpulan, pemberian stroberi, apel Rome beauty, dan kombinasinya signifikan menurunkan kadar glukosa darah puasa pasien DM tipe II dengan penurunan tertinggi dan bermakna pada apel Rome beauty.


2014 ◽  
Vol 3 (4) ◽  
pp. 893-902 ◽  
Author(s):  
Aresta Wulan Purnamasari ◽  
Muflidah Isnawati

Latar Belakang : Hiperkolesterolemia merupakan faktor utama dan faktor risiko independen penyakit kardiovaskuler. Penurunan kolesterol total merupakan salah satu strategi dalam terapi penyakit kardiovaskuler.  Buah pare dan jeruk nipis memilki potensi menurunkan kolesterol total. Penelitian ini bertujuan untuk mengetahui pengaruh jus pare, jus jeruk nipis dan kombinasi kedua  buah dalam menurunkan kolesterol total.Metode : Penelitian ini merupakan true experimental dengan rancangan  pre-post test randomized control group design. Sampel terdiri dari 28 tikus jantan Sprague Dawley hiperkolesterolemia yang dibagi menjadi 4 kelompok. Intervensi dilakukan selama 14 hari dengan kelompok kontrol hanya diberi pakan standar, perlakuan 1 (P1) diberi jus pare 2 ml/ekor/hari, perlakuan 2 (P2) diberi jus jeruk nipis 2 ml/ekor/hari dan perlakuan 3 (P3) diberi kombinasi jus pare dan jus jeruk nipis sebanyak 4 ml/ekor/hari. Kadar kolsterol total dianalisis dengan metode CHOD-PAP. Data dianalisis dengan uji Paired t-test dan one way Anova.Hasil : Penelitian ini menunjukkan terjadi penurunan kolesterol total setelah pemberian jus pare (22,51%), jus jeruk nipis (28,93%) dan kombinasi jus pare+jeruk nipis (24,04%) (p<0,05). Namun tidak terdapat perbedaan rerata perubahan kadar kolesterol total antara kelompok kontrol dan perlakuan  dengan p=0,105 (p>0,05)Simpulan : Tidak terdapat perbedaan pengaruh pemberian pare, jus jeruk nipis dan kombinasi jus pare+jeruk nipis terhadap penurunan kolesterol total tikus hiperkolesterolemia.


2016 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Devi Puspita Handayani ◽  
Dewi Puspitasari ◽  
Nurdiana Dewi

The effect of immersion of decoction water of Red Betel Leaf (Piper crocatum) on the surface hardness of composite resin. The purpose of this study was to determine the effect of immersion of decoction water of red betel leaf on the surface hardness of composite resin compared to alcoholic mouth rinse. It was a pure experimental study with post-test only with control group design. The total samples were 27 samples divided into 2 treatment groups and 1 control group, each of which consisted of 9 samples. The treatment groups were immersed in the decoction water of red betel leaf and alcoholic mouth rinse. The control group was immersed in aquadest. After the immersion, the samples were measured using Vickers Micro hardness Tester. Analysis with one way anova and post hoc Bonferroni showed a significant difference (p<0.05) on the surface hardness of composite resin after being immersed in decoction water of red betel leaf(79,81±3,76) kg/mm2 and alcoholic mouth rinse (67,11±2,51) kg/mm2. Based on this research, it can be concluded that there was an effect of immersion of decoction water of red betel leaf if compared with alcoholic mouth rinse. The value of surface hardness of composite resin immersed in alcoholic mouth rinse was lower than the decoction water of red betel leaf.ABSTRAKPenelitian ini bertujuan untuk mengetahui efek perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Penelitian ini merupakan penelitian eksperimental murni dengan post-test only with control group design. Jumlah sampel sebanyak 27 yang dibagi dalam 2 kelompok perlakuan dan 1 kelompok kontrol dengan masing-masing kelompok sebanyak 9 sampel. Kelompok perlakuan direndam dengan air rebusan daun sirih merah dan obat kumur beralkohol. Kelompok kontrol direndam dengan akuades steril. Setelah itu dilakukan pengukuran menggunakan Vickers Microhardness Tester. Hasil uji One Way Anova dan Post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan bermakna nilai kekerasan permukaan resin komposit yang direndam dengan air rebusan daun sirih merah (79,81±3,76) kg/mm2 dan obat kumur beralkohol (67,11±2,51) kg/mm2 dengan nilai kemaknaan (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat efek lebih rendah pada perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Nilai kekerasan permukaan resin komposit yang direndam obat kumur beralkohol lebih rendah dibandingkan air rebusan daun sirih merah.


2019 ◽  
Vol 5 (2) ◽  
pp. 97
Author(s):  
Elistiana Safitri ◽  
Kosim Kosim ◽  
Ahmad Harjono

The aim of this research is to know the effect of using Predict Observe Explain (POE) method toward students’ achievement in Physics. This is an experimental research by using experimental group and control group. The research design was Post-test Only Control Group Design. The population of this research was the students of class VII SMPN 1 Lembar academic year 2015/2016. The sampling technique was Cluster Random Sampling in which class VII 2 as the control group and class VII 3 as the experimental group. Both of the groups were given a pre-test before the treatment to know the homogeneity of the groups. The instrument used is an objective test in form of multiple choices. The finding showed that the mean of the posttest in experimental group was 70 and the control group was 60.67, in which both of them were distributed normal and homogeneous. The post-test result was analyzed by using t-test (t-test polled variants) in which the value of the was 2.473 and the  was 2.015 with dk=46 and the significant level was 5%. It showed that the was accepted and was rejected. Therefore, it can be concluded that Predict Observe Explain (POE) Method gave significant effect to the students’ achievement in Physics at Class VII SMPN 1 Lembar Academic year 2015/2016.


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