scholarly journals Evaluation of Nephrotoxic and Hepatotoxic Potential of Artesunate in Malaria Patients

2020 ◽  
pp. 17-24
Author(s):  
Ugonna D. Nwankpa ◽  
Henry N. Ogbonna ◽  
Chinedu E. Udekwu ◽  
Chibuzo V. Nwokafor
Keyword(s):  
Social Sciences ◽  
Treatment Group ◽  
Total Bilirubin ◽  
Control Group ◽  
Duration Of Treatment ◽  
Biochemical Tests ◽  
Normal Ranges ◽  
Normal Individuals ◽  
The Right ◽  
One Way Anova

Aim: To evaluate the nephrotoxic and hepatotoxic potentials of artesunate in humans. Place and Duration of Study: Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria, between November and December 2019. Methodology: 70 blood samples were collected from 35 normal individuals (control group), and 35 malaria patients treated with parenteral artesunate (treatment group). These were analyzed for biochemical parameters, including blood urea nitrogen (BUN), creatinine, total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP). The treatment group was further regrouped according to gender (19 males and 16 females), age (20 patients aged 20-29 and 15 patients aged 30-40 years) and duration of treatment (29 patients on 3rd or 4th day and 6 patients on 5th or 6th day of treatment). Biochemical tests were carried out using standard Randox test kits. One-way ANOVA was done on the parameters using statistical package for social sciences (SPSS), and comparisons were made. Results: Compared to control group, the treatment group showed significant increases (p<0.05) in BUN (15.89+1.30 against 11.69+0.62), Creatinine (0.96+0.62 against 0.82+0.03) and AST (22.14+2.45 against 16.66+0.85), a non-significant increase (p 0.05) in ALT (26.57+3.18 against 21.66+2.56) and ALP (85.31+4.06 against 77.54+3.09) and a non-significant decrease (p 0.05) in total bilirubin (0.59+0.06 against 0.65+0.06). However, all parameters examined were within the normal ranges. There was no significant relationship found in any parameter in a comparison of gender, age and duration of treatment. Conclusion: Since all parameters examined were in the normal ranges, administration of artesunate in the recommended dosage and the right duration may not have any significant toxic effect on the kidney and liver. However, further studies may be necessary to ascertain if the observed elevations could be attributed wholly to artesunate or other medications taken by the malaria patients.

scholarly journals Association between risk factors and retinal nerve fiber layer loss in early stages of diabetic retinopathy

2021 ◽  
Vol 14 (2) ◽  
pp. 255-262
Author(s):  
Zhong-Qi Wan ◽  
◽  
Min Cui ◽  
Yong-Jie Zhang ◽  
◽  
...  
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Nerve Fiber ◽  
Systolic Pressure ◽  
Control Group ◽  
Diabetic Patients ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Normal Individuals ◽  
The Right

AIM: To investigate the changes of retinal nerve fiber layer (RNFL) among normal individuals, diabetic patients without diabetic retinopathy (NDR) and non-proliferative diabetic retinopathy (NPDR), and explore the possible risk factors of early diabetic retinopathy (DR). METHODS: In this cross-sectional study, 107 participants were divided in three groups. Totally 31 normal individuals (control group), 40 diabetic patients without DR (NDR group) and 36 patients with NPDR (NPDR group) were included. Optical coherence tomography (OCT) was used to detect RNFL thickness and other optic disc parameters among different groups. The potential association between RNFL loss and systemic risk factors were assessed for DR, including diabetes duration, body mass index (BMI), hemoglobin A1c (HbA1c), serum lipids, and blood pressure. RESULTS: The average and each quadrant RNFL thickness were thinner in NPDR group compared to control group of the right (P=0.00, P=0.01, P=0.01, P=0.02, P=0.04) and left eyes (P=0.00, P=0.00, P=0.00, P=0.03, P=0.04). The average, superior and inferior RNFL thickness were thinner in NDR group compared to the NPDR group of the right (P=0.00, P=0.02, P=0.03) and left eyes (P=0.00, P=0.00, P=0.01). Diabetic duration was negatively correlated with the superior, inferior, and average RNFL thickness of the right (r=-0.385, P=0.001; r=-0.366, P=0.001; r=-0.503, P=0.000) and left eyes (r=-0.271, P=0.018; r=0.278, P=0.015; r=-0.260, P=0.023). HbA1c was negatively correlated with the superior, inferior, and average RNFL thickness of the right (r=-0.316 P=0.005; r=-0.414, P=0.000; r=-0.418, P=0.000) and left eyes (r= -0.367, P=0.001; r=-0.250, P=0.030; r=-0.393, P=0.000). Systolic pressure was negatively correlated with the inferior and average RNFL thickness of the right eye (r=-0.402, P=0.000; r=-0.371, P=0.001) and was negatively correlated with the superior and average RNFL thickness of the left eye (r=-0.264, P=0.021; r=-0.233, P=0.043). CONCLUSION: RNFL loss, especially in the superior and inferior quadrants, may be the earliest structural change of the retina in diabetic patients, and is also associated with diabetic duration, HbA1c, and systolic pressure.

scholarly journals RESULTS OF CLINICAL AND INSTRUMENTAL STUDY OF DIGITAL OCCLUSION INDICES DURING REGISTRATION OF INTERMAXILLARY INTERCUSPAL POSITION IN PATIENTS WITH UNILATERAL DEFECTS AND INTACT DENTITIONS

2021 ◽  
pp. 49-62
Author(s):  
Т.R. Hlushko ◽  
Yu.V. Vovk ◽  
V.Yu. Vovk ◽  
P.S. Kryukov
Keyword(s):  
Treatment Group ◽  
Dental Treatment ◽  
Instrumental Analysis ◽  
Dental Occlusion ◽  
Control Group ◽  
Time Duration ◽  
Occlusal Force ◽  
Spatio Temporal ◽  
The Right ◽  
And Control

Introduction. Determination of the patients’ dentitions ratios is an important in the orthopedic dental treatment of defects of the dentofacial system (DFS). The aim of the study. Performance of the comparative clinical and instrumental analysis of ICP occlusal relationships registration results in groups of patients with intact dentitions and unilateral defects of dentitions. Materials and methods. Examination of 10 patients of both sexes aged 24 to 50 years was conducted. All examined patients were divided into treatment and control groups. The first treatment group of the study included 5 patients with class A2 unilateral defects of dentitions of the DFS according to the Eichner classification. The control group consisted of 5 patients with intact dentitions. Results. As a result of the study conducted it was found that at the stage of transition from ICP to MIC, the OT index in patients of the control group with the use of Futar D registration material was (0,37±0,07) sec, values of the proportion of the occlusal force (COF) on the right were determined in the interval (65,2±7,71) %, on the left they were (34,8±7,71) %, length of the occlusal trajectory (L) was (8,6±2,94) mm. OT index in patients of the treatment group with the use of Futar D registration material during the transition from ICP to MIC made up (0,37±0,07) sec, values of the proportion of the occlusal force (COF) on the right were determined in the interval (32,4±6,22) %, on the left they were (67,6±6,22) % (p<0,05), length of occlusal displacement trajectory (L) increased to (12,6±2,88) mm (p≥0,05). Conclusions: An important feature of physiologically coordinated functioning of the dentofacial system of patients is the uniform occlusion of dentition with simultaneous contact of all groups of At the time of static and dynamic occlusion, frequent sliding contacts are observed in the end position of the ICP. As the occlusal pressure increases towards the maximum intercuspation (MIC), the area of the contact surfaces of the teeth increases. Under this condition, an occlusal pressure occurs, causing redistribution of the functional load of the DFS The interval of dental occlusion between the ICP and MIC positions, or delta (∆), which can be determined using Tekscan III digital technology, demonstrates spatio-temporal indices of redistribution of intermaxillary relations. Their values in patients with partial loss of teeth cause a particular With the use of Futar D registration material, clinical and instrumental analysis of digital indices of the transition from ICP to MIC allowed the establishment of the extension of time duration of dental occlusion by 1,2, increase in the length of the occlusal trajectory by 1,5, a significant change in proportional participation of the sides of dentitions (p<0,05) in patients of the treatment group compared to the control Prospects for further research. The conducted instrumental studies demonstrate challenging opportunities to identify individualized features of static and dynamic occlusal balance at clinical registration of intermaxillary position of ICP with the help of various registration materials and techniques.

scholarly journals Asymmetrical fatiguing of the gluteus maximus muscles in the elite short-track female skaters.

2020 ◽  
Author(s):  
Mariusz Konieczny ◽  
Paweł Pakosz ◽  
Mateusz Witkowski
Keyword(s):  
Repeated Measures ◽  
Gluteus Maximus ◽  
Signal Frequency ◽  
Control Group ◽  
National Team ◽  
Muscle Work ◽  
Risk Of Injury ◽  
Gluteus Maximus Muscle ◽  
The Right ◽  
One Way Anova

Abstract Background: According to research, fast skating on short distances causes asymmetry in the physiology of muscle work. As has been proven in many sporting disciplines, this asymmetry can increase the risk of injury. The aim of the study was to analyze the level of right and left fatigue asymmetry of gluteus maximus muscle in elite skaters on a short track and to compare this phenomenon to a control group. The muscles were chosen deliberately, due to their influence in maintaining the right position during training on ice. Methods: The experiment compared a group of eight members of the Polish Women’s National Team in short track with a group of eight non-training people. The subjects did the Biering-Sorensen test, in which sEMG (surface electromyography) signal frequency was measured in the gluteus maximus muscles during an isometric contraction. Fatigue slopes were analyzed with a one-way ANOVA with repeated measures.. In the skaters, the fatigue differed between the right and the left gluteus maximus muscles. All the skaters had higher fatigue in the right leg. This phenomenon was not observed in the non-training subjects, who on average had similar fatigue in both legs. Results: The results suggest that professional short-track training leads to considerable asymmetry in fatigability of gluteus maximus muscles, thereby increasing the risk of injury in training and competition. Conclusions: Training should thus be planned in a way that minimizes the risk of causing muscle fatigue asymmetry in skaters despite the typically asymmetrical muscle work during training on ice and competition, thus new trainign protocols should be developed or considered to decrease that asymmetry. Trial registration: The tests were previously approved by the Bioethical Commission of the Chamber of Physicians in Opole. (Resolution No. 235 of 13 December 2016).

scholarly journals Instructional Packages Geography Based on Ecosystem (PIGeoEk) Development in Improving Students’ Knowledge About Ecosystem Concepts and Relation to Students’ Environmental Behavior

2018 ◽  
Vol 3 (1) ◽  
pp. 1-22
Author(s):  
Ning Setianti
Keyword(s):  
Social Sciences ◽  
Treatment Group ◽  
Knowledge Transfer ◽  
Environmental Education ◽  
Research And Development ◽  
Environmental Behavior ◽  
T Test ◽  
Control Group ◽  
Gain Score ◽  
Significant Difference

The learning have been tended to put more emphasis on knowledge transfer. One of the efforts in improving students' knowledge about the concepts of ecosystem and relation to students’ environmental behavior is integrating Geography and environmental education developing instructional packages based on ecosystem for teachers of Geography. This study aims to develop an instructional packages geography based on ecosystem (PIGeoEk) in improving students' knowledge of the concepts of the ecosystem and related to students’ environmental behavior. A research and development (R & D) based on Borg and Gall (2007), refering to the Dick and Carey design (2009), steps has been applied by involving 80 students of grade XI majoring in social sciences of SMAN 5 Depok for treatment, and grade XI majoring in social sciences of SMAN 3 Depok as a control group. There are four instructional packages geography based on ecosystem (PIGeoEk) have been developed and instrument test used for measuring knowledge about the concepts of ecosystem and relation to students’ environmental behavior. The are four t-test have been applied to verify the effectiveness of Instructional Pakages. Research results indicate that there is a significant difference between mean of gain score obtained from post and pre test at treatment group compare to control group. Therefore, the instructional packages geography based on ecosystem (PIGeoEk) could be implemented in enhancing students' knowledge about the concepts of the ecosystem in relation to students’ environmental behavior effectively.

scholarly journals Evaluation of The Effects of Different Remineralization agents on Initial Enamel Lesions by Scanning Electron Microscope and Energy-Distributed X-ray Analysis

2021 ◽  
Author(s):  
munevver kilic ◽  
Taskin Gürbüz
Keyword(s):  
Artificial Saliva ◽  
Water Soluble ◽  
Control Group ◽  
Edx Analysis ◽  
Demineralized Enamel ◽  
Calcium Magnesium ◽  
Casein Phosphopeptide ◽  
The Right ◽  
Tooth Mousse ◽  
One Way Anova

Aim: The present study compares the effectiveness of four different remineralization agents on the demineralized enamel of permanent human incisors. The purpose of this study is to evaluate the effectiveness of remineralization agents on the initial enamel lesion. Material- Methods: Crowns affected by demineralization were divided into two equal parts. The right halves of the teeth were subjected to no other processes after demineralization for control purposes and were kept in artificial saliva for the duration of the experiment. The left halves of the crowns were remineralized using a 5% NaF-containing fluoride varnish (GC MI Varnish GC Corp, Tokyo, Japan), a casein phosphopeptide and amorphous calcium toothpaste (GC Tooth Mousse, GC Corp, Tokyo, Japan), fluoride, hydroxyapatite, and xylitol, containing a water-soluble remineralization paste (Remin Pro™, Voco, Germany) and calcium, magnesium and phosphate-containing gel (Medical Remineralizing gel (R.O.C.S. Trading GmbH, Munich, Germany). After a 21-day remineralization process, and SEM/EDX analysis was performed, and a One Way Anova was used for statistical analysis. Results: According to EDX analysis, the R.O.C.S. medical remineralizing gel was found to have a lower Ca/P ratio than the other material groups (p =0.04). Remin Pro™, Voco, and the R.O.C.S. were higher than the control group in evaluating the Ca / P ratio (p=0.014), (p=0.025). Conclusions: The R.O.C.S group, treated with fluoride-free xylitol-containing, a remineralization agent, showed the lowest Ca/P ratio. Compared to demineralized halves of the teeth (control groups), Remin Pro™, Voco, and R.O.C.S. medical remineralizing gel may be considered as affecting on initial enamel lesions. Key Words: Remineralizing Agents, EDX, SEM, Enamel,

scholarly journals What Are the Effects of Short Video Storytelling in Delivering Blockchain-Credentialed Australian Beef Products to China?

Foods ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2403
Author(s):  
Shoufeng Cao ◽  
Marcus Foth ◽  
Warwick Powell ◽  
Jock McQueenie
Keyword(s):  
Supply Chain ◽  
Treatment Group ◽  
Online Survey ◽  
Consumer Perception ◽  
Control Group ◽  
Negative Effects ◽  
Chinese Consumers ◽  
Beef Products ◽  
Short Video ◽  
The Right

Short videos have become the most-liked medium for Chinese consumers to learn about a brand’s products or services. This paper assesses how short video storytelling shapes Chinese consumers’ perceptions towards blockchain-credentialed Australian beef and their willingness to pay (WTP). A controlled experiment with a one-minute short video was implemented in an online survey. Respondents in the treatment group watched the video before filling out the survey, whereas respondents in the control group did not. The paper analyses and compares the empirical results from local (n = 76) and foreign (n = 27) consumers. Results illustrate that the short video, as part of our food communications, positively shapes consumer perception towards meat quality, labelling and traceability trust of Australian beef but has only slight or even negative effects on WTP. This could be due to the short video offering consumers a sense of supply chain visibility but not delivering the right messages to meet their expectation of blockchain credentials. Furthermore, short video storytelling effects vary among consumers with different socio-economic characteristics. Our results posit that short video storytelling can be a useful tool in communicating blockchain-credentialed food products but require the design of a tailor-made storytelling experience for diverse consumers.

scholarly journals Gambaran Histopatologi Paru Mencit (Mus musculus) Setelah Pemaparan Paraquat

2018 ◽  
Vol 11 (2) ◽  
pp. 7
Author(s):  
Aulia Wiradi ◽  
Wiwit Ade Fidiawati ◽  
Sri Melati Munir
Keyword(s):  
Experimental Study ◽  
Treatment Group ◽  
Mus Musculus ◽  
Lung Fibrosis ◽  
Control Group ◽  
Post Test ◽  
Lung Histopathology ◽  
Post Hoc ◽  
One Way Anova

Paraquat destroys organs including lung. Purpose of this study was to determine the effect of paraquat on histopathologyof lung, exspecially fibrosis in mice (Mus musculus). This study was an experimental study with post-test only withcontrol design and using 15 mice as sample. Samples were divided into 5 groups consist of one control group and fourdifferent doses of paraquat treatment group (25 mg / kg / day, 50 mg / kg / day, 75 mg / kg / day and 100 mg / kg / day for7 days with spraying). Analysis of the data have used One-Way ANOVA then post-hoc test with tukey to assesseddifferences of each groups. The results showed increasing of lung fibrosis with increasing doses and have significantcorrelations (p = 0.000). In conclusion, there are significant changes in lung histopathology of mice (Mus musculus)after paraquat exposure for 7 days.

scholarly journals PENGARUH PELATIHAN SIDE JUMP SPRINT DAN SCISSOR JUMP TERHADAP DAYA LEDAK OTOT TUNGKAI PADA SISWA PUTRA PESERTA EKSTRAKURIKULER BOLAVOLI SMP NEGERI 3 ABIANSEMAL TAHUN PELAJARAN 2016/2017

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
I Gede Sunarba . ◽  
Dr. I Ketut Sudiana, S.Pd. M Kes . ◽  
Gede Doddy Tisna, M.S., S.Or., M.Or. .
Keyword(s):  
Treatment Group ◽  
Vertical Jump ◽  
Control Group ◽  
Limb Muscle ◽  
Sprint Training ◽  
Jump Training ◽  
Explosive Power ◽  
Significant Difference ◽  
And Control ◽  
One Way Anova

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan side jump sprint dan scissor jump terhadap peningkatan daya ledak otot tungkai. Jenis penelitian ini adalah eksperimen semu dengan rancangan the non-randomized control group pretest posttest design. Subjek penelitian adalah siswa putra peserta ektrakurikuler bolavoli SMP Negeri 3 Abiansemal tahun pelajaran 2016/2017 berjumlah 45 orang, kemudian dibagi menjadi 3 kelompok dengan menggunakan teknik ordinal pairing, yaitu 15 orang diberikan pelatihan side jump sprint, 15 orang diberikan pelatihan scissor jump, dan 15 orang kelompok kontrol. Daya ledak otot tungkai diukur dengan test vertical jump. Data yang di dapat dianalisis dengan uji F (one way anova) pada taraf signifikansi (α) = 0,05 dengan bantuan komputer program SPSS 16.0. Hasil analisis data dari kelompok perlakuan side jump sprint terjadi peningkatan daya leda kotot tungkai sebesar 0,097, pada kelompok perlakuaan scissor jump sebesar 0,136 dan pada kelompok control sebesar 0,116. Hasil one awy anova variable daya ledak otot tungkai antara kelompok perlakuan dan kelompok kontrol didapat Fhitung 67,628 dan signifikansi 0,000 yang berarti terdapat perbedaan pengaruh pelatihan side jump sprint dan scissor jump terhadap daya ledak otot tungkai. . Berdasarkan hasil uji least significant difference (LSD), kelompok pelatihan side jump sprint lebih baik pengaruhnya sebesar 44,733 dibandingkan pelatihan sciisor jump terhadap peningkatan daya ledak otot tungkai. Disimpulkan bahwa; (1) pelatihan side jump sprint dan scissor jump berpengaruh pada peningkatan daya ledak otot tungkai. (2) terdapat perbedaan pengaruh pelatihan side jump sprint dan scissor jump terhadap peningkatan daya ledak otot tungkai. (3) pelatihan side jump sprint lebih baik dari pada pelatihan scissor jump terhadap peningkatan daya ledakotot tungkai Kata Kunci : side jump sprint , scissor jump, daya ledak otot tungkai. This research aims to know the influence of side jump sprint and scissor jump towards the improvement the explosive power of limp muscle. This research is a quasi experiment with the non-randomized control group pretest post test design. The subjects were students of extracurricular participants of volley ball at SMP Negeri 3 Abiansemal academic year 2016/2017 amounted to 45 people, then divided into 3 groups using ordinal pairing technique, 15 people were given side jump sprint training, 15 people were given scissor jump training, and 15 People control group. Limb muscle explosive power is measured by a vertical jump test. The data can be analyzed by F (one way anova) test at significance level (α) = 0,05 with computer program of SPSS 16.0. The result of data analysis from side sprint treatment group happened increased limb muscle explosive power of 0.097, in scissor jump treatment group 0.136 and control group 0.116. The result of one way anova variable of explosive muscle limb power between treatment group and control group was obtained Fcount 67,628 and significance 0,000 which mean there is difference of influence of training of side jump sprint and scissor jump on explosive power of limb muscle. . Based on the least significant difference (LSD) test results, the side jump sprint training group had a better effect of 44.733 than the scissor jump training on increasing the muscle limb power. It was concluded that; (1) the training of side jump sprints and scissor jumps has an effect on increasing the muscle tone of the leg muscles. (2) there is a difference in the effect of training of side jump sprint and scissor jump on the increase of explosive power of limb muscle. (3) side jump sprint training is better than scissor jump training on increasing the limbs . keyword : side jump sprint, scissor jump, explosive muscle limb power.

scholarly journals POTENTIAL ETHANOL OF Carica papaya L. EXTRACT AS IMMUNOMODULATORY THROUGH HISTOLOGY OBSERVATION AT MICE BALB/C SPLEEN

2017 ◽  
Vol 13 (2) ◽  
pp. 205
Author(s):  
Sri Tasminatun ◽  
Ria Pravitasari ◽  
SN. Nurul Makiyah
Keyword(s):  
Treatment Group ◽  
Carica Papaya ◽  
Negative Control Group ◽  
Negative Control ◽  
The Body ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
One Way Anova

Abstract: The diameter of the alba pulp of the spleen will be enlarged, when the body responds to allergens by increasing the activity of the immune system. Papaya fruits (Carica papaya L.) containing flavonoid that can be as an immunomodulator. This study aims to determine the effect of C. papaya extract to the diameter size alba pulp of the spleen of Ovalbumin (OVA) induced Balb/C mice. The research design was experimental in vivo animal test with post-test only control group design. Thirty male Balb/C mice, ±20grams weight, 8 weeks old, divided into six groups consists of a normal control, negative control, Methylprednisolone, and C. papaya extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day). The extract and Methylprednisolone are given for 28 days, while OVA is given on 15thand 22ndday (intraperitoneal,) and 23rd until 28thday (peroral). On the 29thday the mice are sacrificed and the duodenum was made into histological preparation with HE staining. The immunomodulator effect is assessed by the average of the diameter size alba pulp of the spleen under a light microscope. The data were analyzed using SPSS15 with one way ANOVA continued with Tukey test. The average of the diameter size alba pulp of the spleen for control group is 10,165 ± 0,195; negative control group is 30,357 ± 0,826; methylprednisolone group is 10,220 ± 0,346; 175mg/kgbb dose extract is 14,956 ± 1,057; 350mg/kgbb dose extract is 14,030 ± 0,667; and 700mg/kgbb dose extract is 12,504 ± 0,729. The conclusion of this study is Carica papaya L. extract treatment group (175mg/kg, 350mg/kg and 700mg/kg dose per day) has an effect to the average of the diameter size alba pulp of the spleen in OVA-induced Balb/C mice significantly. 700mg/kg dose per day has the same effect with the methylprednisolone group. Keywords: immunomodulator, Carica papaya L., alba pulp of the spleen, ovalbumin

scholarly journals RANKL expressions in preservation of surgical tooh extraction treated with Moringa (Moringa oleifera) leaf extract and demineralized freeze-dried bovine bone xenograft

2018 ◽  
Vol 50 (3) ◽  
pp. 149
Author(s):  
S. Soekobagiono ◽  
Adrian Alfiandy ◽  
Agus Dahlan
Keyword(s):  
Treatment Group ◽  
Bone Resorption ◽  
Tooth Extraction ◽  
Leaf Extract ◽  
Control Group ◽  
Bovine Bone ◽  
Freeze Dried ◽  
Immunohistochemical Techniques ◽  
One Way Anova ◽  
Moringa Leaf Extract

Background: Preservation of sockets is a procedure aimed to reduce bone resorption after tooth extraction. One of the most commonly used xenograft materials is demineralized freeze-dried bone bovine xenograft (DFDBBX). Meanwhile, one of the key regulations in osteoclast genesis process is RANKL bond. A decrease in the number of RANKL expressions can suppress the osteoclast genesis process so that bone resorption can be prevented. The combination of Moringa leaf extract and DFDBBX, as a result, is expected to decrease the number of RANKL. Purpose: This study aimed to measure RANKL expressions in tooth extraction socket treated with Moringa leaf extract combined with DFDBBX. Methods: Fifty six Cavia cobaya rats were divided into eight groups. The first group was a control group with PEG administration onto their extraction sockets. The second group was a treatment group with DFDBBX administration. The third group was a treatment group with Moringa leaf extract administration. The fourth group was a treatment group induced with a combination of DFDBBX and Moringa leaf extract. Examination then was performed on days 7 and 30. After 7 and 30 days, those Cavia cobaya rats were executed and tested with immunohistochemical techniques. Further research data collected then were tested with one-way ANOVA. Results: There were significant differences between the control group and the groups induced with the combination of Moringa leaf extract and DFDBBX. On days 7 and 30, the groups induced with the combination of Moringa leaf extract and DFDBBX had the lowest number of RANKL expressions. Conclusion: The combination of Moringa leaf extract and DFDBBX can decrease the number of RANKL expressions in Cavia cobaya rats on the day 7 and day 30 after tooth extraction.

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