Seroprevalence of hepatitis A in Iranian adolescents: is it time to introduce a vaccine?

2015 ◽  
Vol 144 (2) ◽  
pp. 291-296 ◽  
Author(s):  
S. G. HOSEINI ◽  
R. KELISHADI ◽  
B. ATAEI ◽  
M. YARAN ◽  
M. E. MOTLAGH ◽  
...  
Keyword(s):  
Rural Areas ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Seroconversion Rate ◽  
Cost Effective ◽  
Serum Samples ◽  
Symptomatic Disease ◽  
Adolescent Students ◽  
Significant Difference ◽  
Nationally Representative

SUMMARYUniversal vaccination of children for hepatitis A virus (HAV) has emerged as a cost-effective strategy to prevent this infection in regions with high incidence of symptomatic disease. Age-specific seroprevalence surveys are practical and reliable methods to estimate the rate of susceptibility in populations, and to help the implementation of vaccination policies. We surveyed the age-specific HAV seroprevalence in a nationally representative sample of Iranian adolescent students aged 10–18 years. Serum samples (n = 2494) were tested by enzyme immunoassay for total anti-HAV antibody. The overall rate of HAV seropositivity was 64% [95% confidence interval (CI), 62–66), which increased sharply from 14·8% (95% CI 7–23) at age 10 years to 72·9% (95% CI 68–78) at age 13 years, without a significant increase up to age 18 years. No significant difference in HAV seroprevalence was observed between males and females (63% vs. 65·1%), or urban and rural areas (63·4% vs. 65·2%); the seropositivity rate was similar in four different socioeconomic regions of Iran. We conclude that the seroconversion rate of HAV is high in Iranian adolescents and therefore mass vaccination of children may be necessary and should be considered by national health authorities.

scholarly journals Status of Immunity Against the Hepatitis A Virus in Healthy Population: A Report From Southeastern Iran

2021 ◽  
Vol 16 (4) ◽  
Author(s):  
Alireza Bakhshipour ◽  
Narjes Sargolzaie ◽  
Raheleh Rafaiee
Keyword(s):  
General Population ◽  
Rural Areas ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Enzyme Linked Immunosorbent Assay ◽  
Published Data ◽  
Healthy Population ◽  
Serum Samples ◽  
Igg Antibody ◽  
Urban And Rural Areas

Background: Recently, epidemiological studies on hepatitis A virus (HAV) infection showed the seroprevalence has been changing due to changes in lifestyle. To the best of our knowledge, there have been no published data on the seropositivity of HAV in Zahedan, southeastern Iran. Objectives: This study aimed to investigate the seroprevalence of HAV immunoglobulin G (IgG) antibody in Zahedan, southeastern Iran, to provide the required information for better planning in preventive strategies. Methods: In this cross-sectional study, using the available sampling method, a total of 250 serum samples (18 years and above) in both the urban and rural areas of Zahedan were evaluated for anti-HAV IgG by enzyme-linked immunosorbent assay. Results: Based on the results, it was observed that 228 out of 250 (91.2%) serum samples were positive for HAV IgG antibody. Male gender, family size, parents’ education, mother’s occupation, and history of jaundice before the age of 12 years were associated with positive HAV antibody (P < 0.001). The seroprevalence HAV rates were not statistically different between the residents of urban and rural regions. Conclusions: The seropositivity of HAV is high in both the urban and rural areas of Zahedan, Iran. Therefore, the HAV vaccination of the general population is not necessary. It is recommended to monitor HAV seroprevalence in the general population to determine high-risk groups, including anti-HAV seronegative individuals, for HAV vaccination in the residents of the southeast border.

scholarly journals Potentially Infectious Novel Hepatitis A Virus Strains Detected in Selected Treated Wastewater Discharge Sources, South Africa

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1468
Author(s):  
Saïd Rachida ◽  
Maureen Beatrice Taylor
Keyword(s):  
South Africa ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Wastewater Treatment Plants ◽  
Treated Wastewater ◽  
Wastewater Discharge ◽  
Public Health Importance ◽  
Symptomatic Disease ◽  
Before And After ◽  
Amino Acid Mutations

Hepatitis A virus (HAV) is a waterborne pathogen of public health importance. In South Africa (SA), unique HAV subgenotype IB strains have been detected in surface and wastewater samples, as well as on fresh produce at the point of retail. However, due to the use of molecular-based assays, the infectivity of the detected strains was unknown. Considering the potential shift of HAV endemicity from high to intermediate, which could increase the risk of severe symptomatic disease, this study investigated the identity of HAV strains detected before and after viability treatment of selected wastewater discharge samples. For one year, 118 samples consisting of sewage, treated wastewater discharge and downstream dam water were collected from five wastewater treatment plants (WWTP 1, 2, 3, 4 and 5). Unique HAV IB strains were detected in samples from all five WWTPs, with 11 of these strains carrying amino acid mutations at the immunodominant and neutralisation epitopes. A quasispecies dynamic of HAV has also been detected in sewage samples. The subsequent application of viability PCR revealed that potentially infectious HAV strains were discharged from WWTP 1, 2, 4 and 5 into the dam. Therefore, there is a potential risk of HAV exposure to communities using water sources downstream the WWTPs.

scholarly journals Exposure to enteroviruses and hepatitis A virus among divers in environmental waters in France, first biological and serological survey of a controlled cohort

1994 ◽  
Vol 113 (3) ◽  
pp. 541-549 ◽  
Author(s):  
D. Garin ◽  
F. Fuchs ◽  
J. M. Crance ◽  
Y. Rouby ◽  
J. C. Chapalain ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Training School ◽  
Environmental Waters ◽  
Viral Isolation ◽  
Viral Contamination ◽  
Coxsackievirus B4 ◽  
Concentration Technique ◽  
Significant Difference ◽  
Stool Specimens

SUMMARYAn epidemiological study of hepatitis A and enteroviruses was conducted in a military diving training school, by evaluating the viral contamination of water using an ultrafiltration concentration technique, and assessing seroconversion and the presence of virus in stool specimens obtained from 109 divers and 48 controls. Three of 29 water specimens were positive for enterovirus by cell culture and 9 by molecular hybridization. There was little or no risk of virus infection during the training course (49 h exposure) because there was no significant difference between divers and controls for both viral isolation and seroconversion. However, a higher percentage of coxsackievirus B4 and B5 seropositive divers suggests that these were more exposed during previous water training. No hepatitis A virus (HAV) detection and no seroconversion to HAV was observed. The rate of HAV seropositive subjects was 17% in this 24·5-year-old population

scholarly journals Prevalensi obesitas dan hubungan konsumsi fast food dengan kejadian obesitas pada remaja SLTP kota dan desa di Daerah Istimewa Yogyakarta

2004 ◽  
Vol 1 (2) ◽  
pp. 69
Author(s):  
Mahdiah Mahdiah ◽  
Hamam Hadi ◽  
Susetyowati Susetyowati
Keyword(s):  
High School ◽  
Food Consumption ◽  
Junior High School ◽  
Rural Areas ◽  
Fast Food ◽  
Junior High ◽  
Adolescent Students ◽  
Fast Food Consumption ◽  
Significant Difference ◽  
Prevalence Of Obesity

Background: The improvement in socioeconomic status has led to sedentary life style and more fast food consumption. Whether fast food consumption contributes to obesity in Indonesian adolescents remains unclear.Objective: The study was conducted to estimate the prevalence of obesity and to assess the association between fast food consumption and obesity in junior high school students.Methods: A cross-sectional survey was conducted in 2003 to estimate the prevalence of obesity in adolescent students of Yogyakarta Special Province. Subjects of this survey were junior high school students from urban (n= 4747) and rural areas (n=4602) were included in this survey. To further analyze the association between food consumption and obesity, a sample of 140 obese (of 460 obese students) and 140 non obese students (of 8889 non obese students) was randomly selected. Data on fast food consumption were collected using Food Frequency Questionnaire (FFQ) method from the selected obese and non-obese sample.Results: The prevalence of obesity among adolescent students was 7.9% in urban and 2% in rural areas. There was a significant difference in variety, quantity, and frequency of fast food consumption per month and hereby energy intake from fast food between obese and non-obese adolescent students (p<0.05).Conclusions: The prevalence of obesity in urban area was much higher than that in rural area. Obese students consumed fast food more frequently and more variably than non-obese students.

scholarly journals Difference in seroprevalence of IgG antibodies against hepatitis A virus on general population in 1998 and 2019 in Iwate Prefecture, Japan

2020 ◽  
Author(s):  
Akio Miyasaka ◽  
Yuichi Yoshida ◽  
Akiko Suzuki ◽  
Yasuhiro Takikawa
Keyword(s):  
General Population ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Action Plan ◽  
Age Group ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Chemiluminescent Immunoassay ◽  
General Populations ◽  
Iwate Prefecture

Abstract Background: Hepatitis A virus (HAV) infection, a sporadically occurring disease in general populations, is a major cause of acute hepatitis, but rarely causes death. It is important to know the current situation regarding this infection rate among the general population so that an effective strategy and action plan for HAV vaccination or treatment can be established. Here, we investigated the seroprevalence of IgG antibodies against HAV (anti-HAV) in Iwate Prefecture, Japan, in 1998 and 2019, and compared the seroprevalence patterns over these past two decades. Methods: Altogether, 777 randomly selected serum samples were obtained from health check-up residents in Iwate prefecture in 1998 and 2019. Serum anti-HAV IgG levels were measured by radioimmunoassay (in 1998) and chemiluminescent immunoassay (in 2019). Results: Altogether, 586 serum samples (278 from males, 308 from females; mean age 53 years; range 30–89 years) and 191 serum samples (96 from males, 95 from females; mean age 54 years; range 30–89 years) from 1998 and 2019 were tested, respectively. The overall anti-HAV IgG prevalence in 2019 [16.8% (95% confidence interval, CI; 1.8–22.8%)] was significantly lower than that in 1998 [47.8% (95% CI 43.7–51.9%)] (p<0.001). Subgroup analysis of each age group showed that the anti-HAV IgG prevalence tended to be low in the young, increased with age, and each age group’s prevalence became older across the two decades. The anti-HAV IgG prevalence for those older than 50 years in 2019 [28.1% (95% CI 11.8–22.8%)] was significantly lower than that in 1998 [75.6% (95% CI 43.7–51.9%)] (p<0.001). Conclusions: A shift toward older across in anti-HA IgG prevalence was observed from 1998 to 2019, revealing that the younger population lacks immunity to HAV. Thus, selective HAV vaccination might be necessary for prevent severe HAV infection.

scholarly journals Viral Superinfection in Previously Unrecognized Chronic Carriers of Hepatitis B Virus with Superimposed Acute Fulminant versus Nonfulminant Hepatitis

1999 ◽  
Vol 37 (1) ◽  
pp. 235-237 ◽  
Author(s):  
Chia-Ming Chu ◽  
Chau-Ting Yeh ◽  
Yun-Fan Liaw
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hepatitis B Surface Antigen ◽  
Significant Difference ◽  
B Virus ◽  
Hdv Infection

The role of viral superinfection in hepatitis B surface antigen carriers with superimposed fulminant (n = 60) versus nonfulminant (n = 90) acute hepatitis was studied. The frequency of hepatitis A virus (HAV) (0 versus 2.2%), HCV (18.3 versus 21.1%), HDV (15.0 versus 7.8%), and HEV (1.7 versus 4.4%) infection showed no significant difference, while simultaneous HCV and HDV infection was significantly more prevalent in the former (8.3 versus 0%). Only 3.6% of fulminant cases and 3.3% of nonfulminant controls were HGV RNA positive.

scholarly journals Spatial Analysis of HIV Infection and Associated Risk Factors in Botswana

2021 ◽  
Vol 18 (7) ◽  
pp. 3424
Author(s):  
Malebogo Solomon ◽  
Luis Furuya-Kanamori ◽  
Kinley Wangdi
Keyword(s):  
Risk Factors ◽  
Hiv Infection ◽  
Rural Areas ◽  
Tertiary Education ◽  
Cost Effective ◽  
Female Gender ◽  
Hiv Prevalence ◽  
Scan Statistics ◽  
Nationally Representative ◽  
Associated Risk Factors

Botswana has the third highest human immunodeficiency virus (HIV) prevalence globally, and the severity of the epidemic within the country varies considerably between the districts. This study aimed to identify clusters of HIV and associated factors among adults in Botswana. Data from the Botswana Acquired Immunodeficiency Syndrome (AIDS) Impact Survey IV (BIAS IV), a nationally representative household-based survey, were used for this study. Multivariable logistic regression and Kulldorf’s scan statistics were used to identify the risk factors and HIV clusters. Socio-demographic characteristics were compared within and outside the clusters. HIV prevalence among the study participants was 25.1% (95% CI 23.3–26.4). HIV infection was significantly higher among the female gender, those older than 24 years and those reporting the use of condoms, while tertiary education had a protective effect. Two significant HIV clusters were identified, one located between Selibe-Phikwe and Francistown and another in the Central Mahalapye district. Clusters had higher levels of unemployment, less people with tertiary education and more people residing in rural areas compared to regions outside the clusters. Our study identified high-risk populations and regions with a high burden of HIV infection in Botswana. This calls for focused innovative and cost-effective HIV interventions on these vulnerable populations and regions to curb the HIV epidemic in Botswana.

scholarly journals Anti-Hepatitis A Virus Immunoglobulin M Antibodies in Urine Samples for Rapid Diagnosis of Outbreaks

2003 ◽  
Vol 10 (3) ◽  
pp. 492-494 ◽  
Author(s):  
Licel de los Angeles Rodríguez Lay ◽  
Osmany Larralde Díaz ◽  
Raiza Martínez Casanueva ◽  
Aidonis Gutiérrez Moreno
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Rapid Diagnosis ◽  
Immunoglobulin M ◽  
Urine Samples ◽  
Test Results ◽  
Serum Samples ◽  
Igm Antibodies ◽  
Urine And Serum

ABSTRACT The main goal of this study was to test the feasibility of using urine for diagnosing hepatitis A virus (HAV) infections. A correlation of 90.78% between the test results of urine and serum samples was obtained. Four outbreaks of hepatitis A were confirmed by testing only urine samples. The levels of anti-HAV immunoglobulin M (IgM) antibodies in urine samples remained stable during 6 months of storage at −70°C but decreased when the samples were stored at 4°C. The results of tests of samples obtained 2 and 6 months after infection suggested that IgM levels decline more rapidly in urine than in serum.

scholarly journals Serological markers for hepatitis a among captive and free-living wild mammals in the State of Pará, Brazil

2021 ◽  
Vol 42 (3Supl1) ◽  
pp. 1635-1646
Author(s):  
Marcella Katheryne Marques Bernal ◽  
◽  
Alex Júnior Souza de Souza ◽  
Heloisa Marceliano Nunes ◽  
Andreza Pinheiro Malheiros ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Animal Health ◽  
The State ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serum Samples ◽  
Free Living ◽  
Wild Mammals ◽  
Basic Sanitation ◽  
The Impact

The hepatitis A virus (HAV, Hepatovirus A) in humans has a relevant impact on public health, especially in geographic regions with poor basic sanitation, such as the Brazilian Amazon. Isolates related to hepatoviruses have been described in non human primates, chiropterans, marsupials, rodents, marmots, shrews, and terrestrial hedgehogs. However, the circulation of these viruses in the Amazonian mammal fauna remains unexplored. This study aimed to evaluate the prevalence of antibodies against this hepatovirus in captive and free-living wild mammals belonging to the orders Didelphimorphia, Primates, Carnivora, and Artiodactyla. Serum samples from 71 animals, from three municipalities in the State of Pará (Belém, Santarém, and Capitão-Poço) were tested for total anti-HAV and anti-HAV IgM through enzyme-linked immunosorbent assay (ELISA). Total anti-HAV antibodies were detected in 29.5% (21/71) of non-human primates, 8.4% (6/71) of carnivores, and 5.6% (4/71) of didelphos. All tayassuidos 0% (0/2) were seronegative. Anti-HAV IgM antibodies were not detected in any of the samples tested. The highest total anti-HAV seropositivity in the municipalities studied was in Santarém with 54.24% (12/22), followed by Capitão Poço with 50% (15/30), and then Belém with 21.05% (4/19). Among the seropositive animals, animals kept in exposure cages showed 43.9% (18/41), quarantined animals with 60% (9/15), and free-living animals with 26.6% (4/15). The serological results indicated a profile of previous exposure to hepatovirus among these animals. Therefore, additional studies to characterize HAV-related viruses in captive and free living wild animals need to be conducted to better understand the impact of the circulation of this virus on human and animal health.

scholarly journals Serosurvey of hepatitis A virus and E virus infection among municipal sweepers working in the largest city in the south of Iran

2021 ◽  
Author(s):  
Jamal Sarvari ◽  
Seyed Younes Hosseini ◽  
Negar Joharinia ◽  
Seyed Ali Hosseini ◽  
Saeed Firoozi Ghahestani ◽  
...  
Keyword(s):  
Work Experience ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Normal Population ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Personal Hygiene ◽  
The South ◽  
Cross Sectional ◽  
Significant Difference

Abstract Background Given the importance of Hepatitis A (HAV) and Hepatitis E (HEV) infection in careers like street sweeping, this study was conducted to determine the exposure rate in urban solid waste collectors/sweepers in the south of Iran. Materials and methods In this cross-sectional study, the sera samples of 385 waste collectors/sweepers from all districts of Shiraz, southern Iran, were collected. A questionnaire was used to gather data on their demographic and occupational characteristics, as well as their awareness of viral hepatitis disease. The rate of HAV and HEV sero-prevalence was determined by commercial ELISA kits. Results All partisans were male with a mean age of 41 ± 8 years. ELISA assay showed that all of participants were positive for anti-HAV Ab. Moreover, 62out of 385 (16.1%) subjects were positive for anti-HEV IgG Ab. Also, statistical analysis showed that the frequency of IgG Ab against HEV among the age group of 20–30, 31–40, 41–50 and over 50 years old was 4.5%, 10.1%, 17.4%, and 36.7% that was statistically significant (P < 0.001). Based on the work experience, current and previous jobs, residency, personal hygiene and knowledge status of hepatitis disease and transmission, the results showed that there was no statistically significant difference between anti-HEV positive and negative sweepers (p˃0.05). Conclusion Our results indicated that the frequency of anti-HAV and HEV IgG among sweepers is slightly higher than the normal population; it does not seem that garbage collecting/sweeping career could be a significant risk factor for HAV and HEV infection.

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