A COMPARATIVE STUDY OF ABG PATTERN IN PATIENTS OF COPD WITH OR WITHOUT COR PULMONALE

INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a major public health problem. COR PULMONALE describes the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance or increased pulmonary artery pressure. Hypoxic pulmonary vasoconstriction, hypercapnia, respiratory acidosis and pulmonary vascular remodeling in COPD can cause an increase in right ventricular (RV) after load, which in turn, results in RVfailure leading to COR PULMONALE AIM:The purpose of the study is to compare the ABG pattern in patients of COPD with or without COR PULMONALE. MATERIALS AND METHODS: This prospective observational study was conducted in the Department of Medicine of DMCH, Laheriasarai, Bihar. The study was conducted with duration of 2 years. Atotal of 100 patients admitted as a case of COPD with or without COR PULMONALE. The patients were put into two subgroups, COPD with and without COR PULMONALE. RESULT: The mean duration was 10.17 years and 9.20 years respectively in patients with and without COR PULMONALE. There was no statistically signicant difference regarding mean duration of disease (p value =0.304). Mean CAT score was 16.59 ± 6.26 and mean mMRC was 3.19± 0.45 in COPD patients with COR PULMONALE group. Mean CAT score was 14.06 ± 4.46 and mean mMRC was 3.10 ± 0.44 in COPD patients without COR PULMONALE group. We found no signicant difference among these variables between groups. Although COR PULMONALE patients had higher CATscore and mMRC score, the difference was not signicant (p value = >0.05). CONCLUSION:ABG ANALYSIS should be recommended for all patients of COPD with or without COR PULMONALE to assess the degree of hypoxemia, hypercapnea, respiratory acidosis and also, we can identify individuals who need more close monitoring and intensive treatment.

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GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease

Bioscience Reports ◽

10.1042/bsr20194459 ◽

2020 ◽

Vol 40 (6) ◽

Author(s):

Xi-Juan Zhang ◽

Zhong-Hua Cui ◽

Yan Dong ◽

Xiu-Wen Liang ◽

Yan-Xin Zhao ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Large Scale ◽

Enrichment Analysis ◽

Gene Set Enrichment Analysis ◽

Chronic Obstructive ◽

P Value ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Size Population

Abstract Osteoporosis (OP) is significant and debilitating comorbidity of chronic obstructive pulmonary disease (COPD). We hypothesize that genetic variance identified with OP may also play roles in COPD. We have conducted a large-scale relation data analysis to explore the genes implicated with either OP or COPD, or both. Each gene linked to OP but not to COPD was further explored in a mega-analysis and partial mega-analysis of 15 independently collected COPD RNA expression datasets, followed by gene set enrichment analysis (GSEA) and literature-based pathway analysis to explore their functional linked to COPD. A multiple linear regression (MLR) model was built to study the possible influence of sample size, population region, and study date on the gene expression data in COPD. At the first step of the analysis, we have identified 918 genes associated with COPD, 581 with OP, and a significant overlap (P<2.30e-140; 210 overlapped genes). Partial mega-analysis showed that, one OP gene, GPNMB presented significantly increased expression in COPD patients (P-value = 0.0018; log fold change = 0.83). GPNMB was enriched in multiple COPD pathways and plays roles as a gene hub formulating multiple vicious COPD pathways included gene MMP9 and MYC. GPNMB could be a novel gene that plays roles in both COPD and OP. Partial mega-analysis is valuable in identify case-specific genes for COPD.

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Machine-learning based feature selection for a non-invasive breathing change detection

BioData Mining ◽

10.1186/s13040-021-00265-8 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Juliana Alves Pegoraro ◽

Sophie Lavault ◽

Nicolas Wattiez ◽

Thomas Similowski ◽

Jésus Gonzalez-Bermejo ◽

...

Keyword(s):

New Technologies ◽

Load Capacity ◽

Public Health Problem ◽

Signal Amplitude ◽

Respiratory Pattern ◽

Chronic Obstructive ◽

Rate Variation ◽

Major Public Health Problem ◽

Breathing Rate ◽

Obstructive Pulmonary Disease

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is one of the top 10 causes of death worldwide, representing a major public health problem. Researchers have been looking for new technologies and methods for patient monitoring with the intention of an early identification of acute exacerbation events. Many of these works have been focusing in breathing rate variation, while achieving unsatisfactory sensitivity and/or specificity. This study aims to identify breathing features that better describe respiratory pattern changes in a short-term adjustment of the load-capacity-drive balance, using exercising data. Results Under any tested circumstances, breathing rate alone leads to poor capability of classifying rest and effort periods. The best performances were achieved when using Fourier coefficients or when combining breathing rate with the signal amplitude and/or ARIMA coefficients. Conclusions Breathing rate alone is a quite poor feature in terms of prediction of breathing change and the addition of any of the other proposed features improves the classification power. Thus, the combination of features may be considered for enhancing exacerbation prediction methods based in the breathing signal.Trial Registration : ClinicalTrials NCT03753386. Registered 27 November 2018, https://clinicaltrials.gov/show/NCT03753386

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Differences in the Outcome of Patients with COPD according to Body Mass Index

Journal of Clinical Medicine ◽

10.3390/jcm9030710 ◽

2020 ◽

Vol 9 (3) ◽

pp. 710 ◽

Cited By ~ 2

Author(s):

Zichen Ji ◽

Javier de Miguel-Díez ◽

Christian Reynaldo Castro-Riera ◽

José María Bellón-Cano ◽

Virginia Gallo-González ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Hospital Admissions ◽

Obesity Paradox ◽

Chronic Obstructive ◽

P Value ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Critical Unit

Background: In chronic obstructive pulmonary disease (COPD), the “obesity paradox” is a phenomenon without a clear cause. The objective is to analyze the complications of COPD patients according to their body mass index (BMI). Methods: An observational study with a six-year prospective follow-up of 273 COPD patients who attended a spirometry test in 2011. Survival and acute events were analyzed according to the BMI quartiles. Results: A total of 273 patients were included. BMI quartiles were ≤24.23; 24.24–27.69; 27.70–31.25; ≥31.26. During the follow-up, 93 patients died. No differences were found in exacerbations, pneumonia, emergency visits, hospital admissions or income in a critical unit. Survival was lower in the quartile 1 of BMI with respect to each of the 2–4 quartiles (p-value 0.019, 0.013, and 0.004, respectively). Advanced age (hazard ratio, HR 1.06; 95% confidence interval, CI 1.03–1.09), low pulmonary function (HR 0.93; 95% CI 0.86–0.99), exacerbator with chronic bronchitis phenotype (HR 1.76; 95% CI 1.01–3.06), high Charlson (HR 1.32, 95% CI 1.18–1.49), and the quartile 1 of BMI (HR 1.99, 95% CI 1.08–3.69) were identified as risk factors independently associated with mortality. Conclusions: In COPD, low BMI conditions a lower survival, although not for having more acute events.

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Urinary incontinence in female patients with chronic obstructive pulmonary disease

South African Journal of Physiotherapy ◽

10.4102/sajp.v57i4.521 ◽

2001 ◽

Vol 57 (4) ◽

pp. 29

Author(s):

M. Papadopoulos ◽

I. Muller ◽

S. Cullen

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Urinary Incontinence ◽

Stress Urinary Incontinence ◽

Pulmonary Disease ◽

Smoking History ◽

Chronic Obstructive ◽

P Value ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Copd Patients

Background: Urinary incontinence has been experienced as a problem since 1500 BC. In the twentieth century it is still a major problem that remains a source of distress for many sufferers. A lack of literature regarding the prevalence of stress urinary incontinence (SUI) amongst chronic obstructive pulmonary disease (COPD) patients lead to this studyObjective: To determine the prevalence of stress urinary incontinence in female COPD patients between the ages of 30 and 70 years.Methods: This cross-sectional study included 67 female COPD patients (aged 30-70 years) who were interviewed during a three month period. A structured COPD / incontinence questionnaire was used to obtain data. Statistical analysis of results included Fisher’s exact test and two-tailed t-tests. A p-value of < 0,05 was considered to be statistical significant.Results: The prevalence of SUI in female COPD patients was estimated as 82,1%. Smoking history was the only variable with a significant positive correlation regarding the patients presenting with SUI (p < 0,05). The proportion of smokers in the subjects presenting with SUI (SUI group - 29/55) is significantly higher than the subjects with no symptoms of SUI (normal group - 2/12).Discussion and Conclusion: The outcome of this study revealed a high prevalence of SUI in female COPD patients. Cigarette smoking, as the major contributing factor, revealed a strong statistical correlation between COPD and SUI.

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Hubungan derajat penyakit paru obstruktif kronik dengan malnutrisi pada pasien penyakit paru obstruktif kronik di poli Rumah Sakit Umum Meuraxa

Jurnal Kedokteran Syiah Kuala ◽

10.24815/jks.v20i1.18295 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Husnah Husnah

Keyword(s):

Public Health Problem ◽

Chronic Obstructive ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Relationship Strength ◽

Copd Patients ◽

Cross Sectional Design ◽

Relationship Of ◽

Spearman Test ◽

The Relationship

Abstrak. Latar Belakang: Penyakit paru obstruksi kronik (PPOK) merupakan masalah kesehatan masyarakat yang menjadi peringkat keempat kematian di dunia. Pasien PPOK sering mengalami kehilangan berat badan sekitar 15-50% pada PPOK ringan sampai parah. Tujuan penelitian ini untuk mengetahui hubungan derajat PPOK dengan resiko malnutrisi pada pasien PPOK di poli paru RSU Meuraxa. Metode: Jenis penelitian analitik observasional dengan desain cross-sectional, teknik sampel secara accidental sampling. Penilaian derajat PPOK dengan spirometri dan resiko malnutrisi menggunakan Mini Nutrition Assesment (MNA), dengan waktu penelitian tanggal 1 maret sampai 7 april 2014 didapatkan sejumlah 60 responden. Hasil: Jenis kelamin laki-laki 40 orang (66.7%), usia terbanyak antara 51-60 tahun 25 orang (41.7%), malnutrisi sebanyak 45 orang (75%), PPOK dengan derajat sedang 28 (47.7%), dan pola makan salah 43 orang (71.7%). Analisis secara uji spearman terdapat hubungan antara derajat PPOK dengan malnutrisi nilai p = 00,1 (α0,05). r = -0,665 dengan kekuatan hubungan sedang dimana semakin berat derajat PPOK maka risiko malnutrisi semakin besar.Kata kunci: Derajat PPOK, Malnutrisi, MNA Abstract. Background: Chronic Obstructive Pulmonary Disease (COPD) is a public health problem being ranked 4th death in the world. COPD patients often experience weight loss of approximately 15-50% in mild to severe COPD. The purpose of this study was to determine the relationship of the degree of COPD at risk of malnutrition in patients with COPD. Methods: observational analytic study with cross-sectional design, engineering samples of accidental sampling. Assessment of the degree of COPD with spirometry and risk of malnutrition using Mini Nutrition Assesment (MNA), the research time on 1 March to 7 April 2014 there were 60 respondents. Results: Male gender is 40 people (66.7%), most of them are between 51-60 years of age, 25 people (41.7%), 45 people with malnutrition (75%), 28 people with moderate COPD (47.7%), and 43 people with wrong diet (71.7%). Analysis by means of the spearman test, there was a relationship between the degree of COPD and malnutrition, the value of p = 00.1 (α 0.05). r = -0.665 with moderate relationship strength where the heavier the degree of COPD, the greater the risk of malnutrition.Keywords: Degree of COPD, Malnutrition, MNA

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Prevalence of Metabolic Syndrome in Chronic Obstructive Pulmonary Disease in Rural Population of Developing Country-A Cross-sectional Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/47594.14663 ◽

2021 ◽

Author(s):

Atul Tiwari ◽

SK Piruwa ◽

SK Agrawaal ◽

GN Srivastava ◽

Deepak Shah

Keyword(s):

Cross Sectional Study ◽

Airflow Limitation ◽

Chronic Obstructive ◽

P Value ◽

Age Group ◽

Sectional Study ◽

Cross Sectional ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Healthy Control

Introduction: Metabolic Syndrome (MetS) is characterised by the clustering of central obesity, hypertension, dyslipidemia, and hyperglycemia that predisposes patients to Cardiovascular Disease (CVD). It is a representative group of conditions with systemic inflammation, which is a potential mechanism responsible for both Chronic Obstructive Pulmonary Disease (COPD) and MetS. Aim: To detect incidence of MetS in COPD patients and its correlation with severity of COPD. Materials and Methods: The present study was an observational cross-sectional study which was conducted on 62 COPD patients in SS Hospital, BHU, Varanasi, Uttar Pradesh, India, from June 2015 to June 2017, diagnosed on basis of Global initiative for Lung Disease (GOLD) guidelines. 62 age and sex matched control having no cardio-respiratory history were included. All relevant investigations were done for all selected subjects and modified Medical Research Council (mMRC) dyspnoea grading was done in all the subjects. Standardised treatment modules were followed and spirometry and post-bronchodialater spirometry was performed 15-30 mins after inhalation of 400 mcg Salbutamol. Patients obstruction was classified according to the severity of airflow limitation based on post-bronchodilator Forced Expiratory Volume in one second (FEV1) as follows: mild (≥80% predicted); moderate (80>FEV1 ≥50% predicted); severe (50%> FEV1 ≥30% predicted); very severe (<30% predicted). Complete work-up and data collection were analysed by using Statistical Package for the Social Sciences (SPSS) version 23.0 software, descriptive cross tables, univariate and multivariate analysis. Independent Student’s t-test was used to compare the means of cases and controls. The p-value <0.05 was considered statistically significant. Results: Total 62 patients along with age and sex matched 62 healthy control in 1:1 ratio have been taken in the study, majority were in age group of 50-70 years. On comparing the mean values of different parametres of MetS in COPD cases and controls, significantly raised triglyceride level and fasting blood sugar in COPD cases (p-value <0.001 and 0.005 respectively) were observed. MetS was present in 29 cases (46.8%) of COPD whereas in healthy control population only 19 people (30.6%) were positive for MetS. Total of 55.2% cases of COPD with MetS was in group D whereas 84.8% cases of COPD without MetS were in group B of GOLD staging. Statistically significant (p<0.001) higher incidence of acute exacerbation was observed in cases of COPD with MetS. Conclusion: MetS was more prevalent among the COPD patient in 50-70 years age group with mild to moderate airflow limitation. More waist circumference i.e., central obesity, impaired fasting glucose, dyslipidemia, increases the risk of cardiovascular complication in these patients. MetS is an important co-morbidity in patients of COPD which fasten the natural course of disease by increasing the frequency of acute exacerbation.

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The effect of uphill and downhill aerobic exercises on serum Apolipoprotein A1 and Apolipoprotein B levels and their ratio in patients with chronic obstructive pulmonary disease

Current Respiratory Medicine Reviews ◽

10.2174/1573398x17666210831160728 ◽

2021 ◽

Vol 17 ◽

Author(s):

Rostam Yazdani ◽

Hamid Marefati ◽

Armita Shahesmaeili ◽

Alireza Bagheri ◽

Ahmad Alinaghi Langari ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Serum Levels ◽

Apolipoprotein A1 ◽

Chronic Obstructive ◽

P Value ◽

Obstructive Pulmonary Disease ◽

Apo B ◽

Copd Patients ◽

Before And After

Background: Chronic obstructive pulmonary disease (COPD) is a major health issue worldwide. Introduction: This study aimed to evaluate the effect of aerobic exercises at steep surfaces on Apo A1 and Apo B serum levels and their ratio in COPD patients. Methods: This interventional study was undertaken on 16 COPD patients. The sample was selected by using the random sampling method. Patients were randomly divided into 2 groups of 8 members: uphill and downhill. Spirometry was conducted prior to the exercises and pulmonary volumes were measured. Aerobic exercises (stationary bicycle and treadmill) were started 3 times a week for 8 weeks. The duration of exercises in each session was determined based on the patients’ ability (30-40 min). In the first and second group, exercises were performed on sloped surfaces that were downwards and upwards at a 10-degree angle, respectively. Blood samples were taken from the patients before and after the 8 weeks. Apo A1 and Apo B serum levels and Apo A1 to Apo B ratio were measured. Data were analyzed by SPSS software. P<0.05 was considered statistically significant. Results: ApoA1/Apo B ratio in the uphill group before and after the intervention was 1.43±0.21 and 1.53±0.24 mg/dL, respectively, with P-value=0.36. In the downhill group, this value was 1.27±0.17 and 1.30±0.18, respectively, with a P-value=0.032. Conclusion: In light of the results of the present study, incorporating downhill exercises in COPD patients' rehabilitation program can help improve pulmonary function and prevent atherosclerotic events.

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Prevalence of Chronic Cor Pulmonale in Chronic Obstructive Pulmonary Disease Patients in a Teaching Hospital in Nepal

Journal of Institute of Medicine ◽

10.3126/jiom.v41i1.28586 ◽

2019 ◽

Vol 41 (1) ◽

pp. 15-19

Author(s):

Matina Sayami ◽

Suman Baral ◽

Rakshya Shrestha ◽

Dambar B Karki

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Teaching Hospital ◽

College Teaching ◽

Cor Pulmonale ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Chronic Cor Pulmonale ◽

Severe Copd

Introduction: Chronic obstructive pulmonary disease (COPD) is the most common cause of cor pulmonale. Cor pulmonale in COPD is associated with decreased survival, increased hospitalization and mortality. In this study we aim to find out the prevalence of chronic cor pulmonale in COPD patients which would help in prevention of right sided heart failure and improve patients’ quality of life. Methods: This was a cross sectional observational study done in Kathmandu Medical College Teaching Hospital, Nepal. 50 COPD patients above the age of 30 years attending the outpatient department or admitted in wards were included. All COPD patients diagnosed by pulmonary function test (PFT) were assessed for cor pulmonale by echocardiography (ECHO). The demographic data, chest X-ray, PFT, electrocardiography (ECG) and ECHO findings were recorded, entered and analyzed using SPSS software, version 17. Results: Most of the patients enrolled in the study were between age group of 51-60 with female preponderance. 68% of the COPD patients had chronic cor pulmonale. Out of 21 male, 76.2% and out of 29 female COPD patients, 62.06% had cor pulmonale. Cor pulmonale was present in 53.12% and 94.4% of patients who had COPD for < 10 years and ≥10 years duration respectively. Cor pulmonale was present in 76% patients with severe COPD, 75% of patients with moderate COPD, 64.2% patients with very severe COPD and none of the patients with mild COPD. Pulmonary hypertension (PH) was present in 67.64% of cor pulmonale patients. Conclusion: The prevalence of chronic cor pulmonale in COPD patients was 68%. It was more in male patients, highest in patients with severe COPD, and the prevalence increased with duration of COPD. PH was present in 67.64% of cor pulmonale patients.

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Health expenditures of asthma-COPD overlap in Northern Jordan

PLoS ONE ◽

10.1371/journal.pone.0257566 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257566

Author(s):

Shoroq M. Altawalbeh ◽

Bushra Hijazi ◽

Lara Kufoof ◽

Iman A. Basheti

Keyword(s):

Disease Severity ◽

Health Expenditures ◽

University Hospital ◽

Chronic Obstructive ◽

P Value ◽

Obstructive Pulmonary Disease ◽

Asthmatic Patients ◽

Billing System ◽

Copd Patients ◽

Northern Jordan

Objective To investigate the characteristics and medical expenditures of patients with Asthma- chronic obstructive pulmonary disease (COPD) overlap (ACO) compared to asthma and COPD patients. Methods This was a retrospective cohort study involving patients diagnosed with ACO, asthma or COPD as of January 2016. Medical records for patients attending King Abdullah University Hospital (KAUH), in northern Jordan, during the years 2015–2016 were used to identify eligible patients and all relevant clinical characteristics. Both respiratory and all-cause charges were extracted from KAUH billing system during the year 2016. Total, inpatient, outpatient, and pharmacy charges were described and compared across the three disease categories. Charges were measured in Jordanian Dinar (JOD, equal to 1.41 US Dollar). Results Of a total of 761, 87 ACO patients, 494 asthmatic patients and 180 COPD patients were identified and included in this study. The average total respiratory-related charges were significantly higher in patients with ACO compared to patients with asthma (601.4 versus 354.3 JODs; P value < 0.001). Average all-cause charges were higher in case of ACO and COPD compared to patients with asthma (1830.8 and 1705.4 versus 1251.7 JODs; P value < 0.001). ACO was a significant predictor of higher respiratory and all-cause related charges. Respiratory charges were also higher in older patients and those with higher disease severity. Conclusions ACO is a risk factor for incurring higher health expenditures in Jordan. Higher respiratory expenditures are also associated with older ages and higher disease severity.

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A study on the prevalence of chronic obstructive pulmonary disease among adults in Madurai, Tamil Nadu

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20174629 ◽

2017 ◽

Vol 4 (11) ◽

pp. 4113

Author(s):

Mohamed Saleem ◽

Sivasubramanian Priya ◽

Manimaran Pradeep ◽

Kalifulla Sabeetha

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Tamil Nadu ◽

Population Sample ◽

Public Health Problem ◽

Chronic Obstructive ◽

Cluster Sampling ◽

Major Public Health Problem ◽

Obstructive Pulmonary Disease ◽

Study Population

Background: Chronic obstructive pulmonary disease (COPD) is a major public health problem with increasing prevalence especially in developing countries. Burden of disease estimation is important for decision making, planning, prioritising and allocating funds. It has been found that the recent data on prevalence of COPD is less in south India, especially Tamil Nadu. Hence this study was undertaken in order to estimate the prevalence of COPD in Madurai among adults and its association with socio demographic variables. Methods: This is a community based cross-sectional study done in Kallendiri block of Madurai district with adults aged >30 years of both the sexes as study population. Sample size was 480. Using cluster sampling method, study participants were interviewed with semi-structured questionnaire and peak expiratory flow rate was measured using peak flow meter. Results: Prevalence of COPD was 22.1% among the study population. Males (39.2%) had higher prevalence than females (12.2%). COPD prevalence was significantly higher among increasing age, male sex, illiteracy, low BMI, smokers, inadequate ventilation and those using biomass fuels for cooking. Conclusions: This study has established the fact that COPD is highly prevalent among adults in rural area. For practitioners, the results call for a high index of suspicion of COPD among >30 years with substantial exposure to risk factors. For health policy makers, the results of the current study urge for the development of COPD prevention programs failing which the burden of COPD might result in increased mortality, morbidity and economic burden.

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