scholarly journals Automatic Segmentation of Skin Regions in Thermographic Images: an Experimental Study

2021 ◽  
Vol 17 ◽  
pp. 57-64
Author(s):  
Cristina M. R. Roseiro ◽  
Luis Roseiro
Keyword(s):  
Skin Temperature ◽  
Health Care Professionals ◽  
Automatic Segmentation ◽  
Skin Inflammation ◽  
Medical Applications ◽  
Skin Infections ◽  
Inflammatory Processes ◽  
Opening And Closing ◽  
Identification Analysis ◽  
Control Skin

Infrared thermography can be applied in medical applications, such as monitoring skin temperature in inflammatory processes. The possibility for health care professionals and patients to be able to easily, quickly and economically, at anytime and anywhere, monitor the skin temperature distribution through the acquisition of images to control skin infections is extremely important nowadays. This work aims to develop an automatic methodology for the segmentation, identification, analysis and diagnosis of skin inflammation based on thermographic images. The study compares thermographic images from subregions of the hand skin and presents an experimental investigation to segment and identify features in the images automatically. Left and righthand images from two volunteers’ obtained in different conditions, such as cold action, activity action (opening and closing the hand), and friction action (rub both hands), were considered and analyzed. The obtained results demonstrate the feasibility of the implemented procedures and encourage developing and implementing an operating system to monitor skin infections in thermographic images.

scholarly journals Early Changes and Indicators Characterizing Lung Aging in Neonatal Chronic Lung Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Jennifer Sucre ◽  
Lena Haist ◽  
Charlotte E. Bolton ◽  
Anne Hilgendorff
Keyword(s):  
Lung Disease ◽  
Chronic Lung Disease ◽  
Health Care Professionals ◽  
Treatment Strategies ◽  
Oxygen Toxicity ◽  
Growth Factor Signaling ◽  
Inflammatory Processes ◽  
Long Term Consequences ◽  
Neonatal Chronic Lung Disease

Infants suffering from neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, are facing long-term consequences determined by individual genetic background, presence of infections, and postnatal treatment strategies such as mechanical ventilation and oxygen toxicity. The adverse effects provoked by these measures include inflammatory processes, oxidative stress, altered growth factor signaling, and remodeling of the extracellular matrix. Both, acute and long-term consequences are determined by the capacity of the immature lung to respond to the challenges outlined above. The subsequent impairment of lung growth translates into an altered trajectory of lung function later in life. Here, knowledge about second and third hit events provoked through environmental insults are of specific importance when advocating lifestyle recommendations to this patient population. A profound exchange between the different health care professionals involved is urgently needed and needs to consider disease origin while future monitoring and treatment strategies are developed.

Medical Imaging Importance in the Real World

2020 ◽  
pp. 136-162
Author(s):  
Ramgopal Kashyap
Keyword(s):  
Image Segmentation ◽  
Edge Detection ◽  
Level Set ◽  
Real World ◽  
Medical Image ◽  
Automatic Segmentation ◽  
Medical Image Segmentation ◽  
Image Resolution ◽  
Variational Model ◽  
Medical Applications

In the medical image resolution, automatic segmentation is a challenging task, and it's still an unsolved problem for most medical applications due to the wide variety connected with image modalities, encoding parameters, and organic variability. In this chapter, a review and critique of medical image segmentation using clustering, compression, histogram, edge detection, parametric, variational model. and level set-based methods is presented. Modes of segmentation like manual, semi-automatic, interactive, and automatic are also discussed. To present current challenges, aim and motivation for doing fast, interactive and correct segmentation, the medical image modalities X-ray, CT, MRI, and PET are discussed in this chapter.

scholarly journals Cnicin from Centaurea benedicta L. is an active compound against skin inflammation in a mouse model

2021 ◽  
Author(s):  
Orlando Vieira Sousa ◽  
Guilherme C. Gonçalves ◽  
Lucas S. Queiroz ◽  
Everton A. Ferreira ◽  
Bruna C. S. Santos ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Mouse Model ◽  
Skin Inflammation ◽  
Cyclooxygenase 1 ◽  
Tnf Α ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Oxide Synthase

Abstract Centaurea benedicta L., commonly known as “cardo santo,” is used as a tonic, antidepressant, anti-inflammatory, antibacterial, and antiseptic in traditional medicine. This study evaluated the topical anti-inflammatory potential of an extract (ECB) and cnicin (CNI) from C. benedicta leaves in a mouse model. Activity was assessed using the ear edema method with croton oil, phenol, capsaicin, and histamine as phlogistic agents. Myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), nitric oxide (NO), t umor necrosis factor α (TNF-α), interleukin 6 (IL-6), and histopathology were assessed as markers of edema/inflammation. Interaction profiles between CNI and cyclooxygenase-1 and -2, induced nitric oxide synthase, and glucocorticoid receptor were examined with molecular docking. Twenty-four h after induction of inflammation, ECB and CNI treatments decreased the thickness and weight of ears by 39.59%– 94.72%. MPO, NAG, NO, TNF-α, and IL-6 levels were also reduced. Histopathological, treatments reduced edema thickness, leukocytes, and vasodilation. Inflammation induced by phenol and histamine was inhibited by ECB and CNI, and ECB suppressed capsaicin-induced inflammation. CNI interacts with cyclooxygenase-1 and nitric oxide synthase through conventional hydrogen bonds, indicating inhibition of these enzymes. ECB and its compound cnicin reduce chemically-induced inflammation in mice suggesting new possibilities for the treatment of diseases associated with dermal inflammatory processes.

scholarly journals miR-424(322) is a molecular switch controlling pro-inflammatory vs anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling

2020 ◽  
Author(s):  
Victoria Zyulina ◽  
Koon-Kiu Yan ◽  
Bensheng Ju ◽  
Christina Passegger ◽  
Carmen Tam-Amersdorfer ◽  
...  
Keyword(s):  
Decisive Role ◽  
Skin Inflammation ◽  
Molecular Switch ◽  
Blood Monocytes ◽  
Low Levels ◽  
Anti Inflammatory ◽  
Tgf Β1 ◽  
Control Skin

AbstractTGF-β family ligands are key regulators of dendritic cell (DC) differentiation and activation. Epidermal Langerhans cells (LCs) require TGF- β family signaling for their differentiation and canonical TGF-β1 signaling secures a non-activated LC state. LCs reportedly control skin inflammation and are replenished from peripheral blood monocytes, which also give rise to pro-inflammatory monocyte-derived DCs (moDCs). Among all the miRNAs differentially expressed in LC vs moDCs, we observed miR-424 to be strongly induced during moDC differentiation from monocytes. We discovered that miR-424 is required for moDC differentiation from human and murine precursor cells in vitro and for inflammation-associated moDC in vivo. Mechanistically we found that low levels of miR-424 facilitate TGF-β1-dependent LC differentiation at the expense of moDC differentiation. Loss of miR-424 in monocyte/DC precursors resulted in the induction of TGF-β pathway. Therefore, miR-424 plays a decisive role in anti-inflammatory LC vs pro-inflammatory moDC differentiation from monocytes, and its repression allows TGF-β ligands to promote LC differentiation.Short summaryMonocytes give rise to two distinct DC subsets in skin inflammation, exhibiting opposite roles in inflammation. This study identified miR-424(322) as a molecular switch controlling pro-inflammatory (moDC) vs anti-inflammatory LC subset differentiation by modulating TGF-β signaling.

scholarly journals Post-Genomics and Skin Inflammation

2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Daniela Braconi ◽  
Giulia Bernardini ◽  
Annalisa Santucci
Keyword(s):  
Scientific Community ◽  
Inflammatory Diseases ◽  
Skin Inflammation ◽  
Point Of View ◽  
Future Research ◽  
Genomic Technologies ◽  
Research Challenges ◽  
Common Skin ◽  
Inflammatory Processes ◽  
Chronic Skin

Atopic dermatitis and psoriasis are two chronic skin inflammatory diseases that have so far received a greater attention within the scientific community through different post-genomic approaches; on the contrary, acne, which is undoubtedly one of the most common skin disorders involving inflammatory processes, seems to be still quite neglected under the post-genomic point of view. In this paper, we will review how post-genomic technologies have provided new fundamental tools for the analysis of these three conditions and we will cast light on their potential in addressing future research challenges.

scholarly journals Staphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Majd Mohammad ◽  
Manli Na ◽  
Zhicheng Hu ◽  
Minh-Thu Nguyen ◽  
Pradeep Kumar Kopparapu ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Skin Inflammation ◽  
Skin Lesions ◽  
Lesion Size ◽  
Abscess Formation ◽  
Skin Infections ◽  
Human Immune System ◽  
Immune Evasion Mechanism ◽  
Human Immune

AbstractDespite being a major bacterial factor in alerting the human immune system, the role of Staphylococcus aureus (S. aureus) lipoproteins (Lpp) in skin infections remains largely unknown. Here, we demonstrated that subcutaneous injection of S. aureus Lpp led to infiltration of neutrophils and monocytes/macrophages and induced skin lesions in mice. Lipid-moiety of S. aureus Lpp and host TLR2 was responsible for such effect. Lpp-deficient S. aureus strains exhibited smaller lesion size and reduced bacterial loads than their parental strains; the altered phenotype in bacterial loads was TLR2-independent. Lpp expression in skin infections contributed to imbalanced local hemostasis toward hypercoagulable state. Depletion of leukocytes or fibrinogen abrogated the effects induced by Lpp in terms of skin lesions and bacterial burden. Our data suggest that S. aureus Lpp induce skin inflammation and promote abscess formation that protects bacteria from innate immune killing. This suggests an intriguing bacterial immune evasion mechanism.

Temperature control system for water-perfused suits

1977 ◽  
Vol 42 (4) ◽  
pp. 656-660 ◽  
Author(s):  
G. L. Brengelmann ◽  
M. McKeag ◽  
L. B. Rowell
Keyword(s):  
Water Temperature ◽  
Skin Temperature ◽  
Temperature Control ◽  
Cold Water ◽  
Human Subjects ◽  
Temperature Control System ◽  
Thermal Mass ◽  
Rates Of Change ◽  
Wave Forms ◽  
Control Skin

A system used to control skin temperature in human subjects wearing water-perfused garments is described, It supplies 8 l/min at 10 psi with water temperature controlled within +/-0.1 degree C. Temperature control is facilitated by a low circulating thermal mass and a fast responding heater based on a commercially available quartz heat lamp. The system is open so that hot or cold water can be added from the building mains to produce rates of change or water temperature exceeding 5 degrees C/min. These capabilities allow semiautomatic control of skin temperature within +/-1 degree C of desired wave forms. Potential hazards and associated safety devices are described.

Relationships Between Skin Temperature and Temporal Summation of Heat and Cold Pain

2003 ◽  
Vol 90 (1) ◽  
pp. 100-109 ◽  
Author(s):  
Andre P. Mauderli ◽  
Charles J. Vierck ◽  
Richard L. Cannon ◽  
Anthony Rodrigues ◽  
Chiayi Shen
Keyword(s):  
Skin Temperature ◽  
Temporal Summation ◽  
Heat Pain ◽  
Cold Stimulation ◽  
Cold Pain ◽  
Heat Stimulation ◽  
Second Pain ◽  
Skin Temperatures ◽  
Control Skin ◽  
Temperature Surface

Temporal summation of heat pain during repetitive stimulation is dependent on C nociceptor activation of central N-methyl-d-aspartate (NMDA) receptor mechanisms. Moderate temporal summation is produced by sequential triangular ramps of stimulation that control skin temperature between heat pulses but do not elicit distinct first and second pain sensations. Dramatic summation of second pain is produced by repeated contact of the skin with a preheated thermode, but skin temperature between taps is not controlled by this procedure. Therefore relationships between recordings of skin temperature and psychophysical ratings of heat pain were evaluated during series of repeated skin contacts. Surface and subcutaneous recordings of skin temperatures revealed efficient thermoregulatory compensation for heat stimulation at interstimulus intervals (ISIs) ranging from 2 to 8 s. Temporal summation of heat pain was strongly influenced by the ISIs and cannot be explained by small increases in skin temperature between taps or by heat storage throughout a stimulus series. Repetitive brief contact with a precooled thermode was utilized to evaluate whether temporal summation of cold pain occurs, and if so, whether it is influenced by skin temperature. Surface and subcutaneous recordings of skin temperature revealed a sluggish thermoregulatory compensation for repetitive cold stimulation. In contrast to heat stimulation, skin temperature did not recover between cold stimuli throughout ISIs of 3–8 s. Psychophysically, repetitive cold stimulation produced an aching pain sensation that progressed gradually and radiated beyond the site of stimulation. The magnitude of aching pain was well related to skin temperature and thus appeared to be established primarily by peripheral factors.

scholarly journals Nanofibers Offer Alternative Ways to the Treatment of Skin Infections

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
T. D. J. Heunis ◽  
L. M. T. Dicks
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Conventional Treatment ◽  
Protective Layer ◽  
Silver Ions ◽  
The Body ◽  
Skin Infections ◽  
Antimicrobial Compounds ◽  
Natural Antimicrobial ◽  
Control Skin

Injury to the skin causes a breach in the protective layer surrounding the body. Many pathogens are resistant to antibiotics, rendering conventional treatment less effective. This led to the use of alternative antimicrobial compounds, such as silver ions, in skin treatment. In this review nanofibers, and the incorporation of natural antimicrobial compounds in these scaffolds, are discussed as an alternative way to control skin infections. Electrospinning as a technique to prepare nanofibers is discussed. The possibility of using these structures as drug delivery systems is investigated.

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