scholarly journals EFFECT OF STRENUOUS PHYSICAL ACTIVITY ON THE SUM OF LEUKOCYTES IN WISTAR STRAIN MALE MICE

2020 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Annisa Nurul Hikmah ◽  
Chodidjah Chodidjah ◽  
Nur Anna Chalimah Sadyah
Keyword(s):  
Physical Activity ◽  
Treatment Group ◽  
The Body ◽  
Control Group ◽  
Male Mice ◽  
Control Group Design ◽  
A Value ◽  
Wistar Strain ◽  
Strenuous Physical Activity ◽  
Biomedical Laboratory

This research aims to determine the effect of strenuous physical activity on the sum of leukocytes. The study used experimentally with the posttest only control group design approach. The study subjects of 10 male mice were randomly divided into two groups. The control group was not given heavy physical activity and the treatment group was given heavy physical activity. On the 27th day of blood retrieval for an examination of the sum of leukocytes in the Integrated Biomedical Laboratory, in July-August 2020. The mean on the sum of leukocytes increased in the treatment group compared to the control group. The Mann Whitney test showed that the sum of leukocytes in the control group was significantly different from the treatment group with a value of p = 0.009 (p <0.05). More research is needed on strenuous physical activity in IL-6 levels and calculates leukocytes as one of the study boosters. This research can be used as a reference in the control of the immune system of the body.

scholarly journals The Effect of Propanolol on C-Reactive Protein in Patients with Severe Burns at Dr Soetomo Hospital Surabaya

2021 ◽  
Vol 4 (1) ◽  
pp. 27
Author(s):  
Muhammad Aulia U H ◽  
Iswinarno Doso Saputro ◽  
Magda Rosalina Hutagalung
Keyword(s):  
Treatment Group ◽  
Albumin Level ◽  
Mean Value ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Severe Burns ◽  
Hypermetabolic State ◽  
Post Test ◽  
The Mean

Background: The incidence of burns in Indonesia progressively increases with the increase in its population and industries. From January to September 2000, 158 patients were treated in the burn unit of Dr Soetomo Hospital with a mortality rate reaching 5,8%. Burns have a direct effect in causing both local and systemic changes in the body, not occurring in other injuries. In severe burns, a hypermetabolic state can occur, which increases cardiac workload and causes muscle atrophy and other morbidities. The purpose of this study is to examine the effect of propranolol on the hypermetabolic state in severely burned patients by measuring various clinical & laboratory parameters.Methods : This is an experimental study using pre and post test control group design with the objective of assessing the treatment outcome with oral propranolol given in 15 consecutive days for burn patients involving 25%- 60% TBSA. Measurements were taken three times, on day 0, 7 and 14.Results : Obtained 16 samples divided into 2 groups. In the treatment group, there was a significant decrease in CRP levels on days 0, 7 and 14 (p <0.05). The Mid Arm Circumference variable did not obtain a significant decreasing on days 0, 7 and 14. The albumin level studied showed a significant decreasing on day 0 & 7 days with a value of p = 0.045. From the comparison between the two groups, there were significant differences in CRP levels on days 0 & 14, with the mean value of the treatment group -5.12 + 2.88 and the mean value of the control group 2.86 + 7.37, and the value of p = 0.019.Conclusions: This study successfully proved that the administration of propranolol can overcome the effects of hypermetabolism which is characterized by decreasing in CRP levels.

scholarly journals EFFECT OF BACK EXERCISE TO DECREASE LOW BACK PAIN OF BATIK ARTISANTS IN KAUMAN VILLAGE, SOKARAJA

2019 ◽  
Vol 11 (1) ◽  
pp. 45
Author(s):  
Siti Harwanti ◽  
Budi Aji ◽  
Nur Ulfah
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Treatment Group ◽  
Exercise Therapy ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Low Back ◽  
Control Group Design ◽  
And Control

ABSTRACT Low back pain ( LBP ) is a musculoskeletal disorder that occurs in the lower back which can be caused by various diseases and  activity of the body being less good. One effort to overcome the LBP is back exercise. The research purpose is to find out the effect of back exercise therapy which concern to lowering painful complaint of batik artisants in Kauman village Sokaraja subsdistrict. This research is using Quasi Experiment technique phenomenological non equivalen control group design (pre -post test). Sample taking is using purposive sampling technique. Data analysis use Friedman experiment for treatment group and Repeated Annova experiment for control group. Experiment analysis is different between treatment group and control group with using Mann Whitney experiment. The result of Friedman experiment in treatment group shows that p-value=0,000(p<0,05), it means the therapy those given is effective to lowering painful complaint. The result of Repeated Annova experiment in control group shows that p-value=0,234(p>0,05), it means the painful complaint seems not different in control group. The result of Mann Whitney experiment shows that p-value=0,000(p<0,05) it means there are differences between painful complaint in treatment group and control group after doing back exercise. There is the effect by giving back exercise therapy which concern to lowering the complaint of low back pain for batik artisants in Kauman village Sokaraja subdistrict.   Key words: Handmade Batik, Low back pain, back exercise

scholarly journals Pengaruh Pemberian Susu Coklat Terhadap Kadar F2Isoprostan pada Siswa di Pusat Pendidikan dan Latihan Olahraga Pelajar (PPLP) Sumatera Barat

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Dezi Ilham ◽  
Afriwardi Afriwardi ◽  
Eti Yerizel
Keyword(s):  
Free Radicals ◽  
Treatment Group ◽  
Physical Exercise ◽  
T Test ◽  
The Body ◽  
Control Group ◽  
Milk Chocolate ◽  
Control Group Design ◽  
Paired Sample ◽  
Before And After

Abstrak Latihan fisik yang berlebihan dapat meningkatkan produksi radikal bebas di dalam tubuh. Peningkatan radikalbebas ini kalau tidak dinetralisasi oleh antioksidan di dalam tubuh, maka terjadilah stres oksidatif yang dapatmenyebabkan terjadinya peroksidasi lipid, sehingga menghasilkan produk senyawa F2-isoprostan yang dapatberdampak terhadap berbagai masalah kesehatan. Tujuan penelitian ini adalah untuk menentukan pengaruhpemberian susu coklat terhadap kadar F2-isoprostan. Penelitian ini merupakan eksperimental pre and post test controlgrup design terhadap 36 siswa atlet, yang memenuhi kriteria inklusi dan ekslusi. Subjek dibagi dua kelompok yaituyang diberikan perlakuan susu coklat dan kontrol susu putih. Susu diminum setelah latihan fisik rutin atlet sebanyaksatu kali sehari selama 15 hari. Kadar F2-isoprostan dinilai sebelum dan sesudah secara ELISA. Data dianalisisdengan paired sample t-Test, bermakna bila p<0,05. Hasil penelitian didapatkan rerata kadar F2-isoprostan sebelumperlakuan pada kelompok susu coklat adalah 65,98±14,61 pg/ml dan sesudah perlakuan adalah 45,55±13,74 pg/ml.Rerata kadar F2-isoprostan sebelum perlakuan pada kelompok kontrol susu putih adalah 54,24±20,44 pg/ml dansesudah perlakuan adalah 48,80±20,23 pg/ml. Kesimpulan yang diperoleh ada pengaruh yang bermakna dari reratakadar F2-isoprostan sebelum dan sesudah perlakuan baik pada kelompok perlakuan susu coklat dan kelompok kontrolsusu putih.Kata kunci: latihan fisik, radikal bebas, F2-isoprostan, susu coklatAbstract Excessive physical exercise can increase the production of free radicals in the body. The increase in freeradicals if not neutralized by antioxidants in the body and it caused oxidative stress which can cause lipid peroxidation,resulting in F2-isoprostane product compounds that can affect a variety of health problems. The objective of this studywas to determine the influence of milk chocolate on F2-isoprostane levels. This study was an experimental pre andpost test control group design to the 36 student athletes, who meet the inclusion and exclusion criteria. The subjectswere divided in two groups: the treatment given milk chocolate and white milk is given control, drunk after a routinephysical exercise athlete, once a day for 15 days. F2-isoprostane levels were assessed before (pre) and after (post) byELISA, the data were analyzed by Paired Sample t-Test, significant if p <0.05. The results showed average levels ofF2-isoprostane before treatment group was 65.98 ± chocolate milk 14.61 pg / ml and after treatment was 45.55 ±13.74 pg / ml. Average F2-isoprostane levels before treatment in the control group was 54.24 ± white milk 20.44 pg /ml and after treatment was 48.80 ± 20.23 pg / ml. There is a significant influence on the mean levels of F2-isoprostaneboth before and after treatment in the treatment group and the control group of milk chocolate and white milkKeywords: physical exercise, free radicals, f2-isoprostane, milk chocolate

scholarly journals Effect of Dates Consumption On Bleeding, Duration, And Types of Labor

2019 ◽  
Vol 4 (1) ◽  
pp. 85
Author(s):  
Kuswati Kuswati ◽  
Rohmi Handayani
Keyword(s):  
Treatment Group ◽  
Pregnant Women ◽  
Design Research ◽  
Sampling Technique ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
Fisher Exact Test ◽  
Control Group Design ◽  
Exact Test

Dates are a good source of nutrition for the body if consumed regularly both in the form of dried fruit, wet, as well as in the form of palm juice extracts, especially for pregnant and maternal mothers. Pregnant women who are going to give birth are in desperate need of drinks and foods that are rich in sugar, this is because of the many contractions of the uterine muscles when it comes to removing the baby, especially if it takes a long time. Dates contain potuchin hormone which functions to bind the uterus and muscles of the uterus so that it can help reduce postpartum bleeding. Besides, there is the hormone oxytocin which can help stimulate contractions in the muscles of the uterus so as to facilitate labor. The purpose of this study was to determine the effect of consumption of dates on bleeding, length of labor and type of labor. This type of research is a Pre experiment with a post-test Only Control Group Design research design. The population in this study were all pregnant women in the working area of South Klaten Public Health Center with estimated deliveries from July to September 2018. While the sample size was 60 samples consisting of 30 treatment group respondents and 30 control group respondents. The sampling technique used in this study was Quota sampling. Data analysis using Fisher Exact test and Mann-Whitney U test with p-value considered significant is p = 0.05. The results of the study of bleeding showed that there were no significant differences in the estimation of blood loss and during labor and type of delivery between the treatment group and the control group (p-value = 0.5). The results of the study about the length of labor showed that there was an effect of date consumption on the length of labor, with a value of p = 0,000

scholarly journals Perbandingan kadar serum kreatinin pada pasien DM tipe 2 dengan frekuensi senam prolanis 1 kali per minggu dan 3 kali per minggu

2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Angela Pangemanan ◽  
Sylvia R. Marunduh ◽  
Joice N.A. Engka
Keyword(s):  
Physical Activity ◽  
Creatinine Level ◽  
Muscle Metabolism ◽  
The Body ◽  
Rank Test ◽  
Control Group ◽  
Design Data ◽  
Control Group Design ◽  
Significant Difference ◽  
Signed Rank Test

Abstract: Creatinine is formed in muscles from creatinine phosphate and a byproduct of muscle metabolism. Creatinine is almost completely cleared from the body by filtration in the glomeruli. Physical activity can affect renal hemodynamics and protein excretion as well as creatinine level. Prolanis gymnastics is programmed for people who suffer from chronic diseases. This study was aimed to find out whether physical activity could affect serum creatinine by comparing Prolanis gymnastics practised 1 time/week and 3 times/week among patients with type 2 diabetes mellitus (T2DM). This was an experimental study with a pre-post test control group design. Subjects were 30 T2DM patients who practised Prolanis gymnastics at Husada Clinic Sario Manado, divided into two equal groups (15 people in each group). The results showed that in 1 time/week group, there was decreased creatinine level in 1 person (7%), increased creatinine level in 2 people (13%), and unchanged level in 13 people (87%). Meanwhile, in 3 times/week group there was no decrease of creatinine level but increased creatinine level in 4 people (27%) and unchanged in 11 people (73%). The Wilcoxon Signed Rank test showed a significant difference in creatinine levels between the two groups (p=0.001). Conclusion: Prolanis gymnastics 3 times/week was more effective than 1 time/week in affecting creatinine level in T2DM patients. Keywords: Prolanis gymnastics, creatinine, T2DM patients Abstrak: Kreatinin dibentuk di jaringan otot dari kreatinin fosfat dan merupakan produk sampingan metabolisme otot. Hampir seluruh kreatinin dikeluarkan dari tubuh melalui filtrasi glomerulus. Aktivitas fisik dapat memengaruhi hemodinamik ginjal dan ekskresi protein, termasuk kreatinin. Senam Prolanis merupakan program yang dibuat untuk masyarakat yang menderita penyakit kronis. Penelitian ini bertujuan untuk mengetahui pengaruh aktivitas fisik terhadap kadar kreatinin serum dengan membandingkan senam 1 kali/minggu dan 3 kali/minggu pada pasien diabetes melitus tipe 2 (DMT2). Jenis penelitian ialah eksperimental dengan pre-post control group test design. Data yang diperoleh diolah dengan menggunakan uji Wilcoxon Signed Ranks. Hasil penelitian mendapatkan subjek penyandang DMT2 berjumlah 30 orang (15 orang untuk masing-masing kelompok) yang mengikuti senam Prolanis di Klinik Husada Sario Manado. Pada kelompok 1 kali/minggu, terjadi penurunan kreatinin pada 1 orang (7%), kenaikan pada 2 orang (13%) dan tetap pada 13 orang (87%), sedangkan pada kelompok 3 kali/minggu, tidak terjadi penurunan kreatinin, tetapi ada kenaikan pada 4 orang (27%) dan tetap pada 11 orang (73%). Hasil uji Wilcoxon Signed Ranks mendapatkan perbedaan kadar kreatinin yang bermakna antara kedua kelompok (p=0,001). Simpulan: Senam Prolanis 3 kali/minggu lebih efektif daripada senam Prolanis 1 kali/minggu dalam memengaruhi kadar kreatinin pada pasien DMT2.Kata kunci: senam Prolanis, kreatinin, DMT2

scholarly journals Zalacca fruit consumption to reduce nausea and vomiting in trimester I pregnant women in Banjarnegara District

2021 ◽  
Vol 9 (1) ◽  
pp. 11
Author(s):  
Umi Fajri ◽  
Dian Nirmala Sari
Keyword(s):  
Treatment Group ◽  
Pregnant Women ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Repeated Measure ◽  
Control Group ◽  
Control Group Design ◽  
A Value ◽  
Test Assessment ◽  
Post Test

<p><strong><em>Introduction</em></strong><em> </em><em>: Nausea and vomiting occur in 80-85% of pregnancies during the first trimester with annoying vomiting symptoms in 52%. The way to deal with nausea and vomiting is pharmacochemical by consuming fresh fruit, namely zalacca. In 100 mg of </em><em>zalacca fruit contains B6 0.2 mg which can reduce nausea. </em></p><p><strong><em>Objectives</em></strong><em> : </em><em>To  find out that </em><em>zalacca fruit can reduce nausea and vomiting in pregnant women in the 1st trimester. </em></p><p><strong><em>Methods</em></strong><em> :</em><em> The research used was a quasy experimental design with a pretest posttest control group design. The variables in this study were zalacca</em><em> fruit, nausea and vomiting. The number of samples is 30 respondents. The treatment group received 100 mg of zalacca</em><em> fruit and B6 3 x 10 mg per day for 10 days while the control group received anti-nausea therapy, namely B6 3 x 10 mg / day for 10 days, before the intervention, the control group and the treatment group would get pre-test (assessment of nausea and vomiting) and then continued with the intervention for 10 days and ended with a post test (assessment of nausea and vomiting). Data analysis was univariate, bivariate using the Repeated Measure Anova (Test of Between-Subjects Effect) test. </em></p><p><strong><em>Result :</em></strong><em>  Showed that there was an effect of consuming zalacca</em><em> fruit to reduce nausea (p = 0.000) and vomiting with a value of p = 0.012</em><em>. </em></p><p><strong><em>Conclusion :</em></strong><em> Consumption of 100mg zalacca can reduce nausea and vomiting in 1st trimester pregnant women.</em></p>

scholarly journals Prevention of Transmission of TB Disease with the Approach of Neuman System Model in Kawangu Community Health Center East Sumba Regency Indonesia

2018 ◽  
Vol 13 (2) ◽  
pp. 57
Author(s):  
Yosephina Elizabeth Sumartini Gunawan
Keyword(s):  
Treatment Group ◽  
Significant Influence ◽  
Community Health Center ◽  
System Model ◽  
Control Group ◽  
Control Group Design ◽  
A Value ◽  
Significant Difference ◽  
The Family ◽  
Neuman System Model

<strong>Introduction</strong>: Family empowerment needs to be done to improve the knowledge, awareness and willingness of the family in its efforts to prevent the transmission of TB disease. This study aims to explain  the influence of the approach <em>Neuman’s System Model</em> to the prevention of transmission of TB. <strong>Methods</strong>: The design of this study is quasy experimental with the approach of the pre-post mehod with control group design. Sample research as many as 32 of the family, namely the 16 families in the treatment group and 16 families in the control group were determined purposively. <strong>Results</strong>: there is significant effect of treatment against the level of knowledge of the treatment group with z by -2.432 and significant value  of 0.001 and a significant influence of the treatment given to the prevention control groups with z value -2.039 and significant value of 0.041. Different test showed significant difference on the knowledge of the control group ang the treatment of 0.039 and z values -2.066 and there is a significant difference in prevention efforts of the control group and the treatment of 0.000 with a value of z -4.642. <strong>Conclusions:</strong> the approach of <em>Neuman’s System Model</em> performed in the treatment group have a significant influence on the increased knowledge and prevention of transmission of TB disease conducted by the family.

scholarly journals POTENTIAL ETHANOL OF Carica papaya L. EXTRACT AS IMMUNOMODULATORY THROUGH HISTOLOGY OBSERVATION AT MICE BALB/C SPLEEN

2017 ◽  
Vol 13 (2) ◽  
pp. 205
Author(s):  
Sri Tasminatun ◽  
Ria Pravitasari ◽  
SN. Nurul Makiyah
Keyword(s):  
Treatment Group ◽  
Carica Papaya ◽  
Negative Control Group ◽  
Negative Control ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
One Way Anova

Abstract: The diameter of the alba pulp of the spleen will be enlarged, when the body responds to allergens by increasing the activity of the immune system. Papaya fruits (Carica papaya L.) containing flavonoid that can be as an immunomodulator. This study aims to determine the effect of C. papaya extract to the diameter size alba pulp of the spleen of Ovalbumin (OVA) induced Balb/C mice. The research design was experimental in vivo animal test with post-test only control group design. Thirty male Balb/C mice, ±20grams weight, 8 weeks old, divided into six groups consists of a normal control, negative control, Methylprednisolone, and C. papaya extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day). The extract and Methylprednisolone are given for 28 days, while OVA is given on 15thand 22ndday (intraperitoneal,) and 23rd until 28thday (peroral). On the 29thday the mice are sacrificed and the duodenum was made into histological preparation with HE staining. The immunomodulator effect is assessed by the average of the diameter size alba pulp of the spleen under a light microscope. The data were analyzed using SPSS15 with one way ANOVA continued with Tukey test. The average of the diameter size alba pulp of the spleen for control group is 10,165 ± 0,195; negative control group is 30,357 ± 0,826; methylprednisolone group is 10,220 ± 0,346; 175mg/kgbb dose extract is 14,956 ± 1,057; 350mg/kgbb dose extract is 14,030 ± 0,667; and 700mg/kgbb dose extract is 12,504 ± 0,729. The conclusion of this study is Carica papaya L. extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day) has an effect to the average of the diameter size alba pulp of the spleen in OVA-induced Balb/C mice significantly. 700mg/kg dose per day has the same effect with the methylprednisolone group. Keywords: immunomodulator, Carica papaya L., alba pulp of the spleen, ovalbumin

scholarly journals Moderate Intensity Exercise is Most Influential in The Expression of UCP-1 in Mice Male

2019 ◽  
Vol 3 (12) ◽  
pp. 490-492
Author(s):  
Chabib Fachry Albab ◽  
Purwo Sri Rejeki ◽  
Muhammad Miftahussurur ◽  
Soebagijo Adi Soelistijo
Keyword(s):  
Treatment Group ◽  
Exercise Intensity ◽  
Intensity Variation ◽  
Negative Control Group ◽  
Negative Control ◽  
Moderate Intensity ◽  
Control Group ◽  
Male Mice ◽  
Moderate Intensity Exercise ◽  
Control Group Design

Sufficient exercise was considered enough to reduce the number of obesities through the process of fat browning. This research was conducted to prove the effect of exercise intensity on fat browning process through increased UCP-1 expression in male mice. Laboratory experimental research with a post test only control group design approach using 24 mice was divided into 4 groups. Determination of the group was based on the negative control group, mild intensity swimming treatment group, moderate intensity swimming treatment group, and heavy intensity swimming treatment group. The treatment was carried out for four weeks with a frequency of three times a week. The control group had UCP-1 expression of 5.47 ± 0.83 IRS / LP, the mild intensity swimming group had UCP-1 expression of 7.23 ± 1.57 IRS / LP, the moderate intensity swimming group had UCP-1 expression of 9.17 ± 1.65 IRS / LP, and the heavy intensity swimming group had an expression of 6.93 ± 1.42 IRS / LP. The giving of exercise intensity variation affects the expression of UCP-1 in male mice. Moderate intensity exercise has the highest UCP-1 expression. Keywords: exercise intensity; UCP-1; male mice

scholarly journals Nigella sativa EXTRACT IMPROVES SEMINIFEROUS TUBULE EPITHELIAL THICKNESS IN LEAD ACETATE-EXPOSED BALB/C MICE

2017 ◽  
Vol 53 (3) ◽  
pp. 180
Author(s):  
Alis Nur Diana ◽  
Reny I’tishom ◽  
Sri Agus Sudjarwo
Keyword(s):  
Treatment Group ◽  
Mus Musculus ◽  
Group Treatment ◽  
Lead Acetate ◽  
Nigella Sativa ◽  
The Body ◽  
Control Group ◽  
Tubular Epithelium ◽  
Control Group Design ◽  
Black Cumin

Lead that enters the body may lead to increased production of ROS (Reactive Oxygen Species) that may affect reproductive system. Black cumin (Nigella sativa) extract contains high antioxidant, tymoquinone, that may be used to suppress oxidative stress induced by lead in animal experiments. This study aimed to prove that black cumin (Nigella sativa) extract improves the thickness of seminiferous tubular epithelium in Balb/c mice exposed to lead (Pb) acetate. This study used post-test only control group design. The subjects in this study were 30 Balb/c male mice (Mus musculus), divided into 5 groups. K-group: control group without lead acetate and black cumin extract, K+ group: group with 50 mg/kgBW of lead acetate for 28 days, P1 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.3 mg/gBW of black cumin extract for 21 days, P2 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.6 mg/gBW of black cumin extract for 21 days, and P3 group: treatment group with 50 mg/gBW of lead acetate for 28 days + 1.2 mg/gBW black cumin extract for 21 days. The results showed that the mean ± standard deviation of the highest thickness of seminiferous tubular epithelium was 45.80 ± 2.73 in the group that was exposed to acetate + 0.6 mg/gBW of black cumin (P2), and the lowest was 32.75 ± 4.07 in the group that was exposed to lead acetate (K+). The results were then analyzed by Anova test. The results showed that there was significant differences in the thickness of seminiferous tubular epithelium between P1, P2, P3 and K+. In conclusion, black cumin extract administration was proved to improve the thickness of seminiferous tubular epithelium in lead (Pb) acetate-exposed Balb/c mice (Mus musculus).

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