EVALUASI PENGGUNAAN OBAT PROTON PUMP INHIBITOR PADA PASIEN RAWAT JALAN DENGAN GANGGUAN LAMBUNG (GASTRITIS) DI RUMAH

Gastritis is an inflammatory process in the gastric mucosa and gastric mucosa. Gastritis is a state of inflammation or bleeding off the gastric mucosa that is acute, chronic, diffuse, or local. Gastritis or heartburn is an inflammation of the stomach wall, this disease is often found to arise suddenly which is usually characterized by nausea or vomiting, bleeding pain, weakness, decreased appetite or headache. The purpose of this study was to determine the PPI class of drugs most widely used by outpatients with gastric gastritis disorders. Knowing the factors that most often influence of gastric gastritis disorders.To find out the age most often affected by gastric gastritis. This research method used an observational method with the research design used was data collection carried out retrospectively, namely by tracing records at the outpatient installation of Imelda Hospital Medan from January 1 to December 31, 2019. The data obtained at the installation is descriptive and evaluate the use of PPIs with the treatment of gastritis aimed at improving the patient's quality of life, relieving complaints, curing gastritis, preventing recurrences and complications. Besed on the results of the study, the most outpatients with gastritis at the Imleda Hospital Medan were 15 women (17%), 6 men (29%), And the most commonlyused PPI drugs for gastritis patients were lansoprazole in 18 patients (86%), Omeprazole 3 patients (14%).

PENGARUH MINUMAN JAHE MERAH (ZINGIBER OFFCINALE ROSCOE VAR. RUBRUM) TERHADAP PENURUNAN SKALA NYERI DISMENOREA PRIMER PADA MAHASISWI DI PROGRAM STUDI S1 FARMASI UNIVERSITAS IMELDA MEDAN

Dysmenorrhoea is a gynecological complaint caused by an imbalance of the progesterone hormone in the blood, which causes pain and is most often characterized by menstrual cramps. A safe way to treat dysmenorrhoea is by boiling helbal, which is red ginger drink. The purpose of this study was to determine the effect of red ginger drink on reducing the scale of dysmenorrhoea pain on students at the University of Imelda Medan.This research method uses quantitative research with a descriptive design. The number of respondents in this study were 42 people using the sampling technique with the Slovin formula. The instrument used was a questionnaire with yes or no answer choices. The results of the study of 42 respondents, the majority who experienced pain or dysmenorrhoea, were 32 respondents with a percentage (92.9%). And the effect of red ginger drink on the dysmenorrhoea pain scale was 29 respondents with a percentage (69.0%). The effect of red ginger drink on the primary dysmenorrhoea pain scale is sufficient.

ANALISIS KETERAMPILAN PSIKOMOTORIK DALAM MENGGUNAKAN MIKROSKOP PADA MAHASISWA FARMASI

This study aims to analyze the psychomotor skills of Pharmacy students in using a microscope. This research is an observational study using a quantitative approach. The population in this study were all active students of Pharmacy of Imelda Medan University. Sampling was done by using simple random sampling technique. Data analysis was carried out by means of descriptive analysis, namely to get an overview of the distribution of research results for each variable categorically with descriptive percentages. The results showed that on average, UIM Pharmacy students were skilled in using a microscope. The highest percentage of the assessed aspects is in the aspect of turning on and off the microscope with a skilled presentation of 64.10%. While the lowest presentation is in the aspect of holding glass objects, with the percentage of unskilled at 25, 64% and less skilled at 28,21%.

KAJIAN ETNOBOTANI DAN BIOAKTIFITAS TUMBUHAN OBAT KABUPATEN TAPANULI UTARA

Traditional medicinal plants have the potential for health maintenance and alternative medicine as well as increasing the competitiveness of the national economy because Indonesia is one of the countries rich in biodiversity. This research was conducted in March-June 2021 in Tapanuli Regency, North Sumatra, 3 different villages that are part of the Parmonangan sub-district, namely, Aekraja Village, Hutatinggi Village, Sisordak Village. The objectives to be achieved are to find out how to use medicinal plants. The research method used includes selecting respondents for traditional healers, ethnobotanical surveys including field surveys, interviews and sampling of medicinal plants and preparing herbarium specimens. The results obtained were then analyzed descriptively by calculating the index values ​​of U, RFC and RI. Where the largest UV results are UV analysis, the Zingiber officinale value is found to have a value (the largest UV is 0.4), and the highest RFC use values ​​include: Zingiber Offiicinale (RFC 0.4), and the highest Relative Impotance values ​​include: Zingiber Offiicinale (RFC 0.67) then Based on the results of bioactivity observations; It can be seen that the use of Zingiber officinale contains glucan chemical and polygalacturonan with biactivity as an antitussive. This traditional utility is attempted to be linked to reports from previous scientific studies published electronically such as PubMed, Google Scholar, PubChem, and ScienceDirect

EFEK EKSTRAK TANAMAN ASHITABA PADA KADAR SERUM ALKALIN FOSFATASE (ALP) PADA TIKUS YANG TERPAPAR LUKA BAKAR

Serum alkaline phosphatase (ALP) levels increases in burn tissue damage. Several bioactive compounds found in Ashitaba, are expected to reduce serum ALP levels and enhance the process of wound healing. This study aims to prove that administration of oral Ashitaba extract can reduce serum ALP levels in rats exposed to burn trauma. This study uses true experimental post-test control group design with a total of 20 Sprague dawley rats as samples. All samples were inflicted with 2nd degree burn wound and divided into 2 groups, treatment group (Ashitaba extract 300 mg/KgBW) and control group. Blood serum were analyzed for ALP levels on the 2nd, 8th and 14th days. Kinetic-IFCC method was used to find serum ALP levels. Data was analyzed using Mann-Whitney Test, paired T-test amd independence T-test. Scalded wound size was measured macroscopically over the course of 21 days to find contracture rate. In conclusion, Ashitaba extract is not proven to significantly reduce the serum ALP levels, increase contracture rate and enhance burn wound healing process. However, there was slight increase in contracture rate in treatment group as compared to control group. In addition, there was a lower ALP levels in treatment group as compared to control group in day 8.

EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN LANJUT USIA DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

Hypertension is called the "silent killer" which is a risk factor for heart disease, stroke and kidney failure. High blood pressure that can not protect properly will increase the mortality and morbidity. Elderly patients aged ≥ 60 years, most of them already have hypertension and even have experienced the risk factors caused by hypertension. The goal of therapy is not to exacerbate organ damage and reduce mortality and improve patient quality so that evaluation is necessary, especially for the selection of antihypertensive drugs. This study aims to meet the suitability of the types of antihypertensive drugs given to elderly patients at the General Hospital of Imelda Pekerja Indonesia Medan with the standard of hypertension treatment. Research data collection was carried out in a retrospective manner in the period January-April 2020. Data were analyzed using the SPSS 21, JNC VIII (2016) method. There were 9 patients (28.1%), the use of antihypertensive drugs in elderly patients who did not comply with the standard recommendations for hypertension therapy and 23 patients (71.9%) who used antihypertensive drugs in accordance with JNC VIII standards.

ISOLASI DAN ELUSIDASI STRUKTUR SENYAWA DARI EKSTRAK BAWANG DAYAK SERTA UJI AKTIVITAS ANTIBAKTERINYA

Skrining aktivitas antibakteri dilakukan terhadap 10 spesies tanaman obat yang secara empiris telah digunakan dalam pengobatan tradisional di Indonesia, di antaranya umbi bawang dayak (Eleutherine bulbosa), herba ki tolod (Isotoma longiflora), buah ketepeng cina (Cassia alata), dan daun bluntas (Pluchea indica). Berdasarkan hasil skrining aktivitas antibakteri, ekstrak umbi bawang dayak (Eleutherine bulbosa) menunjukkan aktivitas antibakteri paling dominan terhadap Bacillus subtilis dan Staphylococcus aureus pada konsentrasi ekstrak 200 dan 100 μg/ml, serta terhadap Klebsiella pneumoniae pada konsentrasi ekstrak 200 μg/ml. Purifikasi dan isolasi senyawa serta uji aktivitas antibakteri dilakukan untuk mengetahui senyawa yang bertanggung jawab atas aktivitas antibakteri dari ekstrak bawang dayak. Dari hasil purifikasi dan isolasi senyawa menggunakan MPLC, kolom kromatografi, serta KLT preparatif, dihasilkan suatu senyawa isolat (4 mg). Senyawa tersebut dianalisis menggunakan LR-EIMS serta 1D-2D NMR, dan selanjutnya diidentifikasi sebagai Hongconin. Uji aktivitas antibakteri ekstrak bawang dayak dan senyawa isolat menunjukkan hasil ekstrak bawang dayak mempunyai aktivitas antibakteri yang tergolong moderat/sedang terhadap B. subtilis, S. aureus, dan K. pneumoniae, ditunjukkan dengan nilai KHM antara 100-200 μg/ml. Sementara itu, senyawa isolat (Hongconin) mempunyai aktivitas antibakteri yang tergolong lemah terhadap semua jenis bakteri patogen yang diujikan, ditunjukkan dengan nilai KHM >200 μM. Kata kunci: bawang dayak, antibakteri, isolasi, Hongconin

EVALUASI KEPATUHAN PASIEN ANAK PENDERITA DIARE TERHADAP PENGGUNAAN ANTIBIOTIK DI RUMAH SAKIT UMUM (RSU) KARYA BAKTI UJUNG BANDAR RANTAUPRAPAT

Diare merupakan salah satu penyebab kematian terbesar pada anak-anak di dunia.kebanyakan diare disebabkan oleh virus, bakteri,dan parasite. Dalam proses pengobatan penyakit diare pada anak dibutuhkan antibiotik. Penggunaan antibiotik yang tidak tepat dapat meningkatkan biaya obat dan efek samping antibiotik serta masalah kekebalan antimikrobial. Penelitian ini bertujuan untuk mengetahui evaluasi kepatuhan pasien anak penderita diare terhadap penggunaan antibiotik di Rumah Sakit Umum Karya Bakti Ujung Bandar Rantauprapat Tahun 2019.Penelitian ini bertujuan untuk mengetahui bagaimana penggunaan obat pada pasien diare pada anak berdasarkan tepat pasien, tepat indikasi, tepat obat dan tepat dosis di ruang rawat inap Rumah Sakit Umum Karya Bakti Ujung Bandar Rantauprapat.Penelitian ini menggunakan metode statistik dengan Pengumpulan data dilakukan secara retrospektif dari instalasi rekam medik pasien diare pada anak di instalasi rawat inap Rumah Sakit Umum Karya Bakti Ujung Bandar Rantauprapat Tahun 2019. Hasil penelitian ini, penelitian terhadap distribusi kerasionalan berdasarkan tepat pasien sebanyak 42 pasien di Rumah Sakir Umum Ujung Bandar Rantauprapat.

EVALUASI POLA PENGGUNAAN ANTIBIOTIK DENGAN BERBAGAI PENYAKIT DI RUMAH SAKIT UMUM IMELDA PEKERJA INDONESIA MEDAN

Penyakit infeksi merupakan masalah utama yang terjadi di negara berkembang disebabkan adanya mikroorganisme patogen pada tubuh manusia.Terapi antibiotik yang diberikan pada pasien rawat inap Rumah Sakit Umum Imelda Pekerja Indonesia Medan seperti golongan β-laktam, sefalosporin, makrolida, quinolon dan tiamphenicol. Penggunaan terapi antibiotik oral terbanyak pada tahun 2018 adalah amoxicillin dan levofloxacin. Penelitian ini bersifat observasional yang dilakukan secara retrospektif dan dianalisa dengan metode statistik deskriptif. Analisa dengan metode statistik hanya berhubungan dengan bagaimana menguraikan atau memberikan keterangan mengenai suatu data, keadaan, dan fenomena sehingga mudah dipahami. Pengolahan data menggunakan program SPSS 21. Hasil penelitian diperoleh antibiotik oral yang paling banyak digunakan adalah adalah cefadroxil 83 (18,5%) dan antibiotik sedikit INH 1 (0,2%).Penggunaan antibiotik oral pada pasien rawat inap di Rumah Sakit Umum Imelda Pekerja Indonesi tahun 2019 sudah sesuai dengan formularium Rumah Sakit.

EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN PENYAKIT DIABETES MELITUS TIPE II DI INSTALASI RAWAT INAP RSU KARYA BAKTI UJUNG BANDAR RANTAUPRAPAT

Diabetes Melitus Tipe-2 adalah penyakit yang ditandai dengan kadar glukosa darah yang mlenbihi normal atau hiperglikemia akibat tubuh kekurangan insulin. Diabetes melitus adalah kondisi seumur hidup yang merupakan salah satu penyebab utama kematian di dunia,dalam pengobatan penyakit diabetes melitus tipe-2 dibutuhkan antibiotik. Penggunaan antibiotik yang rasional sangat diperlukan untuk mengurangi terjadinya resistensi, tingkat keparahan penyakit,biaya pengobatan dan lama waktu perawatan bagi penderita penyakit diabetes melitus tipe -2. Penelitian ini bertujuan untuk mengetahui evaluasi kepatuhan pasien pada penderita diabetes melitus tipe-2 terhadap penggunaan antibiotik di Instalasi Rawat Inap Rumah Sakit Karya Bakti Ujung Bandar Rantauprapat Tahun 2019. Penelitian ini menggunakan metode deskriptif dengan pengumpulan data secara retrospektif, Pengumpulan data dilakukan secara retrospektif dari instalasi rekam medik pasien diabetes melitus di instalasi rawat inap Rumah Sakit Karya Bakti Ujung Bandar Rantauprapat Tahun 2019. Hasil penelitian terhadap distribusi kerasionalan berdasarkan tepat pasien sebanyak 50 pasien (100%). Tepat indikasi sebanyak 50 pasien (100%). Tepat obat sebanyak 70 resep (100%) dan tepat dosis sebanyak 100%