CRITERIA FOR SELECTION OF PREPARATIONS IN THE DEVELOPMENT OF SORPTION-DETOXIFYING COMPLEXES FOR AGRICULTURAL ANIMALS

2018 ◽  
Vol 1 (2) ◽  
pp. 94-100
Author(s):  
L.L. Zakharova ◽  
◽  
G.A. Zhorov ◽  
V.I. Dorozhkin ◽  
◽  
...  
Keyword(s):  
Chemical Nature ◽  
Negative Impact ◽  
Physiological State ◽  
Animal Husbandry ◽  
Biologically Active ◽  
Combined Pollution ◽  
Wide Range ◽  
Active Substances ◽  
Criteria For Selection ◽  
Selection Of

Negative impact on the environment as a result of economic activity of man increasingly becomes the character of combined pollution of ecotoxicants, including xenobiotics of radiation and chemical nature. In animal husbandry in ecologically unfavorable regions, sorbtion-detoxication technologies based on the complex application of bioprotective substances of different origin are used to reduce the intake and accumulation of xenobiotics, to normalize the physiological state of animals and to obtain safe products. It is necessary to observe certain principles ensuring compatibility of components, a wide range of bioprotective action, efficiency and safety at their use in developing the compositions of such sorption-detoxifying complexes. The article substantiates the criteria that should be followed in creating sorption-detoxifying complexes and presents groups of drugs with different mechanisms of action (sorbents, antioxidants, immunomodulators, adaptogens and other biologically active substances) for inclusion in the formulations of combined compositions.

scholarly journals CRITERIA FOR SELECTING AEROSOL PACKAGING AND DETERMINING THE OPTIMUM QUANTITY OF A PROPELLANT

2020 ◽  
Vol 4 ◽  
pp. 15-20
Author(s):  
Bogdan Putyatin ◽  
Ekaterina Kunitsia ◽  
Natalia Sytnik
Keyword(s):  
Essential Oils ◽  
Mass Fraction ◽  
Negative Impact ◽  
Excess Pressure ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Correct Selection ◽  
Cosmetic Products ◽  
Active Substances ◽  
Selection Of

Development of a new generation of functional antiage cosmetics is a most important area of cosmetic industry development. An integral part of such products are biologically active substances (BAS) with essential oils, being among the sources of which. Each essential oil is characterized by a well balanced unique composition of biologically active substances. Development of new cosmetic products consists of correct selection of the required composition of components with required properties and selection of a suitable package, preserving product properties throughout its shelf life. During production of cosmetic products in aerosol package a number of issues are solved, unlike with antiage-products in form of creams in customary tubes. The degree of oxidation-reduction reactions, having negative impact on the properties of essential oils, is substantially reduced. The concentration providing for the optimum degree of evacuation and excess pressure in the packaging are essential issues. The aim of this research is to determine the degree of evacuation of the contents, excess pressure, and mass fraction of a propellant in the product test samples to find the samples of aerosol package with optimum parameters. A number of tests to determine the degree of evacuation of the contents from aerosol package, excess pressure and a mass fraction of a propellant have been performed. The greatest degree of evacuation of products was observed with mass fraction of propellant of 13.79%. Based on the results of the tests for excess pressure in aerosol packaging, it has been found, that with mass fraction of a propellant of 13.79% excess pressure is 0.4 MPa, which was taken as an optimum value. The test showed that the mass of a propellant of 16 g evacuates the product from aerosol package to the maximum extent and does not exceed the acceptable limits for excess pressure (0.2–0.6 MPa)

The content of decenoic acids in drone brood preparations and combined preparations based on it

Biomics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 389-393
Author(s):  
D.V. Mitrofanov ◽  
N.V. Budnikova
Keyword(s):  
Royal Jelly ◽  
Storage Conditions ◽  
Water Soluble ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strict Adherence ◽  
Drone Brood ◽  
Wide Range ◽  
Active Substances ◽  
Melanin Complex

The drone brood contains a large number of substances with antioxidant activity. These substances require stabilization and strict adherence to storage conditions. Among these substances are unique decenoic acids, the content of which is an indicator of the quality of drone brood and products based on it. The ability of drone brood to reduce the manifestations of oxidative stress is shown. There are dietary supplements for food and drugs based on drone brood, which are used for a wide range of diseases. Together with drone brood, chitosan-containing products, propolis, royal jelly can be used. They enrich the composition with their own biologically active substances and affect the preservation of the biologically active substances of the drone brood. Promising are the products containing, in addition to the drone brood, a chitin-chitosan-melanin complex from bees, propolis, royal jelly. The chitin-chitosan-melanin complex in the amount of 5% in the composition of the adsorbent practically does not affect the preservation of decenic acids, while in the amount of 2% and 10% it somewhat worsens. The acid-soluble and water-soluble chitosan of marine crustaceans significantly worsens the preservation of decenoic acids in the product. Drone brood with royal jelly demonstrates a rather high content of decenoic acids. When propolis is introduced into the composition of the product, the content of decenoic acids increases according to the content of propolis.

THE INFLUENCE OF SORPTION-DETOXIFYING MEANS ON CUMULATION OF 90SR IN BONE TISSUE OF WHITE RATES WITH COMBINED INTAKE OF 137CS, CD AND PB

2018 ◽  
Vol 1 (3) ◽  
pp. 129-133
Author(s):  
L. L. Zakharova ◽  
◽  
G. A. Zhorov ◽  
V. N. Obryvin ◽  
◽  
...  
Keyword(s):  
Bone Tissue ◽  
Chemical Nature ◽  
Mechanisms Of Action ◽  
The Body ◽  
Biologically Active ◽  
Laboratory Studies ◽  
Animal Body ◽  
White Rats ◽  
Combined Use ◽  
Active Substances

The article presents the results of laboratory studies of the effect of sorption-detoxifying means on the accumulation of 90Sr in the body of white rats. The efficiency of a number of selective and polyfunctional sorbents, detoxicants and other biologically active substances and the developed on their basis sorption-detoxifying complexes as means of efferent therapy and detoxification of the animal body at the combined intake of xenobiotics of radiation and chemical nature was evaluated. It was found that 90Sr cumulation in bones (at the level of 53,3–60,8%) was reduced to the greatest extent with the combined use of substances of different mechanisms of action and origin. The effectiveness of separate use of detoxifying drugs did not exceed 29,1%.

BACKGROUND CONTENT OF TECHNOGENIC AND NATURAL RADIONUCLIDES IN DETOXIFYING AND BIOLOGICALLY ACTIVE SUBSTANCES

2021 ◽  
Vol 1 (2) ◽  
pp. 223-229
Author(s):  
G.А. Zhorov ◽  
◽  
L.L. Zakharova ◽  
V.N. Obryvin ◽  
◽  
...  
Keyword(s):  
Specific Activity ◽  
Raw Materials ◽  
Natural Radionuclides ◽  
Animal Husbandry ◽  
Maximum Level ◽  
Feed Additives ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Radioactive Isotopes ◽  
Active Substances

For correctly assess the effectiveness and safety of the use of sorption-detoxifying agents and feed additives intended for animals receiving feed with an excess content of toxicants, it is necessary to take into account the background levels of radionuclides, toxic elements, pesticides and other technogenic and natural pollutants in the studied substances. The need for such studies is due both to the existence of areas with a naturally elevated level of natural toxicants in the sources of raw materials for the production of additives and drugs, and to the increasing anthropogenic influence, accompanied by the entry of xenobiotics into environmental objects. In series of radiometric studies, the specific activity of technogenic and natural radioactive isotopes (90Sr, 137Cs, 40К, 226Ra, 232Th) in a number of sorption-detoxifying and biologically active substances and preparations used in animal husbandry and veterinary medicine as part of feed additives and pharmacological agents was determined. It was found that in 43% of the studied samples, the level of specific activity of 1,1Sr in 3-90 times higher than allowed by the current standards. The maximum level of 90Sr, equal to (137±9) Bq/kg, was detected in perlite. The specific activity of 137Cs did not exceed the permissible level: in mineral sorbents its amount reached (40±7) Bq/kg, in organic and complex sorbents – (24±4), and in feed additives – (29±8) Bq/kg. The maximum levels of 40K were (1429±83) Bq/ kg in minerals (radionite) and (2613±100) Bq/kg in organic substances (lignohumate). The levels of 226Ra and 232Th did not exceed (153±13) and (79±13) Bq/kg, respectively, and were higher in the mineral samples.

INVESTIGATION OF BACTERIOTROPIC PROPERTIES OF JUICE FROM GREEN WHEAT SPROUTS

2021 ◽  
pp. 144-149
Author(s):  
Neschiclyaev V.A. ◽  
Hohryakova M.D. ◽  
Bronnikov T.B.
Keyword(s):  
Negative Impact ◽  
Growth Parameters ◽  
Physiological State ◽  
Biologically Active ◽  
Biological Assessment ◽  
Health Improvement ◽  
Carbohydrate Utilization ◽  
Adequate Model ◽  
Bacterial Cultures ◽  
Indigenous Microflora

Juice «vitgrass» made from green wheat sprouts is a valuable biologically active product that has a stimulating effect on the physiological state of a person. Hydroponically grown raw materials for juice production contain proteins, fats, carbohydrates, a large group of vitamins, macro- and microelements, antioxidants, enzymes and other substances. As a part of health programs, the use of this juice is recommended for overweight people to optimize the metabolic processes of the macroorganism. A healthy lifestyle involves reducing the negative impact of environmental factors, including diet correction, on the microbiota of the gastrointestinal tract. The cumulative biological assessment of wheatgrass juice should take into account the results of its effect on the indigenous microflora. Lacto- and bifidobacteria, including industrial strains for the manufacture of probiotic preparations, represent an adequate model for studying the bacteriotropic effect of any plant-based product. The experimental results indicate a pronounced stimulating effect of juice from green wheat sprouts on the growth parameters of probiotic bacterial cultures. Strains of lacto- and bifidobacteria when cultivated under conditions of maximum limitation of nutrients in the composition of the "poor" nutrient medium with the addition of "Vitgrass" juice reacted with an increase in the level of accumulation of cell biomass and a higher activity of acid formation in comparison with the control. The analysis of the results obtained makes it possible to estimate the magnitude of the effects of stimulation in relation to both bacterial cultures as quite comparable, taking into account the known intersstrain differences in growth parameters and their biochemical aspects. This is confirmed by an almost similar increased level of carbohydrate utilization in both variants of culture liquids in the presence of juice. The potential of the positive bacteriotropic activity of "Vitgrass" juice in relation to the representatives of the indigenous microflora can be realized in different ways. It seems expedient to use the product from green wheat sprouts more widely as part of programs for the complex health improvement of the macroorganism, including the prevention and correction of dysbiotic conditions.

scholarly journals Biologically Active Substances of Siberian Medical Plants in Functional Wgey-Based Drinks

2019 ◽  
Vol 49 (1) ◽  
pp. 14-22
Author(s):  
Светлана Иванова ◽  
Svetlana Ivanova ◽  
Ирина Милентьева ◽  
Irina Milenteva ◽  
Людмила Асякина ◽  
...  
Keyword(s):  
Callus Cultures ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Rhodiola Rosea ◽  
Plant Materials ◽  
Rhaponticum Carthamoides ◽  
Wide Range ◽  
Mountain Ash ◽  
Active Substances ◽  
Mineral Base

The use of infusions and extracts from domestic plant materials is a promising direction in the development of functional beverages since they contain a wide range of substances of various pharmacological properties. Drinks fortified with physiologically active natural components maintain a certain level of this content in human body. They can have a healing or prophylactic effect. However, there is a lack of technologies for the effective production of biologically active substances from plant materials. Moreover, the development of cultivated botanical medicinal plant species remains quite poor. The present study features the qualitative and quantitative composition of biologically active substances of medicinal plants that are endemics of Siberia. They are Rhodiola rosea (Rhodiola rosea L.) and maral root (Rhaponticum carthamoides). The paper introduces a method for increasing their biosynthetic activity. An experiment helped to select a composition of the nutrient medium for the cultivation of callus cultures of Rhodiola rosea (Rhodiola rosea L.) and maral root (Rhaponticum carthamoides) in vitro, which contributed to an increase in the biosynthesis of biologically active substances. For callus cultures of Rhodiola Rosea (line R.r-1k) the following composition was used: mineral base – MS; sucrose – 30 g; inositol – 100 mg; thiamine – 1.0 mg; pyridoxine – 1.0 mg; Ca-panthetonate – 10 mg; kinetin – 0.05 g; naphthyl acetic acid – 0.1 g; 2.4-D – 0.5. For callus cultures of maral root (line R.c -2k): mineral base – SH; sucrose – 30 g; inositol – 100 mg; thiamine – 5.0 mg; pyridoxine – 0.5 mg; nicotinic acid – 5.0 mg; kinetin – 0.1 g; indoleacetic acid – 1.0 g. The authors developed a technology for the production of functional whey-based tonic drink fortified with extract of carotenoids isolated from the fruits of mountain ash and the extract of biologically active substances Rhodiola rosea and maral root. The presence of biologically active substances in the plant and medicinal raw materials gives the drink antioxidant and bactericidal properties, as well as helps to raise the overall state of the organizm and strengthen the immune system.

scholarly journals Results of studies of the influence of phytopreparations on cows and calfs

2021 ◽  
Vol 282 ◽  
pp. 04003
Author(s):  
V.S. Kozyr ◽  
P.P. Antonenko ◽  
N.I. Suslova ◽  
R.V. Mylostyvyi
Keyword(s):  
Reproductive Function ◽  
Biologically Active ◽  
Pharmacological Effects ◽  
Cattle Breeding ◽  
Biochemical System ◽  
Efficient Management ◽  
Wide Range ◽  
Newborn Calves ◽  
Young Cattle ◽  
Active Substances

Purpose. To establish the influence of the “Phytochol”, “Phytopunk” and “Gastroacide” phytopreparations developed by the authors on the reproductive function of cows, resistance and safety for calves. Methods. Biological, biochemical, hematological, immunological, analytical, biometric, zootechnical. Results. It has been established that in homeopathic doses, the studied drugs are non-toxic, have a wide range of pharmacological effects and contain biologically active substances that have strengthening, tonic properties, metabolism normalizing in the “cow-calf” biochemical system. Conclusions. To normalize the reproductive function of cows, it is advisable to use “Phytochol”and “Phytopunk”. The resistance of newborn calves is strengthened by feeding them “Phytopunk” and “Gastroacide”. The productivity of young cattle can be increased by introducing the drug “Phytochol” into the ration. The use of phytopreparations “Phytopunk”, “Phytochol” in homeopathic doses in cattle breeding contributes to a more efficient management of the industry.

scholarly journals Technology of growing young carp in fish farm Ltd “Mykolaivska RMS”

2021 ◽  
Vol 23 (94) ◽  
pp. 56-60
Author(s):  
V. V. Senechyn ◽  
E. O. Yakimova
Keyword(s):  
Land Reclamation ◽  
Normal Growth ◽  
Fish Farming ◽  
Biologically Active ◽  
Production Methods ◽  
Planting Material ◽  
Constant Control ◽  
Active Substances ◽  
Artificial Reservoirs ◽  
Selection Of

We have studied the possibility of increasing the production of young carp by applying a set of intensification measures and the introduction of innovative production methods, when growing it in artificial reservoirs. Works that has been carried out works provided with technology of cultivation of young fishes as one of the first stages of production of marketable products in aquaculture, secures the selection of qualitative and viable breeding material, providing it with appropriate environmental conditions for normal growth and development, search of optimum and balanced compound feeds which will supplement natural fodder base of ponds, and carrying out of complex measures concerning intensification of fish farming taking into account natural-climatic and geographical-zonal features of a separate economy. The main purpose of the work was to improve the technology of growing young fish in the carp farm of Ltd "Mykolaivska RMS" when using in the feeding of this year's granular feed. Generally accepted hydrochemical, hydrobiological and fish farming methods were used in order to achieve this goal. The technological features of growing carp fish planting material at low planting densities were studied in the ponds of the experimental fishery. The effect of land reclamation, fertilization of ponds to improve the natural feed base, feeding fish with granular feed with a well-balanced content of nutrients and biologically active substances, with constant control of temperature and hydrochemical regimes of ponds on morphometric parameters expediency of carrying out such measures in fisheries. Our research results indicate that the natural fodder basis of ponds of the experimental carp farm Ltd "Mykolaivska RMS" does not fully meet the regulatory conditions for growing young carp and carrying out the above set of intensification measures in combination with feeding young carp granular concentrated organic feed environmentally friendly and economically feasible.

scholarly journals The biography and scientific work of the Soviet microbiologist Z.V. Yermolyeva: historiographic characteristics of post-Soviet publications

2020 ◽  
Vol 9 (4) ◽  
pp. 268-271
Author(s):  
Aleksandr Vladimirovich Gorshenin
Keyword(s):  
Scientific Work ◽  
Research Direction ◽  
Biologically Active ◽  
Soviet Period ◽  
Woman Scientist ◽  
Scientific Biography ◽  
Russian Science ◽  
Wide Range ◽  
History Of ◽  
Active Substances

This paper provides a brief analysis of works that consider the main stages of the scientific biography of the famous Soviet scientist-microbiologist, academician of medicine Zinaida Vissarionovna Yermolyeva (18981974). Among the most famous achievements of the scientist are the receipt of the first Soviet penicillin and the prevention of the cholera epidemic in Stalingrad during the Great Patriotic War. Her scientific interests had a fairly wide range: from cholera and antibiotics to lysozyme, interferon and other biologically active substances. Speaking about Z.V. Yermolyeva, the famous Soviet microbiologist and epidemiologist, academician N.F. Gamaleya noted that she as a researcher is characterized by a desire to work in the area that is currently the most urgent for socialist health care. Indeed, getting acquainted with the biography of this amazing woman scientist, it becomes clear why she switched from one research direction into another this was her ability to quickly respond to the needs of the country and the challenges of the time. Given a great importance to the figure of Z.V. Yermolyeva in the history of Russian science, it seems relevant to establish a degree of study of this problem. The author of this paper has already carried out a brief analysis of the historiography of the works in the Soviet period on the history of Zinaida Yermolyevas scientific activities; therefore this paper is its logical continuation.

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