scholarly journals Neurological manifestations associated with COVID- 19: a review

2021 ◽  
Vol 1 (4) ◽  
pp. 31-44
Author(s):  
Yasmim Berni Ferreira ◽  
Flávia Maria Ramos Freire ◽  
Victor Oliveira Araújo ◽  
Isadora Mônica Ponte De Oliveira ◽  
Lara Maria de Oliveira Paiva Freitas ◽  
...  
Keyword(s):  
Neurological Complications ◽  
Brain Parenchyma ◽  
Neurological Manifestations ◽  
Term Care ◽  
Pubmed Database ◽  
The Social ◽  
Wide Range ◽  
Systemic Manifestations ◽  
Novel Coronavirus ◽  
The Brain

The knowledge of the spinal cord irrigation is important for the therapeutic planning "COVID-19" is a potentially serious, highly transmissible infectious disease that was first identified in Wuhan, China in December 2019. Individuals infected with SARS-CoV-2 can evolve asymptomatically, with respiratory symptoms or with systemic manifestations affecting, for example, the nervous system. This review aims to discuss the neurological manifestations of SARS-CoV-2 infection, citing the prevalence of each. This study analyzed scientific articles published from 2010 to 2021 in the PubMed database. More than 35% of patients who contract the novel coronavirus develop neurological symptoms. SARS-CoV enters the brain mainly through the olfactory bulb and spreads rapidly via transneuronal route to other related areas such as cerebellum, insula, encephalon, vessels and nerves, and the brain parenchyma itself. This causes manifestations in the CNS (dizziness and ataxias), PNS (anosmia and ageusia), and the musculoskeletal system. Given existing knowledge of other coronaviruses and respiratory viruses, the wide range of CNS and PNS associations with COVID-19 is not surprising, and this is the focus of most current reports. Neurological complications, particularly encephalitis and stroke, can cause lifelong disability, requiring long-term care and substantial costs in the social and economic sphere.

scholarly journals Neurological manifestations of COVID-19: A literature review

2021 ◽  
Vol 10 (2) ◽  
pp. 97-102
Author(s):  
Suman Adhikari ◽  
Prabin Bhandari ◽  
Naresh Poudel ◽  
Nikunj Yogi ◽  
Balgopal Karmacharya ◽  
...  
Keyword(s):  
Severe Disease ◽  
Neurological Complications ◽  
Neurological Manifestations ◽  
Altered Consciousness ◽  
Angiotensin Converting Enzyme 2 ◽  
The Common ◽  
Novel Coronavirus ◽  
And Control ◽  
The Brain ◽  
Common Manifestation

A novel coronavirus that started from the Wuhan province of China is affecting the whole world. As of this date, more than 222 million cases are reported with more than 4.60 million fatalities. Nepal has more than 771,000 cases reported with almost 11,000 death recorded to date. Though most of the patients present with flu-like symptoms, people with comorbidities like Diabetes mellitus, hypertension, lung, and heart disease most likely suffer from severe disease and even death. As reported, neurological manifestations are common in critically ill patients. The most common manifestation of CNS is headache, dizziness, and encephalopathy whereas loss of smell and taste is the common PNS manifestation. Other neurological complications seen are fatigue, myalgias, hemorrhage, altered consciousness, Guillain-Barre Syndrome, syncope, seizure, and stroke. Non-specific neurological symptoms may be present in the early stages which can mislead the treatment. In some cases, neurological manifestations precede the typical presentation of fever, cough, and shortness of breath and later develop into typical features. The virus enters the brain through 2 systems: hematogenous route or olfactory route. Angiotensin-converting enzyme-2 (ACE-2) is the port of entry to the brain for COVID- 19(SARS-CoV-2) which was also the entry point for SARS-CoV. Covid-19 cases are increasing in the world and prevention and control of spread are a must. Understanding the neurological invasion pathogenesis, and manifestation will help the neurologists and physicians on frontlines to recognize early cases with nervous system involvement, neurological complications, and sequelae during and after the pandemic.

scholarly journals SARS-CoV-2 and the Nervous System: From Clinical Features to Molecular Mechanisms

2020 ◽  
Vol 21 (15) ◽  
pp. 5475 ◽  
Author(s):  
Manuela Pennisi ◽  
Giuseppe Lanza ◽  
Luca Falzone ◽  
Francesco Fisicaro ◽  
Raffaele Ferri ◽  
...  
Keyword(s):  
Nervous System ◽  
Molecular Mechanisms ◽  
Neuronal Damage ◽  
Neurological Complications ◽  
Neurological Manifestations ◽  
Wide Range ◽  
Inflammatory State ◽  
Acute Polyneuropathy ◽  
The Central Nervous System ◽  
The Impact

Increasing evidence suggests that Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) can also invade the central nervous system (CNS). However, findings available on its neurological manifestations and their pathogenic mechanisms have not yet been systematically addressed. A literature search on neurological complications reported in patients with COVID-19 until June 2020 produced a total of 23 studies. Overall, these papers report that patients may exhibit a wide range of neurological manifestations, including encephalopathy, encephalitis, seizures, cerebrovascular events, acute polyneuropathy, headache, hypogeusia, and hyposmia, as well as some non-specific symptoms. Whether these features can be an indirect and unspecific consequence of the pulmonary disease or a generalized inflammatory state on the CNS remains to be determined; also, they may rather reflect direct SARS-CoV-2-related neuronal damage. Hematogenous versus transsynaptic propagation, the role of the angiotensin II converting enzyme receptor-2, the spread across the blood-brain barrier, the impact of the hyperimmune response (the so-called “cytokine storm”), and the possibility of virus persistence within some CNS resident cells are still debated. The different levels and severity of neurotropism and neurovirulence in patients with COVID-19 might be explained by a combination of viral and host factors and by their interaction.

scholarly journals Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease 19 (COVID-19)

2021 ◽  
Author(s):  
Biyan Nathanael Harapan ◽  
Hyeon Joo Yoo
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Case Reports ◽  
Case Series ◽  
Altered Mental Status ◽  
Neurological Complications ◽  
Neurological Symptoms ◽  
Neurological Manifestations ◽  
Fisher Syndrome ◽  
Novel Coronavirus ◽  
The Impact

AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, is responsible for the outbreak of coronavirus disease 19 (COVID-19) and was first identified in Wuhan, China in December 2019. It is evident that the COVID-19 pandemic has become a challenging world issue. Although most COVID-19 patients primarily develop respiratory symptoms, an increasing number of neurological symptoms and manifestations associated with COVID-19 have been observed. In this narrative review, we elaborate on proposed neurotropic mechanisms and various neurological symptoms, manifestations, and complications of COVID-19 reported in the present literature. For this purpose, a review of all current published literature (studies, case reports, case series, reviews, editorials, and other articles) was conducted and neurological sequelae of COVID-19 were summarized. Essential and common neurological symptoms including gustatory and olfactory dysfunctions, myalgia, headache, altered mental status, confusion, delirium, and dizziness are presented separately in sections. Moreover, neurological manifestations and complications that are of great concern such as stroke, cerebral (sinus) venous thrombosis, seizures, meningoencephalitis, Guillain–Barré syndrome, Miller Fisher syndrome, acute myelitis, and posterior reversible encephalopathy syndrome (PRES) are also addressed systematically. Future studies that examine the impact of neurological symptoms and manifestations on the course of the disease are needed to further clarify and assess the link between neurological complications and the clinical outcome of patients with COVID-19. To limit long-term consequences, it is crucial that healthcare professionals can early detect possible neurological symptoms and are well versed in the increasingly common neurological manifestations and complications of COVID-19.

scholarly journals Neurological manifestations associated with SARS-CoV-2 infection: a narrative review

2021 ◽  
Author(s):  
Poliana Rafaela dos Santos Araújo ◽  
Kauan Alves Sousa Madruga ◽  
Bruna Alves Rocha ◽  
Lucas Oliveira Braga
Keyword(s):  
Nervous System ◽  
Meta Analysis ◽  
Neurological Complications ◽  
Neurological Symptoms ◽  
Narrative Review ◽  
Common Symptom ◽  
Neurological Manifestations ◽  
Cns Involvement ◽  
Pubmed Database ◽  
Critical Patients

Background: Coronavirus disease (COVID-19), once identified, soon spread globally, becoming a pandemic. Although patients present mainly with respiratory complaints, several neurological symptoms have been reported. Symptoms range from headache and nonspecific dizziness to seizures and cerebrovascular disease (CVD). It has also been shown that the severity of the infection is directly proportional to the development of neurological symptoms, especially CVD and changes in mental status. Objective: The present study aims to briefly review the neurological manifestations of COVID-19 and discuss the pathogenic mechanisms of Central Nervous System (CNS) involvement. Methods: This is an exploratory narrative review with a descriptive approach, consisting of an active search for scientific articles in the PubMed database. The descriptors “coronavirus infections”, “COVID-19” and “Nervous system” were used, with the Boolean operators “OR” and “AND”. Eighteen articles of systematic review and meta-analysis were included. Results: CNS manifestations included, among others: encephalitis, encephalopathy, consciousness decrease, headache, dizziness, acute myelitis, and stroke. As for the peripheral nervous system, skeletal muscle damage, chemosensory dysfunction, and Guillain-Barré syndrome were observed, with hyposmia being the most common symptom. CNS involvement may be related to a worse prognosis. Conclusion: The clinical involvement of the nervous system in COVID-19 is not uncommon, and can result in several neurological complications, especially in the most critical patients. The pathophysiological mechanisms of these events still need further investigation. In the meantime, physicians should value extra-respiratory symptoms ranging from hyposmia, to potentially fatal manifestations, such as stroke and encephalopathy.

scholarly journals Cerebrovascular events in COVID-19 patients

2020 ◽  
Vol 90 (2) ◽  
Author(s):  
Ajay Kumar Mishra ◽  
Kamal Kant Sahu ◽  
Anu Anna George ◽  
Jennifer Sargent ◽  
Amos Lal
Keyword(s):  
Computed Tomography ◽  
Vascular Injury ◽  
Neurological Deficits ◽  
Severe Illness ◽  
Cytokine Storm ◽  
Neurological Manifestations ◽  
The Poor ◽  
Cerebrovascular Events ◽  
Pubmed Database ◽  
The Brain

Neurological manifestations in patients with COVID–19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this review we summarize the published literature on cerebrovascular events in patients with COVID-19 as available on the PubMed database. So far, 3 studies have reported cerebrovascular events. Cerebrovascular events were identified on screening patients with decreased consciousness or in the presence of focal neurological deficits. These events were common in elderly, critically ill patients and in patients with prior cardio-cerebrovascular comorbidities. The diagnosis of cerebrovascular events was confirmed with computed tomography of the brain in most studies reporting neurological events. Multiple pathological mechanisms have been postulated regarding the process of neurological and vascular injury among which cytokine storm is shown to correlate with mortality. Patients with severe illness are found to have a higher cardio- cerebrovascular comorbidity. With an increasing number of cases and future prospective studies, the exact mechanism by which these cerebrovascular events occur and attribute to the poor outcome will be better understood.

scholarly journals Assessing visual requirements for social context-dependent activation of the songbird song system

2008 ◽  
Vol 276 (1655) ◽  
pp. 279-289 ◽  
Author(s):  
Erina Hara ◽  
Lubica Kubikova ◽  
Neal A Hessler ◽  
Erich D Jarvis
Keyword(s):  
Social Context ◽  
Driving Forces ◽  
Sensory Modality ◽  
Brain Activation ◽  
Visual Input ◽  
Related Area ◽  
The Social ◽  
Wide Range ◽  
Context Dependent ◽  
The Brain

Social context has been shown to have a profound influence on brain activation in a wide range of vertebrate species. Best studied in songbirds, when males sing undirected song, the level of neural activity and expression of immediate early genes (IEGs) in several song nuclei is dramatically higher or lower than when they sing directed song to other birds, particularly females. This differential social context-dependent activation is independent of auditory input and is not simply dependent on the motor act of singing. These findings suggested that the critical sensory modality driving social context-dependent differences in the brain could be visual cues. Here, we tested this hypothesis by examining IEG activation in song nuclei in hemispheres to which visual input was normal or blocked. We found that covering one eye blocked visually induced IEG expression throughout both contralateral visual pathways of the brain, and reduced activation of the contralateral ventral tegmental area, a non-visual midbrain motivation-related area affected by social context. However, blocking visual input had no effect on the social context-dependent activation of the contralateral song nuclei during female-directed singing. Our findings suggest that individual sensory modalities are not direct driving forces for the social context differences in song nuclei during singing. Rather, these social context differences in brain activation appear to depend more on the general sense that another individual is present.

scholarly journals The Buffering Effects of Social Insurance for the Spread of Covid-19

2021 ◽  
Vol 12 (4(I)) ◽  
pp. 19-27
Author(s):  
Moein Mirani Ahangarkolaei ◽  
Eser Demir ◽  
Tolga Constantinou ◽  
Mostafa Toranji ◽  
Tadashi Adino ◽  
...  
Keyword(s):  
Social Insurance ◽  
Transmission Rate ◽  
The Novel ◽  
Negative Consequences ◽  
Welfare Programs ◽  
Monthly Data ◽  
The Social ◽  
Wide Range ◽  
Novel Coronavirus ◽  
Low Educated

Global pandemics are associated with substantial losses of human capital. The best strategy of policymakers in public health before a population-wide vaccination is to reduce the outbreak of the disease and finding ways to alleviate its negative consequences in society. Previous studies show that welfare programs have externalities in unintended areas and for unplanned outcomes including a wide range of health outcomes. In this paper, we show that payments under the Unemployment Insurance (UI) program have the potential to reduce the spread of the novel coronavirus. Applying a difference-in-difference technique on monthly data of all US counties from January 2020 to January 2021, we document that the social insurance under the umbrella of UI payments can reduce the transmission rate of Covid-19. The results show heterogeneity across subsample with the largest effects among blacks, poor, and low educated regions

scholarly journals The Common Neurological Presentations and Clinical Outcomes of Coronavirus Disease 2019 in Saudi Arabia

2021 ◽  
Vol 12 ◽  
Author(s):  
Walid A. Alkeridy ◽  
Mohammed H. Alanazy ◽  
Nada Alamri ◽  
Awyshah Alqahtani ◽  
Adel Alhazzani ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Clinical Outcomes ◽  
Neurological Disease ◽  
Neurological Complications ◽  
Arab Countries ◽  
Neurological Manifestations ◽  
Older Individuals ◽  
Wide Range ◽  
The Common ◽  
Poor Outcomes

Background: Neurological manifestations have increasingly become recognized in COVID-19. People from different ethnic backgrounds are experiencing different outcomes related to SARS-CoV-2 infection. Several cohort studies reported the common neurological manifestations and complications associated with COVID-19 disease around the world however, the prevalence of neurological complications associated with SARS-CoV-2 infection in the Arab countries and Saudi Arabia is still unknown.Objective: To study the prevalence, risk factors, and characteristics of the neurological complications associated with COVID-19 and their relationship with clinical outcomes.Methods: We conducted a prospective, single-center, observational, cohort study of consecutive hospitalized adults COVID-19 patients with and without neurological manifestation admitted between March 2020 until the end of December 2020. Data was collected prospectively using electronic medical records; Cases and controls were observed until they either get discharged from the hospital or died. The primary outcomes were death, survival, and survival with sequalae.Results: Among 497 patients with COVID-19, 118 patients (23.7%) had neurological complications, 94 patients (18.9%) had encephalopathy, and 16 patients (3.2%) had cerebrovascular accidents (CVA). Patients with COVID-19-related neurological complications were older and more likely to have a pre-existing neurological disease. The most common neurological syndrome associated with COVID-19 were encephalopathy (18.9%) and headache (13.7%). Pre-existing neurological disease and an elevated neutrophil count were the strongest predictors of developing any neurological complications. Death form COVID-19 was associated with age (OR 1.06, 95% CI 1.02–1.10, P = 0.001), invasive ventilation (OR 37.12, 95% CI 13.36–103.14), COVID-19-related-neurological complications (OR 3.24, 95% CI 1.28–8.21, P = 0.01), and elevated CRP level (OR 1.01, 95% CI 1.00–1.01, P = 0.01).Conclusions: COVID-19 is associated with a wide range of neurological manifestations in people living in Saudi Arabia, with older individuals and those with underlying neurological disorders being most at risk. The presence of neurological complications was associated with increased mortality and poor outcomes.

scholarly journals ENCEPHALOPATHY AND ENCEPHALITIS DUE ACUTE SARS-COV-2 INFECTION: CASE REPORT

2021 ◽  
Keyword(s):  
Nervous System ◽  
Disease Process ◽  
Vascular Diseases ◽  
Acute Disseminated Encephalomyelitis ◽  
Brain Dysfunction ◽  
Brain Parenchyma ◽  
Neurological Manifestations ◽  
Inflammatory Processes ◽  
Drug Interventions ◽  
The Brain

Although Covid-19 disease is primarily considered an infection of the respiratory tract, it is currently known that damage and adverse reactions in the course of and after this disease affect several other bodily systems, however these issues are not yet fully understood, especially in tangent its neurological manifestations.3,4 In this sense, this report aims to add the list of many cases that are being reported/described in the literature which warn about the direct effects of the virus on the nervous system, to a disease for -infectious or post-infectious immune-mediated to COVID-19, such as acute disseminated encephalomyelitis, muscular diseases of the peripheral nervous system (Guillain-Barré syndrome), cerebrovascular and vascular diseases (CVA), and acute inflammatory processes such as that of the brain parenchyma in this case of Viral Encephalitis. Encephalitis is a diffuse or focal inflammatory process of the brain parenchyma associated with brain dysfunction, which can be divided into two main categories: alluding to systemic infections or vaccination and alluding to the entry of the pathogen into the CNS. Thus, based on the premise that several neurological manifestations are related to SARS-CoV-2 infection, a better understanding of the immune response to this infection can help not only for prevention but also can provide a valuable contribution to knowledge of the health-disease process, next human approaches, therapeutic and drug interventions

scholarly journals Neurological Manifestations of Novel Coronavirus Disease in a 2-Month-Old Infant: A Case Report

2020 ◽  
Author(s):  
Mojtaba Kamali Aghdam ◽  
Hassan Bakhtiari ◽  
Diana Noemi Diaz ◽  
Kambiz Eftekhari
Keyword(s):  
Respiratory Symptoms ◽  
Clinical Evidence ◽  
Neurological Manifestations ◽  
Computed Tomography Scan ◽  
Chain Reaction ◽  
Polymerase Chain ◽  
Novel Coronavirus ◽  
A Minor ◽  
The Brain ◽  
Tomography Scan

AbstractThe main manifestations of novel coronavirus usually include fever and cough. Neurological manifestations have not been properly identified in children. A 65-day-old infant was hospitalized due to poor feeding, weakness, lethargy, and occasional cough. She suffered several seizures during her hospitalization. The brain computed tomography scan depicted a minor hemorrhage. Due to the exacerbation of her condition during hospital stay and the presence of respiratory symptoms in her parents, coronavirus disease was suspected. Reverse transcription–polymerase chain reaction (PCR) of coronavirus was positive for both: child and parents. In children with neurological manifestations such as lethargy, recurrent seizures, cerebral hemorrhage, and clinical evidence of respiratory symptoms in his/her relatives, PCR testing for coronavirus is recommended.

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