The Visible Portion of Anterior Teeth at Rest

2004 ◽  
Vol 5 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Khalid A. Al Wazzan
Keyword(s):  
Racial Differences ◽  
Clinical Situation ◽  
Sufficient Information ◽  
Maxillary Central Incisor ◽  
Anterior Teeth ◽  
Excellent Starting Point ◽  
Starting Point ◽  
The Face ◽  
Tooth Surfaces ◽  
Vertical Positioning

Abstract The visibility of anterior tooth surfaces with lips at rest or during function is an important factor in determining prosthodontic outcome. There is a lack of sufficient information published on this subject. The aim of this study was to investigate the degree of visibility of maxillary and mandibular anterior teeth surfaces when the lips are at rest. Four hundred seventy three adults were examined. All the subjects had maxillary and mandibular anterior teeth present with no caries, restorations, severe attrition, mobility, extrusion, or obvious deformities. The portions of anterior teeth that were visible were measured vertically using a Boley gauge from the border of the lip to the incisal edge for the incisors and to the cusp tip for the canines. The measurement was taken at the midpoint of the tooth when the lips and lower jaw were at the rest position. The length of the upper lip was measured from the base of the columella to the tip of the philtrum at the midline of the face. Males showed more of the maxillary lateral, canine, and mandibular anterior teeth than females. With increasing age, the amount of maxillary anterior teeth that was visible at rest decreased. The subjects with shorter upper lips displayed more maxillary central incisor structure than those with longer upper lips. Racial differences were not found. The amount of visible portions of anterior teeth is determined by muscle positions that vary from person to another. It provides an excellent starting point for vertical positioning anterior teeth that can be modified as necessary in any clinical situation. The findings of this study should help the dentist in providing aesthetic prosthodontic treatment that involves replacement of anterior teeth. A useful guideline for positioning anterior teeth is suggested. Citation Al Wazzan KA. The Visible Portion of Anterior Teeth at Rest. J Contemp Dent Pract 2004 February;(5)1:053-062.

scholarly journals A Clinical Study to Correlate the Facial Form and Maxillary Central Incisor Tooth Form in Males and Females of Davangere Population

2016 ◽  
Vol 04 (03) ◽  
pp. 156-164
Author(s):  
Deepak Bansal ◽  
Shruti Sharma ◽  
Manjit Kumar ◽  
Amrit Khosla
Keyword(s):  
Facial Appearance ◽  
Central Incisor ◽  
Incisor Tooth ◽  
Maxillary Central Incisor ◽  
Anterior Teeth ◽  
The Face ◽  
Tooth Form ◽  
Males And Females ◽  
Selection Of ◽  
Made In

AbstractAn altered facial appearance is more difficult to face, than problems related to ill-fitting denture or eating. The selection of maxillary anterior teeth for complete denture has long posed problem in clinical practice and a controversy about the best method to employ still exists. An attempt is made in the present study to clinically correlate the face form with maxillary central incisor tooth form in males and females of Davangere population. In 1914, Leon William's projected the “the form method” where he classified facial forms as square, tapering, and ovoid. Maxillary central incisors were selected according to the facial forms.Of total 100 subjects four different tooth forms and face forms were evaluated. They are: square, ovoid, square-tapered, tapered. No significant correlation existed between face form in male and females. Females exhibited greater correlation between face forms and inverted tooth form but that correlation is not sufficient to serve as a guide for selection of anterior teeth.

Maintenance of diastema with a loop connector fixed partial denture: A Case Report

2021 ◽  
Vol 1 (4) ◽  
pp. 232-242
Keyword(s):  
Case Report ◽  
Clinical Situation ◽  
Point Of View ◽  
Partial Denture ◽  
Maxillary Central Incisor ◽  
Fixed Partial Denture ◽  
Anterior Teeth ◽  
Fixed Prosthesis ◽  
Functional Point ◽  
Natural Tooth

The replacement of a single maxillary central incisor is a unique prosthodontic challenge from esthetic as well as a functional point of view. Loss of anterior teeth with existing natural diastema presents problems such as increased mesiodistal space available for pontic which makes it very difficult to give conventional fixed prosthesis with rigid connector and wider pontics can be very unesthetic to look in the esthetic zone. This clinical situation is a major challenge for a prosthodontist; leaves him in a dilemma whether to close the space or to maintain it in a final fixed prosthesis simulating the natural tooth appearance. If implant-supported prosthesis is not possible fixed partial denture along with loop connector is the best solution to maintain the existing diastema and esthetics. This article presents a case report where fixed partial denture along with loop connector was used to achieve esthetic rehabilitation in maxillary anterior region maintaining natural existing diastema.

scholarly journals Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Johanna Rokka ◽  
Eva Schlein ◽  
Jonas Eriksson
Keyword(s):  
Methyl Iodide ◽  
Water Solution ◽  
Synthesis Method ◽  
Radiochemical Yield ◽  
Preparative Hplc ◽  
Step Method ◽  
Synaptic Density ◽  
Excellent Starting Point ◽  
Starting Point

Abstract Introduction [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmitter release in neurons and endocrine cells. The localisation of SV2A in the synaptic terminals makes it a viable target for in vivo imaging of synaptic density in the brain. Several SV2A targeting compounds have been evaluated as PET tracers, including [11C]UCB-J, with the aim to facilitate studies of synaptic density in neurological diseases. The original two-step synthesis method failed in our hands to produce sufficient amounts of [11C]UCB-J, but served as an excellent starting point for further optimizations towards a high yielding and simplified one-step method. [11C]Methyl iodide was trapped in a clear THF-water solution containing the trifluoroborate substituted precursor, potassium carbonate and palladium complex. The resulting reaction mixture was heated at 70 °C for 4 min to produce [11C]UCB-J. Results After semi-preparative HPLC purification and reformulation in 10% ethanol/phosphate buffered saline, the product was obtained in 39 ± 5% radiochemical yield based on [11C]methyl iodide, corresponding to 1.8 ± 0.5 GBq at EOS. The radiochemical purity was > 99% and the molar activity was 390 ± 180 GBq/μmol at EOS. The product solution contained < 2 ppb palladium. Conclusions A robust and high yielding production method has been developed for [11C]UCB-J, suitable for both preclinical and clinical PET applications.

scholarly journals Globalization Impact on Multinational Enterprises

World ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 216-230
Author(s):  
Justine Kyove ◽  
Katerina Streltsova ◽  
Ufuoma Odibo ◽  
Giuseppe T. Cirella
Keyword(s):  
Developing Country ◽  
Multinational Enterprises ◽  
Developed Countries ◽  
Global Market ◽  
Data Availability ◽  
Negative Effects ◽  
Developed Country ◽  
Excellent Starting Point ◽  
Starting Point ◽  
The Impact

The impact of globalization on multinational enterprises was examined from the years 1980 to 2020. A scoping literature review was conducted for a total of 141 articles. Qualitative, quantitative, and mixed typologies were categorized and conclusions were drawn regarding the influence and performance (i.e., positive or negative effects) of globalization. Developed countries show more saturated markets than developing countries that favor developing country multinational enterprises to rely heavily on foreign sales for revenue growth. Developed country multinationals are likely to use more advanced factors of production to create revenue, whereas developing country multinationals are more likely to use less advanced forms. A number of common trends and issues showed corporate social responsibility, emerging markets, political issues, and economic matters as key to global market production. Recommendations signal a strong need for more research that addresses contributive effects in the different economies, starting with the emerging to the developed. Limitations of data availability and inconsistency posed a challenge for this review, yet the use of operationalization, techniques, and analyses from the business literature enabled this study to be an excellent starting point for additional work in the field.

scholarly journals Analysis of saponins detoxification genes in Ilyonectria mors-panacis G3B inducing root rot of Panax notoginseng by RNA-Seq

2021 ◽  
Author(s):  
Guohong Zeng ◽  
Jin Li ◽  
Yuxiu Ma ◽  
Qian Pu ◽  
Tian Xiao ◽  
...  
Keyword(s):  
Root Rot ◽  
Molecular Mechanisms ◽  
Management Strategies ◽  
Panax Notoginseng ◽  
Glycoside Hydrolases ◽  
Rna Seq ◽  
Host Interaction ◽  
Excellent Starting Point ◽  
Starting Point ◽  
Genes Encoding

AbstractSaponins are kinds of antifungal compounds produced by Panax notoginseng to resist invasion by pathogens. Ilyonectria mors-panacis G3B was the dominant pathogen inducing root rot of P. notoginseng, and the abilities to detoxify saponins were the key to infect P. notoginseng successfully. To research the molecular mechanisms of detoxifying saponins in I. mors-panacis G3B, we used high-throughput RNA-Seq to identify 557 and 1519 differential expression genes (DEGs) in I. mors-panacis G3B with saponins treatments for 4H (Hours) and 12H (Hours) compared with no saponins treatments, respectively. Among these DEGs, we found 93 genes which were simultaneously highly expressed in I. mors-panacis G3B with saponins treatments for 4H and 12H, they mainly belong to genes encoding transporters, glycoside hydrolases, oxidation–reduction enzymes, transcription factors and so on. In addition, there were 21 putative PHI (Pathogen–Host Interaction) genes out of those 93 up-regulated genes. In this report, we analyzed virulence-associated genes in I. mors-panacis G3B which may be related to detoxifying saponins to infect P. notoginseng successfully. They provided an excellent starting point for in-depth study on pathogenicity of I. mors-panacis G3B and developed appropriate root rot disease management strategies in the future.

scholarly journals 4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4118
Author(s):  
Tjaša Mazej ◽  
Damijan Knez ◽  
Anže Meden ◽  
Stanislav Gobec ◽  
Matej Sova
Keyword(s):  
Monoamine Oxidase ◽  
Docking Studies ◽  
Monoamine Oxidase B ◽  
Mao B ◽  
Initial Expectation ◽  
Excellent Starting Point ◽  
Starting Point ◽  
Dependent Inhibition ◽  
Dual Inhibitors ◽  
Time Dependent Inhibition

The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible monoamine oxidase B (MAO-B) inhibitor, we aimed to introduce a carbamate moiety on the aromatic ring to impart cholinesterase (ChE) inhibition, and to furnish multifunctional ligands targeting two enzymes that are intricately involved in AD pathobiology. In this study, we synthesized three dual hMAO-B/hBChE inhibitors 13–15, with compound 15 exhibiting balanced, low micromolar inhibition of hMAO-B (IC50 of 4.3 µM) and hBChE (IC50 of 8.5 µM). The docking studies and time-dependent inhibition of hBChE confirmed the initial expectation that the introduced carbamate moiety is responsible for covalent inhibition. Therefore, dual-acting compound 15 represents an excellent starting point for further optimization of balanced MTDLs.

scholarly journals Revisiting the CompCars Dataset for Hierarchical Car Classification: New Annotations, Experiments, and Results

Sensors ◽  
2021 ◽  
Vol 21 (2) ◽  
pp. 596
Author(s):  
Marco Buzzelli ◽  
Luca Segantin
Keyword(s):  
Real World ◽  
High Performance ◽  
Ad Hoc ◽  
Future Research ◽  
Levels Of Detail ◽  
Excellent Starting Point ◽  
Starting Point ◽  
Hierarchical Nature ◽  
Multiple Levels ◽  
Entire Dataset

We address the task of classifying car images at multiple levels of detail, ranging from the top-level car type, down to the specific car make, model, and year. We analyze existing datasets for car classification, and identify the CompCars as an excellent starting point for our task. We show that convolutional neural networks achieve an accuracy above 90% on the finest-level classification task. This high performance, however, is scarcely representative of real-world situations, as it is evaluated on a biased training/test split. In this work, we revisit the CompCars dataset by first defining a new training/test split, which better represents real-world scenarios by setting a more realistic baseline at 61% accuracy on the new test set. We also propagate the existing (but limited) type-level annotation to the entire dataset, and we finally provide a car-tight bounding box for each image, automatically defined through an ad hoc car detector. To evaluate this revisited dataset, we design and implement three different approaches to car classification, two of which exploit the hierarchical nature of car annotations. Our experiments show that higher-level classification in terms of car type positively impacts classification at a finer grain, now reaching 70% accuracy. The achieved performance constitutes a baseline benchmark for future research, and our enriched set of annotations is made available for public download.

Pan cancer analysis of the intra-tumoral microbiome’s correlation with racial disparities.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 2519-2519
Author(s):  
Wei Tse Li ◽  
Matthew Uzelac ◽  
Jaideep Chakladar ◽  
Lindsay M. Wong ◽  
Aditi Gnanasekar ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
African Americans ◽  
Racial Disparities ◽  
Racial Differences ◽  
Asian Americans ◽  
Environmental Influence ◽  
Microbial Abundance ◽  
Risk Of Death ◽  
Incidence And Mortality ◽  
Starting Point

2519 Background: Microbiome composition can influence cancer development and is moderated by diet, hygiene, sanitation, and other environmental variables. For example, a Mediterranean diet could increase breast Lactobacillus abundance, while the gut microbiome changes dramatically with fructose intake. Recent studies have revealed correlations between microbial abundance and racial disparities in cancer. Given these reports, it is critical to examine whether environmental influences on the microbiome contribute to racial disparities in cancer incidence and prognosis. Methods: We examined the intra-tumoral microbiome in the lungs, breasts, bladder, colon, rectum, cervix, head and neck, prostate, and pancreas (n = 4,169). Raw tumor RNA sequencing data were downloaded from The Cancer Genome Atlas (TCGA) and aligned to bacterial genomes. Microbial abundance was correlated to race, ethnicity, and prognostic variables (Kruskal-Wallis test or Cox regression, p< 0.05). Results: We identified several microbes correlated with racial disparities for breast and bladder cancer, two microbes for lung squamous cell carcinoma, and one microbe for colon cancer. For breast cancer, African Americans have the highest mortality rate, followed by white Americans and Asian Americans. We found that four microbes, all under the order Burkholderiales, were positively correlated with poor prognosis and were most abundant in African Americans and least abundant in Asian Americans. Therefore, increased abundance of these microbes may contribute to the observed mortality differences between races. For bladder cancer, Asian Americans have the lowest incidence and mortality rates. Seven microbes, including two Geobacillus, two Pseudomonas, and two Burkholderiales, positively correlate with good prognosis and are upregulated in Asian Americans. High Pseudomonas fluorescens abundance is positively correlated with decreased risk of death (HR: 0.57, 95% CI: 0.38-0.85). High abundance of the Burkholderiales R. pickettii (HR: 0.62, 95% CI: 0.42-0.92) and V. paradoxus (HR: 0.59, 95% CI: 0.36-0.98) also exhibit the same trend. Geobacillus and Pseudomonas are both present in food, while Burkholderiales can cause nosocomial infections and are altered by diet. Conclusions: Our study is the most comprehensive to date investigating racial differences in the intra-tumoral microbiome. Our data serve as a starting point for exploring whether environmental influence of microbial abundance contributes to racial disparities in cancer.

scholarly journals Saudi anti-human cancer plants database (SACPD): A collection of plants with anti-human cancer activities

2018 ◽  
Author(s):  
Ateeq Ahmed Al-Zahrani
Keyword(s):  
Saudi Arabia ◽  
Cell Lines ◽  
Anticancer Drugs ◽  
Plant Species ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Anticancer Activities ◽  
Excellent Starting Point ◽  
Starting Point

Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD). The database contains most of the reported information about the naturally growing Saudi anticancer plants. SACPD comprises the scientific and local names of 91 plant species that grow naturally in Saudi Arabia. These species belong to 38 different taxonomic families. In Addition, 18 species that represent16 family of medicinal plants and are intensively sold in the local markets in Saudi Arabia were added to the database. The website provides interesting details, including plant part containing the anticancer bioactive compounds, plants locations and cancer/cell type against which they exhibit their anticancer activity. Our survey revealed that breast, liver and leukemia were the most studied cancer cell lines in Saudi Arabia with percentages of 27%, 19% and 15%, respectively. The current SACPD represents a nucleus around which more development efforts can expand to accommodate all future submissions about new Saudi plant species with anticancer activities. SACPD will provide an excellent starting point for researchers and pharmaceutical companies who are interested in developing new anticancer drugs. SACPD is available online at https://teeqrani1.wixsite.com/sapd

Tests of transmission of cynodon white leaf phytoplasma to sugarcane and maize in northern Australia

2003 ◽  
Vol 54 (4) ◽  
pp. 423 ◽  
Author(s):  
K. R. Blanche ◽  
L. Tran-Nguyen ◽  
K. S. Gibb
Keyword(s):  
Cynodon Dactylon ◽  
Field Trials ◽  
Insect Species ◽  
Sufficient Information ◽  
Agricultural Crops ◽  
Northern Australia ◽  
Saccharum Spp ◽  
White Leaf ◽  
Starting Point ◽  
White Leaf Disease

Cynodon white leaf disease is associated with cynodon white leaf phytoplasma in Cynodon dactylon growing in Darwin, Northern Territory. In order to effectively assess and manage the risk to agricultural crops posed by this phytoplasma, it is necessary to establish whether there is an insect species capable of transmitting it from C.�dactylon to grasses like Saccharum spp. hybrids and Zea mays. We used field and cage trials to investigate transmission of cynodon white leaf phytoplasma in these grasses. No transmission of the phytoplasma occurred in any of the trials, even to C. dactylon, the known host, and the phytoplasma did not persist in the potential leafhopper vector, Chiasmus varicolor. These results suggest that C. varicolor is not a vector of cynodon white leaf phytoplasma and that some requirement for successful transmission was not met in our field trials. We do not have sufficient information to determine whether transmission to Saccharum spp. hybrids or Z. mays is possible. Our study demonstrates the techniques that can be applied to this problem and provides a starting point for further investigation using different transmission conditions and insect species.

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