scholarly journals COMPARATIVE PHYSICOCHEMICAL ANALYSIS OF WET AND DRY GUDUCHI (TINOSPORA CORDIFOLIA WILLD.) MIERS.

2020 ◽  
Vol 11 (6) ◽  
pp. 7-11
Author(s):  
Sushma Dongre ◽  
Shishir Pande
Keyword(s):  
Ph Value ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Physicochemical Characteristics ◽  
Physicochemical Analysis ◽  
Matter Content ◽  
Water Soluble ◽  
Tinospora Cordifolia ◽  
Foreign Matter ◽  
Characteristics Analysis

Bhaishajya Kalpana is a branch of Ayurveda which deals with pharmaceutics. It is based on certain scientific principles which need to be followed for quality pharmaceutical preparations. Use of dry form drugs over fresh form in pharmaceutical preparation is one of the principles. It excludes some drugs such as Guduchi (Tinospora cordifolia) As Guduchi is being widely used in Ayurveda for preventive as well as curative purpose; it has been selected for the study. In order to find difference between morphological and physicochemical characteristics analysis of wet and dry Guduchi, was carried as per standards of Ayurved Pharmacopeia of India (API). It was noticed that almost all the Macroscopic and Microscopic profile matches with standard parameters of Guduchi in API. It is observed that pH Value of fresh Guduchi was more than its dry form which is directed to its alkaline nature. Foreign matter content was found to be negligible in Fresh form. Fresh Guduchi also showed more water soluble extractive than dry, however alcohol soluble extractive was higher in dry form. This study has added new analytical parameters for wet Guduchi i.e. pH. Value, Total ash, water soluble and alcohol soluble extractive other than foreign matter and moisture content. So, it could be considered as a standard for future study. This study evidenced classical principle of using Fresh Guduchi over dry. Further qualitative analysis needs to be done by using qualitative parameters.

scholarly journals Spectrophotometric Determination of Bisacodyl in Pure and Pharmaceutical Preparation via Oxidative Coupling Organic Reaction

2017 ◽  
Vol 14 (1) ◽  
pp. 181-188
Author(s):  
Baghdad Science Journal
Keyword(s):  
Oxidative Coupling ◽  
Pharmaceutical Preparation ◽  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Molar Absorptivity ◽  
Water Soluble ◽  
Alkaline Media ◽  
Oxidative Coupling Reaction ◽  
Relative Standard ◽  
Limit Of Quantitation

A simple, accurate and sensitive spectrophotometric way is used to determine Bisacodyl in pure and pharmaceutical preparations. The proposed method depends on using 2,4-Dinitrophenylhydrazine as chromogenic reagent . The method was based on the oxidative coupling reaction of Bisacodyl with 2,4-Dinitrophenylhydrazine with Sodium periodate in the presence of sodium hydroxide as alkaline media to form red water soluble dye product , that has a maximum absorption at ?max 522nm . Beer ,s law is obeyed in the concentration of (2.00–20.00) ?g.ml -1 .The molar absorptivity is (6505) L.mol-1.cm-1,a sandall sensitivity of(0.0555) ?g.cm-2), correlation coefficient of (0.9970) , Limitof detection (LOD) (0.0312 ?g.ml-1), limit of Quantitation (LOQ) (0. 3125 ?g.ml-1) and the relative standard deviation of RSD% (1.6). The method gave a successful determination for Bisacodyl in pharmaceutical preparations and the value of recovery % was better than (100.16%)

scholarly journals PHYSICOCHEMICAL ANALYSIS & STANDARDIZATION OF SHIRISH TWAK KWATH CHURNA

2021 ◽  
Vol 9 (4) ◽  
pp. 602-605
Author(s):  
Shah Neha ◽  
◽  
Jhunjhunwala Amita ◽  
Keyword(s):  
Physicochemical Properties ◽  
Bronchial Asthma ◽  
Skin Diseases ◽  
Pharmaceutical Preparation ◽  
Well Being ◽  
Physicochemical Analysis ◽  
Water Soluble ◽  
The Earth ◽  
The Gift ◽  
Anti Inflammatory

As per Ayurvedic classics no herb in the earth is devoid of medicinal properties.In many Ayurvedic texts it is mentioned to use Shirish for various therapeutic purposes like Kustha (skin diseases), Premeha (diabetes), Swasrogas (bronchial asthma), Vranaropaka (wound healer), Sothahara (anti-inflammatory) and many more. Acharya Charak has mentioned Shirish as Sresthavishagnadravya (anti-toxic). Aim- Pharmaceutical preparation and standardization of Shirish twakkwathchurna. Material & Method-Shirish twakkwathchurna was prepared and its physicochemical testing & standardization was done by following the standard protocols. Results-Shirish twakKwathchurna was evaluated for different standardization parameters which showedLoss on drying (5.30%), Total ash (12.68%), Acid insoluble ash (1.24%), Water soluble extractive (4.69%) and Alcohol soluble Extractive (5.56%). Conclusion-Each plant is the gift of nature which can used for the well-being of mankind but this can only be done when we are well aware of its physicochemical properties. This paper highlights the physicochemical picture of widely used plant Shirish and the data developed from the study can be espoused for allocating the standards for Shirish twakkwathchurna.

scholarly journals Evaluation of Physico-chemical And Chromatographic Profile of Kasani Seeds (cichorium intybus l.)

2017 ◽  
Vol 5 (5) ◽  
Author(s):  
Meenakshi R. Rathi ◽  
Surekha T. Landge
Keyword(s):  
Raw Materials ◽  
Modern Medicine ◽  
Matter Content ◽  
Water Soluble ◽  
Foreign Matter ◽  
Primary Health ◽  
Physico Chemical ◽  
Chromatographic Profile ◽  
Materials Used ◽  
Effective Source

Medicinal plants constitute an effective source of traditional and modern medicine. In India, about 80% of the rural population depends on medicinal herbs and/or indigenous system of medicine for primary health care.One of such traditional herb is kasani. The Kasani, Cichoriumintybusof family Asteraceae , class Magnoliopsida, which is also known as Chicory, is well known traditional herb included in many system of medicine like Ayurveda, Unani and Siddha system of medicine[1]. Kasani is extensively used in many ayurvedic and herbal formulations.For proper and effective results of such medicines,raw materials used should be of perfect parameters like its foreign matter content, total ash, acid insoluble ash, water soluble ash, its extractive value etc. as described in API.Standard parameters of Kasani are not mentioned in API[2].The present article reviews the Ayurvedic aspects of Kasani well supported by the available literature and its physico-chemical and chromatographicanalysis. Through this article, we have set perfect range of parameters of all physico-chemical and chromatographic  analysis carried out by water and alcohol extraction at Unijules pharmacy, Kalmeshwar, Nagpur.

Formulation and Evaluation of Turmeric Emulgel

2021 ◽  
pp. 213-219
Author(s):  
Rutuja Saurabh Shah
Keyword(s):  
Drug Release ◽  
Ph Value ◽  
Research Work ◽  
Physical Appearance ◽  
Physicochemical Characteristics ◽  
High Viscosity ◽  
Water Soluble ◽  
Gelling Agent ◽  
Water Soluble Polymer

The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Turmeric. Emulgel formulations of Turmeric were prepared using Carbopol 934 as a gelling agent. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using. The main purpose of this research was to design to formulate and evaluate a topical gellified emulsions (Emulgel) of Turmeric by using high molecular weight water soluble polymer Carbapol 934. This Carbapol possesses very high viscosity, transparency, film forming properties at low concentration and reported to be useful in formation of gel with an objective to increase transparency and spreadability. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The influence of the type of gelling agent on the drug release from the prepared emulgels was investigated and carbopol 934 showed good results not only in the drug release but also in physical evaluation parameters. From the drug release studies, F3 formulation showed 90.05% drug release in 6 h with good clarity and physical appearance and viscosity 2250cps.Stability studies showed that the physical appearance, rheological study, in vitro drug release, and anti-inflammatory activity in all the prepared emulgel remained unchanged upon storage for 3 months. It was finally concluded that the formulation F3 with 1%w/w Carbopol 934 was found to be more promising formulations as it shows better physicochemical characteristics and antiinflammatory activity compared to other formulations.

scholarly journals Concept of Kshara Nirmana Out of Kanji with Reference to Rasayansara- A Pharmaceutico-Analytical Study

2021 ◽  
pp. 259-266
Author(s):  
Mahesh S. Pawar ◽  
M. R. Pandya ◽  
A. N. Jayaprakash ◽  
Abhaya Kumar Mishra ◽  
Lopamudra Dash
Keyword(s):  
Analytical Study ◽  
Ph Value ◽  
Physicochemical Analysis ◽  
Pharmaceutical Product ◽  
Water Soluble ◽  
Special Method ◽  
Innovative Methods ◽  
Unique Method ◽  
Similar Preparation ◽  
Pharmaceutical Processes

Kanji (sour rice gruel) is an acidic fermented preparation mentioned in many of the Ayurveda classics for various purpose like therapeutic use, pharmaceutical processes etc. A special method of kanji preparation is mentioned in Rasaratnasamuchchaya commentary by Acharya Dattatreya Anant Kulkarni and similar preparation is also mentioned in Rasayansara book recommended for the Parada samskara (mercurial processes) with some difference in ingredients. Kshara (alkaline preparation/ alkali) is an important preparation mentioned in classics. In Rasayansara text, Acharya Shyamsundar Vaishyaji has described a unique method of Kshara nirmana out of the leftover material of the Kanji. This kind of innovative methods should be adopted to recycle the leftover waste matters. It will help in regenerate the new pharmaceutical product. Here an attempt has been done by preparing the kanji and the kshara out of its residue material as mentioned in Rasayansara. First Kanji was prepared as per the reference of Rasayansara book and the leftover after filtration was dried. The kshara was prepared out of this dried leftover. Organoleptic and physicochemical analysis of the prepared kshara was done. The average yield of obtained kshara was 4.88%. The moisture content of the final product found very less while total ash value found on higher side. The pH value suggests its alkaline nature. It shows good solubility in various solvents and good water-soluble extractive value. Exploration of such innovative procedures where waste stuff is been recycled should be increased in present time.

Simultaneous Spectrophotometric Determination of Salbutamol by Coupling with Diazotized 4-Aminobenzoic acid

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Hind Hadi ◽  
Gufran Salim
Keyword(s):  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Dosage Forms ◽  
Water Soluble ◽  
Trace Determination ◽  
Aminobenzoic Acid ◽  
Optimum Conditions ◽  
Colored Product ◽  
Versus Concentration

A simple, rapid and sensitive spectrophotmetric method for trace determination of salbutamol (SAL) in aqueous solution and in pharmaceutical preparations is described. The method is based on the diazotization coupling reaction of the intended compound with 4-amino benzoic acid (ABA) in alkaline medium to form an intense orange, water soluble dye that is stable and shows maximum absorption at 410 nm. A graph of absorbance versus concentration indicates that Beer’s law is obeyed over the concentration range of 0.5-30 ppm, with a molar absorbtivity 3.76×104 L.mol-1 .cm-1 depending on the concentration of SAL. The optimum conditions and stability of the colored product have been investigated and the method was applied successfully to the determination of SAL in dosage forms.

Molecularly Imprinted Sensor for Ascorbic Acid Based on Gold Nanoparticles and Multiwalled Carbon Nanotubes

2020 ◽  
Vol 16 (7) ◽  
pp. 905-913
Author(s):  
Youyuan Peng ◽  
Qingshan Miao
Keyword(s):  
Carbon Nanotubes ◽  
Gold Nanoparticles ◽  
Ascorbic Acid ◽  
Multiwalled Carbon Nanotubes ◽  
Ph Value ◽  
Biological Fluids ◽  
Water Soluble ◽  
Multiwalled Carbon ◽  
Experimental Conditions ◽  
Molecularly Imprinted

Background: L-Ascorbic acid (AA) is a kind of water soluble vitamin, which is mainly present in fruits, vegetables and biological fluids. As a low cost antioxidant and effective scavenger of free radicals, AA may help to prevent diseases such as cancer and Parkinson’s disease. Owing to its role in the biological metabolism, AA has also been utilized for the therapy of mental illness, common cold and for improving the immunity. Therefore, it is very necessary and urgent to develop a simple, rapid and selective strategy for the detection of AA in various samples. Methods: The molecularly imprinted poly(o-phenylenediamine) (PoPD) film was prepared for the analysis of L-ascorbic acid (AA) on gold nanoparticles (AuNPs) - multiwalled carbon nanotubes (MWCNTs) modified glass carbon electrode (GCE) by electropolymerization of o-phenylenediamine (oPD) and AA. Experimental parameters including pH value of running buffer and scan rates were optimized. Scanning electron microscope (SEM), fourier-transform infrared (FTIR) spectra, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were utilized for the characterization of the imprinted polymer film. Results: Under the selected experimental conditions, the DPV peak currents of AA exhibit two distinct linear responses ranging from 0.01 to 2 μmol L-1 and 2 to 100 μmol L-1 towards the concentrations of AA, and the detection limit was 2 nmol L-1 (S/N=3). Conclusion: The proposed electrochemical sensor possesses excellent selectivity for AA, along with good reproducibility and stability. The results obtained from the analysis of AA in real samples demonstrated the applicability of the proposed sensor to practical analysis.

scholarly journals Microbial Respiration and Enzyme Activity Downstream from a Phosphorus Source in the Everglades, Florida, USA

Land ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 696
Author(s):  
Sanku Dattamudi ◽  
Saoli Chanda ◽  
Leonard J. Scinto
Keyword(s):  
Nutrient Dynamics ◽  
Microbial Respiration ◽  
Organic Matter Content ◽  
Physicochemical Analysis ◽  
Matter Content ◽  
Enzyme Assays ◽  
Co2 Efflux ◽  
Soil Organic Matter Content ◽  
Phosphorus Source ◽  
P Distribution

Northeast Shark River Slough (NESS), lying at the northeastern perimeter of Everglades National Park (ENP), Florida, USA, has been subjected to years of hydrologic modifications. Construction of the Tamiami Trail (US 41) in 1928 connected the east and west coasts of SE Florida and essentially created a hydrological barrier to southern sheet flow into ENP. Recently, a series of bridges were constructed to elevate a portion of Tamiami Trail, allow more water to flow under the bridges, and attempt to restore the ecological balance in the NESS and ENP. This project was conducted to determine aspects of soil physiochemistry and microbial dynamics in the NESS. We evaluated microbial respiration and enzyme assays as indicators of nutrient dynamics in NESS soils. Soil cores were collected from sites at certain distances from the inflow (near canal, NC (0–150 m); midway, M (150–600 m); and far from canal, FC (600–1200 m)). Soil slurries were incubated and assayed for CO2 emission and β-glucoside (MUFC) or phosphatase (MUFP) activity in concert with physicochemical analysis. Significantly higher TP contents at NC (2.45 times) and M (1.52 times) sites than FC sites indicated an uneven P distribution downstream from the source canal. The highest soil organic matter content (84%) contents were observed at M sites, which was due to higher vegetation biomass observed at those sites. Consequently, CO2 efflux was greater at M sites (average 2.72 µmoles g dw−1 h−1) than the other two sites. We also found that amendments of glucose increased CO2 efflux from all soils, whereas the addition of phosphorus did not. The results indicate that microbial respiration downstream of inflows in the NESS is not limited by P, but more so by the availability of labile C.

scholarly journals Technosols Development in an Abandoned Mining Area and Environmental Risk Assessment

2021 ◽  
Vol 11 (15) ◽  
pp. 6982
Author(s):  
Chiara Ferronato ◽  
Gilmo Vianello ◽  
Mauro De Feudis ◽  
Livia Vittori Antisari
Keyword(s):  
Central Italy ◽  
Organic Matter Content ◽  
Chemical Properties ◽  
Soil Surface ◽  
Mining Area ◽  
Physicochemical Characteristics ◽  
Matter Content ◽  
Mine Tailing ◽  
Inorganic Materials ◽  
Soil Features

The study of Technosols development, spatial distribution and physicochemical characteristics is becoming more and more important in the Anthropocene Era. The aim of the present study was to assess soil features and potential heavy metal release risk of soils developed on different mine tailing types after the waste disposal derived from mining activity in Central Italy. Soils were analyzed for their morphological, physical and chemical properties, and a chemical sequential extraction of heavy metals was performed. The investigated soils were classified as Technosols toxic having in some layer within 50 cm of the soil surface inorganic materials with high concentrations of toxic elements. Our findings showed that the bioavailability of potentially toxic element concentrations in the soil changed according to the origin of the mine tailing. However, because of the acidic pH, there is a serious risk of metals leaching which was reduced where the soil organic matter content was higher.

Jam processing: Effect of pectin replacement by locust bean gum on its characteristics

2020 ◽  
pp. 1-12
Author(s):  
Aida Mekhoukhe ◽  
Nacer Mohellebi ◽  
Tayeb Mohellebi ◽  
Leila Deflaoui-Abdelfettah ◽  
Sonia Medouni-Adrar ◽  
...  
Keyword(s):  
Cold Water ◽  
Physicochemical Characteristics ◽  
Water Soluble ◽  
Sensory Profile ◽  
Locust Bean Gum ◽  
Locust Bean ◽  
Preference Map ◽  
The Right ◽  
High Level ◽  
The Impact

OBJECTIVE: the present work proposed to extract Locust Bean Gum (LBG) from Algerian carob fruits, evaluate physicochemical and rheological properties (solubility). It aimed also to develop different formulations of strawberry jams with a mixture of LBG and pectin in order to obtain a product with a high sensory acceptance. METHODS: the physicochemical characteristics of LBG were assessed. The impact of temperature on solubility was also studied. The physical and the sensory profile and acceptance of five Jams were evaluated. RESULTS: composition results revealed that LBG presented a high level of carbohydrate but low concentrations of fat and ash. The LBG was partially cold-water-soluble (∼62% at 25°C) and needed heating to reach a higher solubility value (∼89% at 80 °C). Overall, the sensorial acceptances decreased in jams J3 which was formulated with 100% pectin and commercial one (J5). The external preference map explained that most consumers were located to the right side of the map providing evidence that most samples appreciated were J4 and J2 (rate of 80–100%). CONCLUSION: In this investigation, the LBG was used successfully in the strawberry jam’s formulation.

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