scholarly journals Pengaruh Ekstrak Paederia foetida pada Kadar Kolesterol Total Tikus Model Hiperlipidemia yang Diinduksi Deksametason

2022 ◽  
Vol 7 (1) ◽  
pp. 137
Author(s):  
Dhia Farhan Taufik ◽  
Indri Safitri Mukono ◽  
Nurmawati Fatimah
Keyword(s):  
Point Of Care ◽  
Point Of Care Testing ◽  
Randomized Design ◽  
Disability Adjusted Life ◽  
Post Test ◽  
Paederia Foetida ◽  
Post Hoc ◽  
Disability Adjusted Life Year ◽  
One Way Anova

Hiperlipidemia merupakan istilah yang mengacu pada kelainan yang menyebabkan peningkatan profil lipid dalam tubuh manusia. Menurut WHO, secara global, sepertiga penyakit jantung iskemik dikaitkan dengan kadar kolesterol yang tinggi. Peningkatan kadar kolesterol diperkirakan menyebabkan 94,9 juta disability adjusted life year (DALYs) dan 4,32 juta kematian. Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak etanol Paederia foetida (EEPF) pada kadar kolesterol total tikus model hiperlipidemia yang diinduksi deksametason. Penelitian Penelitian eksperimen in vivo ini dilakukan dengan menggunakan   desain penelitian post-test only complete randomized design (CRD). Proses penelitian dilaksanakan di Departemen Biokimia, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia, dari bulan Juni 2021 hingga November 2021. Pembuatan EEPF dilakukan dengan metode maserasi pada pelarut etanol 96%. Hewan coba yang digunakan adalah tikus galur Wistar albino jantan berjumlah 30 ekor, sehat, dan berat badan 150-200 gram. Penelitian dilaksanakan dengan membagi rata hewan coba secara acak menjadi kelompok kontrol normal, kontrol patogen, kelompok simvastatin, kelompok EEPF 250 mg/kg, dan kelompok EEPF 500 mg/kg. Sampel darah diambil dari vena pada bagian ekor dan kadar kolesterol total diukur dengan metode point of care testing (POCT). Analisis data dilakukan dengan One-way ANOVA dilanjutkan dengan uji post hoc Dunnett. Hasil penelitian menunjukkan, pemberian deksametason (10 mg/kg) selama 14 hari menyebabkan peningkatan kadar kolesterol total yang signifikan, sedangkan pada kelompok perlakuan simvastatin, EEPF 250 mg/kg, dan EEPF 500 mg/kg terjadi penurunan signifikan pada kadar kolesterol total jika dibandingkan dengan kelompok kontrol patogenik (P<0,001, P<0,05, P<0,05). Pemberian ekstrak etanol Paederia foetida dapat menurunkan kadar kolesterol total pada tikus model hiperlipidemia yang diinduksi deksametason.

scholarly journals The Robusta coffee grounds residues to adsorb the heavy metal Lead (Pb) in the water

2018 ◽  
Author(s):  
Anita Dewi Moelyaningrum ◽  
Khoirul Ngibad ◽  
S.Pd Lilla Puji Lestari ◽  
Dessy Agustina Sari ◽  
Cahya Fajar Budi Hartanto ◽  
...  
Keyword(s):  
High Carbon ◽  
Control Groups ◽  
Robusta Coffee ◽  
Randomized Design ◽  
Coffee Grounds ◽  
Coffee Ground ◽  
Completely Randomized Design ◽  
Post Hoc ◽  
One Way Anova ◽  
Ks Test

This paper has been published in IOP Conf. Series: Journal of Physics: Conf. Ser1i2e3s415161748(9200‘1’8“)”012058 Lead (Pb) were toxic. Lead found in pipes, batteries, paint, dyes ceramic glaze, gasoline, and final waste disposal. The robusta coffee grouds residues had high carbon, nitrogen etc which can adsorb heavy metal.The purpose of this study is to analyze the robusta coffee grounds residues to adsorb the Pb in the water. The method of this research is a True Experimental using completely randomized design (CRD) method. There were control groups (C) and three treatments groups (T1; T2;T3; 5gram/ litre; 8gram/ litre; 10gram/ litre) with six repetitions. The robusta coffee ground residues were contacted for 2 hours.Total samples were24 samples which analyzed each parameter of the Pb with Atomic Adsorption Spectophotometry Analysis. The results showed that the more coffee ground residues that are exposed, increasingly turbid. The KS test showed that data were a normal distribution (sig=0,324). One way ANOVA test; Turkey post Hoc showed that there was sig difference between the control and treatment (F=4,326, Sig= 0,017). There were sig difference between control and treatment 2 and 3 (Sig=0,019; Sig=0,038). Robusta coffee grounds residues can reuse to adsorb the Pb pollution in the water. It can be a solution for treating the lead pollution in the water because of it easy to the application.

scholarly journals Pengaruh Senam Nifas terhadap Penurunan Tinggi Fundus Uteri dan Lochea pada Ibu Pasca Bersalin yang Mendapatkan Inisiasi Menyusu Dini dan Mobilisasi Dini

2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan
Keyword(s):  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.

scholarly journals UJI EFEK ANTI BAKTERI EKSTRAK BUNGA CENGKEH TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Antibacterial Effects ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Clove Extract ◽  
Post Hoc ◽  
One Way Anova

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans

scholarly journals Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level

2020 ◽  
Vol 3 (1) ◽  
pp. 172-177
Author(s):  
Hesty Wahyuningsih ◽  
Andina Putri Aulia
Keyword(s):  
Liver Injury ◽  
Brassica Oleracea ◽  
Control Group ◽  
Drug Induced ◽  
Red Cabbage ◽  
Drug Induced Liver Injury ◽  
Post Test ◽  
Male Wistar Rats ◽  
Post Hoc ◽  
One Way Anova

Red cabbage (Brassica oleracea var. Capitata f. Rubra) is a vegetable widely used in Indonesian cuisine. Red cabbage is rich in anthocyanins to reduce SGPT levels in drug-induced liver injury (DILI). This study aims to determine the effect of red cabbage juice on SGPT levels in acetaminophen-induced liver injury. In this post-test, only the control group study, male Wistar rats (300g), were randomly divided into 5 groups (K1-K2-K3-K4-K5). Acetaminophen was given to induce liver injury in rats. The rats were treated with the cabbage juice (at the dose of 0.5g/ml or 0.7g/ml or 0.9g/ ml. Data were analyzed using One way ANOVA and LSD post hoc test. Mean SGPT levels for K1, K2, K3, K4, K5 was 58.43 ± 7.18 UI / L, 71.20 ± 9.13 UI/L, 55.73 ± 9.51 UI / L, 72.80 ± 3.47 UI /L, 72.63 ± 3.01 UI /L, respectively. One way ANOVA resulted in p=0.00 (p <0.05). The post hoc LSD test showed significant differences (P <0.05) between all groups except between groups K1-K3, K2-K4, and K2-K5 (p> 0.05). Red cabbage juice can reduce SGPT in acetaminophen-induced liver injury in rats. The most effective dose was 0.5 g/ml.

scholarly journals Comparison of Orthodontic Bracket Debonding Force and Bracket Failure Pattern on Different Teeth In Vivo by a Prototype Debonding Device

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Tamzid Ahmed ◽  
Norma Ab Rahman ◽  
Mohammad Khursheed Alam
Keyword(s):  
Failure Pattern ◽  
Point Scale ◽  
Orthodontic Bracket ◽  
Adhesive Remnant Index ◽  
Significant Difference ◽  
Different Types ◽  
Post Hoc ◽  
Bracket Failure ◽  
One Way Anova

Objective. To compare the orthodontic bracket debonding force and assess the bracket failure pattern clinically between different teeth by a validated prototype debonding device. Materials and Method. Thirteen (13) patients at the end of comprehensive fixed orthodontic treatment, awaiting for bracket removal, were selected from the list. A total of 260 brackets from the central incisor to the second premolar in both jaws were debonded by a single clinician using a validated prototype debonding device equipped with a force sensitive resistor (FSR). Mean bracket debonding forces were specified to ten (10) groups of teeth. Following debonding, Intraoral microphotographs of the teeth were taken by the same clinician to assess the bracket failure pattern using a 4-point scale of adhesive remnant index (ARI). Statistical analysis included one-way ANOVA with post hoc Tukey HSD and independent sample t -test to compare in vivo bracket debonding force, Cohen’s kappa ( κ ), and a nonparametric Kruskal-Wallis test for the reliability and the assessment of ARI scoring. Results. A significant difference ( p < 0.001 ) of mean debonding force was found between different types of teeth in vivo. Clinically, ARI scores were not significantly different ( p = 0.921 ) between different groups, but overall higher scores were predominant. Conclusion. Bracket debonding force should be measured on the same tooth from the same arch as the significant difference of mean debonding force exists between similar teeth of the upper and lower arches. The insignificant bracket failure pattern with higher ARI scores confirms less enamel damage irrespective of tooth types.

scholarly journals The effect of exposure to liquid air freshener on histological of the bronchial mice (Mus musculus)

2021 ◽  
Vol 6 (02) ◽  
Author(s):  
Warobi Warobi ◽  
Delima Engga Maretha ◽  
Asnilawati Asnilawati ◽  
Mashuri Masri
Keyword(s):  
Mus Musculus ◽  
The Body ◽  
Control Group ◽  
Epithelial Tissue ◽  
Treatment Groups ◽  
Histological Picture ◽  
Randomized Design ◽  
Post Test ◽  
The One ◽  
Post Hoc

Air fresheners are products that contain chemicals aimed at reducing unpleasant odours in confined spaces. The use of synthetic air fresheners turns out to harm health because some of their leased Volatile Organic Compounds are classified as toxic compounds and are carcinogens. Air freshener enters the body through the inhalation process in the respiratory system. Modern air fresheners are available in liquid (aerosol) and gel forms. Air fresheners contain addictive substances and solvents such as 1,4-dichlorobenzene which can affect pulmonary function. The purpose of this study is to know the effect of exposure to liquid air freshener on the histology of bronchi of mice (Mus musculus). This study used 20 male mice (Mus musculus) consisting of 4 treatments with 5 replications. The research design is true experimental in the form of a post-test only control group with Completely Randomized Design (CRD). The post-test was done by observing the histological picture of the mice's bronchi after exposure to liquid air freshener given 3x/day for a period of P1 = 2 weeks, P2 = 4 weeks and P3 = 6 weeks. Quantitative data on bronchial histology was tested using the One Way ANOVA statistical test followed by the Post Hoc Tukey test. The results of the study found changes in the histology of the bronchi, thickening of the epithelial tissue of mice. Analysis of comparative data between the control and treatment groups statistically obtained p = 0.010 <0.05, meaning that there was a significant effect and change in the bronchial tubes exposed to liquid air freshener. Histologically there were differences in histology between the control and treatment groups. It was concluded that liquid air freshener had a significant effect on the histological picture of the mice's bronchi.

scholarly journals FOAM EKSTRAK DAUN BAKUNG PUTIH (CRINUM ASIATICUM L.) SEBAGAI INOVASI PENYEMBUHANLUKA PADA TIKUS PUTIH JANTAN DIABETES MELITUS

2020 ◽  
Vol 7 (1) ◽  
pp. 13-18
Author(s):  
Ni Made Ari Widayani ◽  
Anisa Hanifatin Rahayu
Keyword(s):  
Group Design ◽  
Post Hoc ◽  
Crinum Asiaticum ◽  
One Way Anova ◽  
Diabetes Melitus

Pendahuluan: Komplikasi mikrovaskular yang sering dialami pasien Diabetes Melitus (DM) adalah gangguan penyembuhan luka. Daun Bakung Putih (Crinum asiaticum L.) memiliki kandungan flavonoid, saponin, dan alkaloid, sedangkan foam bermanfaat untuk menjaga kelembapan luka yang dibutuhkan untuk mempercepat penyembuhan luka. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh foam dengan ekstrak daun bakung putih, dalam mempercepat kontraksi luka.  Metode: Penelitian ini menggunakan desain true experimenta llaboratory in vivo metode yang digunakan yaitu randomized posttes tonly controlled group design dengan jumlah tikus 25 ekor dibagi menjadi 5 kelompok (n=7). Data yang diukur adalah kontraksi luka setelah pemberian dengan rute transdermal, dan dianalisis dengan uji normalitas data, uji homogenitas varian, uji One-way ANOVA, uji Posthoc (ujiTukey) dengan tingkat signifikansi 0,05 (p<0,05) dan taraf kepercayaan 95% (α=0,05).  Hasil: Berdasarkan hasil uji One Way ANOVA, data persentase luas kontraksi luka menunjukan angka signifikasi (p< 0,05), sehingga terbukti terdapat perbedaan persentase luas kontraksi luka yang signifikan antar kelompok uji. Hasil uji post hoc (uji tukey) kontraksi luka kelompok tikus DM dibaluti foam dengan ekstrak daun bakung putih 0.2 g memiliki perbedaan signifikan dengan kelompok tikus DM dibaluti foam tanpa ekstrak (p=0,01; α=0,05).  Kesimpulan: Simpulan adalah penggunaan CFD (Crinum asiaticum L.) Foam dengan kandungan ekstrak 0.2 g dapat mempercepat kontraksi luka dibandingkan penggunaan foam tanpa ekstrak dan dengan kandungan ekstrak 2 g, serta 4 g.

scholarly journals Efek perendaman rebusan Daun Sirih Merah (Piper crocatum) terhadap kekerasan permukaan resin komposit

2016 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Devi Puspita Handayani ◽  
Dewi Puspitasari ◽  
Nurdiana Dewi
Keyword(s):  
Composite Resin ◽  
Surface Hardness ◽  
Control Group ◽  
Mouth Rinse ◽  
Control Group Design ◽  
Treatment Groups ◽  
Betel Leaf ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

The effect of immersion of decoction water of Red Betel Leaf (Piper crocatum) on the surface hardness of composite resin. The purpose of this study was to determine the effect of immersion of decoction water of red betel leaf on the surface hardness of composite resin compared to alcoholic mouth rinse. It was a pure experimental study with post-test only with control group design. The total samples were 27 samples divided into 2 treatment groups and 1 control group, each of which consisted of 9 samples. The treatment groups were immersed in the decoction water of red betel leaf and alcoholic mouth rinse. The control group was immersed in aquadest. After the immersion, the samples were measured using Vickers Micro hardness Tester. Analysis with one way anova and post hoc Bonferroni showed a significant difference (p<0.05) on the surface hardness of composite resin after being immersed in decoction water of red betel leaf(79,81±3,76) kg/mm2 and alcoholic mouth rinse (67,11±2,51) kg/mm2. Based on this research, it can be concluded that there was an effect of immersion of decoction water of red betel leaf if compared with alcoholic mouth rinse. The value of surface hardness of composite resin immersed in alcoholic mouth rinse was lower than the decoction water of red betel leaf.ABSTRAKPenelitian ini bertujuan untuk mengetahui efek perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Penelitian ini merupakan penelitian eksperimental murni dengan post-test only with control group design. Jumlah sampel sebanyak 27 yang dibagi dalam 2 kelompok perlakuan dan 1 kelompok kontrol dengan masing-masing kelompok sebanyak 9 sampel. Kelompok perlakuan direndam dengan air rebusan daun sirih merah dan obat kumur beralkohol. Kelompok kontrol direndam dengan akuades steril. Setelah itu dilakukan pengukuran menggunakan Vickers Microhardness Tester. Hasil uji One Way Anova dan Post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan bermakna nilai kekerasan permukaan resin komposit yang direndam dengan air rebusan daun sirih merah (79,81±3,76) kg/mm2 dan obat kumur beralkohol (67,11±2,51) kg/mm2 dengan nilai kemaknaan (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat efek lebih rendah pada perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Nilai kekerasan permukaan resin komposit yang direndam obat kumur beralkohol lebih rendah dibandingkan air rebusan daun sirih merah.

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