Ferulic acid in animal feeding: Mechanisms of action, productive benefits, and future perspectives in meat production

2021 ◽  
pp. 101247
Author(s):  
Karen Mariela Valadez-García ◽  
Leonel Avendaño-Reyes ◽  
César A. Meza-Herrera ◽  
Miguel Mellado ◽  
Raúl Díaz-Molina ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Mechanisms Of Action ◽  
Meat Production ◽  
Future Perspectives ◽  
Animal Feeding

scholarly journals The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1266
Author(s):  
Andreja Figurek ◽  
Merita Rroji ◽  
Goce Spasovski
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Current Knowledge ◽  
Fibroblast Growth Factor 23 ◽  
Mechanisms Of Action ◽  
Fibroblast Growth ◽  
Normal Kidney ◽  
Future Perspectives ◽  
Therapeutic Possibilities

Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.

scholarly journals Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis

2018 ◽  
Vol 2018 ◽  
pp. 1-19 ◽  
Author(s):  
Kyeong-Ah Kwak ◽  
Hyun-Jae Cho ◽  
Jin-Young Yang ◽  
Young-Seok Park
Keyword(s):  
Liver Cirrhosis ◽  
Stem Cell ◽  
Mechanisms Of Action ◽  
Clinical Applications ◽  
Hepatic Regeneration ◽  
Future Perspectives ◽  
Cell Type ◽  
Cell Based Therapy ◽  
Preclinical And Clinical Studies ◽  
Different Origins

Liver cirrhosis is a major cause of mortality and a common end of various progressive liver diseases. Since the effective treatment is currently limited to liver transplantation, stem cell-based therapy as an alternative has attracted interest due to promising results from preclinical and clinical studies. However, there is still much to be understood regarding the precise mechanisms of action. A number of stem cells from different origins have been employed for hepatic regeneration with different degrees of success. The present review presents a synopsis of stem cell research for the treatment of patients with liver cirrhosis according to the stem cell type. Clinical trials to date are summarized briefly. Finally, issues to be resolved and future perspectives are discussed with regard to clinical applications.

scholarly journals Bioactivities and Future Perspectives of Chaetoglobosins

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Jinhua Chen ◽  
Wenzhou Zhang ◽  
Qingfeng Guo ◽  
Weijiang Yu ◽  
Yongna Zhang ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Large Class ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Chaetomium Globosum ◽  
Future Perspectives ◽  
Anti Inflammatory ◽  
Anti Hiv ◽  
Fungal Secondary Metabolites

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

scholarly journals Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

2021 ◽  
Author(s):  
Celina Eugenio Bahule ◽  
Tamiris Natalice Santos Silva
Keyword(s):  
Production Cost ◽  
Strong Influence ◽  
Animal Species ◽  
Mechanisms Of Action ◽  
Feed Additives ◽  
Future Perspectives ◽  
Growth Promoters ◽  
Resistant Strains ◽  
Feed Costs ◽  
Broiler Feed

Feed additives have a strong influence on the production cost of broilers as growth-promoter’s to cover variations in profits due to fluctuation in feed costs. Antibiotics as additives were fundamental and indispensable, however, studies have shown their connection with the emergence of resistant strains of pathogens in animals and humans, therefore in recent years they have been less encouraged. Research is in progress concerning additives that can replace antibiotics as growth promotors and also as prophylactics. It was demonstrated that probiotics, which are living microorganisms and without residual effect’s have a potential to be used as microbials. However, they are not always guaranteed as growth promoters, as there are mechanisms of action regarding their interaction with the host that cannot yet be properly understood. The main advances in the use of probiotics in broilers in recent years, as well as the gaps, challenges, and future perspectives were carefully discussed and analyzed in this study. It was considered as a future premise, the possibility of reviewing the traditional methodologies used to test the hypotheses related to the effect of probiotics in broilers, which may also be extended to other animal species.

scholarly journals Immunotherapies for pediatric cancer: current landscape and future perspectives

2019 ◽  
Vol 38 (4) ◽  
pp. 573-594 ◽  
Author(s):  
Brian Hutzen ◽  
Siddhi Nath Paudel ◽  
Meisam Naeimi Kararoudi ◽  
Kevin A. Cassady ◽  
Dean A. Lee ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Drug Administration ◽  
Pediatric Cancer ◽  
Positive Impact ◽  
Mechanisms Of Action ◽  
Lessons Learned ◽  
Childhood Cancers ◽  
Future Perspectives ◽  
The Us ◽  
Near Future

AbstractThe advent of immunotherapy has revolutionized how we manage and treat cancer. While the majority of immunotherapy-related studies performed to date have focused on adult malignancies, a handful of these therapies have also recently found success within the pediatric space. In this review, we examine the immunotherapeutic agents that have achieved the approval of the US Food and Drug Administration for treating childhood cancers, highlighting their development, mechanisms of action, and the lessons learned from the seminal clinical trials that ultimately led to their approval. We also shine a spotlight on several emerging immunotherapeutic modalities that we believe are poised to have a positive impact on the treatment of pediatric malignancies in the near future.

scholarly journals Antimicrobial Activity of Oleanolic and Ursolic Acids: An Update

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Jéssica A. Jesus ◽  
João Henrique G. Lago ◽  
Márcia D. Laurenti ◽  
Eduardo S. Yamamoto ◽  
Luiz Felipe D. Passero
Keyword(s):  
Antimicrobial Activity ◽  
Animal Health ◽  
Mechanisms Of Action ◽  
Human Pathogens ◽  
Future Perspectives ◽  
Pharmacological Activities ◽  
Long Period ◽  
Wide Range ◽  
Potential Use

Triterpenoids are the most representative group of phytochemicals, as they comprise more than 20,000 recognized molecules. These compounds are biosynthesized in plants via squalene cyclization, a C30hydrocarbon that is considered to be the precursor of all steroids. Due to their low hydrophilicity, triterpenes were considered to be inactive for a long period of time; however, evidence regarding their wide range of pharmacological activities is emerging, and elegant studies have highlighted these activities. Several triterpenic skeletons have been described, including some that have presented with pentacyclic features, such as oleanolic and ursolic acids. These compounds have displayed incontestable biological activity, such as antibacterial, antiviral, and antiprotozoal effects, which were not included in a single review until now. Thus, the present review investigates the potential use of these triterpenes against human pathogens, including their mechanisms of action, viain vivostudies, and the future perspectives about the use of compounds for human or even animal health are also discussed.

Fecal Microbiota Transplantation: Present and Future Perspectives

2020 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Monica Ganan
Keyword(s):  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Mechanisms Of Action ◽  
Health Conditions ◽  
Future Perspectives ◽  
Microbial Dysbiosis ◽  
Recurrent Clostridium Difficile Infection ◽  
Promising Treatment ◽  
Underlying Mechanisms ◽  
Very High

Fecal Microbiota Transplantation (FMT) became a well-established clinical procedure and probably the most promising treatment option for recurrent Clostridium difficile infection (CDI). Beyond the treatment of CDI an increasing number of studies show that FMT also has the potential for managing various other disorders related to gut microbial dysbiosis, as well as for some extra-gut diseases. However, result variability in clinical practice is still very high. This is mainly due to the lack of consensus on the methodology of choice; as well as a limited understanding of what a healthy gut microbiome looks like, and a reduced knowledge regarding the underlying mechanisms of action of FMT for different health conditions.

scholarly journals Effects of some phenolic compounds on soybean seed germination and on seed-borne fungi

2003 ◽  
Vol 46 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Flávia Tavares Colpas ◽  
Elizabeth Orika Ono ◽  
João Domingos Rodrigues ◽  
José Raimundo de Souza Passos
Keyword(s):  
Phenolic Compounds ◽  
Seed Germination ◽  
Ferulic Acid ◽  
Soybean Seed ◽  
Mechanisms Of Action ◽  
Fungistatic Activity

Studies were carried out on the effects of coumarin, ferulic acid and naringenin on soybean seed germination and on the growth of seed-borne fungi at concentrations of 50 and 100 mg.L-1. The compounds showed good inhibition of seed germination, especially at 50 mg.L-1, but little fungistatic activity. Possible mechanisms of action are discussed.

scholarly journals Diverse Effects of Phytoestrogens on the Reproductive Performance: Cow as a Model

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Izabela Wocławek-Potocka ◽  
Chiara Mannelli ◽  
Dorota Boruszewska ◽  
Ilona Kowalczyk-Zieba ◽  
Tomasz Waśniewski ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Digestive Tract ◽  
Reproductive Performance ◽  
Biological Effects ◽  
Mechanisms Of Action ◽  
Polyphenolic Compounds ◽  
Common Source ◽  
Bone Meal ◽  
Animal Reproduction ◽  
Animal Feeding

Phytoestrogens, polyphenolic compounds derived from plants, are more and more common constituents of human and animal diets. In most of the cases, these chemicals are much less potent than endogenous estrogens but exert their biological effects via similar mechanisms of action. The most common source of phytoestrogen exposure to humans as well as ruminants is soybean-derived foods that are rich in the isoflavones genistein and daidzein being metabolized in the digestive tract to even more potent metabolites—para-ethyl-phenol and equol. Phytoestrogens have recently come into considerable interest due to the increasing information on their adverse effects in human and animal reproduction, increasing the number of people substituting animal proteins with plant-derived proteins. Finally, the soybean becomes the main source of protein in animal fodder because of an absolute prohibition of bone meal use for animal feeding in 1995 in Europe. The review describes how exposure of soybean-derived phytoestrogens can have adverse effects on reproductive performance in female adults.

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