scholarly journals FORMULASI DAN UJI EFEKTIVITAS GEL EKSTRAK BUAH PARE (Momordica charantia L) Terhadap BAKTERI Staphylococcusepidermidis dan Propionibacterium acnes PENYEBAB JERAWAT

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Nur Ain Thomas ◽  
Widy Susanti Abdulkadir ◽  
Mega Agustiwi Mohi
Keyword(s):  
Staphylococcus Epidermidis ◽  
Propionibacterium Acnes ◽  
Scientific Data ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Fruit Extract ◽  
Propionibacterium Acne ◽  
Extract Concentration ◽  
Irritation Test ◽  
Bitter Fruit

FORMULASI DAN UJI EFEKTIVITAS GEL EKSTRAK BUAH PARE (Momordica charantia L) Terhadap BAKTERI Staphylococcusepidermidis dan Propionibacterium acnes PENYEBAB JERAWAT Nur Ain Thomas1), Widysusanti Abdulkadir1), Mega Agustiwi Mohi1) 1)Jurusan Farmasi, Fakultas Olahraga dan KesehatanUniversitas Negeri Gorontalo ABSTRACT Acne is a skin disease in the form of inflammation in the layer of polysebaseus triggered by the bacteria Staphyloccoccus epidermidis and Propionibacterium acnes. One plant that is empirically and based on scientific data has anti-acne properties is bitter melon (Momordica charantia L). In pare fruit extract contains flavonoids which are thought to be able to act as active compounds in the form of anti-acne. This study aims to formulate bitter melon extract as an anti-acne gel and determine the inhibition of bitter melon extract gel against acne-causing bacteria, namely Staphylococcus epidermidis and Propionibacterium acne. Pare fruit extract gel with 3 variations of extract concentration, namely 5%, 7.5% and 10%. Evaluation of gel preparations included organoleptic test, homogeneity, spreadability, pH, viscosity, and irritation test. Data analysis using Oneway ANOVA. Based on the results of the research conducted, it can be concluded that bitter fruit extract (Momordica charantia L) can be formulated as an anti-acne gel, and the preparation of bitter fruit extract gel (Momordica charantia L) at a concentration of 10% has a inhibition of 10 mm against Staphylococcus epidermidis and 7, 1 mm against the bacterium Propionibacterium acne which is included in the medium category. Keywords: Acne, Extract, Gel , Stahpylococcus epidermidis, Propionibacterium acnes  ABSTRAK Jerawat merupakan penyakit kulit berupa peradangan pada lapisan polisebaseus yang dipicu oleh bakteri Staphyloccoccus epidermidis dan Propionibacterium acnes. Salah satu tanaman yang secara empiris dan berdasarkan data ilmiah memiliki khasiat antijerawat adalah buah pare (Momordica charantia L). Dalam ekstrak buah pare terkandung flavonoid yang diduga dapat berperan  sebagai senyawa aktif sedian antijerawat. Penelitian ini bertujuan untuk  memformulasikan ekstrak buah pare sebagai gel antijerawat dan menentukan daya hambat gel ekstrak buah pare terhadap bakteri penyebab jerawat yaitu Staphylococcus epidermidis dan Propionibacterium acne. Gel ekstrak buah pare dengan 3 variasi konsentrasi ekstrak yaitu 5%, 7,5% dan 10%. Evaluasi sediaan gel meliputi uji organoleptik, homogenitas, daya sebar, pH, viskositas, dan uji iritasi.Analisis data menggunakan ANOVA Oneway. Berdasarkan hasil penelitian yang dilakukan maka dapat disimpulkan bahwa ekstrak buah pare (Momordica charantia L) dapat diformulasikan sebagai gel antijerawat, dan sediaan gel ekstrak buah pare (Momordica charantia L) pada konsentrasi 10% mempunyai daya hambat 10 mm terhadap bakteri Staphylococcus epidermidis dan 7,1 mm terhadap bakteri Propionibacterium acne yang termasuk dalam kategori sedang.Kata Kunci :Jerawat, Ekstrak Buah Pare, Gel, Stahpylococcus epidermidis, Propionibacterium acnes  

scholarly journals Uji Efektivitas GELL Obat Jerawat Dari Ekstrak Etanol Buah Pare (Momordica charantia L.) Terhadap Pertumbuhan Bakteri Propionibacterium acnes

2020 ◽  
Vol 3 (1) ◽  
pp. 1-6
Author(s):  
Herviani Sari ◽  
Firdaus Fahdi
Keyword(s):  
Psychological Factors ◽  
Propionibacterium Acnes ◽  
Ethanol Extract ◽  
Dietary Factors ◽  
Bitter Melon ◽  
Sebaceous Glands ◽  
Good Resistance ◽  
Fruit Extract ◽  
Propionibacterium Acne ◽  
Extract Concentration

Bacterial infection is a major factor in causing acne. The causes of acne are many (multifactorial), including genetic, endocrine, dietary factors, the activity of the sebaceous glands themselves, psychological factors, mucin, infection by Propionibacterium acne, cosmetics, and other chemicals. Pare extract can be formulated as a gell pimple, which can inhibit the growth of propionibacterium acne. The samples in this study were gell preparations of the ethanol extract of bitter melon with a concentration of 5%, 7.5%, 10%. Based on the results obtained, the addition of the ethanol extract concentration of bitter melon fruit depends on the extract produced. The higher the concentration of gell preparations, the better it is to inhibit bacterial growth. The  results showing that pare fruit extract with a concetration of 5%, 7,5%, 10%, and as gell verile 0,025% get a variety of results. And a good resistance zone on the three concentrations that are most close to verile effectiveness is 10% concentration. In conclusion, bitter melon extract can be formulated as an acne medication that can inhibit the growth of the Propionibacterium acnes bacteria.

scholarly journals FORMULASI DAN UJI STABILITAS FISIK SEDIAAN TABLET EKSTRAK BUAH PARE (Momordica charantia L.) SECARA GRANULASI BASAH

2019 ◽  
Vol 2 (1) ◽  
pp. 25
Author(s):  
Ira Nur Fadhilah ◽  
Dwi Saryanti
Keyword(s):  
Physical Stability ◽  
Momordica Charantia ◽  
Wet Granulation ◽  
Bitter Melon ◽  
Fruit Extract ◽  
Glucose Levels ◽  
Binding Material ◽  
Gelatin Concentration ◽  
Bitter Fruit ◽  
Melon Fruit

<p>Bitter melon fruit is one type of medicinal plant used by the community. Charantin is one of the efficacious compounds contained in bitter melon fruit and can be used to reduce glucose levels in the blood. Tablets have advantage that are easy to consume and exactly the size, so in this study bitter melon is made from tablet preparations. The purpose of this study was to determine the concentration of gelatin binder which can produce tablets of bitter fruit extract (<em>Momordica charantia</em> L.) with good physical quality, and to determine the effect of gelatin as a binder on the physical stability test of bitter melon extract tablets (<em>Momordica charantia</em> L.) making bitter melon extract tablets is by wet granulation method, because the active ingredient of bitter melon fruit is not resistant to warming above 600C. Formulation tablets of bitter melon extract (<em>Momordica charantia</em> L.) with gelatin binder at a concentration of 5%, 7.5%, 10% able to produce tablets that meet the requirements of tablet physical examination for 28 days. Gelatin binding concentration has an effect on the physical properties of tablets, the best concentration of gelatin binder is formula III with 10% gelatin concentration. The higher the concentration of the binding material, the higher the hardness, and fragility decreases.<br />Keywords: Bitter Melon Extract (<em>Momordica charantia</em> L.), Gelatin binder, Wet Granulation.</p>

Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation

2012 ◽  
Vol 135 (3) ◽  
pp. 976-984 ◽  
Author(s):  
Chin Hsu ◽  
Tsung-Hsien Tsai ◽  
You-Yi Li ◽  
Wen-Huey Wu ◽  
Ching-Jang Huang ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Bioactive Components

scholarly journals STRATEGY TO MASK THE BITTER TASTE OF MOMORDICA CHARANTIA EXTRACT USING ALGINATE–GELATIN BEADS

2018 ◽  
Vol 10 (1) ◽  
pp. 381
Author(s):  
Sutriyo . ◽  
Raditya Iswandana ◽  
Fauzana Fauzi
Keyword(s):  
Particle Distribution ◽  
Bitter Taste ◽  
Momordica Charantia ◽  
Process Efficiency ◽  
Cross Linking ◽  
Ionic Gelation ◽  
Bitter Melon ◽  
Fruit Extract ◽  
Round Shape ◽  
Melon Fruit

Objective: This study is aimed to develop a strategy to mask the bitter taste of Momordica charantia Linn. extract using alginate–gelatin beads.Methods: Beads of bitter melon fruit extract (M. charantia Linn) were prepared using an ionic gelation method in which cross-linking occurs betweensodium alginate and calcium chloride that serves to mask the bitter taste. Beads were prepared using sodium alginate (1.5% w/v) with variousconcentrations of bitter melon fruit extract (1:2, 1:1, and 1:0.5), gelatin (2% w/v), and CaCl2 3%. The obtained beads were then characterized bothphysically and functionally, and their morphology, process efficiency, particle distribution, swelling index, and water content were recorded.Results: Formula 1 beads, with a 1:2 ratio of extract: alginate, displayed a near-round shape with a diameter of 600–1 200 μm, a swelling index of113.21%, and a moisture content of 15.34%. In addition, these beads were able to significantly cover the bitter taste (p<0.05).Conclusion: Formula 1 beads with a 1:2 ratio of extract: alginate can effectively mask the bitter taste of M. charantia Linn.

scholarly journals Comparative Literature Study of Bligo Fruit Extract (Benincasa hispida (Thunb) Cogn) and Bitter Melon (Momordica charantia L.) Extract on the Minimum Inhibition of Salmonella typhi Bacteria

2021 ◽  
Vol 17 (2) ◽  
pp. 167
Author(s):  
Mei Rizqi Putri Afifah ◽  
Noer Kumala Indahsari
Keyword(s):  
Salmonella Typhi ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Literature Study ◽  
Fruit Extract ◽  
Benincasa Hispida ◽  
Narrative Literature ◽  
Narrative Literature Review ◽  
Inhibitory Power ◽  
Comparative Literature Study

Abstract: Salmonella typhi is a gram-negative bacteria species that causes typhoid fever. Salmonella typhi is sensitive to antibiotics such as amoxicillin, chloramphenicol, ciprofloxacin, and cotrimoxazole. However, there has been some increase in antibiotic resistance, so there is a need for new antibacterials that do not have a resistance effect to treat infection. Bligo fruit (Benincasa hispida (Thunb) Cogn) and bitter melon (Momordica charantia L.) contain saponins, tannins, flavonoids, alkaloids, and triterpenoids which have antibacterial power. The purpose of this study was to compare the effectiveness of the bligo fruit extract (Benincasa hispida (Thunb) Cogn) and bitter melon extract (Momordica charantia L.) on the minimum inhibition of Salmonella typhi bacteria. The method used is narrative literature review. The results of the journal study showed that the extract of bitter melon (Momordica charantia L.) was more effective in inhibiting Salmonella typhi bacteria than the extract of bligo (Benincasa hispida (Thunb) Cogn) with a minimum inhibitory power at a concentration of 20%, namely 8.5 mm. Keywords: Bligo Fruit (Benincasa hispida (Thunb) Cogn), Bitter Melon (Momordica charantia L.), Salmonella typhi.

scholarly journals Perbandingan kualitas spermatozoa tikus wistar (rattus norvegicus) yang diberi ekstrak buah pare (momordica charantia L) dengan ekstrak biji pepaya (carica papaya L)

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Kyrie E. Wenur ◽  
Lusiana Satiawati ◽  
Lydia Tendean
Keyword(s):  
Rattus Norvegicus ◽  
Wistar Rats ◽  
Carica Papaya ◽  
Seed Extract ◽  
Momordica Charantia ◽  
Bitter Melon ◽  
Fruit Extract ◽  
Treatment Groups ◽  
Papaya Seeds

Abstract: Male participation in contraception is still lacking. Pare (Momordica charantia L) is known having an inhibitory effect spermatogenesis and seeds of papaya (Carica papaya L) contain the alkaloid compounds that are anti-fertility, both can be used as a male contraceptive. The purpose of this study was to determine sperm quality comparison Wistar rats (Rattus norvegicus) were given a fruit extract of pare (Momordica charantia L) with the seed extract of papaya (Carica papaya L). The research used a completely randomized experimental design. There are nine samples of Wistar rats (Rattus norvegicus) males were divided into three groups and one group consisting three Wistar rats. Over the past 50 days, extracts of pare (Momordica charantia L) is given to the group 1 at 70mg / kg/day, while in the group 2 given seed extract of papaya (Carica papaya L) of 70mg / kg/day and the control group was given no treatment. The results showed significant differences in sperm motility among the treatment groups 1 with extract of bitter melon fruit (Momordica charantia L) and 2 treatment groups with the extract of papaya seeds (Carica papaya L), namely a decrease in sperm motility (p = 0.002). Conclusion, the fruit extract of bitter melon (Momordica charantia L) and seed extract of papaya (Carica papaya L) affects the quality of spermatozoa.Keywords: pare, papaya seeds, quality of spermatozoa. Abstrak: Partisipasi pria dalam menggunakan alat kontrasepsi masih sangat kurang. Pare (Momordica charantia L) diketahui memiliki efek penghambatan spermatogenesis dan biji pepaya (Carica papaya L) mengandung senyawa alkaloid yang bersifat antifertilitas, keduanya dapat digunakan sebagai bahan kontrasepsi pria. Tujuan penelitian ini adalah mengetahui perbandingan kualitas spermatozoa tikus wistar (Rattus norvegicus) yang diberi ekstrak buah pare (Momordica charantia L) dengan ekstrak biji pepaya (Carica papaya L). Penelitian ini menggunakan metode penelitian eksperimental dengan menggunakan rancangan acak lengkap. Sampel yang digunakan adalah sembilan tikus wistar (Rattus norvegicus) jantan yang dibagi menjadi tiga kelompok dan satu kelompok terdiri dari tiga ekor tikus wistar. Selama 50 hari, ekstrak buah pare (Momordica charantia L) diberikan pada kelompok perlakuan 1 sebesar 70mg/kgBB per hari, sedangkan pada kelompok perlakuan 2 diberikan ekstrak biji pepaya (Carica papaya L) sebesar 70mg/kgBB per dan kelompok kontrol tidak diberikan perlakuan. Hasil penelitian menunjukan adanya perbedaan signifikan pada motilitas spermatozoa antara kelompok perlakuan 1 dengan pemberian ekstrak buah pare (Momordica charantia L) dan kelompok perlakuan 2 dengan pemberian ekstrak biji pepaya (Carica papaya L) yaitu penurunan motilitas spermatozoa ( p = 0,002).Kesimpulan, ekstrak buah pare (Momordica charantia L) dan ekstrak biji pepaya (Carica papaya L) berpengaruh terhadap kualitas spermatozoa. Kata kunci: buah pare, biji pepaya, kualitas spermatozoa

scholarly journals Bitter melon (Momordica charantia) fruit extract ameliorates methotrexate‐induced reproductive toxicity in male rats

2021 ◽  
Author(s):  
Fatma KANPALTA ◽  
Dilek OZBEYLI ◽  
Ali SEN ◽  
Özge CEVIK ◽  
Göksel SENER ◽  
...  
Keyword(s):  
Reproductive Toxicity ◽  
Momordica Charantia ◽  
Male Rats ◽  
Bitter Melon ◽  
Fruit Extract

scholarly journals ACTIVITY ETHANOL EXTRACT, ETHYLE ACETATE FRACTION, N-HEXAN FRACTION OF SOFO-SOFO LEAVES (Acmella cf) Against Propionibacterium acnes AND Staphylococcus epidermidis AS ANTIBACTERIES

2021 ◽  
Vol 7 (1) ◽  
pp. 28
Author(s):  
Eva Diansari Marbun ◽  
Alfi Sapitri ◽  
Vivi Asfianti
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Propionibacterium Acnes ◽  
Ethanol Extract ◽  
Ash Content ◽  
Hexane Extract ◽  
Diffusion Method ◽  
Soluble Extract ◽  
Propionibacterium Acne ◽  
Extract Content

Sofo-sofo leaves are traditional medicinal plants that have been known by the Nias people to cure fever, coughs, diarrhea and antimicrobial infections on the skin surface. The  purpose  of  this  study  was  to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethylacetate fraction Sofo-sofo leaf (Acmella cf) against Propionibacterium acnes and Staphylococcus epidermidis. Simplicia powder was characterized and phytochemical screening was performed. Furthermore, it was isolated using 96% ethanol solvent and fractionated with  n-hexane and ethylacetate to obtain extracts. Then test the antibacterial activity of each extract against Propionibacterium acne and Staphylococcus epidermidis by using a diffusion method disc paper. The research results obtained water content 5.66%, water soluble extract content 27.33%, ethanol soluble extract content 13.61%, total ash  content 14.39%, and  acid insoluble ash content 6.25%. The highest antibacterial activity was given by ethylacetate extract at a concentration of 2% (23.4 ± 0.2) compared to ethanol extract with a concentration of 2% (21.06 ± 0.85) and 2% concentrated n-hexane extract (19.36 ± 0.16) against the Propionibacterium acne bacteria. The highest antibacterial activity was ethyl acetate extract at a concentration of 2% (23.24 ± 0.23), ethanol extract with a concentration of 2% (16.36 ± 1.76) and n-hexane extract at a concentration of 2% (15.36 ± 0 , 11) against Staphylococcus epidermidis bacteria. The  antibacterial activity results were analyzed by the one way ANOVA test method. Based on these results it can be concluded that there are differences between treatment groups, which is indicated by a significant value <0.05.

scholarly journals Uji Daya Hambat Sediaan Sabun Transparan Ekstrak Jarak Pagar (Jatropha curcas) Terhadap Pertumbuhan Bakteri Uji Propionibacterium acnes

2017 ◽  
Vol 3 (02) ◽  
pp. 103-109
Author(s):  
Risky Juliansyah ◽  
Rismawati Paotonan
Keyword(s):  
Staphylococcus Aureus ◽  
Jatropha Curcas ◽  
Staphylococcus Epidermidis ◽  
Propionibacterium Acnes ◽  
Propionibacterium Acne

Jerawat  merupakan  penyakit  peradangan  yang  terjadi  akibat  penyumbatan  pada pilosebasea  yang  ditandai  dengan  adanya  komedo,  papul,  pastul,  dan  bopeng (scar) pada daerah  wajah,  leher,  lengan  atas,  dada,  dan  punggung.  Peradangan  dipicu  oleh Propionibacterium  acne,  Staphylococcus  epidermidis, dan Staphylococcus  aureus. Kandungan fitokimia dalam daun Jarak pagar yaitu tanin, steroid dan triterpenoid, flavanoid, saponin, antraquinon, dan alkaloid. Dalam formulasi sabun transparan penambahan bahan aktif tanaman dapat membantu peningkatan aktivitas antibakteri.                Dari hasil penelitian uji daya hambat sabun transparan ekstrak  jarak pagar  ( Jatropha curcas) terhadap pertumbuhan Bakteri Propionibacterium acnes menghasilkan zona hambatan pertumbuhan pada bakteri dengan konsentrasi hambatan minimum  yaitu 5 %. Untuk kontrol positif sendiri digunakan ekstrak jarak pagar  memberikan diameter  hambat sebesar 11,02 mm serta pada kontrol negatif digunakan sabun transparan tanpa penambahan ekstrak jarak pagar  memberikan diameter hambatan sebesar 5,32 mm. Sehingga konsentrasi minimum pada penghambatan pertumbuhan bakteri uji pada sediaan sabun transparan pada  konsentrasi  5%  dengan diameter hambatan 9,07 mm.  

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