Synthesis,Characterization, and Antibacterial Activity of Quaternized of N-Aromatic Chitosan Derivatives

2011 ◽  
Vol 138-139 ◽  
pp. 1202-1208 ◽  
Author(s):  
Yong Ping Han ◽  
Qiang Lin
Keyword(s):  
Antibacterial Activity ◽  
Chemical Structure ◽  
Water Solubility ◽  
Positive Charge ◽  
Inhibition Zone ◽  
Hydroxyl Group ◽  
Schiff’S Base ◽  
Chitosan Derivatives ◽  
Gram Positive Bacteria ◽  
Chemical Structures

The quaternized of N-aryl chitosan (CTS) derivatives containing different aromatic moieties were synthesized by two steps, N-aromatic Schiff and the quaternization. The chemical structures of all chitosan derivatives, N-vanillin Schiff’s base chitosan (NVCh), N-cinnamaldehyde Schiff’s base chitosan (NCCh), N-benzaldehyde Schiff’s base CTS (NBCh), and their quaternized of N-aromatic CTS derivatives were characterized by ATR-FTIR. The water solubility of the N-aromatic Schiff’s base CTS derivatives had very poor water solubility. But after quaternized, the water solubility of CTS derivatives was obviously improved. The antibacterial studies of these CTS derivatives were carried out by the inhibition zone diameters methods against E.coli (Gram-negative), S.aurueus and P.aeruginosa (Gram-positive) bacteria, and against V.Aspergillus niger (fungal). It was found that the quaternized NVSCTS showed higher antibacterial activity than quaternized NCCh and quaternized NVBCh at the almost same DQ and ES level. In comparison to each of the chemical structure, it was found that the phenol hydroxyl group effect on antibacterial activity was even higher than that of positive charge density of CTS.

scholarly journals THE ANTIBACTERIAL ACTIVITY OF COMPOUNDS FROM LEAVES OF ARCTOSTAPHYLOS UVA-URS

2018 ◽  
pp. 53-60
Author(s):  
Владимир (Vladimir) Александрович (Аleksandrovich) Куркин (Kurkin) ◽  
Татьяна (Tat'yana) Константиновна (Konstantinovna) Рязанова (Ryazanova) ◽  
Александр (Аleksandr) Викторович (Viktorovich) Жестков (Zhestkov) ◽  
Артем (Аrtem) Викторович (Viktorovich) Лямин (Lyamin) ◽  
Елена (Elena) Владимировна (Vladimirovna) Авдеева (Avdeeva) ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Ester ◽  
Uv Spectroscopy ◽  
Alcoholic Extract ◽  
Gram Positive Bacteria ◽  
Chemical Structures ◽  
Main Component ◽  
First Time ◽  
And Staphylococcus Aureus ◽  
Perm Region

The aim of this paper is the isolation of individual compounds, which are caused the antibacterial activity of the leaves of the bearberry [Arctostaphylos uva-ursi (L.) Spreng.]. The leaves of Arctostaphylos uva-ursi, collected in Perm region, there were extracted with 70% ethanol, the obtained water-alcoholic infusion there was evaporated in vacuum.By means of the chromatographic methods with the using of silica gel 40/100 and eluent systems (chloroform and ethanol in several ratio) from the evaporated water-alcoholic extract of the leaves of Arctostaphylos uva-ursi, a substance with antibacterial activity, ethyl ester of p-digallic acid, which is a new natural compound, was isolated along with arbutin ((1-О-b-D-glucopyranoside of hydroquinone) from the leaves of this plant. The chemical structures of the ethyl ester of p-digallic acid and arbutin were established with the using of data of 1H-NMR-spectroscopy, UV-spectroscopy and mass-spectrometry..The antibacterial activity of ethyl ester of p-digallic acid against test cultures of gram-positive bacteria Bacillus cereus and Staphylococcus aureus, gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa for the first time was determined. By antibacterial activity, arbutin was inferior not only to ethyl ester of p-digallic acid, but also to decoction from the leaves of the bearberry. Consequently, the ethyl ester of p-digallic acid is one in main component, which is take the contribution in the antibacterial activity of the decoction and other preparations of the leaves of Arctostaphylos uva-ursi.

scholarly journals Antimicrobial Activity of two Mentha Species Essential Oil and its Dependence on Different Origin and Chemical Diversity

2018 ◽  
Vol 13 (8) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Mária Pl'uchtová ◽  
Teresa Gervasi ◽  
Qada Benameur ◽  
Vito Pellizzeri ◽  
Daniela Grul'ová ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Inhibition Zone ◽  
Chemical Diversity ◽  
Diffusion Method ◽  
Salmonella Spp ◽  
Disk Diffusion Method ◽  
Gram Positive Bacteria ◽  
Growth Inhibition Zone

Genus Mentha presents group of plants which are the most studied in family Lamiaceae. Aboveground parts are used for different purposes in pharmacy, food industry or confectionery. Most important is natural product extracted from leaves - essential oil (EO). The aim of presented experiment was to demonstrate different chemotype and compare antibacterial activity of two Mentha species EO. Plant samples were obtained from various environments – from Slovakia and from Italy. Dominant compounds were determined by GC/MS. The results showed high amount of menthol and menthone in tested Slovak peppermint EO. On the other hand, carvone and 1,8-cineole were determinate as dominant compounds in Italian spearmint EO. The antimicrobial activity of the EO was investigated by disc diffusion and broth micro dilution methods. EO was evaluated for their antibacterial activity against 7 microorganisms: Enterobacter cloacae, Salmonella spp., Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes. The determination results of antibacterial activity by agar disk diffusion method ranged from 7 to 14 mm of the growth inhibition zone. MIC of tested mint EO varied from 0.625 to 2.5 μg/mL. In addition, both EO showed relatively the same antibacterial activity against the selected Gram-negative bacteria. However, there is a variation in the antibacterial activity against Gram-positive bacteria.

scholarly journals Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39367-39380 ◽  
Author(s):  
Waldemar Tejchman ◽  
Bartosz Orwat ◽  
Izabela Korona-Głowniak ◽  
Anna Barbasz ◽  
Ireneusz Kownacki ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Microwave Synthesis ◽  
Chemical Structure ◽  
Biological Properties ◽  
Microwave Assisted Synthesis ◽  
Chemical Structures ◽  
Microwave Assisted ◽  
Highly Efficient

An efficient microwave-assisted synthesis of rhodanine and 2-thiohydantoin derivatives, and the correlation between their chemical structure and biological properties is reported.

scholarly journals Physical and Antimicrobial Properties of Hydroxypropyl Starch Bio-plastics Incorporated with Nyamplung (Calophyllum inophyllum) Cake Extract as an Eco-Friendly Food Packaging

2019 ◽  
Vol 125 ◽  
pp. 07011
Author(s):  
Rini Umiyati ◽  
Chusnul Hidayat ◽  
Ria Millati ◽  
Teguh Ariyanto
Keyword(s):  
Food Packaging ◽  
Water Solubility ◽  
Antimicrobial Properties ◽  
Sample Surface ◽  
Inhibition Zone ◽  
Spectroscopy Analysis ◽  
Calophyllum Inophyllum ◽  
Gram Positive Bacteria ◽  
Highest Weight ◽  
Hydroxypropyl Starch

Nyamplung (Calophyllum inophyllum) cake as a by-product of nyamplung oil production is still limited. This research aimed to evaluate characteristics of antimicrobial bio-plastic made from hydroxypropyl starch as a basic ingredient and Nyamplung cake extract as additive. Nyamplung cake extract addition affected bio-plastic mechanical property by reduction of tensile strength but improved physical properties by reduction of vapor and oxygen permeability, water solubility, and increased elongation. This was probably due to the extract serve as natural crosslinking. Fourier Transform Infrared Spectroscopy analysis showed no difference in five bio-plastic samples, which probably caused by low concentration of extract. Thermogravimetry analysis showed the highest weight reduction in control of 95.824% and the lowest on Ext2% of 84.471%. Morphology analysis showed agglomeration of the extract on sample surface due to uneven ingredient distribution in mixture. Bio-plastic was more sensitive against gram positive bacteria than gram negative with their respective largest inhibition zone of 30 mm (Staphylococcus aureus) and 23 mm (Escherichia coli). This was probably due to the content of the extract serve as natural crosslinking and antibacterial agent.

Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mariam Achir ◽  
Mohamed Dakir ◽  
Abdelhakim El Makssoudi ◽  
Asmae Belbachir ◽  
Farida Adly ◽  
...  
Keyword(s):  
Inhibition Zone ◽  
Spectroscopic Properties ◽  
High Yield ◽  
Gram Positive Bacteria ◽  
Chemical Structures ◽  
Soxhlet Apparatus ◽  
Juniperus Phoenicea ◽  
Antibacterial And Antifungal ◽  
First Time ◽  
Better Than

Abstract Objectives A mixture of Z and E communic acid is isolated for the first time from the cones of Juniperus phoenicea. Its biological activity was studied. Methods The plant material was extracted in a Soxhlet apparatus with n-hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties 1H and 13C NMR data with those reported in the literature. The antimicrobial assay of hexanic extract and isolated compounds was carried out by the disc diffusion and micro-dilution methods. Results A mixture of two diterpene acids isomers was isolated, with a high yield (68%). Their chemical structures were confirmed after comparing their spectral data with published reports. These natural products exhibited a significant antibacterial and antifungal activity against the tested strains. Indeed, for Bacillus cereus, Staphylococcus aureus, and Pseudomonas aeruginosa, the inhibition zone diameters (36–37 mm) was better than penicillin, novobiocin, and amoxicillin. For Candida albicans activity, it show that the mixture possess an activity similar to that of Metrazol. Against Escherichia coli, the inhibitory activity was found less than Amoxicillin. This is the first report of isolation of communic acid from J. phoenicea. Conclusions These results showed that the cones of J. phoenicea were an important source of communic acid, and its hexanic extract had the greatest potential antibacterial activity against both Gram-negative and Gram-positive bacteria and C. albicans.

scholarly journals Antibacterial activity of ethanolic extracts of some moss species

2017 ◽  
Vol 63 (3) ◽  
pp. 11-17 ◽  
Author(s):  
Tomasz M. Karpiński ◽  
Artur Adamczak
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Moss Species ◽  
Gram Positive Bacteria ◽  
Agar Disc ◽  
Ethanolic Extracts ◽  
Antiviral Activities ◽  
First Time

Summary Introduction: For centuries, mosses have been used in traditional medicine due to their antibacterial, antifungal, and antiviral activities. Objective: The present study was designed to evaluate the antibacterial activity of ethanolic extracts obtained from 12 moss species: Brachythecium albicans, Bryum argenteum, Ceratodon purpureus, Dicranum scoparium, Dryptodon pulvinatus, Orthotrichum anomalum, Oxyrrhynchium hians, Plagiomnium undulatum, Polytrichum juniperinum, P. piliferum, Schistidium crassipilum, and Syntrichia ruralis. Methods: The antimicrobial activity of extracts was investigated against three Gram(+) bacteria (Enterococcus faecalis, Staphylococcus aureus, and Streptococcus pyogenes) and two Gram(-) bacteria (Escherichia coli and Klebsiella pneumoniae), using the agar disc-diffusion method. Results: The high activity against all investigated bacteria was determined for extracts of D. pulvinatus, P. undulatum, B. argenteum, S. crassipilum, O. anomalum (mean inhibition zone: 11.3-13.1 mm) and to a lesser extent in the case of D. scoparium (8.3 mm). Extracts from P. juniperinum and P. piliferum showed activity only against Gram-positive bacteria, with an inhibition zone from 7.3 to 9.7 mm. Four species: B. albicans, C. purpureus, O. hians, and S. ruralis had not antibacterial properties. Conclusions: The obtained results indicate that mosses could be a significant source of antibacterial agents. For the first time, we presented antibacterial activity of ethanolic extracts from S. crassipilum and O. anomalum.

scholarly journals In vitro Evaluation of Antibacterial Activity and Protective Effects on Cardiomyocytes with H/R Injury of Garlic/Onion Oil

2020 ◽  
Author(s):  
Yifei Lu ◽  
Hui Lv ◽  
Lihua Li ◽  
Chao Yang ◽  
Da Pan ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Survival Rate ◽  
Antibacterial Effect ◽  
Inhibition Zone ◽  
Protective Effects ◽  
Volatile Oils ◽  
Gram Positive ◽  
Gram Positive Bacteria ◽  
Garlic Oil

Abstract Background: At present, the research concerning in vitro experiments of garlic oil and onion oil is limited. The objective of this study was to carry out the research on the effective components of garlic and onion, and to study the antibacterial activity of the two essential oils and their protective effects on cardiomyocytes with hypoxia/reoxygenation (H/R) injury.Method: The protective effect of volatile oils at different concentrations (200, 100, 50, 25, 12.5, 6.3, 3.1mg/L) on the endothelial cell of microvascular in cardiac muscle against H/R injury was examined by MTT and flow cytometer method. The survival rate and apoptosis situation were record. Inhibition zone test was used to evaluate antibacterial activity of volatile oils. MIC and MBC were calculated as well.Results: To achieve a higher survival rate, the optimum concentrations of garlic oil and onion oil were 12.5mg/L and 6.13mg/L and high concentrations of garlic and onion oil decreased the survival rate. Both the 12.5mg/L onion and garlic oil reduced the apoptosis situation of cardiomyocytes. Both garlic oil and onion oil had antibacterial effect on gram-positive bacteria and gram-negative bacteria, and had the best antibacterial effect on cocci of gram-positive bacteria.Conclusion: Garlic and onion oil do have antibacterial activity and protective effects on cardiomyocytes with H/R injury in a concentration range.

scholarly journals Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida

Antibiotics ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 63 ◽  
Author(s):  
Israt J. Biva ◽  
Chi P. Ndi ◽  
Susan J. Semple ◽  
Hans J. Griesser
Keyword(s):  
Antibacterial Activity ◽  
Acetone Extract ◽  
Antimicrobial Compounds ◽  
Resin Layer ◽  
Gram Positive Bacteria ◽  
Chemical Structures ◽  
Antibacterial Performance ◽  
Australian Plant ◽  
Wide Range ◽  
Recent Attention

Plants in the Australian genus Eremophila (Scrophulariaceae) have attracted considerable recent attention for their antimicrobial compounds, which possess a wide range of chemical structures. As they are typically associated with the oily-waxy resin layer covering leaves and green branchlets, and Eremophila lucida is prominent among the species containing a pronounced sticky resin layer, this species was considered of interest for assessing its antibacterial constituents. The n-hexane fraction of the crude acetone extract of the leaves exhibited antibacterial activity against Staphylococcus aureus. Isolation led to the known compounds cembratriene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (1), the sesquiterpenoid, farnesal (2) and the viscidane diterpenoid, 5α-hydroxyviscida-3,14-dien-20-oic acid (3). The purified compounds were tested for antibacterial activity with 2 and 3 showing moderate antibacterial activity against Gram-positive bacteria.

scholarly journals Antibacterial Activity and Chemical Composition of Red Peacock Flower (Caesalpinia pulcherrima L.) Leaf Essential Oil

2019 ◽  
Vol 22 (6) ◽  
pp. 269-274
Author(s):  
Novena Risnalani Rintank Constani ◽  
Hartati Soetjipto ◽  
Sri Hartini
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Inhibition Zone ◽  
Diffusion Method ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Leaf Essential Oil

Peacock flower (Caesalpinia pulcherrima L.) leaves contain essential oils which can be used as an ingredient in cosmetics, perfume, aromatherapy, medicine, and supplements. The study was conducted to obtain essential oils from peacock flower leaves and determine the antibacterial activity against gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and gram-negative (Escherichia coli and Pseudomonas aeruginosa). Antibacterial activity test was carried out by the agar diffusion method, using paper discs. Measurements were made for the inhibition zone diameter (IZD) that appeared, while the essential oil component was analyzed using GC-MS. The results showed that the peacock flower leaves (C. pulcherrima) had a moderate to strong antibacterial effect at a concentration of 7.5%-20% against gram-positive bacteria (B. subtilis and S. aureus) and gram-negative bacteria (E. coli and P. aeruginosa). Gram-negative E. coli bacteria are relatively more sensitive to peacock flower leaf essential oil compared to other test bacteria. Peacock flower (C. pulcherrima) leaf essential oil is composed of 7 main components namely β-Cubebene 33.87%; Caryophyllene 23.00%; γ-Elemene 13.18%; α-Pinene 10.96%; Cadina-1(10),4-diene 10.20%; Copaene; 7.09%; β-Pinene 1.70%.

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