scholarly journals Relationship between Pneumonia and the Thymus Gland in Children with COVID-19: A Volumetric Computed Tomography Study

2021 ◽  
Author(s):  
Furkan E. Urfali ◽  
Damla Geçkalan Soysal ◽  
Sahinde Atlanoglu ◽  
Mehmet Korkmaz ◽  
Özlem Genc ◽  
...  
Keyword(s):  
Severe Disease ◽  
Thymus Gland ◽  
Control Group ◽  
Total Lung Volume ◽  
Reactive Protein ◽  
Laboratory Values ◽  
Group A ◽  
Involvement Rate ◽  
Novel Coronavirus ◽  
The Relationship

Abstract Objective Many studies showed that less-severe disease symptoms and fewer mortality rates have been reported in pediatric novel coronavirus disease 2019 (COVID-19) patients. In this study, we aimed to reveal the relationship between the volume of thymus gland, which provides T lymphocyte maturation in children, with the severity of lung involvement and blood laboratory values in pediatric patients with COVID-19 infection. Methods Thymus density and thymus and cardiac volumes were measured in pediatric COVID-19 patients and a control group that underwent thoracic tomography for reasons other than infection. Thymus/heart ratios were calculated to index the thymus volumes of the patients to their body dimensions. The severity of pneumonia was demonstrated by proportioning the involved lung parenchymal volume to the total lung volume in patients with typical involvement in thoracic tomography. The relationship between volumetric and blood laboratory values was statistically evaluated. Results Thymus density (p = 0.015) and thymus/heart ratio (p = 0.04) significantly differed between patients with COVID-19 infection and the control group. A correlation was observed between the pneumonia involvement rate and C-reactive protein (CRP) (k: 0.451, p = 0.08) and white blood cell (WBC; k: 0.419, p = 0.015) values in the thoracic tomography of the COVID-19 group. Conclusion The thymus gland is enlarged as an indicator of activation in COVID-19 infection. We hope that our study will guide new studies on the prognostic value of thymus size in lymphopenic patients with severe disease.

Role of antioxidant therapy in patients with moderate and severe COVID-19

2021 ◽  
Vol 19 (1) ◽  
pp. 159-164
Author(s):  
E.K. Shavarova ◽  
◽  
E.R. Cazakhmedov ◽  
M.V. Alekseeva ◽  
L.G. Ezhova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intervention Group ◽  
Clinical Manifestations ◽  
Organ Damage ◽  
Control Group ◽  
Reactive Protein ◽  
Virus Rna ◽  
Active Intervention Group ◽  
Group 2 ◽  
Novel Coronavirus

The coronavirus disease COVID-19 is characterized by high mortality and the lack of effective etiotropic therapy. Activation of oxidative stress may be one of the links in the pathogenesis of organ damage of this infection. Objective. To assess the ability of Mexidol® to influence the rate of clinical improvement in pneumonia caused by the SARSCoV-2 virus in hospitalized patients with the novel coronavirus disease COVID-19 and concomitant discirculatory encephalopathy. 62 patients over the age of 18 years with confirmed new coronavirus disease COVID-19 according to computed tomography (CT) of the lungs (stages CT1, CT2, CT3) and PCR of a swab from the nasopharynx and oropharynx for SARS-CoV-2 virus RNA were included. After randomization patients of group 1 received an infusion of Mexidol® at a dose of 1000 mg/day, patients of group 2 – an infusion of isotonic sodium chloride solution for 7 days. Compared with the control group, the patients receiving Mexidol® therapy showed a significantly more pronounced decrease in body temperature, a tendency towards a decrease in the severity of shortness of breath. In the Mexidol® group, the concentration of superoxidedismutase did not change, while in the control group there was a tendency to its decrease, C-reactive protein decreased 2.2 times more than in the control group (p = 0.09). There was a tendency for a more rapid decrease in ferritin in the active intervention group. Mexidol® therapy can have a positive effect on the clinical manifestations and severity of laboratory-inflammatory syndrome in patients with the new coronavirus disease COVID-19. Key words: coronavirus disease COVID-19, oxidative stress, Mexidol

Disturbances of the hemostasis system and expression of inflammatory reaction in patients with new coronaviral pneumonia

2020 ◽  
Vol 65 (12) ◽  
pp. 744-749
Author(s):  
M. V. Presnyakova ◽  
E. A. Galova ◽  
L. N. Sosnina ◽  
A. N. Popovicheva ◽  
N. A. Lyubavina ◽  
...  
Keyword(s):  
Platelet Count ◽  
Inflammatory Response ◽  
Blood Clot ◽  
Control Group ◽  
Reactive Protein ◽  
Hemostasis System ◽  
Coagulation Status ◽  
Novel Coronavirus ◽  
Diagnostic Capabilities ◽  
Apparently Healthy

Disorders of the hemostatic system and inflammation play a key role in the pathogenesis of new coronavirus pneumonia (NCP), determining its course and outcome. To study the dynamics of the state of the hemostasis system and the severity of the acute phase response in patients with new coronavirus pneumonia. We determined APTT, prothrombin time (PT), fibrinogen (F), D-dimers (D-d), antitrombin III (AT III), C-reactive protein (CRP), platelet count in 22 patients. In 49 patients, the viscoelastic properties of a blood clot were studied by thromboelastography (TEG) with koalin. The age of the patients ranged from 40 to 77 years. According to CT, the severity of 100% cases corresponded to CT2-CT3. Acute respiratory failure (ARF) was diagnosed in 16 patients. A control group included 25 apparently healthy subjects. During hospitalization, patients with NCP were characterized by: an increase in the concentration of D-d, CRP, Fg, lengthening of APTT and PT, ATIII activity and platelet count not differing from the normal range. 10 days after hospitalization and against the background of ongoing therapy, patients with NCP showed positive dynamics in the hemostasiological profile and the severity of the inflammatory response. Thromboelastography indices in patients with LCP did not differ from control values both at hospitalization and on day 10.Thus, in patients with novel coronavirus pneumonia, an increased prothrombotic activity and a pronounced inflammatory response are recorded. Against the background of treatment, there is a positive dynamics in both the coagulation status and the inflammatory response. Additional studies are needed to determine the diagnostic capabilities of thromboelastography in patients with NCP.

scholarly journals THE ROLE OF INFLAMMATION AND COAGULATION CASCADE IN THE PATHOGENESIS OF ATRIAL FIBRILLATION

ASJ. ◽  
2020 ◽  
Vol 3 (41) ◽  
pp. 8-10
Author(s):  
L. Hazarapetyan ◽  
S. Grigoryan ◽  
A. Sarksyan
Keyword(s):  
Atrial Fibrillation ◽  
Coagulation Cascade ◽  
Control Group ◽  
Atrial Remodeling ◽  
Inflammation Markers ◽  
Reactive Protein ◽  
Gender And Age ◽  
The Impact ◽  
The Relationship

Introduction: Atrial fibrillation (AF) is associated with prothrombotic or hypercoagulable states, various inflammation markers such as interleukin-6 (IL-6) and hsC-reactive protein (hsCRP) have also been associated with AF. The aim of this study is to investigate the relationship between inflammation markers and the prothrombotic state in the setting of AF and the impact on outcome in patients with AF. Methods: We observed 141 patients with non-valvular AF. As a control group patients similar in gender and age without AF were examined. Clinical, instrumental and laboratory tests were performed on the observed patients. The markers of the coagulation cascade (TF and F) and of inflammatory markers (hsCRP and IL-6) were studied additionally by ELISA on the analyzer "Stat Fax 303 Plus". Studies were conducted using SPSS 13.0 and EXCEL-2013. Results: The obtained results showed that compared to the control group, AF patients had significantly higher levels of IL-6 (p = 0.043), hsCRP (p = 0.002), TF (p = 0.026), and F (p = 0.025). Moreover, levels of hsCRP were higher among AF patients at "high" risk of stroke by CHA2DS2-VASc Score (p = 0.003). Besides, the levels of hsCRP and IL-6 were markedly elevated in patients with dilated left atrium (p = 0.001), poorly functioning left atrial appendage (p = 0.023) and longer duration of AF (p = 0.002). Conclusion: We have demonstrated that the increased plasma levels of IL-6 and hsCRP are related to indices of the coagulation cascade and contribute to structural atrial remodeling in patients with AF.

scholarly journals Influence of Covid-19 infection on fetal thymus size after recovery

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sule Goncu Ayhan ◽  
Ezgi Turgut ◽  
Deniz Oluklu ◽  
Eda Ozden Tokalioglu ◽  
Dilek Menekse Beser ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Control Group ◽  
City Hospital ◽  
Long Term Effects ◽  
Distribution Width ◽  
Fetal Thymus ◽  
Reactive Protein ◽  
Novel Coronavirus ◽  
Thymus Size ◽  
Demographic Features

Abstract Objectives To investigate the long-term effects of the SARS-CoV-2 infection on the fetal immune system by fetal thymus size measurements with ultrasound (USG). Methods This prospective study was conducted in the Turkish Ministry of Health Ankara City Hospital between November 1, 2020 and April 1, 2021, with recovered, pregnant women, four weeks after they had been confirmed for the SARS-CoV-2 infection by real-time polymerase-chain-reaction (RT-PCR). COVID-19 recovered (CR) pregnant women compared with age-matched pregnant controls in terms of demographic features, fetal thymic-thoracic ratio (TTR), and laboratory parameters. Results There was no difference in demographic features between the two groups. TTR found significantly lower in the CR group than the control group (p=0.001). The fetal TTR showed a significant and moderate correlation with maternal monocyte counts, monocyte to lymphocyte ratio (MLR), and red cell distribution width (RDW); while it did not correlate with lymphocyte counts, c-reactive protein (CRP), and procalcitonin levels. Conclusions The 2019 novel coronavirus disease (COVID-19) reduces fetal thymus size in pregnant women with mild or moderate symptoms after recovery from the infection.

Videogame Play and Wellbeing Among a First Episode Psychosis Population

2021 ◽  
Vol 5 (CHI PLAY) ◽  
pp. 1-23
Author(s):  
Daniel Johnson ◽  
Victoria Gore-Jones ◽  
Frances Dark ◽  
Stephen D. Parker ◽  
Sharon Foley ◽  
...  
Keyword(s):  
Stressful Life Events ◽  
Control Sample ◽  
First Episode Psychosis ◽  
Need Satisfaction ◽  
First Episode ◽  
Control Group ◽  
Harmonious Passion ◽  
Episode Psychosis ◽  
Group A ◽  
The Relationship

With ongoing interest in the relationship between videogame and mental health alongside recent focus on gaming's role in coping with stressful life events, we sought to explore the relationship between videogame play and wellbeing among people experiencing their first episode of psychosis. Specifically, we aimed to explore the associations between videogame play and wellbeing among consumers of a first episode psychosis (FEP) service and further to compare their motivations for play, need satisfaction, passion for play and wellbeing to a control group. A sample of 88 people experiencing FEP (57 who played videogames and 31 who did not) and a control sample of 46 (all of whom played videogames) completed a survey containing a range of questionnaires related to the variables of interest. Key findings include that among those experiencing FEP, people who played videogames reported better wellbeing outcomes than those who did not. Among participants who played videogames, the FEP sample reported lower levels of need satisfaction through gaming, lower levels of harmonious passion, higher levels of external types of motivation and lower levels of internal types of motivation for play than the control group. Finally, the relationships between passion orientation (both harmonious and obsessive) and psychological distress were stronger in the control group than the FEP sample, suggesting that passion for gaming may be less influential on wellbeing for those experiencing FEP.

Relationship Between Gingivitis and Anterior Teeth Irregularities Among 18 to 26 Years Age Group: A Hospital Based Study in Belgaum, Karnataka

2010 ◽  
Vol 4 (3) ◽  
pp. 61-66
Author(s):  
Anil Ankola ◽  
V. Chandrasekhara Reddy ◽  
B R Ashok Kumar
Keyword(s):  
Control Group ◽  
Dental Arch ◽  
Study Group ◽  
Age Group ◽  
Gingival Index ◽  
Anterior Teeth ◽  
Group A ◽  
The Mean ◽  
Anterior Segments ◽  
The Relationship

ABSTRACT Aim To study the relationship between gingivitis and irregular teeth in the anterior segments of dental arches. Materials & Methods The sample size of 120 subjects who satisfied the inclusion criteria was randomly selected for the study. These subjects were selected between the age group of 18 to 26 years and divided into two groups. The study group (cases) consists of 60 subjects with irregular teeth in the anterior segments of dental arch. The control group (controls) consists of 60 subjects with well-aligned teeth in the anterior segments of dental arches. Results The mean gingival index of cases & controls were 0.9513 and 0.5959 with standard deviations of 0.7014 and 0.4909 respectively. The t-value was 3.1093 with p<0.001 which was highly significant. Conclusion The mean gingival index of study group was higher than the gingival score of the control group (P<0.001).

scholarly journals The Effect of Acupuncture to SP6 on Skin Temperature Changes of SP6 and SP10: An Observation of “Deqi”

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Jia-Min Yang ◽  
Xiao-Yu Shen ◽  
Ling Zhang ◽  
Song-Xi Shen ◽  
Dan-Dan Qi ◽  
...  
Keyword(s):  
Skin Temperature ◽  
Saline Control ◽  
Control Group ◽  
Group Model ◽  
Model Group ◽  
Saline Control Group ◽  
Temperature Changes ◽  
Group A ◽  
Group B ◽  
The Relationship

Background. Deqi sensation is a complex but an important component for acupuncture effect. In this study, we tried to observe the relationship between Deqi and skin temperature changes and whether there was some relativity between Deqi and needle stimulations on cold congealing and dysmenorrhea rat model. Thirty-two female Sprague Dawley (SD) rats were randomly divided into four groups (Saline Control Group, Model Group, Group A with strong stimulation, and Group B with small stimulation). Group A and Group B were performed with different stimulations. We found that, compared with saline control group, model group, and Group B, Group A showed that the skin temperature changes on right acupoint SP6 and SP10 increased significantly at 5 min–10 min interval. The skin temperature changes on left SP6 decreased at instant–5 min interval. The skin temperature changes on right SP10 decreased significantly at instant–5 min interval and 10 min–20 min interval. Thermogenic action along Spleen Meridian of Foot Greater Yin was manifested as simultaneous skin temperature increase on right SP6 and SP10 at 5 min–10 min interval after needling SP6, which was helpful to illustrate the relationship between the characteristic of Deqi and needle stimulations.

scholarly journals STUDY ON THE ASSOCIATION OF OBESITY INDICES WITH INFLAMMATORY MARKERS IN PRE-DIABETES AND DIABETES

2019 ◽  
pp. 64-68
Author(s):  
PRADEEP KUMAR ◽  
SHAILAZA SHRESTHA ◽  
MAHENDRA PRASAD ◽  
PREETI SHARMA ◽  
MOHIT
Keyword(s):  
Uric Acid ◽  
Inflammatory Markers ◽  
Fasting Blood Glucose ◽  
Diabetic Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Low Grade ◽  
Reactive Protein ◽  
Group A ◽  
Obesity Indices

Objective: In this study, the main objective was to evaluate the association of markers of obesity with the inflammatory markers in pre-diabetes and diabetes. Methods: This study recruited 300 participants (100 control group, 100 pre-diabetic group, and 100 diabetic group). The anthropometric variables such as body mass index (BMI), waist-hip ratio (WHR), and waist circumference (WC), and biochemical variables such as fasting blood glucose, glycated hemoglobin, uric acid, C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), and adiponectin were analyzed in each participant by standard methods. Results: The present study documented significantly high values of BMI and WHR in patient (pre-diabetic and diabetic) groups compared to the control group. Similarly, the level of adiponectin decreased and that of uric acid, CRP, fibrinogen, and IL-6 increased significantly. Both BMI and WC were correlated significantly with inflammatory mediators in diabetic patients. The correlation with adiponectin was negative. In the pre-diabetic group, a significant correlation was observed only between WHR, adiponectin, and uric acid. Conclusion: This study supports the fact that obesity-induced systemic inflammation of low grade is significantly associated with pre-diabetes and diabetes, thereby keeping these individuals at high risk of future complications especially cardiovascular diseases.

Serum Endothelial Cell–Specific Molecule 1 (Endocan) Levels in Patients With Acute Myocardial Infarction and Its Clinical Significance

Angiology ◽  
2016 ◽  
Vol 68 (4) ◽  
pp. 354-359 ◽  
Author(s):  
Chong-Rong Qiu ◽  
Qiang Fu ◽  
Jian Sui ◽  
Qian Zhang ◽  
Peng Wei ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Endothelial Cell ◽  
Endothelial Dysfunction ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
The Relationship

Endothelial dysfunction is involved in the process of acute myocardial infarction (AMI), that is, the endothelial cell–specific molecule 1 (ESM-1; endocan) is a novel endothelial dysfunction marker. However, the relationship between patients with AMI and serum ESM-1 levels is not very clear. Patients with AMI (n = 216) and a control group (n = 60) without AMI were included in the study. High-sensitivity C-reactive protein (hsCRP) was measured, and the severity of AMI was assessed by a modified Gensini stenosis scoring system. Serum ESM-1 levels were significantly higher in the AMI group ( P < .05). High-sensitivity C-reactive protein levels were also significantly higher in the AMI group ( P < .05). In patients with AMI, serum ESM-1 levels were not significantly correlated with hsCRP levels. There was no significant correlation between serum ESM-1 level and Gensini score. Our findings suggest that serum ESM-1 levels may be a novel biomarker of endothelial dysfunction in patients with AMI.

Plasma Concentrations of C-Reactive Protein and Fibrinogen in Ischaemic Stroke

2002 ◽  
Vol 30 (6) ◽  
pp. 591-596 ◽  
Author(s):  
İ İyigün ◽  
Y Bakirci
Keyword(s):  
Ischaemic Stroke ◽  
Cerebral Artery ◽  
Plasma Concentrations ◽  
Control Group ◽  
C Reactive Protein ◽  
Arterial Lesion ◽  
Reactive Protein ◽  
The Difference ◽  
Unconscious Patients ◽  
The Relationship

This study investigated how fibrinogen and C-reactive protein (CRP) levels change in response to neural damage occurring after ischaemia, and the relationship between the distribution of the arterial lesion, the disease prognosis and the levels of these substances. Fibrinogen and CRP levels were measured in blood samples obtained from 83 patients admitted to hospital within 72 h of a first ischaemic stroke. The patients were evaluated clinically with the Glasgow Outcome Scale (GOS), and results were compared with 43 age-matched controls. The fibrinogen and CRP levels in unconscious patients with hemiparesis or hemiplegia were higher than those in conscious hemiplegic patients. Also, the difference in GOS values between the unconscious patients with hemiparesis or hemiplegia and conscious patients with hemiparesis or hemiplegia was statistically significant. Patients with large infarcts in the median cerebral artery and anterior cerebral artery had higher fibrinogen and CRP concentrations than the control group. In conclusion, fibrinogen and CRP may be important measures for determining the prognosis and outcome in patients following ischaemic stroke.

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