scholarly journals Probiotics as a Promising Additive in Broiler Feed: Advances and Limitations

2021 ◽  
Author(s):  
Celina Eugenio Bahule ◽  
Tamiris Natalice Santos Silva
Keyword(s):  
Production Cost ◽  
Strong Influence ◽  
Animal Species ◽  
Mechanisms Of Action ◽  
Feed Additives ◽  
Future Perspectives ◽  
Growth Promoters ◽  
Resistant Strains ◽  
Feed Costs ◽  
Broiler Feed

Feed additives have a strong influence on the production cost of broilers as growth-promoter’s to cover variations in profits due to fluctuation in feed costs. Antibiotics as additives were fundamental and indispensable, however, studies have shown their connection with the emergence of resistant strains of pathogens in animals and humans, therefore in recent years they have been less encouraged. Research is in progress concerning additives that can replace antibiotics as growth promotors and also as prophylactics. It was demonstrated that probiotics, which are living microorganisms and without residual effect’s have a potential to be used as microbials. However, they are not always guaranteed as growth promoters, as there are mechanisms of action regarding their interaction with the host that cannot yet be properly understood. The main advances in the use of probiotics in broilers in recent years, as well as the gaps, challenges, and future perspectives were carefully discussed and analyzed in this study. It was considered as a future premise, the possibility of reviewing the traditional methodologies used to test the hypotheses related to the effect of probiotics in broilers, which may also be extended to other animal species.

scholarly journals Biological Evaluation of Some Plant Bioactives as Feed Additives to Replace Antibiotic Growth Promoters in Broiler Feeds

2020 ◽  
Vol 25 (2) ◽  
pp. 81
Author(s):  
Arnold Parlindungan Sinurat ◽  
Tiurma Pasaribu ◽  
Tresnawati Purwadaria ◽  
Tuti Haryati ◽  
Elizabeth Wina ◽  
...  
Keyword(s):  
Positive Control ◽  
Biological Evaluation ◽  
Negative Control ◽  
Feed Additives ◽  
Poultry Production ◽  
Growth Promoters ◽  
Antibiotic Growth Promoters ◽  
Dietary Treatments ◽  
Better Than ◽  
Broiler Feed

Antibiotics (AGP) have been used as feed additives to promote growth and feed efficiency in poultry production. However, many countries include Indonesia now ban the use of AGP and attempts are made to replace the antibiotic to maintain good performances of broilers. Plant bioactives is one of the alternatives that could replace the AGP. An experiment was conducted in an attempt to replace the AGP in broiler feed with a mixture of some plant bioactives<strong> </strong>(liquid smoke of cashew nutshell, <em>Phyllanthus niruri,</em> and clove leaves). Eight (8) dietary treatments were formulated to have similar nutrients consist of negative control (NC), positive control (NC+AGP), diets supplemented with liquid plant bioactives in 3 levels and diets supplemented with powder plant bioactives in 3 levels.  Each diet was fed to 6 replications of 10 birds each from 1 to 35 days old. The performances and the immune response of the broilers due to the treatments were observed. Results showed that the powder plant bioactives could not improve the performance of broilers. None of the feed additives (AGP or plant bioactives) affect the immune systems of the broilers. However,  liquid plant bioactives in low dose improved the performance of broilers better than the AGP and therefore is suitable to replace the antibiotic as feed additives in broiler diet.

scholarly journals https://www.anbarjvs.edu.iq/wp-content/uploads/2021/06/1.pdf

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Kifah Odhaib ◽  
Measem Alallawee ◽  
Zainab AL-Mousawi
Keyword(s):  
Animal Feed ◽  
Feed Additives ◽  
Commercial Application ◽  
Growth Promoters ◽  
Animal Product ◽  
Deterioration Process ◽  
Herbal Plants ◽  
Feed Costs ◽  
The Stability

The purpose of this review is to summarize the effectiveness, modes of action and commercial application of herbal plants and their derivatives as growth promoters for animal. As described in literature, the increase in the growth of farming prices and feed costs for small ruminant in general, led to increases difficulties in production of livestock. To dissolve this issue, several studies concentrated on new alternative of feed resource, but others have tried to enrich milk products and meat by rising polyphenol compounds content to their by introductions of herbal plants in sheep and goat feed. Currently, consumers demand safety and the quality of feeding. Since antibiotics can be leave residues in ruminant tissues, that could induce subsequent emergence of resistant strains of microorganisms capable of endangering the health of livestock and human. This scenario has given the impetus to explore alternatives to antibiotics in animal nutrition. Consequently, as replacement for the synthetic growth promoter’s antibiotics, natural products like herbs and spice as natural feed additives come to the attention to enhance physiological functions. So, the use of feeds containing bioactive compounds such as thymol, flavonoids, saponins, limonene, thymoquinone, essential oils and others which concentrated in different parts, such as leaves, roots and seeds that can be used for these purpose in animal feed and responsible for the healthy animal product. Furthermore, one of the hot points in the advanced research is the stability of animal product against the oxidative deterioration process that limits the shelf life.

scholarly journals Overview of Prebiotics and Probiotics: Focus on Performance, Gut Health and Immunity – A Review

2017 ◽  
Vol 17 (4) ◽  
pp. 949-966 ◽  
Author(s):  
Pratima Acharya Adhikari ◽  
Woo Kyun Kim
Keyword(s):  
Growth Performance ◽  
Bacterial Resistance ◽  
Intestinal Bacteria ◽  
Mechanisms Of Action ◽  
Feed Additives ◽  
Poultry Production ◽  
Gut Health ◽  
Growth Promoters ◽  
In Ovo ◽  
Poor Growth

AbstractDue to the threat and emergence of bacterial resistance against antibiotics, the use of in-feed antibiotics at therapeutic and subtherapeutic levels has been limited. Complete withdrawal of antibiotics as growth promoters (AGP) has led to poor gut health signs in chickens that include conditions like wet litter, intestinal bacteria overgrowth, poor growth performance, malabsorption and various diseases. Two of the most common alternatives to AGP are prebiotics and probiotics. Both prebiotics and probiotics have become the potential feed additives that improve the gut health, immune system and microbiota by various mechanisms of action, and enhance growth performance of chickens. The review discusses the modes of action like antibacterial, competitive exclusion (CE), and immunomodulatory properties of prebiotics and probiotics, particularly in poultry.In ovofeeding of prebiotics and probiotics with promising effect on growth performance and reduction of pathogens likeSalmonellais also discussed in this review. However, it is necessary to conduct more research with prebiotics and probiotics as well as other feed additives to understand the detailed mechanisms of action and identify better alternatives for poultry production and health.

The effects and mechanisms of acids on the health of piglets and weaners – a review

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Piotr Nowak ◽  
Anita Zaworska-Zakrzewska ◽  
Andrzej Frankiewicz ◽  
Małgorzata Kasprowicz-Potocka
Keyword(s):  
Digestive System ◽  
Buffer Capacity ◽  
Growth Parameters ◽  
Feed Additives ◽  
Feed Additive ◽  
Growth Promoters ◽  
Qualitative And Quantitative ◽  
Inorganic Acids ◽  
Low Activity ◽  
The Eu

AbstractThe rearing of piglets is the most difficult period in the pigs’ production because of their poorly developed digestive system and the low activity of digestive enzymes. Problems in nutrition and stress cause some disorders in the functioning of the digestive system leading to diarrhea and the mortality of piglets. Starting in 2006 in the EU, a total ban on antibiotics in their use as growth promoters was introduced. Since then, new and safe feed additives have been sought in order to replace antibiotics. Organic and inorganic acids as well as their salts were recognized as effective and safe additives. Due to their properties, they can improve feed palatability and digestibility, reduce the buffer capacity of feed, impact the development and functioning of the pig’s digestive system and improve the health and growth parameters. However, the effectiveness of acids is related to their qualitative and quantitative share in the feed additive. In this review, some strategies for using organic acids, their mixtures and also some new multi-component products will be discussed.

Antimicrobial Peptides and their Multiple Effects at Sub-Inhibitory Concentrations

2020 ◽  
Vol 20 (14) ◽  
pp. 1264-1273 ◽  
Author(s):  
Bruno Casciaro ◽  
Floriana Cappiello ◽  
Walter Verrusio ◽  
Mauro Cacciafesta ◽  
Maria Luisa Mangoni
Keyword(s):  
Antimicrobial Peptides ◽  
Inhibitory Concentration ◽  
Multidrug Resistant ◽  
Mechanisms Of Action ◽  
New Drugs ◽  
Lead Compounds ◽  
Bacterial Pathogenicity ◽  
Growth Inhibitory ◽  
Resistant Strains ◽  
Conventional Antibiotics

The frequent occurrence of multidrug-resistant strains to conventional antimicrobials has led to a clear decline in antibiotic therapies. Therefore, new molecules with different mechanisms of action are extremely necessary. Due to their unique properties, antimicrobial peptides (AMPs) represent a valid alternative to conventional antibiotics and many of them have been characterized for their activity and cytotoxicity. However, the effects that these peptides cause at concentrations below the minimum growth inhibitory concentration (MIC) have yet to be fully analyzed along with the underlying molecular mechanism. In this mini-review, the ability of AMPs to synergize with different antibiotic classes or different natural compounds is examined. Furthermore, data on microbial resistance induction are reported to highlight the importance of antibiotic resistance in the fight against infections. Finally, the effects that sub-MIC levels of AMPs can have on the bacterial pathogenicity are summarized while showing how signaling pathways can be valid therapeutic targets for the treatment of infectious diseases. All these aspects support the high potential of AMPs as lead compounds for the development of new drugs with antibacterial and immunomodulatory activities.

scholarly journals Honeybee and Plant Products as Natural Antimicrobials in Enhancement of Poultry Health and Production

2021 ◽  
Vol 13 (15) ◽  
pp. 8467
Author(s):  
Erinda Lika ◽  
Marija Kostić ◽  
Sunčica Vještica ◽  
Ivan Milojević ◽  
Nikola Puvača
Keyword(s):  
Egg Production ◽  
Egg Quality ◽  
Semen Quality ◽  
Biological Activities ◽  
Feed Additives ◽  
Poultry Production ◽  
Growth Promoters ◽  
Safe Alternative ◽  
Botanical Products ◽  
Poultry Diets

The quality and safety attributes of poultry products have attracted increasing widespread attention and interest from scholarly groups and the general population. As natural and safe alternatives to synthetic and artificial chemical drugs (e.g., antibiotics), botanical products are recently being used in poultry farms more than 60% of the time for producing organic products. Medicinal plants, and honeybee products, are natural substances, and they were added to poultry diets in a small amount (between 1% and 3%) as a source of nutrition and to provide health benefits for poultry. In addition, they have several biological functions in the poultry body and may help to enhance their welfare. These supplements can increase the bodyweight of broilers and the egg production of laying hens by approximately 7% and 10% and enhance meat and egg quality by more than 25%. Moreover, they can improve rooster semen quality by an average of 20%. Previous research on the main biological activities performed by biotics has shown that most research only concentrated on the notion of using botanical products as growth promoters, anti-inflammatory, and antibacterial agents. In the current review, the critical effects and functions of bee products and botanicals are explored as natural and safe alternative feed additives in poultry production, such as antioxidants, sexual-stimulants, immuno-stimulants, and for producing healthy products.

scholarly journals A Review of the Effects and Production of Spore-Forming Probiotics for Poultry

Animals ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1941
Author(s):  
Igor V. Popov ◽  
Ammar Algburi ◽  
Evgeniya V. Prazdnova ◽  
Maria S. Mazanko ◽  
Vladimir Elisashvili ◽  
...  
Keyword(s):  
Health Promotion ◽  
One Health ◽  
Mechanisms Of Action ◽  
Human Medicine ◽  
Poultry Industry ◽  
Growth Promoters ◽  
Wide Range ◽  
Antibiotic Growth Promoters ◽  
Spore Forming Bacteria ◽  
Unique Ability

One of the main problems in the poultry industry is the search for a viable replacement for antibiotic growth promoters. This issue requires a “one health” approach because the uncontrolled use of antibiotics in poultry can lead to the development of antimicrobial resistance, which is a concern not only in animals, but for humans as well. One of the promising ways to overcome this challenge is found in probiotics due to their wide range of features and mechanisms of action for health promotion. Moreover, spore-forming probiotics are suitable for use in the poultry industry because of their unique ability, encapsulation, granting them protection from the harshest conditions and resulting in improved availability for hosts’ organisms. This review summarizes the information on gastrointestinal tract microbiota of poultry and their interaction with commensal and probiotic spore-forming bacteria. One of the most important topics of this review is the absence of uniformity in spore-forming probiotic trials in poultry. In our opinion, this problem can be solved by the creation of standards and checklists for these kinds of trials such as those used for pre-clinical and clinical trials in human medicine. Last but not least, this review covers problems and challenges related to spore-forming probiotic manufacturing.

scholarly journals The Complexity of FGF23 Effects on Cardiomyocytes in Normal and Uremic Milieu

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1266
Author(s):  
Andreja Figurek ◽  
Merita Rroji ◽  
Goce Spasovski
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Current Knowledge ◽  
Fibroblast Growth Factor 23 ◽  
Mechanisms Of Action ◽  
Fibroblast Growth ◽  
Normal Kidney ◽  
Future Perspectives ◽  
Therapeutic Possibilities

Fibroblast growth factor-23 (FGF23) appears to be one of the most promising biomarkers and predictors of cardiovascular risk in patients with heart disease and normal kidney function, but moreover in those with chronic kidney disease (CKD). This review summarizes the current knowledge of FGF23 mechanisms of action in the myocardium in the physiological and pathophysiological state of CKD, as well as its cross-talk to other important signaling pathways in cardiomyocytes. In this regard, current therapeutic possibilities and future perspectives are also discussed.

scholarly journals Role of probiotics in nutrition and health of small ruminants

2016 ◽  
Vol 19 (4) ◽  
pp. 893-906 ◽  
Author(s):  
M.M. Abd El-Tawab ◽  
I.M.I. Youssef ◽  
H.A. Bakr ◽  
G.C. Fthenakis ◽  
N.D. Giadinis
Keyword(s):  
Volatile Fatty Acids ◽  
Animal Health ◽  
Small Ruminants ◽  
Nutrient Digestibility ◽  
Feed Additives ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Livestock Farming ◽  
Main Component ◽  
Research On Application

AbstractSmall ruminants represent an important economic source in small farm systems and agriculture. Feed is the main component of livestock farming, which has gained special attention to improve animal performance. Many studies have been done to improve feed utilisation through addition of feed additives. For a long period, antibiotics have been widely used as growth promoters in livestock diets. Due to their ban in many countries, search for alternative feed additives has been intensified. Probiotics are one of these alternatives recognised to be safe to the animals. Use of probiotics in small ruminant nutrition has been confirmed to improve animal health, productivity and immunity. Probiotics improved growth performance through enhancing of rumen microbial ecosystem, nutrient digestibility and feed conversion rate. Moreover, probiotics have been reported to stabilise rumen pH, increase volatile fatty acids production and to stimulate lactic acid utilising protozoa, resulting in a highly efficient rumen function. Furthermore, use of probiotics has been found to increase milk production and can reduce incidence of neonatal diarrhea and mortality. However, actual mechanisms through which probiotics exert these functions are not known. Since research on application of probiotics in small ruminants is scarce, the present review attempts to discuss the potential roles of this class of feed additives on productive performance and health status of these animals.

Ferulic acid in animal feeding: Mechanisms of action, productive benefits, and future perspectives in meat production

2021 ◽  
pp. 101247
Author(s):  
Karen Mariela Valadez-García ◽  
Leonel Avendaño-Reyes ◽  
César A. Meza-Herrera ◽  
Miguel Mellado ◽  
Raúl Díaz-Molina ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Mechanisms Of Action ◽  
Meat Production ◽  
Future Perspectives ◽  
Animal Feeding
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