Relationship Between Self-Reported Concomitant Depressive and Anxiety Symptoms and the Post-Concussion Symptoms Scale (PCSS)

ABSTRACT Objectives: The current study explored how affective disturbances, particularly concomitant anxiety and depressive symptoms, impact baseline symptom self-reporting on the Post-Concussion Symptoms Scale (PCSS) in college athletes. Methods: Athletes were separated into four groups (Healthy Control (HC) (n = 581), Depression Only (n = 136), Anxiety Only (n = 54), Concomitant Depression/Anxiety (n = 62)) based on their anxiety and depression scores. Groups were compared on Total PCSS Score as well as 5 PCSS Symptom Cluster scores (Cognitive, Physical, Affective, Sleep, and Headache). Results: The three affective groups reported significantly greater symptomatology than HCs, with the Concomitant group showing the highest symptomatology scores across all clusters. The depressive symptoms only group also reported significantly elevated symptomatology, compared to HCs, on every symptom cluster except headache. The anxiety symptoms only group differed from HCs on only the cognitive symptoms cluster. Additionally, the Concomitant group reported significantly increased PCSS symptomatology, in terms of total scores and all 5 symptom clusters, compared to the depressive symptoms only and anxiety symptoms only groups. Conclusions: Our findings suggest that athletes experiencing concomitant depressive/anxiety symptoms report significantly greater levels of symptomatology across all 5 PCSS symptom clusters compared to HCs. Further, results suggest that athletes experiencing concomitant affective disturbance tend to report greater symptomatology than those with only one affective disturbance. These findings are important because, despite the absence of concussion, the concomitant group demonstrated significantly elevated symptomatology at baseline. Thus, future comparisons with post-concussion data should account for this increased symptomatology, as test results may be skewed by affective disturbances at baseline.

Download Full-text

Rates of Anxiety and Depressive Symptoms among Female Undergraduate Medical Students at National Medical College and Teaching Hospital

IRA-International Journal of Management & Social Sciences (ISSN 2455-2267) ◽

10.21013/jmss.v14.n2sp.p17 ◽

2019 ◽

pp. 171

Author(s):

Sandesh Sawant ◽

Garima Tripathi ◽

Tripti Pal Raman

Keyword(s):

Depressive Symptoms ◽

Medical Students ◽

Family History ◽

Depression Scale ◽

Anxiety Symptoms ◽

Drop Out ◽

Anxiety And Depression ◽

Female Undergraduate ◽

Undergraduate Medical Students ◽

The Mean

Background: Literature states that Depression and anxiety symptoms carry impairment to medical students, including poor academic performance, drop out, substance abuse and suicide. A high prevalence of anxiety and depression among medical students has been reported worldwide. Higher prevalence is noticed among female students.Aim/Objectives: To study rates of anxiety and depressive symptoms among female undergraduate medical students.Methods: The present study is a cross-sectional study. The purposive sampling method was used. Duration of study was 6 months. A total number of participants’ were 100. Self-developed questionnaire and Hospital Anxiety and Depression scale were used. Results: Findings showed that the mean score of anxiety symptoms was 8.08 (SD± 4.07). Similarly, the mean score of Depressive symptoms was 4.99(SD± 3.28). Fifty-two per cent of the students rated anxiety symptoms and 25% of the student rated depressive symptoms between borderline to the abnormal range. Total 9% of the students reported that they have a family history of mental illness among which 8% reported borderline to an abnormal range of anxiety however 52 % who had no family history also scored the same range. Similarly, 17% of the students reported there were life events which were stressful among which 13% scored borderline to abnormal range anxiety symptoms. Likewise, only 5% of the students scored borderline to the abnormal range of depressive symptoms.Conclusion: It was observed that female undergraduate medical students experience both anxiety and depressive symptoms however the percentage of depressive symptoms were less compared to anxiety symptoms. Further studies are required to evaluate the associated factors responsible for depressive and anxiety symptoms.

Download Full-text

THE EARLY BIRD GETS THE WORM, NOT ANXIETY OR DEPRESSION: HOW INSOMNIA SYMPTOMS PREDICT ANXIETY AND DEPRESSION

Innovation in Aging ◽

10.1093/geroni/igz038.174 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S45-S45

Author(s):

Courtney J Bolstad ◽

Anisha L Thomas ◽

Michael R Nadorff

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Regression Analyses ◽

Symptoms Of Depression ◽

Early Bird ◽

The Impact ◽

Insomnia Symptoms

Abstract Symptoms of insomnia are associated with symptoms of depression and anxiety in older adults, yet less is known about the impact of specific forms of insomnia (i.e. onset, maintenance, and terminal insomnia). We explored how insomnia type predicted symptoms of anxiety and depression in older adults (n = 133; mean age 69, range 65-89). We hypothesized that onset and maintenance insomnia would have stronger relations to depression and anxiety than terminal insomnia. Regression analyses indicated that onset insomnia was the only significant predictor of anxiety symptoms, and maintenance was the only significant predictor of depressive symptoms. Thus, our findings suggest that despite overlap between depression and anxiety, insomnia may have different mechanisms of affecting each disorder. Implications for the treatment of anxiety and depressive symptoms by addressing insomnia problems will be discussed.

Download Full-text

DON’T WORRY, BE HAPPY NOW, PET OWNERS: THE RELATION BETWEEN PET OWNERSHIP AND ANXIETY AND DEPRESSION IN LATE LIFE

Innovation in Aging ◽

10.1093/geroni/igz038.589 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

pp. S165-S165

Author(s):

Courtney J Bolstad ◽

Carolyn E Adams-Price ◽

Michael R Nadorff

Keyword(s):

Older Adults ◽

Depressive Symptoms ◽

Late Life ◽

Later Life ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Future Research ◽

Pet Ownership ◽

Pet Owners ◽

Reported Health

Abstract Pets can provide older adults a means of social support, which can combat problems faced in later life including loneliness, anxiety, and depression. However, current research findings in this area are mixed. The current study explored the differences in anxiety and depression between pet owners and non-pet owners and how pet ownership was associated with these symptoms after accounting for other established correlates. We hypothesized pet owners would endorse fewer symptoms of anxiety and depression than non-pet owners and owning a pet would be associated with these symptoms even after accounting for other common correlates. Participants included 608 older adults aged 70 to 95 that were included in the University of Alabama at Birmingham Study of Aging. As hypothesized, results indicated that pet owners endorsed significantly fewer symptoms of anxiety and depression than non-pet owners. Hierarchical regressions indicated that owning a pet explained a significant amount of variance in anxiety symptoms even after controlling for depression, self-reported health, and demographics. However, owning a pet did not have a significant association with depressive symptoms after accounting for anxiety, self-reported health, and demographics. These results suggest that lower rates of anxiety and depression are related to owning a pet and that pet ownership is associated with fewer anxiety symptoms, but not depressive symptoms, independent of several established correlates of anxiety. Future research is needed to determine the specific mechanisms of pet ownership that comprise this relationship as well as whether pet ownership may longitudinally reduce or buffer against anxiety in late life.

Download Full-text

Anxiety and Depression in Newly Diagnosed Epilepsy: A Matter of Psychological History?

Frontiers in Neurology ◽

10.3389/fneur.2021.744377 ◽

2021 ◽

Vol 12 ◽

Author(s):

Natacha Forthoffer ◽

Alexis Tarrada ◽

Hélène Brissart ◽

Louis Maillard ◽

Coraline Hingray

Keyword(s):

Depressive Symptoms ◽

Focal Epilepsy ◽

Psychological Trauma ◽

Structured Interview ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Psychiatric History ◽

Newly Diagnosed ◽

History Of ◽

And Gender

Purpose: Anxiety and depression are highly prevalent in patients with epilepsy (PWE), and these symptoms can even precede the onset of the pathology. We aimed to define the prevalence of anxiety and depressive symptoms at the time of the epilepsy diagnosis and the factors related to their presence in newly diagnosed adult patients.Methods: One hundred and twelve newly diagnosed patients were assessed, usually in the week after diagnosis. Patients were untreated at this time. We used the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E, cut-off ≥15) and the Generalized Anxiety Disorder 7-Item scale (GAD-7, cut-off >7). A semi-structured interview was conducted to collect sociodemographic and epilepsy data and patients' psychiatric history. We first compared patients with and without anxiety symptoms, then patients with and without depressive symptoms.Results: According to the GAD-7 scale, the prevalence of anxiety symptoms at the time of diagnosis was 35%. Patients with anxiety symptoms had significantly more psychiatric history (26%, p = 0.001) and more history of psychological trauma (51%, p = 0.003) than patients with no anxiety symptoms. According to the NDDI-E scores, the prevalence of depressive symptoms at the time of the diagnosis was 11%. Patients with depressive symptoms had significantly more psychiatric history (43%, p < 0.001) and more history of psychological trauma (65%, p = 0.007) than patients with no depressive symptoms. No difference between groups was found for other sociodemographic variables (age and gender), epilepsy characteristics (number of seizures prior to diagnosis, time from first seizure to diagnosis, type of epilepsy, and localization in focal epilepsy), or neurological comorbidities.Conclusions: Anxiety symptoms are common whereas depressive symptoms are less prevalent at the time of diagnosis. It appears essential to be aware of anxiety and depression in newly diagnosed epileptic patients. They should be screened and routinely monitored, especially those patients with a history of psychological trauma and/or psychiatric disorders. Longitudinal follow-up is required to identify whether these factors and anxiety and depression themselves have an impact on the future course of care.

Download Full-text

Effect of Anxiety and Depression on Survival of Cancer Patients, a 13 Year Follow-up

Asian Pacific Journal of Cancer Care ◽

10.31557/apjcc.2021.6.1.9-13 ◽

2021 ◽

Vol 6 (1) ◽

pp. 9-13

Author(s):

Suriati Mohamed Saini ◽

Susan Tan Mooi Koon ◽

Mohamad Adam Bujang ◽

Gerard Lim Chin Chye ◽

Shalisah Sharip ◽

...

Keyword(s):

Depressive Symptoms ◽

Cancer Patients ◽

Depression Scale ◽

Cox Proportional Hazards ◽

Anxiety Symptoms ◽

High Rate ◽

Anxiety And Depression ◽

Risk Of Death ◽

Increased Risk

Introduction: Anxiety and depression occur at a high rate in cancer patients. However, debate remains regarding the effect of anxiety and depression on cancer survival. Objective: This study aimed to determine the effect of anxiety and depressive symptoms on the survival of cancer patients. Methods: The subjects consisted of 112 cancer patients who attended the Oncology and Radiotherapy outpatient clinic Hospital Kuala Lumpur, Malaysia, in 1999. Anxiety and depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS) questionnaire at inception. Information on patients’ mortality status for extended 13 years follow-up (in 2011) was obtained from the National Registration Department death records. Overall survival for each anxiety and depressive symptoms scores in HADS at 13 years was calculated using Cox proportional hazards regression analysis. Results: Cancer patients experienced more anxiety (83%) compared to depressive symptoms (40.2%). The mean (S.D.) HADS scores for depressive symptoms were 9.9 (2.5), and the anxiety symptoms score was 12.6 (2.1). At 13 years, half of the patients (50.9%) had died. No significant effect of anxiety (p=0.399, 95% C.I.= 6.2-8.4) or depressive symptoms at inception (p=0.749, 95% C.I.= 5.9-8.4) towards cancer patients’ survival was found at 13 years follow-up. Conclusion: The occurrence of anxiety symptoms among cancer patients in this study was 2-folds higher than depressive symptoms. However, no significant increased risk of death was found in cancer patients with anxiety or depressive symptoms at 13 years follow-up. It may imply that as time extended, survival in cancer patients may be related to various interacting elements, and intervening health factors are of importance.

Download Full-text

Extracellular vesicle associated and soluble immune marker profiles of psychoneurological symptom clusters in men with prostate cancer: an exploratory study

Translational Psychiatry ◽

10.1038/s41398-021-01554-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Dilorom Sass ◽

Leorey Saligan ◽

Wendy Fitzgerald ◽

Ann M. Berger ◽

Isaias Torres ◽

...

Keyword(s):

Prostate Cancer ◽

Depressive Symptoms ◽

Sleep Disturbances ◽

Metastatic Prostate Cancer ◽

Extracellular Vesicle ◽

Symptom Clusters ◽

Symptom Cluster ◽

External Beam Radiation ◽

Immune Markers ◽

Bivariate Correlation

AbstractPsychoneurological symptom clusters are co-occurring and interrelated physiological symptoms that may include cancer-related fatigue, pain, depressive symptoms, cognitive disturbances, and sleep disturbances. These symptoms are hypothesized to share a common systemic proinflammatory etiology. Thus, an investigation of systemic immune biomarkers is an important approach to test this hypothesis. Here, we investigated the associations between extracellular vesicle (EV)-associated and soluble cytokines with immune markers and symptom clusters in men with non-metastatic prostate cancer. This observational study included 40 men with non-metastatic prostate cancer at the start (T1) of external beam radiation therapy (EBRT) and 3 months post treatment (T2), as well as 20 men with non-metastatic prostate cancer on active surveillance (AS) seen at one time point. Collected questionnaires assessed patient-reported fatigue, sleep disturbances, depressive symptoms, and cognitive fatigue. In total, 45 soluble and EV-associated biomarkers in plasma were determined by multiplex assays. Principal component analysis (PCA) was used to identify psychoneurological symptom clusters for each study group and their time points. Bivariate correlation analysis was run for each identified PCA cluster with the concentrations of EV-associated and soluble cytokines and immune markers. Both EV-associated and soluble forms of RANTES significantly correlated with the symptom cluster for EBRT at T1, whereas, at T2, soluble IFNα2, IL-9, and IL-17 correlated with the corresponding symptom cluster. For the AS group, soluble survivin correlated with psychoneurological symptoms. Linking specific inflammatory cytokines with psychoneurological symptom clusters in men receiving prostate cancer treatment can enhance understanding of the underlying mechanisms of this phenomenon and aid in developing targeted interventions.

Download Full-text

0320 Psychological Correlates of Morningness/Eveningness in Latinx Pre-Adolescents

SLEEP ◽

10.1093/sleep/zsaa056.317 ◽

2020 ◽

Vol 43 (Supplement_1) ◽

pp. A121-A122

Author(s):

S T Nguyen-Rodriguez ◽

O M Buxton

Keyword(s):

Depressive Symptoms ◽

Perceived Stress ◽

Psychological Health ◽

Depression Scale ◽

Well Being ◽

Anxiety Symptoms ◽

Self Report ◽

Anxiety And Depression ◽

Average Score ◽

Depression Symptoms

Abstract Introduction Chronotype refers to a preference for morning hours (morningness) vs. evening hours (eveningness) when individuals tend to feel their best (e.g., higher energy levels). People may be classified at either end of this spectrum or along a continuum between these preferences. Among adolescents, eveningness is positively related to depression and anxiety, whereas morningness is negatively related to depression. However, less is known about the relationship of chronotype and psychological health in pre-teens and Latinx youth. The present study explored associations of morningness/eveningness with anxiety symptoms, depressive symptoms, and perceived stress among Latinx pre-adolescents in Southern California. Methods A purposive sample of 100 Latinx children, ages 10-12 years old, completed self-report surveys in their homes or a preferred location chosen by the parent. Measures included the Morningness/Eveningness Scale for Children (higher scores indicate morning preference), Revised Child Anxiety and Depression Scale and the Perceived Stress Scale (higher scores indicate higher anxiety, depression and stress, respectively). Associations were tested with Pearson correlations. Results The sample was 47% male with a mean±SD age of 10.9±0.8 years. Average score for morningness/eveningness was M=30.2±4.4 (range: 18-41), for anxiety symptoms was M=0.7±0.7 (range: 0-2.8), for depression symptoms was M=0.5±0.4 (range: 0-1.9) and for perceived stress was M=15.2±5.8 (range: 2-30). Greater morningness/eveningness scores, indicating more morningness, were associated with lower scores for anxiety symptoms (r=-.41, p<.001), depressive symptoms (r=-.36, p<.001) and perceived stress (r=-.33, p=.001). Conclusion As has been found for adolescents, higher morningness in Latinx pre-teens was related to less frequent anxiety and depression symptoms, as well as lower perceived stress. Youth experience a circadian phase delay during adolescence, shifting their preference toward eveningness, which may exacerbate stressors and negative mental health. Therefore, interventions to promote psychological well-being in pre-adolescents may help prevent worse psychological outcomes in Latinx children as they transition to adolescence. Support This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Numbers UL1GM118979, TL4GM118980, and RL5GM118978.

Download Full-text

Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links

European Journal of Cardiovascular Prevention & Rehabilitation ◽

10.1097/hjr.0b013e3280142a02 ◽

2007 ◽

Vol 14 (4) ◽

pp. 547-554 ◽

Cited By ~ 67

Author(s):

Dietrich Rothenbacher ◽

Harry Hahmann ◽

Bernd Wüsten ◽

Wolfgang Koenig ◽

Hermann Brenner

Keyword(s):

Cardiovascular Disease ◽

Coronary Heart Disease ◽

Heart Disease ◽

Depressive Symptoms ◽

Hazard Ratio ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Manifest Anxiety ◽

Cardiovascular Disease Event

Background We evaluated the association of symptoms of anxiety and depression with fatal and non-fatal cardiovascular disease events among patients with coronary heart disease and considered several potential underlying pathogenetic links. Design This was a prospective cohort study. Methods In this study, including coronary heart disease patients undergoing an in-patient rehabilitation program, symptoms of anxiety and depression were evaluated with the Hospital Anxiety and Depression Scale (HADS). Fatal and non-fatal cardiovascular disease events were determined during a 3-year follow-up. Results Of the 1052 patients with CHD 16.1% showed a borderline and 8.3% a manifest anxiety symptoms score, whereas 11.8 and 5.9% showed a borderline and manifest depressive symptoms score, respectively. During the 3-year follow-up fatal and non-fatal cardiovascular disease events were observed in 73 (6.9%) patients. After adjustment for covariates, patients having manifest anxiety symptoms had a statistically significant hazard ratio (HR) of 2.32 [95% confidence interval (CI) 1.14-4.74] for a cardiovascular disease event, and patients with depressive symptoms had an HR of 1.47 (95% CI 0.62-3.51) compared to other patients. In a model considering anxiety and depressive symptom scores simultaneously, the hazard ratio for a cardiovascular disease event associated with anxiety symptoms increased to 3.31 (95% CI 1.32-8.27), whereas the hazard ratio associated with depressive symptoms decreased (HR 0.62; 95% CI 0.20-1.87). We found a positive association of increased anxiety scores with body mass index and systolic blood pressure. Conclusions The study suggests an important role especially for symptoms of anxiety for long-term prognosis of patients with known coronary heart disease. It furthermore suggests that several pathogenetic links may partly explain the increased risk.

Download Full-text

The prevalence of antenatal and postnatal co-morbid anxiety and depression: a meta-analysis

Psychological Medicine ◽

10.1017/s0033291717000617 ◽

2017 ◽

Vol 47 (12) ◽

pp. 2041-2053 ◽

Cited By ~ 64

Author(s):

K. Falah-Hassani ◽

R. Shiri ◽

C.-L. Dennis

Keyword(s):

Depressive Symptoms ◽

Anxiety Disorder ◽

Clinical Diagnosis ◽

Meta Analysis ◽

Perinatal Period ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Unpublished Studies ◽

Co Morbidity ◽

Antenatal Anxiety

To date, the precise prevalence of co-morbidity of anxiety and depression in the perinatal period is not well known. We aimed to estimate the prevalence of co-morbid anxiety and depression in the antenatal and postnatal periods. Systematic searches of multiple electronic databases were conducted for studies published between January 1950 and January 2016. We included 66 (24 published and 42 unpublished) studies incorporating 162 120 women from 30 countries. Prevalence of self-reported antenatal anxiety symptoms and mild to severe depressive symptoms was 9.5% [95% confidence interval (CI) 7.8–11.2, 17 studies, n = 25 592] and of co-morbid anxiety symptoms and moderate/severe depressive symptoms was 6.3% (95% CI 4.8–7.7, 17 studies, n = 27 270). Prevalence of a clinical diagnosis of any antenatal anxiety disorder and depression was 9.3% (95% CI 4.0–14.7, 10 studies, n = 3918) and of co-morbid generalized anxiety disorder and depression was 1.7% (95% CI 0.2–3.1, three studies, n = 3085). Postnatally between 1 and 24 weeks postpartum, the prevalence of co-morbid anxiety symptoms and mild to severe depressive symptoms was 8.2% (95% CI 6.5–9.9, 15 studies, n = 14 731), while co-morbid anxiety symptoms and moderate/severe depressive symptoms was 5.7% (95% CI 4.3–7.1, 13 studies, n = 20 849). The prevalence of a clinical diagnosis of co-morbid anxiety and depression was 4.2% (95% CI 1.9–6.6, eight studies, n = 3251). Prevalence rates did not differ with regard to year of publication, country income, selection bias and attrition bias. The results suggest that co-morbid perinatal anxiety and depression are prevalent and warrant clinical attention given the potential negative child developmental consequences if left untreated. Further research is warranted to develop evidence-based interventions for prevention, identification and treatment of this co-morbidity.

Download Full-text

The effect of anxiety and depression on decline of memory function in Alzheimer's disease

International Psychogeriatrics ◽

10.1017/s1041610209990512 ◽

2009 ◽

Vol 21 (6) ◽

pp. 1142-1147 ◽

Cited By ~ 14

Author(s):

E. J. M. Bierman ◽

H. C. Comijs ◽

C. Jonker ◽

P. Scheltens ◽

A. T. F. Beekman

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Depressive Symptoms ◽

Elderly People ◽

Early Stage ◽

Memory Function ◽

Verbal Learning ◽

Anxiety Symptoms ◽

Anxiety And Depression ◽

Dutch Version

ABSTRACTBackground: Patients with Alzheimer's disease (AD) and concomitant atrophy of the hippocampus may be extra vulnerable to the consequences of psychological distress, leading to greater decline in memory function. The present study investigated whether symptoms of anxiety and depression predict decline of memory function in elderly people diagnosed with early stage AD.Methods: A sample of 44 elderly people diagnosed with early stage AD was tested on their memory function, anxiety and depression and confounding variables with one year follow-up. Episodic memory was measured with a modified Dutch version of the Auditory Verbal Learning Test (AVLT) which measures learning and recall abilities. Linear regression analyses were used to investigate the association between anxiety and depressive symptoms and decline of memory function.Results: Anxiety symptoms predicted a smaller decline in learning on the AVLT. Anxiety symptoms did not predict decline on the recall of the AVLT. No association was found between depressive symptoms and decline in either learning or recall of the AVLT.Conclusions: In early AD, symptoms of anxiety and depression generally seem to be mild, and do not accelerate decline of memory function over time. On the contrary, anxiety symptoms were found to predict a smaller decline in memory function.

Download Full-text