This paper aimed to assess the potential of using limestone dust to replace sand at levels of 0, 20, 40, 60, 80 and 100% by weight. Concrete mix design for cement : fine aggregate : coarse aggregate was 1: 2 : 4 and 0.40, 0.50, 0.60 water-to-cement ratios were used. The study started by testing the basic properties of the material. The compressive strength test was done with curing for 7, 14, 21 and 28 days and modulus of elasticity of concrete at 28 days, after which the microstructural properties of concrete modified with limestone dust were investigated. The study found that the concrete had better workability when increasing the limestone dust content. The incorporation of 40% limestone dust at 0.50 water-to-cement ratios was found to improve the compressive strength of the concrete and resulted in the maximum compressive strength. However, high levels of replacement lead to porous microstructures. Moreover, the use of limestone dust in concrete production tends to be more cost-effective. Therefore, the results of this research seemingly provide confirmation and support for the utilization of these waste materials by reducing the use of natural resources. Further, it is a goal of local governments to help promote the value of limestone dust for future use.