Hepatitis C virus (HCV) infection causes an acute, sometimes icteric, illness and is typically transmitted through contact with blood of an infected person. Roughly 75% of exposed individuals will develop a chronic infection, and 25% of cases will spontaneously resolve, although slightly lower rates of spontaneous clearance have been observed in people living with HIV. Symptoms of acute HCV are similar to other acute viral hepatidites, such as hepatitis A, B, or E, and include jaundice, scleral icterus, nausea, vomiting, fatigue, dark urine, and acholic stools. However, the majority of patients with acute HCV have few symptoms and do not present to medical care. Chronic infection with HCV can cause liver inflammation, scarring, and damage and can lead to cirrhosis, liver cancer, and death, as well as several extrahepatic manifestations. HCV is a curable infection, and therapies have improved significantly with the development of direct-acting antivirals, which can achieve cure rates of 95% and greater with courses of 2 to 3 months of oral therapy.