scholarly journals Physical development and its relationship to the metabolic activity of the intestinal microbiota in young children

2021 ◽  
Vol 20 (5) ◽  
pp. 35-42
Author(s):  
I. V. Vakhlova ◽  
G. V. Fedotova ◽  
L. G. Boronina ◽  
Yu. N. Ibragimova
Keyword(s):  
Young Children ◽  
Intestinal Microbiota ◽  
Metabolic Activity ◽  
Intestinal Resection ◽  
Short Chain Fatty Acids ◽  
Physical Development ◽  
Gas Liquid Chromatography ◽  
Healthy Children ◽  
Fecal Matter ◽  
Important Indicator

Introduction. The metabolic activity of the intestinal microbiota is an important indicator of the functioning of the digestive tract, one of the main functions of which is the absorption of nutrients.The aim of the study was to analyze the content of short chain fatty acids in feces and assess their relationship with the indicators of physical development in children 3 years of age.Materials and methods. A prospective cohort study was conducted in 89 children 3rd year of life. The 1st observation group included children of the I and II health groups, the children of the 2nd group underwent surgical treatment on the intestine in the first months of life, the children of the3rd group are with atopic dermatitis. FD assessment was carried out in accordance with WHO recommendations (2017) the spectrum of FGC in feces was determined by gas-liquid chromatography.Results. It was determined the features of the rates of FD in healthy children, children with a history of intestinal resection and children with atopy in relation to the indicators of metabolic activity of the intestinal microbiota. The percentile distribution of the values of FGC in feces and their comparative assessment in the observation groups are given.Discussion. The content of FGM in feces has differences depending on the health status of children of the 3rd year of life. Different level of FGC shows a close relationship with the indicators of FD. Conclusions. A decrease in growth rates (body length SD: from -1 to -2) was revealed at low values (<25%) of the amount of acids, with an increase in propionate (25%) in feces. Reduced nutrition (body weight SD: from -1 to -2) it was associated with low values of the sum of isoacids and AI(-) (<25%); by 3rd year of life, the risk of low nutrition decreased in 4 times with high values (75%) of the sum of acids in feces (OR=4.33[1.09-17.71]). The multidirectionality of the content of fecal matter in young children and their influence on the indicators of FD emphasizes the versatility of the functions of the intestinal microbiota, which has a local and systemic effect on the human body.

scholarly journals Metabolism of the intestinal microbiota in children of the first year of life with intestinal pathology and its surgical correction as a potential marker of biological age

2020 ◽  
Vol 22 ◽  
pp. 02024
Author(s):  
Galina Fedotova ◽  
Irina Vakhlova ◽  
Lyubov Boronina
Keyword(s):  
Intestinal Microbiota ◽  
Metabolic Activity ◽  
Intestinal Resection ◽  
Short Chain Fatty Acids ◽  
First Year ◽  
Fecal Matter ◽  
Potential Marker ◽  
Intestinal Pathology ◽  
First Year Of Life ◽  
Liquid Chromatographic

The article presents data on the study of the metabolic activity of the intestinal microbiota in children of the first year of life. The study was performed by gas-liquid chromatographic analysis with the determination of short-chain fatty acids (SCFA) in fecal matter, which reflects the microbiota metabolic activity. The content of fecal matter was determined, reflecting the activity of aerobic microbiota-acetic acid (C2); anaerobic microbiota – propionic (C3), butyric (C4) acids; the sum of acids (E); anaerobic index (AI), which is an integral indicator of the intestinal environment. It was found that despite surgical intervention in the intestine in the first months of life, the metabolic activity of microbiota in children with intestinal resection remains stable throughout the first year of life.

scholarly journals Metabolic activity of intestinal microflora in newborns with a different mode of delivery

2019 ◽  
Vol 64 (2) ◽  
pp. 81-86
Author(s):  
I. V. Nikolaeva ◽  
G. S. Shaikhieva ◽  
V. A. Anokhin ◽  
A. D. Tsaregorodtsev ◽  
I. Kh. Sharafutdinov
Keyword(s):  
Liquid Chromatography ◽  
Intestinal Microbiota ◽  
Metabolic Activity ◽  
Intestinal Microflora ◽  
Mode Of Delivery ◽  
Short Chain Fatty Acids ◽  
Main Group ◽  
Control Group ◽  
Gas Liquid Chromatography ◽  
Microbial Composition

The authors studied microbial composition and metabolic activity of the intestinal microbiota in 20 babies born by caesarean section (main group) and 20 babies born vaginally (control group). There were isolated bifidobacteria from meconium at a concentration of 105– 1010 CFU/g by the bacteriological method in 4 (20%) children of the main group and 6 (30%) children in the control group. The gas-liquid chromatography revealed the metabolic activity of various representatives of the intestinal microflora in children of both groups, regardless of the mode of delivery; the indicators of metabolic activity were significantly lower than in the infants. The children in both groups had similar absolute and relative content of short-chain fatty acids in meconium. The data of gas-liquid chromatography indicate the metabolic activity of the meconium microbiota, which is dominated by anaerobic microbial populations and there is a high proportion of proteolytic and conditionally pathogenic flora. The data obtained confirm the process of intrauterine translocation of microbes from mother to child and indicate the importance of the microflora of the future mother in the process of forming the intestinal microbiota of the child.

scholarly journals Effects of Dietary Cereal and Protein Source on Fiber Digestibility, Composition, and Metabolic Activity of the Intestinal Microbiota in Weaner Piglets

Animals ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 109
Author(s):  
Carola Ellner ◽  
Anna G. Wessels ◽  
Jürgen Zentek
Keyword(s):  
Dietary Fiber ◽  
Intestinal Microbiota ◽  
Relative Abundance ◽  
Metabolic Activity ◽  
Short Chain Fatty Acids ◽  
Rapeseed Meal ◽  
Insoluble Dietary Fiber ◽  
Fiber Digestibility ◽  
Degrading Bacteria ◽  
Fermentative Activity

This study aimed to investigate the effect of fiber-rich rye and rapeseed meal (RSM) compared to wheat and soybean meal (SBM) on fiber digestibility and the composition and metabolic activity of intestinal microbiota. At weaning, 88 piglets were allocated to four feeding groups: wheat/SBM, wheat/RSM, rye/SBM, and rye/RSM. Dietary inclusion level was 48% for rye and wheat, 25% for SBM, and 30% for RSM. Piglets were euthanized after 33 days for collection of digesta and feces. Samples were analyzed for dry matter and non-starch-polysaccharide (NSP) digestibility, bacterial metabolites, and relative abundance of microbiota. Rye-based diets had higher concentrations of soluble NSP than wheat-based diets. RSM-diets were higher in insoluble NSP compared to SBM. Rye-fed piglets showed a higher colonic and fecal digestibility of NSP (p < 0.001, p = 0.001, respectively). RSM-fed piglets showed a lower colonic and fecal digestibility of NSP than SBM-fed piglets (p < 0.001). Rye increased jejunal and colonic concentration of short-chain fatty acids (SCFA) compared to wheat (p < 0.001, p = 0.016, respectively). RSM-fed pigs showed a lower jejunal concentration of SCFA (p = 0.001) than SBM-fed pigs. Relative abundance of Firmicutes was higher (p = 0.039) and of Proteobacteria lower (p = 0.002) in rye-fed pigs compared to wheat. RSM reduced Firmicutes and increased Actinobacteria (jejunum, colon, feces: p < 0.050), jejunal Proteobacteria (p = 0.019) and colonic Bacteroidetes (p = 0.014). Despite a similar composition of the colonic microbiota, the higher amount and solubility of NSP from rye resulted in an increased fermentative activity compared to wheat. The high amount of insoluble dietary fiber in RSM-based diets reduced bacterial metabolic activity and caused a shift toward insoluble fiber degrading bacteria. Further research should focus on host–microbiota interaction to improve feeding concepts with a targeted use of dietary fiber.

scholarly journals Dairy products in the nutrition of young children: the evolution from tradition to functionality

2019 ◽  
Vol 64 (4) ◽  
pp. 133-140 ◽  
Author(s):  
R. A. Faizullina ◽  
E. A. Samorodnova ◽  
O. B. Fedotova
Keyword(s):  
Young Children ◽  
Dairy Products ◽  
Nutritional Value ◽  
Physical Development ◽  
Healthy Children ◽  
Daily Diet ◽  
The World ◽  
Traditional Dairy Products ◽  
Adults And Children ◽  
Positive Effect

Dairy products are the most popular and important in their nutritional value products in the diet of adults and children. There are about 400 known types of these products in the world. Traditional dairy products are widely used both in daily diet and complex treatment of various infectious and non-infectious diseases. The probiotic and prebiotic components in their composition makes these products functional, since their regular use has a positive effect on the digestive processes, immune system, and the indicators of the physical development of young children. The surveys demonstrated the effectiveness of functional dairy products both in healthy children for the prevention of diseases and in children with various pathologies in the complex therapy.

scholarly journals Pathogenetic role of intestinal microflora in carbohydrate malabsorption syndrome in early-aged children with rotavirus infection

2021 ◽  
Vol 23 (5) ◽  
pp. 683-690
Author(s):  
N. V. Vorobiova ◽  
O. V. Usachova ◽  
A. H. Kaplaushenko
Keyword(s):  
Fatty Acids ◽  
Intestinal Microbiota ◽  
Metabolic Activity ◽  
Intestinal Microflora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Malabsorption Syndrome ◽  
Rotavirus Infection ◽  
Carbohydrate Malabsorption ◽  
Chain Fatty Acids

The aim is to evaluate the effect of metabolic activity of intestinal microflora on laboratory manifestations of carbohydrate malabsorption syndrome in early-aged children with rotavirus infection by studying the main intestinal metabolites – short-chain fatty acids in faeces. Materials and methods. 60 breastfed children with rotavirus infection aged 1–24 months were examined. The total amount of carbohydrates in faecal samples was determined using Benedict’s test, and the detection of short-chain fatty acids in faeces was carried out using liquid chromatography in the dynamics of the disease – on the 3rd, 5th and 10th day. Results. It was established, that the amount of reducing sugars in faeces decreased with the increasing concentration of intestinal microflora metabolites during the entire period of rotavirus infection. In patients with ≤0.5 % level of carbohydrates in faeces, the total content of short-chain fatty acids was the highest and exceeded by 2.0, 1.8 and 1.7 times the indicators of children with Benedict’s test values >0.5 % on the 3rd, 5th and 10th days of the disease, respectively (p < 0.05). A decrease in the metabolic activity of the intestinal microbiota in the above category of children occurred mainly due to a deficiency in the production of acetic and propionic acids (P < 0.05). In the acute period of the disease, an imbalance in the intestinal microbiota infrastructure was noted towards a deficiency of obligate anaerobes that was expressed in a decrease in the anaerobic index (P < 0.05). The severity of these disorders influenced the severity of carbohydrate malabsorption: with an increase in the level of undigested sugars in faeces >0.5 %, the anaerobic index values were 3 and 5 times lower than at a carbohydrate level ≤0.5 % on the 3rd and 5th days of the disease, respectively (P < 0.05). Conclusions. It has been found that early-aged children with rotavirus infection have structural and functional disorders of the intestinal microflora, which influence the severity of carbohydrate malabsorption syndrome. The lower the saccharolytic activity of intestinal bacteria, the more pronounced the manifestations of this syndrome during the entire period of the disease.

scholarly journals Effect of Yuzu (Citrus junos) Seed Limonoids and Spermine on Intestinal Microbiota and Hypothalamic Tissue in the Sandhoff Disease Mouse Model

2021 ◽  
Vol 9 (1) ◽  
pp. 17
Author(s):  
Mayumi Minamisawa ◽  
Takuma Suzumura ◽  
Sudeep Bose ◽  
Tetsuyuki Taniai ◽  
Gota Kawai ◽  
...  
Keyword(s):  
Mouse Model ◽  
Intestinal Microbiota ◽  
Neuronal Degeneration ◽  
Sandhoff Disease ◽  
Short Chain Fatty Acids ◽  
Rrna Gene ◽  
Wild Type ◽  
Degrading Bacteria ◽  
Citrus Junos ◽  
Hypothalamic Tissue

The effect of limonoids and spermine (Spm) extracted from yuzu (Citrus junos) seeds on the gut and the brain in a mouse model with Sandhoff disease (SD) was investigated. Wild-type and SD mice were fed a normal diet, or a diet supplemented with limonoid, Spm, or limonoid + Spm for 14–18 weeks, and then 16S rRNA gene amplicon sequencing with extracted DNA from their feces was executed. For SD control mice, intestinal microbiota was mostly composed of Lactobacillus and linked to dysbiosis. For SD and wild-type mice fed with limonoids + Spm or limonoids alone, intestinal microbiota was rich in mucin-degrading bacteria, including Bacteroidetes, Verrucomicrobia, and Firmicutes, and displayed a higher production of short-chain fatty acids and immunoglobulin A. Additionally, SD mice fed with limonoids + Spm or limonoids alone had less inflammation in hypothalamic tissues and displayed a greater number of neurons. Administration of limonoids and/or Spm improved the proportions of beneficial intestinal microbiota to host health and reduced neuronal degeneration in SD mice. Yuzu seed limonoids and Spermine may help to maintain the homeostasis of intestinal microbiota and hypothalamic tissue in the SD mouse model.

scholarly journals Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis

2021 ◽  
Vol 25 ◽  
pp. 100892
Author(s):  
Kentaro Tominaga ◽  
Atsunori Tsuchiya ◽  
Takeshi Mizusawa ◽  
Asami Matsumoto ◽  
Ayaka Minemura ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Intestinal Microbiota ◽  
Immunoglobulin A ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Diversion Colitis ◽  
Chain Fatty Acids

scholarly journals Nutritional status of school children living in Northern part of Sri Lanka

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
M. G. Sathiadas ◽  
Annieston Antonyraja ◽  
Arunath Viswalingam ◽  
Kasthuri Thangaraja ◽  
V. P. Wickramasinghe
Keyword(s):  
Sri Lanka ◽  
Nutritional Status ◽  
School Children ◽  
Household Income ◽  
Maternal Education ◽  
Overweight And Obesity ◽  
Growth Spurt ◽  
Healthy Children ◽  
Important Indicator ◽  
Height For Age

Abstract Background Nutritional status is an important indicator for measuring quality of life in children. A region that is recovering from war will face many problems related to nutrition. Very few studies have addressed the nutritional problems in school children. This study was undertaken to identify the prevalence of wasting, stunting and obesity among school children from Northern Sri Lanka and associated socio-demographic factors. Methods A community based cross-sectional study was carried out using multistage stratified proportionate cluster among healthy children attending schools in the Northern part of the country. Height and weight were measured, and Body Mass Index (BMI) calculated [weight (kg)/Height (m) 2]. BMI-for-age z-score (BAZ) and Height for age Z (HAZ) scores were determined and WHO growth references were used to categorise the nutritional status. Correlation between various nutritional problems with Maternal education, household income, number of family members and the residential area was assessed. Results A total of 1012 children were recruited, and the mean age and standard deviation were 11.12±1.77 yrs. Girls in the age ranges of 9–14 were heavier and taller when compared to the boys compatible with the pubertal growth spurt. Stunting based on the height for age was seen in 10.9% of boys and 11.8% of girls. Wasting based on BMI for age WHO standard (WHO 2007) was seen in 30.6% of boys and 29.1% of the girls. The prevalence of overweight was 11% and Obesity was 6.3% of the population. Obesity was predominantly seen in boys (4.2%) and it was significantly higher when compared to the girls (2.1%) (p < 0.001). Obesity in older boys (> 10 years) was significantly more than the younger ones (p < 0.01). Maternal education and family income had a significant impact on the prevalence of wasting, stunting and obesity whereas the family size contributed to the wasting and obesity (p< 0.001). Conclusion Findings suggest that stunting, wasting, overweight and obesity are prevalent among 6–16-year-old leading to concerns in public health. The nutritional status significantly varies according to the geographical location, maternal education and the household income.

scholarly journals Physical Status of Primary School Children with Intellectual Disability Living in the City of Krasnoyarsk

2021 ◽  
pp. 385-393
Author(s):  
Ol’ga V. Smirnova ◽  
◽  
Elizaveta S. Ovcharenko ◽  
Eduard V. Kasparov ◽  
Vera V. Fefelova ◽  
...  
Keyword(s):  
Intellectual Disability ◽  
Primary School ◽  
School Children ◽  
Physical Development ◽  
Primary School Children ◽  
Healthy Children ◽  
Physical Status ◽  
Anthropometric Characteristics ◽  
The City ◽  
Children With Intellectual Disability

Parameters of physical development are known to be informative indicators of health status and adaptation processes, as well as markers of social, hygienic and environmental well-being both in healthy children and those with various pathological conditions. The purpose of this article was to study the characteristics of the physical status of children with intellectual disabilities. Materials and methods. We examined 168 children of primary school age (7–11 years) studying in secondary schools of Krasnoyarsk. The subjects were divided into two groups: the first group included 54 children with intellectual disability (F70, F71 according to ICD-10), the second group included 114 children without intellectual disability. Anthropometric characteristics and level of physical development were studied taking into account regional centile tables. The harmony of physical development was assessed using the Quetelet index. Results. The physical development of children with intellectual disability is characterized by a lag in anthropometric characteristics compared with intellectually healthy children: body length was 133.0 and 137.3 cm (p = 0.048), head circumference 51.0 and 52.5 cm (p = 0.002) respectively. The first group also had a statistically significantly lower percentage of children with harmonious physical development (37 %, p = 0.045) against the background of pronounced disharmony (underweight in 31.5 %, excess body weight in 31.5 % of children) compared to their healthy peers (harmonious development in 55 %, underweight in 16 %, overweight in 29 % of children). Further research into the constitution of children with intellectual disability can form the basis for the development of corrective measures, taking into account the specific typological characteristics of children in this group. For citation: Smirnova O.V., Ovcharenko E.S., Kasparov E.V., Fefelova V.V. Physical Status of Primary School Children with Intellectual Disability Living in the City of Krasnoyarsk. Journal of Medical and Biological Research, 2021, vol. 9, no. 4, pp. 385–393. DOI: 10.37482/2687-1491-Z076

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