scholarly journals Management of a case of supra-acute immune thrombocytopenic purpura in pregnancy finalized with splenectomy

2015 ◽  
Vol 10 (1) ◽  
pp. 73-78
Author(s):  
Adriana NICA ◽  
◽  
Ana Maria VLĂDĂREANU ◽  
Minodora ONISÂI ◽  
Ion DUMITRU ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Red Cell ◽  
Therapeutic Procedure ◽  
Thrombocytopenic Purpura ◽  
Hematological Disorders ◽  
Wide Range ◽  
Haemolytic Anemia ◽  
Immunosuppressant Treatment ◽  
In Pregnancy

Splenectomy is a therapeutic procedure for a wide range of conditions, mainly hematological disorders. From the hematological disorders we can mention the red cell disorders: haemolytic anemia, hereditary spherocytosis and thalassemia, that have indication for splenectomy in case of failure to the drug treatment. A wide variety of thrombocytopenic disorders are improved by splenectomy, and the most common indicatios is for Idiopatic Thrombocitopenic Purpura (ITP). However, splenectomy imparts a high risk of fulminant infections that can be avoided with proper prophylaxis. Although in ITP splenectomy in not curative, it does not remove the autoimmune component, it will lead to relief of symptoms, improved platelet count with the cessation of the immunosuppressant treatment and better quality of life.

scholarly journals Splenectomy – diagnostic and therapeutic option in haematological disorders

2015 ◽  
Vol 62 (1) ◽  
pp. 30-34
Author(s):  
Adriana Nica ◽  
◽  
Ana Maria Vlădăreanu ◽  
Ion Dumitru ◽  
Minodora Onisâi ◽  
...  
Keyword(s):  
Hereditary Spherocytosis ◽  
Therapeutic Option ◽  
Tumor Burden ◽  
Elevated Risk ◽  
Red Cell ◽  
Thrombocytopenic Purpura ◽  
Hematologic Disorders ◽  
Hematologic Disorder ◽  
Wide Range ◽  
Haematological Disorders

For hematologic disorders, splenectomy has a wide range of applications: diagnosis, palliative or curative. The most frequent indication is for red cell disorders: hereditary spherocytosis, autoimmune hemolytic anemia or thalassemia. For the platelet disorders, the greatest benefit is achieved in idiopathic thrombocytopenic purpura. In case of limfoproliferative disorders (leukemia, lymphoma), splenectomy plays a role in diagnosis, palliative care (lowering of tumor burden) and in some cases as a cure. In patients with hematologic disorders, splenectomy is associated with an elevated risk of infections that can be avoided with proper antibiotic prophylaxis and vaccination. Due to the expanding list of applications for splenectomy in hematologic disorder, it is necessary to establish a work protocol that covers all aspects and particularities of these disorders.

scholarly journals Babies born better: o uso do software MaxQDA na análise preliminar das respostas portuguesas à secção qualitativa do inquérito

2018 ◽  
Vol 6 (10) ◽  
pp. 124 ◽  
Author(s):  
Dulce Morgado Neves ◽  
Mário JDS Santos
Keyword(s):  
Maternal Health ◽  
Health Professionals ◽  
Preliminary Analysis ◽  
The Public ◽  
Wide Range ◽  
Qualitative Component ◽  
The Relationship ◽  
Pregnancy And Birth ◽  
In Pregnancy

Resumo: A saúde materna envolve um vasto conjunto de conhecimentos e práticas que visam não só a promoção da saúde na gravidez e parto mas também uma experiência que seja entendida como positiva pelas mulheres. O inquérito Babies Born Better tem como objetivo informar o debate público sobre a qualidade dos cuidados de saúde, partindo do discurso das mulheres. Baseado na componente qualitativa do inquérito, este artigo consiste num ensaio de recurso ao MaxQDA para a análise das respostas portuguesas. A utilização deste software revelou ser útil à mediação entre os dados e a análise, facilitando a sistematização da informação. A análise veio salientar a importância da relação entre as mulheres e os profissionais de saúde, enquanto fator estruturante das experiências de parto.Palavras-chave: Babies Born Better; MaxQDA; Saúde Materna; Portugal. Babies born better: the use of MaxQDA in a preliminary analysis of portuguese responses to the qualitative section of the surveyAbstract: Maternal health involves a wide range of knowledge and practices whose purpose is to promote health in pregnancy and birth and an experience understood as positive by women. The survey Babies Born Better was designed to inform the public debate about the quality of care, learning from women's discourses. Based on the qualitative component of the survey, this paper is an exercise in the use of MaxQDA in the analysis of Portuguese responses. The use of this software proved to be useful to the mediation between data and the analysis, allowing the systematization data. The analysis comes to reveal the importance of the relationship between women and health professionals, as a structuring factor of childbirth experiences.Keywords: Babies Born Better; MaxQDA; Maternal health; Portugal. 

Influence of Thrombotic Thrombocytopenic Purpura on Depressivity, Cognitive Conduction, Quality of Life, and Resilience of Patients

2020 ◽  
Author(s):  
Falter Tanja ◽  
Böschen Sibylle ◽  
Manfred Beutel ◽  
Bernhard Lämmle ◽  
Scharrer Inge ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

COMBINATORIAL POLYNOMIALLY COMPUTABLE CHARACTERISTICS OF SUBSTITUTIONS AND THEIR PROPERTIES

2020 ◽  
Vol 7 (2) ◽  
pp. 34-41
Author(s):  
VLADIMIR NIKONOV ◽  
◽  
ANTON ZOBOV ◽  
Keyword(s):  
Mathematical Expectation ◽  
Point Of View ◽  
Small Range ◽  
Computational Point ◽  
Wide Range ◽  
Bijective Function ◽  
The Difference ◽  
Element Base ◽  
Selection Of

The construction and selection of a suitable bijective function, that is, substitution, is now becoming an important applied task, particularly for building block encryption systems. Many articles have suggested using different approaches to determining the quality of substitution, but most of them are highly computationally complex. The solution of this problem will significantly expand the range of methods for constructing and analyzing scheme in information protection systems. The purpose of research is to find easily measurable characteristics of substitutions, allowing to evaluate their quality, and also measures of the proximity of a particular substitutions to a random one, or its distance from it. For this purpose, several characteristics were proposed in this work: difference and polynomial, and their mathematical expectation was found, as well as variance for the difference characteristic. This allows us to make a conclusion about its quality by comparing the result of calculating the characteristic for a particular substitution with the calculated mathematical expectation. From a computational point of view, the thesises of the article are of exceptional interest due to the simplicity of the algorithm for quantifying the quality of bijective function substitutions. By its nature, the operation of calculating the difference characteristic carries out a simple summation of integer terms in a fixed and small range. Such an operation, both in the modern and in the prospective element base, is embedded in the logic of a wide range of functional elements, especially when implementing computational actions in the optical range, or on other carriers related to the field of nanotechnology.

A reflection of the polyethnic phenomenon in the Slovak novel of the 21 st century

2019 ◽  
pp. 462-471
Author(s):  
Lyudmila Shirokova
Keyword(s):  
Interpersonal Relations ◽  
Slovak Republic ◽  
Main Character ◽  
Jewish Family ◽  
Wide Range ◽  
Provincial Society ◽  
A Chain ◽  
Middle Generation ◽  
Artistic Quality

The historical polyethnicity of the Slovak society and the connected problems of the interrelations of cultures, ethics, interpersonal relations, are reflected in the works of modern Slovak prose. They are represented most clearly in the novels of middle generation writers P. Rankov, S. Lavrík, P. Krištúfek. They dwell upon the dramatical events of the 20 th century. They cover wide range problems, from the fruitful coexistence of various ethnic groups and their representatives to national contradictions and racial repressions. The artistic quality of the mentioned works, their composition, the way of narrating, the type of the main character, can be highly evaluated. For example, in a novel by P. Rankov the plot, in spite of its linearity, is a chain of episodes in the span of 30 years from the life of the main characters. It reflects not only their fates, but also the historical and political changes of the world they live in. The main female character of a S. Lavrík ’s novel narrates about everyday life and tragedies in the lives of the dwellers of a Slovak town in the Slovak Republic during the war. P. Krištúfek in his novel focuses on several decades from the life of a Slovak-Jewish family and dwellers of a Slovak provincial society with types and relations specific for this milieu.

Counterfeit Parts Recognition and Detection for Failure Analysts

2010 ◽  
Author(s):  
Katherine V. Whittington
Keyword(s):  
Thermal Cycle ◽  
Visual Inspection ◽  
Acoustic Microscopy ◽  
Scanning Acoustic Microscopy ◽  
3D Measurement ◽  
X Ray ◽  
Wide Range ◽  
Electronic Parts ◽  
Testing Awareness

Abstract The electronics supply chain is being increasingly infiltrated by non-authentic, counterfeit electronic parts, whose use poses a great risk to the integrity and quality of critical hardware. There is a wide range of counterfeit parts such as leads and body molds. The failure analyst has many tools that can be used to investigate counterfeit parts. The key is to follow an investigative path that makes sense for each scenario. External visual inspection is called for whenever the source of supply is questionable. Other methods include use of solvents, 3D measurement, X-ray fluorescence, C-mode scanning acoustic microscopy, thermal cycle testing, burn-in technique, and electrical testing. Awareness, vigilance, and effective investigations are the best defense against the threat of counterfeit parts.

THE VALUE OF LOVE IN THE SYSTEM OF FORMATION OF THE PROFESSIONAL MATURITY OF THE EDUCATOR

2020 ◽  
Vol 1 (10(79)) ◽  
pp. 12-18
Author(s):  
G. Bubyreva
Keyword(s):  
Russian Federation ◽  
The State ◽  
Educational Process ◽  
Wide Range ◽  
The Family ◽  
The Russian Federation ◽  
The Government ◽  
The Individual ◽  
The Right

The existing legislation determines the education as "an integral and focused process of teaching and upbringing, which represents a socially important value and shall be implemented so as to meet the interests of the individual, the family, the society and the state". However, even in this part, the meaning of the notion ‘socially significant benefit is not specified and allows for a wide range of interpretation [2]. Yet the more inconcrete is the answer to the question – "who and how should determine the interests of the individual, the family and even the state?" The national doctrine of education in the Russian Federation, which determined the goals of teaching and upbringing, the ways to attain them by means of the state policy regulating the field of education, the target achievements of the development of the educational system for the period up to 2025, approved by the Decree of the Government of the Russian Federation of October 4, 2000 #751, was abrogated by the Decree of the Government of the Russian Federation of March 29, 2014 #245 [7]. The new doctrine has not been developed so far. The RAE Academician A.B. Khutorsky believes that the absence of the national doctrine of education presents a threat to national security and a violation of the right of citizens to quality education. Accordingly, the teacher has to solve the problem of achieving the harmony of interests of the individual, the family, the society and the government on their own, which, however, judging by the officially published results, is the task that exceeds the abilities of the participants of the educational process.  The particular concern about the results of the patriotic upbringing served as a basis for the legislative initiative of the RF President V. V. Putin, who introduced the project of an amendment to the Law of RF "About Education of the Russian Federation" to the State Duma in 2020, regarding the quality of patriotic upbringing [3]. Patriotism, considered by the President of RF V. V. Putin as the only possible idea to unite the nation is "THE FEELING OF LOVE OF THE MOTHERLAND" and the readiness for every sacrifice and heroic deed for the sake of the interests of your Motherland. However, the practicing educators experience shortfalls in efficient methodologies of patriotic upbringing, which should let them bring up citizens, loving their Motherland more than themselves. The article is dedicated to solution to this problem based on the Value-sense paradigm of upbringing educational dynasty of the Kurbatovs [15].

BRAFV600E MUTATION IN PAPILLARY THYROID CARCINOMA. CLINICAL AND METHODOLOGICAL ASPECTS

2019 ◽  
Vol 65 (1) ◽  
pp. 16-26
Author(s):  
Pavel Rumyantsev ◽  
Petr Nikiforovich ◽  
Andrey Poloznikov ◽  
Andrey Abrosimov ◽  
Vladimir Saenko ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Kinase Inhibitors ◽  
Anaplastic Carcinoma ◽  
Braf V600e ◽  
Papillary Thyroid ◽  
Brafv600e Mutation ◽  
Wide Range ◽  
Methodological Aspects

Mutation BRAFV600E is highly specific for papillary thyroid carcinoma. It’s detected in 40-70% of all papillary thyroid carcinoma cases. Moreover this mutation is noticed in anaplastic carcinoma in 40-50%.This fact gives a chance to select patients and provide targeted therapy with multi-kinase inhibitors in cases of unresectable anaplastic carcinoma. The influence of BRAF V600E mutation for response to radioactive iodine therapy requires more evidence-based research. Existing methods for determining the BRAFV600E mutation have different accuracy, availability and cost. Other methodological aspects are also associated with the sample preparation of biological material, the quality of reagents, and the cross-validation of research results. In this review, on the basis of our own experience and literature data, the indications for determining the mutation of the BRAFV600E gene in clinical practice are refined, and a comprehensive comparative analysis of modern research methods has been conducted. This review is focused on a wide range of specialists of different types: oncologists, endocrinologists, radiologists, pathologists, and biologists.

Coleridge and Contemplation

2017 ◽  
Keyword(s):  
Historical Background ◽  
New Developments ◽  
English Departments ◽  
Original Essays ◽  
Wide Range ◽  
Romantic Era ◽  
Renaissance Man ◽  
Dynamic Quality ◽  
Philosophical Writings

In his philosophical writings, Coleridge increasingly developed his thinking about imagination, a symbolizing precursor to contemplation, to a theory of contemplation itself, which for him occurs in its purest form as a manifestation of ‘Reason’. Coleridge is a particularly challenging figure because he was a thinker in process, and something of an omnimath, a Renaissance man of the Romantic era. The dynamic quality of his thinking, the ‘dark fluxion’ pursued but ultimately ‘unfixable by thought’, and his extensive range of interests make essential an approach that is philosophical yet also multi-disciplinary. This is the first collection of essays to be written mainly by philosophers and intellectual historians on a wide range of Coleridge’s philosophical writings. With a foreword by Baroness Mary Warnock, and original essays on Coleridge and Contemplation by prominent philosophers such as Sir Roger Scruton, David E. Cooper, Michael McGhee, and Andy Hamilton, this volume provides a stimulating collection of insights and explorations into what Britain’s foremost philosopher-poet had to say about the contemplation that he considered to be the highest of the human mental powers. The essays by philosophers are supported by new developments in philosophically minded criticism from Coleridge scholars in English departments, including Jim Mays, Kathleen Wheeler, and James Engell. They approach Coleridge as an energetic yet contemplative thinker concerned with the intuition of ideas and the processes of cultivation in self and society. Other essays, from intellectual historians and theologians, clarify the historical background, and ‘religious musings’, of Coleridge’s thought regarding contemplation.

Oxford Studies in Agency and Responsibility Volume 6

2019 ◽  
Keyword(s):  
Moral Responsibility ◽  
New Orleans ◽  
Moral Philosophy ◽  
Moral Agency ◽  
Self Control ◽  
Moral Testimony ◽  
Quality Of Will ◽  
Wide Range ◽  
Standing To Blame

This is the sixth volume of Oxford Studies in Agency and Responsibility. The papers were drawn from the fourth biennial New Orleans Workshop in Agency and Responsibility (NOWAR), held November 2–4, 2017. The essays cover a wide range of topics relevant to agency and responsibility: the threat of neuroscience to free will; the relevance of resentment and guilt to responsibility; how control and self-control pertain to moral agency, oppression, and poverty; responsibility for joint agency; the role and conditions of shame in theories of attributability; how one might take responsibility without blameworthy quality of will; what it means to have standing to blame others; the relevance of moral testimony to moral responsibility; how to build a theory of attributabiity that captures all the relevant cases; and how thinking about blame better enables us to dissolve a dispute in moral philosophy between actualists and possibilists.

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