STUDY OF P53 EXPRESSION IN CARCINOMA CERVIX AND NORMAL CERVICAL EPITHELIUM WITH CLINICAL CORRELATION

2021 ◽  
pp. 28-32
Author(s):  
Vemula sreenivas ◽  
Radhika mucharla
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Public Health Problem ◽  
Age Group ◽  
Carcinoma Cervix ◽  
P53 Expression ◽  
Normal Cervical Epithelium ◽  
Year 2000 ◽  
Common Malignancy ◽  
Group 1

Cervical cancer is a world- wide public health problem with an incidence of 530,232 new cases and 275,008 deaths every year. Across the world, carcinoma of the uterine cervix is the second most common malignancy in women, and is a major cause of morbidity and mortality. Cervical carcinoma is the leading cancer in India, common in the females between 15 and 44 years of age group [1]. India accounts for one-fth of the world's burden of cervical cancer and the incidence of cervical carcinoma has increased from 0.11 million in the year 2000 to 0.16 million cases in 2012 [2].

scholarly journals Awareness of carcinoma cervix in nursing personnel of a tertiary care institute, Mumbai, India

2017 ◽  
Vol 7 (1) ◽  
pp. 128
Author(s):  
Pooja K. Bandekar ◽  
Prashant B. Kale
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cervical Carcinoma ◽  
Nursing Staff ◽  
Tertiary Care ◽  
Screening Methods ◽  
Carcinoma Cervix ◽  
Indian Women ◽  
Screening Programs

Background: Carcinoma cervix is the second most common cancer of women all over the world and commonest cancer among Indian women. Awareness about cervical cancer and its prevention low amongst Indian women. The Pap test is a simple cost-effective technique for screening to help early diagnosis of cervical cancer. Nursing staff should be made aware of cervical cancer, so that they can spread the knowledge to the general public. Objectives of present study were to assess the knowledge level regarding symptoms, risk factors, prevention and screening of cervical carcinoma among nursing staff and to find out the behaviour of respondents regarding prevention and screening of cervical carcinomaMethods: A cross-sectional interview-based survey regarding knowledge of cervical carcinoma was conducted among the nursing staff of a tertiary care institutes of Mumbai.A structured questionnaire with multiple choices was used as a tool for data collection. Provision for open-ended responses was also made in the questionnaire. 100 nurses participated in the current study. Data was entered in Microsoft Excel. SPSS statistical software was used to generate statistical parameters like proportion, mean, standard deviation, etc. The test of significance used was the Z test and a P value of <0.05 was considered as the level of significance.Results: We lack an organized opportunistic screening program for cervical cancer in India. Data indicates a slow, but steady, decline in the incidence of cervical cancer. However, the rates are still too high, particularly in the rural areas. It is extremely essential to screen eligible women when they come to health units for other services. Studies have shown it is possible to train nurses to screen for cervical cancer. Attitudes that screening is to be done by doctors or gynaecologists only needs to change. The survey revealed that the hospital played a limited role as a source of information on Pap smear. This calls for a re-orientation of nurses, paramedicals and health workers and a need for introduction of simpler cervical cancer screening methods such as visual inspections that are more sustainableConclusions: Awareness about cervical cancer has to be improved. Education of the nursing personel will strongly contribute to strengthen cervical cancer screening programs. Nursing staff can and should educate the masses to help increase health awareness in women.

scholarly journals PROFIL MALARIA PADA ANAK DI BRSD LUWUK KABUPATEN BANGGAI PROVINSI SULAWESI TENGAH PERIODEJANUARI 2011- DESEMBER 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Feby Bantoyot
Keyword(s):  
Medical Records ◽  
Public Health Problem ◽  
Descriptive Study ◽  
Age Group ◽  
Protozoan Parasites ◽  
Female Age ◽  
Genus Plasmodium ◽  
Moderate Malnutrition ◽  
Central Sulawesi ◽  
Group 1

Abstract: Malaria is a disease caused by protozoan parasites of the genus Plasmodium.  Malaria remains a public health problem in the world. In Indonesia in the last five years Paracite Annual Incidence (API) has been successfully reduced from 1.96 per 1000 population (2008) to 1.69 per 1000 population (2012). In 2010 the incidence of malaria by age group, based on the characteristics of the respondents was highest in the age of 1-4 years (23.9%), according to the characteristics of sex, obtained in men is higher than women. In Central Sulawesi, incidence of malaria in 2011 was 3.08%. In 2008, the highest incidence of malaria in Central Sulawesi contained in Buol district, Donggala and Banggai. This study aims to determine the profile of malaria in children in BRSD Banggai Central Sulawesi period January 2011 - December 2013. This study is a retrospective descriptive study, by accessed the medical records of study subjects. The result of experiment include 75 sample with distribution male a little more than female, age group 1-4 years,  low Hb value, and moderate malnutrition is the most include in this experiment.The type of Plasmodium is dominated by Plasmodium vivax.Keywords: malaria, Plasmodium, malnutrition, BRSD Luwuk  Abstrak: Penyakit malaria merupakan penyakit yang disebabkan oleh parasit Protozoa dari genus Plasmodium. Malaria masih menjadi masalah kesehatan masyarakat di dunia. Di Indonesia dalam lima tahun terakhir Annual Paracite Incidence (API) telah berhasil diturunkan dari 1,96 per 1000 penduduk (2008) menjadi 1,69 per 1000 penduduk (2012) Pada tahun 2010 insiden malaria menurut golongan umur, berdasarkan karakteristik respondenpaling tinggi pada umur 1-4 tahun (23,9%), untuk karakteristik menurut jenis kelamin, didapatkan pada laki-laki lebih tinggi dibandingkan perempuan. Di Provinsi Sulawesi Tengah insiden malaria tahun 2011 sebesar 3,08 %. Pada tahun 2008, insiden malaria tertinggi di Provinsi Sulawesi Tengah terdapat di Kabupaten Buol, Donggala dan Banggai. Penelitian ini bertujuan untuk mengetahui profil malaria pada anak di BRSD Kabupaten Banggai Provinsi Sulawesi Tengah periode Januari 2011 – Desember 2013. Penelitian ini merupakan penelitian yang bersifat deskriptif retrospektif, yaitu dengan mengakses data rekam medis subyek penelitian. Hasil penelitian, didapatkan sampel 75 anak dengan distribusi jeniskelaminlaki-laki sedikit lebih banyak dibandingkan jenis kelamin perempuan, golonganumur 1-4 tahun nilai Hb rendah dan status gizi mal nutrisi sedang paling banyak ditemukan. Jenis Plasmodium yang mendominasi adalah Plasmodium vivax.Kata Kunci :malaria, Plasmodium,malnutrisi,  BRSD Luwuk

scholarly journals Role of Colposcopy in Detection of Dysplastic Cervical Lesion as a Screening Tool

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 33s-33s
Author(s):  
P. Gyawali ◽  
S.R. KC ◽  
S. Ghimire
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Screening Tool ◽  
Cervical Lesion ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
High Grade ◽  
Age Group ◽  
Cervical Lesions ◽  
Papanicolaou Test

Background: Age standardized cervical cancer incidence rate in Nepal is 19.2/100,000 woman, compared with 14.0 worldwide. Similarly, mortality rate is 12.0 women which is significant in comparison with 6.8 worldwide. Cervical intraepithelial neoplasm is a precursor lesion, having high transformation rate into the cervical carcinoma. Data clearly indicates that CIN 2 and 3 has more progression into cervical carcinoma. Despite the fact that Papanicolaou test has remained an important tool in the screening for cervical cancer and has contributed in significant decrease in cervical cancer, sensitivity and specificity of conventional Papanicolaou test is quite low. Colposcopy is visual inspection of cervix under magnification. Study revealed that the positive predictive rate of the colposcopic impression is better as the cervical lesion is more severe. Aim: To find out the significance of colposcopy in the detection of dysplastic cervical lesions and possible use of this method as a screening tool. Methods: This is an observational study done at Cancer Care Foundation, Nepal done from a period of January 2015 to February 2018. Permission was obtained from ethical committee and written consent was obtained from the patients. All the patients suspected having dysplastic or invasive lesions or in whom colposcopy-guided biopsy was performed; were included in the study. Relevant data were collected which included age, colposcopic diagnosis, histopathological diagnosis. Data were entered into Microsoft Excel and statistical analysis was done from statistical package SPSS 21. Results: 6109 females were screened through colposcopy. Out of these 900 patients underwent colposcopy-guided biopsy for being suspected of dysplastic lesions or inflammatory lesions. Mean age of females was 40.65 years. With colposcopy, 407 (45.2%) were suspected to have low grade lesion, followed by 401 (44.6%) high grade lesion and 15 (1.7%) carcinoma. Nonneoplastic lesions were suspected in 77 (8.6%) females. In the histopathological examination low grade dysplasia was observed in 403 (44.8%) followed by 250 (27.8%) high grade dysplasia and 8 (0.9%) carcinoma in-situ or invasive carcinoma. Similarly, 239 (26.6%) patients had nonneoplastic lesions. In colposcopy, high grade lesions were suspected more frequently in females of 41-50 years age group than in 31-40 years age group ( P < 0.01). Correlation between increasing age and dysplastic lesions were also observed ( P < 0.05). There was significant correlation between colposcopic diagnosis and histopathological diagnosis with a P value < 0.01. The sensitivity of colposcopy to diagnose dysplastic lesions were high 96.44% with positive predictive value of 62.65%. The specificity of colposcopy to diagnose various grades of dysplastic lesions is 34.98%. Conclusion: Colposcopy is highly sensitive method of screening dysplastic cervical lesions and should be used more frequently as a screening purpose.

scholarly journals Profile of Children with HIV in an Anti-Retroviral Therapy (ART) Clinic of Western Nepal

2018 ◽  
Vol 37 (2) ◽  
pp. 164-167
Author(s):  
Jagat Jeevan Ghimire ◽  
Ram Hari Chapagain ◽  
Shree Krishna Shrestha ◽  
Ram Chandra Bastola
Keyword(s):  
Clinical Stage ◽  
Public Health Problem ◽  
Cd4 Count ◽  
Age Group ◽  
Immunological Profile ◽  
Route Of Transmission ◽  
Time Of Presentation ◽  
Mother To Child ◽  
Pro Forma ◽  
Group 1

Introduction: HIV in children is a public health problem in a developing country like Nepal. The aim of the study was to determine the clinical, nutritional and immunological profile of HIV +ve children enrolled in the ART clinic of Pokhara Academy of Health Sciences (PAHS).Materials and Method: This was a retrospective study of children enrolled in the ART clinic over a period of 10 years from July 2007 to June 2017. Clinical characters, Nutritional status and immunological status of children enrolled in the ART clinic were noted in the predesigned pro forma from the record of the clinic and review of the chart of the patients.Results: One hundred twelve children were enrolled in the Clinic during the study duration. Out of them 57 were males and 55 were females. All the children acquired infection through mother to child transmission. Majority of them from age group 1 to 5 years at the time of presentation. Forty-six percent were in the clinical stage III. The median CD4 count was 283.Fifty percent of the children were undernourished. Most of the children were started on AZT/3TC/NVP as first line ART.Conclusion: Although perinatal route was the most common route of transmission of HIV in children, diagnosis was late in the age group of 1-5 years and most of them were diagnosed in the advanced stage of HIV with Low CD4 count.

scholarly journals Analysis on the Incidence, Staging and Treatment of Carcinoma Cervix at Delta Medical College and Hospital of Bangladesh

2013 ◽  
Vol 1 (2) ◽  
pp. 31-36
Author(s):  
Parvin A Banu ◽  
Naheed Rukhsana ◽  
Jebunnessa Yasmin ◽  
Lutfun Nahar ◽  
Sadiqur R Malik
Keyword(s):  
Cervical Cancer ◽  
Screening Program ◽  
External Beam Radiotherapy ◽  
Concurrent Chemotherapy ◽  
Time Interval ◽  
Age Group ◽  
Carcinoma Cervix ◽  
Cross Sectional ◽  
Medical College ◽  
Incidence And Mortality

Background: Cervical cancer remains the most common cancer among women in this part of the world. Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women. Cervical cancer is a preventable disease by screening and treatment of pre-invasive condition. Unfortunately, there is no effective screening program in Bangladesh. Objective: The objective was to analyze the clinico-pathologic characteristics and, subsequently the therapy delivered to the patients. Materials and method: This cross sectional study was done from January to December 2011 in oncology division of Delta Medical College and Hospital, Dhaka, Bangladesh. During this period a total of 2264 female carcinoma patients were registered. Out of them 523 patients were with the diagnosis of carcinoma of cervix. Evaluation and characterization of patients with carcinoma cervix were done according to the age group, clinical stages and surgical status. External beam radiotherapy (EBRT) and doses, brachytherapy doses and fractions, time interval between EBRT and brachytherapy, neo-adjuvant and concurrent chemotherapy status were the factors taken into consideration for the analysis of treatment of these patients. Results: The study revealed that the incidence of carcinoma cervix was 23% and highest incidence was between 40-50 years of age group, most of the patients were in Stage IIB (34%) and IIIB (28%) and 31% with unknown stage. About 44% patients were referred postoperatively and most of them with unknown stage. Almost 90% patients received EBRT, 24% patients received concurrent chemo-radiation, 46% of them completed 5 cycles of concurrent chemotherapy and 8.6% patients received neo-adjuvant chemotherapy. About 69% patients received brachytherapy with HDR Co-60 sources and 23% of patients received their brachytherapy treatment after 12 weeks of completion of EBRT. Conclusion: Lack of proper clinical evaluation and documentation, delay in referral and lack of implementation of a standard protocol for the treatment of carcinoma cervix are the major obstacles in our country. DOI: http://dx.doi.org/10.3329/dmcj.v1i2.15915 Delta Med Col J. Jul 2013;1(2):31-36

scholarly journals Burden of Cervical Cancer in the Eastern Mediterranean Region During the Years 2000 and 2017: Retrospective Data Analysis of the Global Burden of Disease Study

10.2196/22160 ◽  
2021 ◽  
Vol 7 (5) ◽  
pp. e22160
Author(s):  
Fereshteh Safaeian ◽  
Shidrokh Ghaemimood ◽  
Ziad El-Khatib ◽  
Sahba Enayati ◽  
Roksana Mirkazemi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mortality Rate ◽  
Cancer Mortality ◽  
Eastern Mediterranean ◽  
Eastern Mediterranean Region ◽  
Absolute Number ◽  
Age Group ◽  
Cervical Cancer Mortality ◽  
The Absolute ◽  
Year 2000

Background Cervical cancer is a growing health concern, especially in resource-limited settings. Objective The objective of this study was to assess the burden of cervical cancer mortality and disability-adjusted life years (DALYs) in the Eastern Mediterranean Region (EMR) and globally between the years 2000 and 2017 by using a pooled data analysis approach. Methods We used an ecological approach at the country level. This included extracting data from publicly available databases and linking them together in the following 3 steps: (1) extraction of data from the Global Burden of Disease (GBD) study in the years 2000 and 2017, (2) categorization of EMR countries according to the World Bank gross domestic product per capita, and (3) linking age-specific population data from the Population Statistics Division of the United Nations (20-29 years, 30-49 years, and >50 years) and GBD’s data with gross national income per capita and globally extracted data, including cervical cancer mortality and DALY numbers and rates per country. The cervical cancer mortality rate was provided by the GBD study using the following formula: number of cervical cancer deaths × 100,000/female population in the respective age group. Results The absolute number of deaths due to cervical cancer increased from the year 2000 (n=6326) to the year 2017 (n=8537) in the EMR; however, the mortality rate due to this disease decreased from the year 2000 (2.7 per 100,000) to the year 2017 (2.5 per 100,000). According to age-specific data, the age group ≥50 years showed the highest mortality rate in both EMR countries and globally, and the age group of 20-29 years showed the lowest mortality rate both globally and in the EMR countries. Further, the rates of cervical cancer DALYs in the EMR were lower compared to the global rates (2.7 vs 6.8 in 2000 and 2.5 vs 6.8 in 2017 for mortality rate per 100,000; 95.8 vs 222.2 in 2000 and 86.3 vs 211.8 in 2017 for DALY rate per 100,000; respectively). However, the relative difference in the number of DALYs due to cervical cancer between the year 2000 and year 2017 in the EMR was higher than that reported globally (34.9 vs 24.0 for the number of deaths and 23.5 vs 18.1 for the number of DALYs, respectively). Conclusions We found an increase in the burden of cervical cancer in the EMR as per the data on the absolute number of deaths and DALYs. Further, we found that the health care system has an increased number of cases to deal with, despite the decrease in the absolute number of deaths and DALYs. Cervical cancer is preventable if human papilloma vaccination is taken and early screening is performed. Therefore, we recommend identifying effective vaccination programs and interventions to reduce the burden of this disease.

scholarly journals Knowledge, Attitude and Practice of Cervical Carcinoma Screening among Bangladeshi Women

2021 ◽  
Vol 20 (1) ◽  
pp. 28-32
Author(s):  
Ayesha Najma Nur ◽  
Juthi Bhowmik ◽  
Shiuly Chowdhury ◽  
Shirin Akter Begum
Keyword(s):  
Higher Education ◽  
Risk Factors ◽  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Education Level ◽  
Good Knowledge ◽  
Carcinoma Cervix ◽  
Attitude And Practice ◽  
Knowledge Attitude And Practice ◽  
Good Attitude

Background: The uterine cervix is the commonest site for female genital cancer. In developing countries, carcinoma cervix is the most common malignancy in females and a major public health problem. It is reported In Bangladesh that the prevalence of carcinoma cervix is 20% among all types of cancer affecting females. To determine the level of knowledge, attitude and practice among Bangladeshi women about screening of cervical carcinoma Materials and methods: A cross-sectional study was conducted on married women above the age of 20 years, attending OPD of Obstetrics & Gynecology, Medicine and Surgery of BSMMU from January 2013 to June 2013. By using purposive sampling technique 225 respondents were enrolled in the study. Results: Mean age of the respondents was 43.34 years with a standard deviation of ± 12.49 years. Most of the respondents (96%) were Muslim and from urban areas. More than two-thirds of the respondents (71.1%) were educated up to secondary level. More than 80% respondents were housewives. About three-fourth of the respondents were form middle class families. Only 20% could mention cervical cancer as the leading cancer among women. About 20% respondents knew that early and multiple marriages were the two risk factors for cervical cancer. Most of the respondents (93.3%) believed that cervical cancer is dangerous disease and was able to mention smoking as one of the important risk factors. About one-third respondents knew that terms Pap’s smear and VIA. But most of the respondents did not undergo any screening procedure under the assumption that the screening was not necessary. It was found that respondents with higher education level possessed good knowledge regarding cervical cancer. It was also true for respondents whose husbands were more educated. Higher education level was positively correlated with good attitude/practices. The respondents who had good knowledge about cervical cancer showed good attitude/practice regarding the same. Conclusion: The knowledge regarding cervical cancer among the participants was not satisfactory. Although most of the participants believed that cervical cancer is dangerous disease few really knew that it is preventable. Higher education level was positively correlated with good knowledge and good attitude/practices regarding cervical cancer. Long term education for women should be started to provide the needed information regarding cervical cancer screening. Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 28-32

scholarly journals Burden of Cervical Cancer in the Eastern Mediterranean Region During the Years 2000 and 2017: Retrospective Data Analysis of the Global Burden of Disease Study (Preprint)

2020 ◽  
Author(s):  
Fereshteh Safaeian ◽  
Shidrokh Ghaemimood ◽  
Ziad El-Khatib ◽  
Sahba Enayati ◽  
Roksana Mirkazemi ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Mortality Rate ◽  
Cancer Mortality ◽  
Eastern Mediterranean ◽  
Eastern Mediterranean Region ◽  
Absolute Number ◽  
Age Group ◽  
Cervical Cancer Mortality ◽  
The Absolute ◽  
Year 2000

BACKGROUND Cervical cancer is a growing health concern, especially in resource-limited settings. OBJECTIVE The objective of this study was to assess the burden of cervical cancer mortality and disability-adjusted life years (DALYs) in the Eastern Mediterranean Region (EMR) and globally between the years 2000 and 2017 by using a pooled data analysis approach. METHODS We used an ecological approach at the country level. This included extracting data from publicly available databases and linking them together in the following 3 steps: (1) extraction of data from the Global Burden of Disease (GBD) study in the years 2000 and 2017, (2) categorization of EMR countries according to the World Bank gross domestic product per capita, and (3) linking age-specific population data from the Population Statistics Division of the United Nations (20-29 years, 30-49 years, and &gt;50 years) and GBD’s data with gross national income per capita and globally extracted data, including cervical cancer mortality and DALY numbers and rates per country. The cervical cancer mortality rate was provided by the GBD study using the following formula: number of cervical cancer deaths × 100,000/female population in the respective age group. RESULTS The absolute number of deaths due to cervical cancer increased from the year 2000 (n=6326) to the year 2017 (n=8537) in the EMR; however, the mortality rate due to this disease decreased from the year 2000 (2.7 per 100,000) to the year 2017 (2.5 per 100,000). According to age-specific data, the age group ≥50 years showed the highest mortality rate in both EMR countries and globally, and the age group of 20-29 years showed the lowest mortality rate both globally and in the EMR countries. Further, the rates of cervical cancer DALYs in the EMR were lower compared to the global rates (2.7 vs 6.8 in 2000 and 2.5 vs 6.8 in 2017 for mortality rate per 100,000; 95.8 vs 222.2 in 2000 and 86.3 vs 211.8 in 2017 for DALY rate per 100,000; respectively). However, the relative difference in the number of DALYs due to cervical cancer between the year 2000 and year 2017 in the EMR was higher than that reported globally (34.9 vs 24.0 for the number of deaths and 23.5 vs 18.1 for the number of DALYs, respectively). CONCLUSIONS We found an increase in the burden of cervical cancer in the EMR as per the data on the absolute number of deaths and DALYs. Further, we found that the health care system has an increased number of cases to deal with, despite the decrease in the absolute number of deaths and DALYs. Cervical cancer is preventable if human papilloma vaccination is taken and early screening is performed. Therefore, we recommend identifying effective vaccination programs and interventions to reduce the burden of this disease.

scholarly journals Clinicopathological Profile of Cervical Carcinoma: An Experience of Tertiary Care Cancer Centre

2019 ◽  
Vol 4 (3) ◽  
pp. 83-86
Author(s):  
Manjit Kaur Rana ◽  
Karuna Singh ◽  
M K Mahajan ◽  
Amrit Pal Singh Rana
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Retrospective Analysis ◽  
Cervical Carcinoma ◽  
Squamous Cell ◽  
Growth Patterns ◽  
Stage Iii ◽  
Carcinoma Cervix ◽  
Clinical Presentations

Context: Cervical cancer is a malignant neoplasm arising mainly in the transformation zone of the cervix. Cervical cancer is the second most common cancer among women worldwide after breast cancer. Squamous cell carcinoma and adenocarcinoma constitute the greatest burden, globally as well as in India.Aims: The current study was aimed to assess the histopathological profile and its correlation with clinical findings.Settings and Design: It was a retrospective analysis of the patients of cervical carcinoma. Methods and Materials: The retrospective analysis of histopathological patterns of carcinoma cervix was done. A total of 120 cervical biopsies were received, amongst which 5 biopsies were chronic cervicitis, 9 were cervical intraepithelial neoplasia (CIN) and 106 cases were of carcinoma. Further histologic subtyping of cervical carcinoma was done and was correlated with clinical presentations and stage. The collected data were analysed. Statistical analysis used: Analysis of data was done for simple means and percentages.Results: The most common age group in carcinoma cervix was fifth and sixth decade with history of bleeding per vagina being the most common clinical presentation. Squamous cell carcinoma (SCC) was the most common variant, ≥Stage III case constituted in majority and also showed poor prognosis.Conclusion: A majority of Indian women presented at later stages of cervical cancer, hence demanding the need of dedicated screening programes. Many variants present with different clinical findings especially as deep infiltrative growth patterns, hence histologic types should be kept in mind clinically while dealing with unfamiliar clinical presentations. In our experience most of the women presented in later stages and patients with ≥ stage III showed poor prognosis.

A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

1990 ◽  
Vol 48 (3) ◽  
pp. 204-205
Author(s):  
Kun Lee ◽  
Jingyi Si ◽  
Ricai Han ◽  
Wei Zhang ◽  
Bingbing Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dot Blot ◽  
Homologous Sequences ◽  
Normal Cervical Epithelium ◽  
The Relationship ◽  
Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

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