scholarly journals Features of bioaccumulation and toxic effects of copper (II) oxide nanoparticles under repeated inhalation exposure in rats

2021 ◽  
Vol 100 (10) ◽  
pp. 1139-1144
Author(s):  
Nina V. Zaitseva ◽  
Marina A. Zemlyanova ◽  
Mark S. Stepankov ◽  
Anna M. Ignatova ◽  
Alena E. Nikolaeva
Keyword(s):  
Surface Area ◽  
Pore Volume ◽  
Large Scale ◽  
Hematological Parameters ◽  
Inhalation Exposure ◽  
Relative Number ◽  
The Body ◽  
Oxide Nanoparticles ◽  
Scale Production ◽  
Cuo Nps

Introduction. Active use in various spheres of economic activity, large-scale production and the availability of data on toxicity determine the relevance of studying the effects of copper (II) oxide nanoparticles (CuO NPs) on the body during inhalation exposure. Material and Methods. The size, surface area, and pore volume of CuO NPs were determined. The study and assessment of biochemical and hematological parameters of blood, the degree of bioaccumulation of nanomaterial, pathomorphological changes in organs of rats exposed to CuO NPs were carried out. The studies were carried out in comparison with a microsized analogue (CuO MPs). Results. The size of CuO NPs in the composition of the native powder is 305.00 times less than that of CuO MPs. The surface area and pore volume are 9.61 and 9.33 times larger, respectively. After exposure to CuO NPs in the blood of rats relative to the control, the levels of activity of ALT, AST, ALP, GGT, LDH, amylase, AOA, MDA and the concentration of CRP increased by 1.49-2.23 times, the content of urea decreased by 1.41 times; relative number of eosinophils, leukocyte count, RDW by 1.31-5.39 times increased, relative number of segmented neutrophils decreased by 1.37 and monocytes by 1.42 times. The effect of NPs, in comparison with MPs, is more pronounced in increasing the activity of ALT, AST, LDH, MDA and the concentration of CRP by 1.25-1.68 times and in reducing the concentration of urea by 1.21 times; in increase the relative number of eosinophils by 2.37 and the count of leukocytes by 1.61 times. The concentration of copper under the action of NPs increases relative to the control in the lungs, liver, stomach, intestines and kidneys by 1.59-6.99 times. The degree of bioaccumulation of nanoparticles is 1.20-2.12 times higher than that of microparticles in the lungs, liver, stomach, and kidneys. Conclusion. Functional and pathomorphological changes caused by CuO NPs are more pronounced in the lungs, stomach, and small intestine in comparison with microparticles. It was confirmed that the studied CuO particles are nanomaterials. They have a more pronounced bioaccumulation and toxic effect relative to the microdispersed analogue.

Features of bioaccumulation and toxic effects of copper (II) oxide nanoparticles under the oral route of intake into the body

2021 ◽  
Vol 29 (6) ◽  
pp. 47-53
Author(s):  
M. A. Zemlyanova ◽  
M. S. Stepankov ◽  
A. M. Ignatova
Keyword(s):  
Specific Surface ◽  
Pore Volume ◽  
Relative Number ◽  
Total Pore Volume ◽  
Oral Route ◽  
The Body ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Oral Toxicity ◽  
Cuo Nps

Introduction. Active use in various spheres of economic activity and the large-scale nature of production determine the relevance of studying the effects of copper (II) oxide nanoparticles (CuO NPs) on the body during the oral route of intake. Material and methods. Particle size was determined by scanning electron microscopy and dynamic laser light scattering; specific surface area - Brunauer, Emmett and Teller; total pore volume - Barrett, Joyner and Khalenda. Acute oral toxicity of CuO NPs was studied in Wistar rats in accordance with GOST 32644-2014, multiple oral toxicity was studied by the Lim method. After repeated exposure, the biochemical and hematological parameters of the blood, the concentration of copper in the organs, and pathomorphological changes in the tissues of the organs were determined. Results. The size of CuO NPs in the composition of the native powder was 45.86 nm, in the aqueous suspension - 307.40 nm, the specific surface area was 17.70 m2/g, and the total pore volume was 0.056 cm3/g. According to the results of a single oral exposure, the LD50 value was > 2000 mg / kg body weight, which corresponds to 3 (GOST 12.1.007-76) and 4 (GOST 32644-2014) hazard classes. With repeated oral exposure, an increase in the levels of activity of ALT, AST, ALP, LDH, amylase, AOA and MDA was noted; the relative number of segmented neutrophils is increased, the number of leukocytes is increased, the relative number of lymphocytes is reduced. The concentration of copper under the action of NPs increases in the lungs, liver, stomach, intestines, kidneys, brain and blood. Pathomorphological changes in the tissues of the liver, kidneys, stomach, small and large intestines and lungs were established. Conclusion. The results obtained prove the presence of toxic properties of CuO NPs and can be used in the development of preventive measures for workers and consumers in contact with products containing CuO NPs.

Features of Bioaccumulation and Toxic Effects of Copper (II) Oxide Nanoparticles Under Repeated Oral Exposure in Rats

2021 ◽  
Vol 09 ◽  
Author(s):  
Mark Sergeevich Stepankov ◽  
Marina Aleksandrovna Zemlyanova ◽  
Nina Vladimirovna Zaitseva ◽  
Anna Mikhailovna Ignatova ◽  
Alena Evgenievna Nikolaeva
Keyword(s):  
Surface Area ◽  
Pore Volume ◽  
Mesangial Cells ◽  
Lethal Dose ◽  
Toxic Effects ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Brown Pigment ◽  
Cuo Nps ◽  
Hematological Analysis

Background: Currently, the range of copper (II) oxide nanoparticles’ (CuO NPs) applications is expanding and the global production of CuO NPs is increasing. In this regard, the risk of exposure of the population to this nanomaterial increases. Objective: The aim of the study is to investigate the patterns of bioaccumulation and toxic effects of CuO NPs after multiple oral exposures. Methods: The particle size was determined by scanning electron microscopy and dynamic laser light scattering. Specific surface area was measured by the method of Brunauer, Emmett, Teller. Total pore volume - by the method of Barrett, Joyner, Khalenda. Twenty-four hours after the final exposure, blood samples were taken for biochemical and hematological analysis, and internal organs were taken to determine their mass, copper concentration and histological analysis. The study was carried out in comparison with copper (II) oxide microparticles (CuO MPs). Results: In terms of size, surface area, and pore volume, the studied copper (II) oxide sample is a nanomaterial. The median lethal dose of CuO NPs was 13187.5 mg/kg of body weight. Bioaccumulation occurs in the stomach, blood, intestines, liver, lungs, kidneys and brain. Pathomorphological changes in the liver are manifested in the form of necrosis, degeneration, hepatitis; kidney - proliferation of mesangial cells, dystrophy; stomach - gastritis; small intestine - hyperplasia, enteritis; large intestine - colitis; lungs - hyperplasia, abscess, pneumonia, bronchitis, vasculitis. Clumps of brown pigment were detected in the kidneys, stomach and lungs. The mass of the stomach and intestines increased, the mass of the liver, kidneys and lungs decreased. Pathomorphological changes in organs are likely to cause an increase in the levels of activity of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase, amylase, malondialdehyde concentration and a decrease in plasma antioxidant activity. The proportion of segmented neutrophils, the number of leukocytes are raised, the proportion of lymphocytes is reduced. Conclusion: The degree of bioaccumulation and toxicity of CuO NPs are more expressed in relation to CuO MPs.

Synthesis and Preparation of Al-MCM-41 Mesoporous Materials Using Oil Shale Residue

2019 ◽  
Vol 944 ◽  
pp. 1192-1198
Author(s):  
Rong Wang ◽  
Zhi Xiang Lin ◽  
Yang Zhao ◽  
Xiao Dong Xu ◽  
Yan Xi Deng
Keyword(s):  
Surface Area ◽  
Mesoporous Materials ◽  
Pore Volume ◽  
Oil Shale ◽  
Bet Surface Area ◽  
Ammonium Bromide ◽  
Scale Production ◽  
Scanning Electron Micrographs ◽  
One Step ◽  
Mcm 41

An Al-supported cage-like mesoporous silica type MCM-41 has been prepared using a simple one-step synthetic procedure using oil shale residue and CTAB(Hexadecyl trimethyl Ammonium Bromide) as the template. The effects of temperature on the porosity, structure and surface area of Al-MCM-41 mesoporous materials were characterized by X-ray powder diffraction, N2adsorption desorption, scanning electron micrographs (SEM), transmission electron microscopy (TEM) techniques and Fourier transform infrared spectroscopy (FT-IR). The results indicated that temperature was a key to the characteristics of Al-MCM-41 materials, and when the temperature up to 333 K, Al-MCM-41 exhibited excellent characteristics with high degree of order, high surface area and pore volume. The one-step hydrothermal synthesized MCM-41 mesoporous material possessed high BET surface area, high pore size and high pore volume. They are respectively 835.1 m2/g, 32.6 Å and 1.22 cm3/g under the condition of the Si : Al =78:1, pH =10, crystallization temperature was 333K, crystallization time was 48h and calcination at 823 K for 5 h in air. All the results indicated the possibility of using oil shale residue as silicon and aluminum source to produce Al-MCM-41, and gave us a new way to recycle a solid waste. As well as this made it impossible to large-scale production of Al-MCM-41. Keywords: Al-MCM-41 mesoporous materials, oil shale residue, one-step synthesis

Synthesis and Thermal Stability of HfO2 Nanoparticles

2010 ◽  
Vol 1256 ◽  
Author(s):  
Girija Shankar Chaubey ◽  
Yuan Yao ◽  
Julien Pierre Amelie Makongo Mangan ◽  
Pranati Sahoo ◽  
Pierre F. P. Poudeu ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Large Scale ◽  
Average Diameter ◽  
Scale Production ◽  
Simple Method ◽  
Good Thermal Stability ◽  
Large Scale Production

AbstractA simple method is reported for the synthesis of monodispersed HfO2 nanoparticles by the ammonia catalyzed hydrolysis and condensation of hafnium (IV) tert-butoxide in the presence of surfactants at room temperature. Transmission electron microscopy shows faceted nanoparticles with an average diameter of 3-4 nm. As-synthesized nanoparticles are amorphous in nature and crystallize upon moderate heat treatment. The HfO2 nanoparticles have a narrow size distribution, large specific surface area and good thermal stability. Specific surface area was about 239 m2/g on as-prepared nanoparticle samples while those annealed at 500 °C have specific surface area of 221 m2/g indicating that there was no significant increase in particle size. This result was further confirmed by TEM images of nanoparticles annealed at 300 °C and 500 °C. X-ray diffraction studies of the crystallized nanoparticles revealed that HfO2 nanoparticles were monoclinic in structure. The synthetic procedure used in this work can be readily modified for large scale production of monodispersed HfO2 nanoparticles.

scholarly journals Mechanochemical synthesis of metal oxide nanoparticles

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Takuya Tsuzuki
Keyword(s):  
Metal Oxide ◽  
Mechanochemical Synthesis ◽  
Large Scale ◽  
Reaction Pathway ◽  
Metal Oxide Nanoparticles ◽  
Energy Storage And Conversion ◽  
Oxide Nanoparticles ◽  
Synthesis Methods ◽  
Scale Production ◽  
Large Scale Production

AbstractIn the last decades, mechanochemical processing has emerged as a sustainable method for the large-scale production of a variety of nanomaterials. In particular, mechanochemical synthesis can afford well-dispersed metal-oxide nanoparticles, which are used in wide-ranging applications including energy storage and conversion, environmental monitoring, or biomedical uses. This article reviews recent progress in the mechanochemical synthesis of metal-oxide nanoparticles, explores reaction mechanisms, and contrasts the influence of chosen process parameters on the properties of end products. The role of choice of reaction pathway, as well as advantages and limitations compared to other synthesis methods are discussed. A prospect for future development of this synthetic method is proposed.

scholarly journals Mycosinthetized Ag, CuO and ZnO nanoparticles from a promising Trichoderma harzianum strain and their antifungal potential against important phytopathogens

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Verónica Fabiana Consolo ◽  
Andrés Torres-Nicolini ◽  
Vera Alejandra Alvarez
Keyword(s):  
Zno Nanoparticles ◽  
Trichoderma Harzianum ◽  
Large Scale ◽  
Mass Scale ◽  
Scale Production ◽  
Dependent Manner ◽  
Zno Nps ◽  
Extracellular Biosynthesis ◽  
Cuo Nps ◽  
Fungal Phytopathogens

AbstractFungal green biosynthesis of nanoparticles (NPs) is a promising eco-friendly method for mass-scale production. In the present study Ag, CuO and ZnO nanoparticles were biogenically synthetized using a cell filtrate of a strain of Trichoderma harzianum as a reducer and stabilizer agent. The structure, morphology and physicochemical properties of the NPs were characterized through transmission electron microscopy, dynamic light scattering, wide angle X-ray scattering and thermogravimetric analysis. Since nanotechnology could offer promising applications in agricultural area, we evaluated the ability of the NPs to reduce the growth of important fungal phytopathogens as Alternaria alternata, Pyricularia oryzae and Sclerotinia sclerotiorum. Silver and CuO NPs reduced significantly the mycelial growth of A. alternata and P. oryzae in a dose dependent manner. This is the first report of a multiple extracellular biosynthesis of NPs from T. harzianum and the first time that CuO and ZnO NPs were obtained from this fungus. In addition, we highlighted the rapid production of NPs, as well as, the potential of Ag and CuO for the control of phytopathogens. On the other hand, the three types of NPs could be easily and sustainably produced on a large scale with the chance of having multiple applications in biotechnological processes.

Classification, synthesis, characterization and biomedical application of nanoparticle: Detailed review

2020 ◽  
Vol 11 (4) ◽  
pp. 7980-7984
Author(s):  
Ranganathan K ◽  
Muruganantham V
Keyword(s):  
Large Scale ◽  
Biomedical Application ◽  
Maximum Growth ◽  
Drug Carriers ◽  
The Body ◽  
Nano Particles ◽  
Scale Production ◽  
Nano Technology ◽  
Nano Science ◽  
Nano Medicine

The branches of science like Nano medicine, Nano technology, Nano chemistry and Nano science are a few of those departments that have the word 'nano' in their name and were frequently published in books and journals and became familiar to the public and the research professionals too. It was an emerging science in the 20th century and is the trend currently. It is not a single isolated technique or method that is applicable in one field, but it is multi-dimensional and is applied in various fields considering the advantages. Its arena ranges from the synthesis, designs, large scale production and potential application of nano-sized materials. They are the systems of a matrix of drug carriers that are uniformly dispersed in the polymeric membranes. This review concentrates on the methods of preparation of nano particles, evaluation methods, advantages and applications of nano particles in medicine. Nanotechnology mostly provides better drug delivery in order to transfer into the smaller parts of the body. This is mostly implemented to enter the ultrathin areas in the body. So, the drugs such as genetic medicine can easily permeated into the cell walls to produce maximum growth within a few more years. The doctors are paid by the patients. The patients who are receiving this therapy shows better bioavailability, decreased drug toxicity, lesser cost of treatment, and extend the life of proprietary drugs.

Kiruna-Type Ore as a Novel Precursor for Large-Scale Production of Small Uniform Iron Oxide Nanoparticles

2020 ◽  
Vol 20 (10) ◽  
pp. 6525-6531
Author(s):  
Majid Mostaghelchi ◽  
Jani Kotakoski ◽  
Christian Rentenberger ◽  
Christian L. Lengauer
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Large Scale ◽  
Critical Size ◽  
Raw Material ◽  
Oxide Nanoparticles ◽  
Scale Production ◽  
X Ray ◽  
Mechanical Attrition ◽  
Wide Range

The wide range of actual and potential applications of nanoparticles, highlight the necessity of a reliable production method for both quality and quantity of the products. Mechanical attrition is one of the first well-known techniques used to produce nanoparticles. However, these approaches have been restricted to produce uniform particles below the critical size of 15 nm because of the attrition balance limit. This paper introduces the magnetite–silicate raw material of a Kiruna-type ore deposit as a novel precursor, which enables the production of small iron oxide nanoparticles below the critical size by mechanical attrition. X-ray fluorescence (XRF), powder X-ray diffractometry (pXRD), dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used for characterization of the precursor and obtained nanoparticles. The results indicate that the particles with a mean diameter of 10.7(2.7) nm consist of mainly less than one crystallite. The significant size reduction below the attrition balance limit can be attributed to the quartz content of the raw material, which operated as supporting micro-balls for transferring the energy during the milling process.

scholarly journals Large scale production of novel g-C3N4 micro strings with high surface area and versatile photodegradation ability

CrystEngComm ◽  
2014 ◽  
Vol 16 (9) ◽  
pp. 1825 ◽  
Author(s):  
Muhammad Tahir ◽  
Chuanbao Cao ◽  
Faheem K. Butt ◽  
Sajid Butt ◽  
Faryal Idrees ◽  
...  
Keyword(s):  
Surface Area ◽  
Large Scale ◽  
High Surface ◽  
High Surface Area ◽  
Scale Production ◽  
Large Scale Production
Sign in / Sign up

Export Citation Format

Share Document