scholarly journals Non-parametric Functional Muscle Network as a Robust Biomarker of Fatigue

2021 ◽  
Author(s):  
Rory O'Keeffe ◽  
Seyed Yahya Shirazi ◽  
Jinghui Yang ◽  
Sarmad Mehrdad ◽  
Smita Rao ◽  
...  
Keyword(s):  
Unmet Need ◽  
Clustering Coefficient ◽  
P Value ◽  
Median Frequency ◽  
Individual Subject ◽  
Before And After ◽  
Network Metrics ◽  
Fatigue Detection ◽  
First Time ◽  
Non Parametric

The possibility of muscle fatigue detection using surface electromyography has been explored and multiple biomarkers, such as median frequency, have been suggested. However, there are contradictory reports in the literature which result in an inconsistent understanding of the biomarkers of fatigue. Thus, there is an unmet need for a statistically robust sEMG-based biomarker for fatigue detection. This paper, for the first time, demonstrates the superior capability of a non-parametric muscle network to reliably detect fatigue-related changes. Seven healthy volunteers completed a lower limb exercise protocol, which consisted of the 30s of a sit-to-stand exercise before and after the completion of fatiguing leg press sets. A non-parametric muscle network was constructed, using Spearman's power correlation, and showed a very reliable decrease in network metrics associated with fatigue (degree, weighted clustering coefficient (WCC)). The network metrics displayed a significant decrease at the group level (degree, WCC: p-value<0.001), individual subject level (degree: p-value<0.035 WCC: p-value<0.004) and particular muscle level (degree: p-value<0.017). Regarding the decrease in mean degree connectivity at particular muscles, all seven subjects followed the group trend. In contrast to the robust results achieved by the proposed non-parametric muscle network, classical spectrotemporal measurements showed heterogeneous trends at the particular muscle and individual subject levels. Thus, this paper for the first time shows that a non-parametric muscle network is a reliable biomarker of fatigue and could be used in a broad range of applications.

scholarly journals The Effect Range of Motion (Rom) Exercise on Lower Extremities Joint Pain Level for Elderly at Gampong Tanjung Selamat Kec. Darussalam Kab. Aceh Besar

2018 ◽  
Vol 5 (1) ◽  
pp. 3473-3476 ◽  
Author(s):  
Cut Rahmiati ◽  
Novi Afrianti
Keyword(s):  
Joint Pain ◽  
Lower Extremities ◽  
The Elderly ◽  
Pain Scale ◽  
P Value ◽  
Homogeneity Test ◽  
Pain Level ◽  
Significant Difference ◽  
Before And After ◽  
Non Parametric

BACKGROUND : Joint pain is a condition that often experienced for elderly and caused by a degenerative disease that causes reduced joint synovial fluid and give a pain and joint stiffness. ROM excercise is an exercise to increasing flexibility of muscles and joints. PURPOSE : The purpose of this research was to find out the effect of ROM excercise on lower extremities joint pain level for elderly. METHODS : The method of this research was a quasi experimental research design consisted of pre and postest without control. The data collected by 6 time for 2 weeks, with amount of sample counted 33 respondents. The level of the lower extremities joint pain was measured by VAS pain scale. The data were analyzed with SPSS 17 program with non parametric statistic test, to see the scale of lower extremities joint pain in elderly when there was no movement was measured by McNemar test, while moving (walk) and to see the general lower extremities pain scale before and after ROM exercise was measured by Marginal Homogenity test. RESULTS : The research result showed the differences of joint pain scale before and after ROM exercise when the elderly has no movement (p value = 0,05), and there is a differences for pain scale before and after ROM exercise when the elderly has movement (p value = 0,005). Generally, there is a difference joint pain level between before and after ROM exercise (p value = 0,014). CONCLUSIONS : After doing ROM exercise for 6 times, the reduction of joint pain in elderly was occured. When there was no any movement, the level of low joint pain in elderly before ROM exercise was about 30,3% to being 3% after ROM exercise. When moving (walk) the level of low joint pain which is being suffering by elderly from 54% before ROM exercise being 36,4% after ROM exercise. While generally before ROM exercise, the level of medium joint pain in elderly was about 15,2% before ROM exercise being null (0%), means that no body suffers joint pain after ROM exercise. Statistically, based on non-parametric test by McNemar and Marginal Homogeneity test, there was the significant difference in scale of average scores in joint pain before and after ROM exercise when there was no any movement with P-value 0,004 and when the was a movement (walk) P-value 0,005. Generally, there was the difference in avarage scores in joint pain in elderly before and after ROM exercise with P-Value 0,014. So, ROM exercise can be used as a way to decrease the scale of joint pain in erderly.

scholarly journals Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer’s and Parkinson’s Disease

Toxins ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 477
Author(s):  
Beatriz Arce-López ◽  
Lydia Alvarez-Erviti ◽  
Barbara De Santis ◽  
María Izco ◽  
Silvia López-Calvo ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Neurodegenerative Disease ◽  
Environmental Contaminants ◽  
Enzymatic Treatment ◽  
P Value ◽  
Healthy Controls ◽  
Disease Pathogenesis ◽  
Before And After ◽  
La Rioja ◽  
First Time

Exposure to environmental contaminants might play an important role in neurodegenerative disease pathogenesis, such as Parkinson´s disease (PD) and Alzheimer´s disease (AD). For the first time in Spain, the plasmatic levels of 19 mycotoxins from patients diagnosed with a neurodegenerative disease (44 PD and 24 AD) and from their healthy companions (25) from La Rioja region were analyzed. The studied mycotoxins were aflatoxins B1, B2, G1, G2 and M1, T-2 and HT-2, ochratoxins A (OTA) and B (OTB), zearalenone, sterigmatocystin (STER), nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, deepoxy-deoxynivalenol, neosolaniol, diacetoxyscirpenol and fusarenon-X. Samples were analyzed by LC-MS/MS before and after treatment with β-glucuronidase/arylsulfatase in order to detect potential metabolites. Only OTA, OTB and STER were detected in the samples. OTA was present before (77% of the samples) and after (89%) the enzymatic treatment, while OTB was only detectable before (13%). Statistically significant differences in OTA between healthy companions and patients were observed but the observed differences might seem more related to gender (OTA levels higher in men, p-value = 0.0014) than the disease itself. STER appeared only after enzymatic treatment (88%). Statistical analysis on STER, showed distributions always different between healthy controls and patients (patients’ group > controls, p-value < 0.0001). Surprisingly, STER levels weakly correlated positively with age in women (rho = 0.3384), while OTA correlation showed a decrease of levels with age especially in the men with PD (rho = −0.4643).

Efficacy of capecitabine in secondary prevention of skin cancer in solid organ-transplanted recipients (OTR)

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 1519-1519
Author(s):  
T. Jirakulaporn ◽  
J. Mathew ◽  
B. R. Lindgren ◽  
A. Z. Dudek
Keyword(s):  
Secondary Prevention ◽  
Cell Carcinoma ◽  
Low Dose ◽  
Incidence Rates ◽  
Rank Test ◽  
P Value ◽  
Solid Organ ◽  
Skin Cancers ◽  
Before And After ◽  
Non Parametric

1519 Background: Skin cancers are the most common malignancies in OTR. Topical 5% 5-FU has been used to successfully treat squamous cell carcinoma (SCC) in situ and actinic keratosis (AK). Capecitabine, an orally-administered prodrug of 5-FU, in combination with interferon was shown to be effective in the treatment of advanced SCC of the skin. This study was to determine the efficacy of low-dose capecitabine in secondary prevention of the skin cancers in OTR. Methods: OTR who developed recurrent skin cancers, SCC, and/or basal cell carcinoma (BCC), were given low-dose capecitabine 1g/m2 divided in two daily doses, day 1–14 of 21-day treatment cycle. Skin surveillances were performed by dermatologists every 1 to 3 months. Cumulative incidence rates of SCC, BCC, and AK before and after treatment were scored and statistically compared for each patient with a non-parametric Wilcoxon signed-rank test. Age and number of transplants were assessed with the Spearman non-parametric correlation analysis for their impact on the outcome. Results: 14 patients (12 males and 2 females) were enrolled with median age of 55 (range 40–73). 11 patients received kidney, two lung and one liver, one heart and one pancreas transplant. Two patients received double organ transplants. Mean incidence rates of SCC, BCC, and AK before treatment were 0.45, 0.05, and 4.99 lesions per month, respectively. Mean incidence rates of SCC, BCC, and AK after treatment were 0.22, 0.04, and 2.80 lesions per month, respectively. The differences in incidence rates of SCC, BCC, and AK before and after treatment were 0.24, 0.02, and 2.08 lesions per month with p value of 0.048, 0.844, and 0.151, respectively. Age and the number of transplants were not significantly related to the change in incidence rates for all skin lesion types. Six of the total of 14 patients experienced grade 3/4 toxicities, including mucositis (2), hand-foot syndrome (3), fatigue (2), nausea (1), diarrhea (2), hyperuricemia (1), and anemia (1), and all six needed capecitabine dose reduction or stopping therapy. Conclusions: Oral capecitabine significantly decreases the incidence rates of recurrent SCC in OTR and has manageable toxicity. No significant financial relationships to disclose.

scholarly journals Application Of The WBZ (Warm Belt Zinger) Method To The Intensity Of Labor Pain At The BL 31-32 Meridian Points In PMB Semarang City

2020 ◽  
Vol 4 (11) ◽  
pp. 375-380
Author(s):  
Lestari Puji Astuti ◽  
Poppy Fransisca Amelia ◽  
Heny Wijayanti ◽  
Sa’adah Mujahidah
Keyword(s):  
Control Design ◽  
Sampling Technique ◽  
Active Phase ◽  
Statistical Test ◽  
Labor Pain ◽  
P Value ◽  
Test Results ◽  
Before And After ◽  
And Control ◽  
First Time

The research purposes to find out the effectiveness of WBZ (Warm Belt Zinger) and warm compresses at the meridian points BL 31 and 32 on the intensity of labor pain during. The pain that a woman experiences while entering labor is a physiological process. Labor pain is the most severe thing felt by women throughout their life. Non-pharmacological efforts are needed to reduce labor pain. Types of research was quasi-experiment with pretest-posttest with control design. The sampling technique used was accidental sampling with sample size of 30 people and divided into two groups intervention WBZ n=15 and control (warm compress) n=15. The subjects were the mothers who gave birth in were in the first phase of the active phase (4-10 cm opening). There was differences in first time pain in the maternity before and after the WBZ group (p-value = 0.000). There was a difference in first-time pain in the maternity before and after in the warm compress (p-value = 0.000). Statistical test results WBZ and warm compresses are effective for decrease the pain in first stage labor (p-value = 0.001). WBZ and warm compresses effective to reduce labor pain in the first stage. Keywords: ginger compress; warm compress; meridian points bl 31 and 32; intensity of labor pain

Untersuchungen zur Quantifizierung der Änderung der Skelettmuskeldurchblutung nach Gefäßrevaskularisationen mit einem 99mTechnetiummarkierten Tracer

1990 ◽  
Vol 29 (05) ◽  
pp. 215-220 ◽  
Author(s):  
R. Benning ◽  
K. Nagel ◽  
M. Jugenheimer ◽  
S. Fischer ◽  
S. Worthmann ◽  
...  
Keyword(s):  
Transluminal Angioplasty ◽  
Lower Limbs ◽  
Surgical Patients ◽  
Treadmill Test ◽  
Negative Results ◽  
Clinical Observations ◽  
Before And After ◽  
Comparative Results ◽  
First Time ◽  
Percutaneous Transluminal

A new 99mTc-labelled tracer (99mTc-Sestanriibi) was used for the first time to demonstrate the perfusion of the skeletal muscle. In 16 patients with obstructive atherosclerosis of the lower limbs the change of perfusion of thigh and lower leg was studied with SPECT before and after vascular surgery (n = 11) or percutaneous transluminal angioplasty (n = 5). Comparative results of scintigraphic measurements and clinical observations (ancle-arm pressure, treadmill test) in 10 surgical patients (14 operated legs) showed correct positive or negative results in 86% (12/14).

Pengaruh Perawatan Metode Kanguru (PMK) terhadap Pencegahan Hipotermi pada Bayi Baru Lahir

2020 ◽  
Vol 2 (2) ◽  
pp. 66-71
Author(s):  
Parti ◽  
Sumiati Malik ◽  
Nurhayati
Keyword(s):  
Birth Weight ◽  
Infant Mortality ◽  
Low Birth Weight ◽  
Health Workers ◽  
Kangaroo Mother Care ◽  
Infant Mortality Rate ◽  
P Value ◽  
Low Birth Weight Infants ◽  
Low Birth Weight Babies ◽  
Before And After

Most causes of infant death are problems that occur in newborn/neonatal (0-28 days old), Low Birth Weight Babies (LBW) is one of the factors which has a contribution to infant mortality, especially in the neonatal period. Infant Mortality Rate (IMR) is a benchmark in determining the degree of public health, both at the National and Provincial levels. This study aimed to determine the effect of the Kangaroo Mother Care Method (KMC) on the prevention of hypothermia in low birth weight infants at Morowali District Hospital in 2019. The type of research used was a quasi-experiment. The population is all low birth weight babies born from May to July 2019. The sample in this study was all newborns with low birth weight born from May to July 2019, totaling 30 babies. There is a difference (influence) on the baby's body temperature before and after KMC with a p-value=0,000. The kangaroo mother care can continue to be affiliated considering its benefits for both infants and mothers, as well as increasing the ability of health workers in conducting KMC so that they can provide in-house training for mothers to be carried out at home.

Trombodynamics Method in the Assessment of Coagulation Parameters in Psychopharmacotherapy of Endogenous Mental Disorders

Psychiatry ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 16-25
Author(s):  
N. S. Karpova ◽  
O. S. Brusov ◽  
I. V. Oleichik ◽  
M. I. Faktor ◽  
N. S. Levchenko ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Response To Therapy ◽  
Procoagulant Activity ◽  
Coagulation Activity ◽  
Continuous Type ◽  
Chronic Neuroinflammation ◽  
Psychopharmacological Treatment ◽  
Before And After ◽  
First Time ◽  
Schizotypal Disorder

Background: currently, it has been proven that the pathogenesis of endogenous mental disorders is associated with the process of neuroinflammation in the brain of patients. It is also known that chronic neuroinflammation, accompanied by a violation the permeability of the blood-brain barrier. It is accompanied by the activation of platelets that generate procoagulant microparticles, which leads to a disturbance of the hemostasis system, causing an increase in blood clotting in patients. Objective: to investigate the dynamics of procoagulant activity of blood in patients with endogenous mental disorders before and after psychopharmacotherapy.Patients and methods: the study included 185 patients aged 16 to 64 years with the following mental disorders: schizophrenia with attack-like/attack-progressive/continuous type of course (F20.00–2), affective disease (F31.1–5; F32.0–3; F33.0–3), schizotypal disorder with affective fluctuations (F21.3–4). The thrombodynamic test (TD) was performed on T-2 Trombodynamis device according to the manufacturer’s instructions (Hemacore LLC, Moscow, Russia). All patients received standard pharmacotherapy according to their condition.Results: a significant decrease of procoagulant activity of spontaneous clots in the patients’ blood after psychopharmacological treatment is observed. Our data on the positive dynamics of changes in the values of TD test’s indicators in most of the examined patients suggest that a decrease in the coagulation activity of the patients’ blood as a result of treatment may be associated with the anti- inflammatory effect of antipsychotics and antidepressants.Conclusion: for the first time, it was shown that there is a positive dynamic in changing the values of the main parameters of the TD test in most patients with endogenous mental diseases. The results of TD tests can be the basis for monitoring the response to therapy.

PENGARUH PIJAT BAYI TERHADAP KUALITAS TIDUR BAYI UMUR 0 – 3 BULAN DI WILAYAH KERJA PUSKESMAS SOSIAL PALEMBANG TAHUN 2016

2019 ◽  
Vol 6 (2) ◽  
Author(s):  
Juliana Widyastuti Wahyuningsih Juliana Widyastuti Wahyuningsih
Keyword(s):  
Experimental Design ◽  
Growth And Development ◽  
Sampling Technique ◽  
P Value ◽  
Development Phase ◽  
Quality Of Sleep ◽  
Infant Massage ◽  
Before And After ◽  
The Brain

ABSTRAK Tidur merupakan kebutuhan yang harus terpenuhi terutama pada fase perkembangan karena selama tidur akan terjadi perkembangan otak maupun tubuh, sehingga gangguan tidur merupakan masalah yang akan menimbulkan dampak buruk terhadap pertumbuhan dan perkembangan bayi. Kualitas tidur bayi yang baik dapat diciptakan dengan memberikan pemijatan bayi secara rutin. Penelitian ini bertujuan untuk membuktikan bahwa pemijatan dapat mempengaruhi kualitas tidur bayi umur 0-3 bulan. Penelitian ini menggunakan desain penelitian Quasy Eksperimental dengan metode One Group Pretest-Postest. Sampel 22 bayi yang dipilih dengan tehnik Total Sampling yang di observasi sebelum dan sesudah diberikan pemijatan. Variabel yang diukur dalam penelitian ini adalah kualitas tidur bayi 0-3 bulan. Hasil penelitian menunjukkan bahwa ada pengaruh pijat bayi terhadap kualitas tidur bayi umur 0-3 bulan (p value  0,008 < α = 0,05).Berdasarkan hasil penelitian ini disarankan agar keluarga dan masyarakat memberikan pemijatan secara rutin dan mandiri untuk meningkatkan kebutuhan tidur bayi yang berkualitas.   ABSTRACT Sleep is a human necessity that must be met, especially in the development phase because during sleep will occur the brain and body developments, so that sleep disturbance is a problem that would cause adverse effects on infants’ growth and development. The good quality of sleep can be created by providing the infants massage routinely. This study aimed to prove that the massage could affect the quality of sleep on the 0-3 months old baby. This study used Quasy-experimental design with One Group Pretest-Posttest. The sample 22 infants selected by total sampling technique observed on before and after the massage. The variables measured in this study are the quality of sleep. The results of study indicate that there is an effect of infant massage to the sleep quality on 0-3 months old babies (p value 0,008 < α = 0,05).Based on the results of this study it recommended for the families and communities to provide infant massage regularly and independently to increase the quality of sleep on the baby.  

Temporal trends in utilization of transcatheter aortic valve implantation and patient characteristics – a nationwide cohort study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
J.E Strange ◽  
C Sindet-Pedersen ◽  
G Gislason ◽  
C Torp-Pedersen ◽  
E.L Fosboel ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Transcatheter Aortic Valve Implantation ◽  
Temporal Trends ◽  
Patient Characteristics ◽  
P Value ◽  
Transcatheter Aortic Valve ◽  
History Of ◽  
Aortic Valve Implantation ◽  
Valve Implantation ◽  
First Time

Abstract Introduction In recent years, there has been a surge in the utilization of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis. Randomized controlled trials have compared TAVI to surgical aortic valve replacement (SAVR) in patients at high-, intermediate-, and low perioperative risk. As TAVI continues to be utilized in patients with lower risk profiles, it is important to investigate the temporal trends in “real-world” patients undergoing TAVI. Purpose To investigate temporal trends in the utilization of TAVI and examine changes in patient characteristics of patients undergoing first-time TAVI. Methods Using complete Danish nationwide registries, we included all patients undergoing first-time TAVI between 2008 and 2017. To compare patient characteristics, the study population was stratified according to calendar year in the following groups: 2008–2009, 2010–2011, 2012–2013, 2014–2015, and 2016–2017. Results We identified 3,534 patients undergoing first-time TAVI. In 2008–2009, 180 patients underwent first-time TAVI compared with 1,417 patients in 2016–2017, resulting in a 687% increase in TAVI procedures performed. During the study period, the median age remained stable (2008–2009: Median age 82 year [25th–75th percentile: 78–85] vs. 2016–2017: Median age 81 years [25th–75th percentile: 76–85]; P-value: 0.06). The proportion of men undergoing first-time TAVI increased over the years (2008–2009: 49.4% vs 2016–2017: 54.9%; P-value for trend: &lt;0.05), also the proportion with diabetes increased (2008–2009: 12.2% vs. 2016–2017: 19.3%; P-value for trend: &lt;0.05). The proportion of patients with a history of stroke decreased over the years (2008–2009: 13.9% vs. 2016–2017: 12.1%; P-value for trend: &lt;0.05). The same trend was seen in patients with a history of myocardial infarction (2008–2009: 24.4% vs. 2016–2017: 11.9%; P-value for trend: &lt;0.05), ischaemic heart disease (2008–2009: 71.7% vs. 2016–2017: 29.4%; P-value for trend: &lt;0.05), and heart failure (2008–2009: 45.6% vs. 2016–2017: 29.4%; P-value for trend: &lt;0.05). Conclusions In this nationwide study, there was a marked increase in the utilization of TAVI in the years 2008–2017. Patients undergoing first-time TAVI had a decreasing comorbidity burden, while the age of the patients at first-time TAVI remained stable. Funding Acknowledgement Type of funding source: None

scholarly journals Influences of the selected additives on the weight loss and organoleptic properties of marinated mussels and squids

2012 ◽  
Vol 81 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Metin Guldas ◽  
Canan Hecer
Keyword(s):  
Weight Loss ◽  
Salt Content ◽  
Meat Products ◽  
Organoleptic Properties ◽  
Highest Weight ◽  
Konjac Flour ◽  
Weight Gains ◽  
Before And After ◽  
Mouth Feel ◽  
First Time

Effects of seven different solutions prepared from various additives (carrageenan, konjac flour, phosphate, yeast extract, xanthan gum and maltodextrin) were used to test for the first time in the marination of experimental seafood. The additives were added into the marination solutions and the samples were analyzed before and after marination. Statistically, the experimental solutions did not cause significant changes in pH, acidity and salt content of the samples (P < 0.05). The highest weight gains were obtained from the solution which contained 0.1% of konjac flour (E425 I) as 4.01, 5.21, 4.61 and 4.88 % in the mussels, big squids, diced squids and small squids, respectively. However, this solution was not preferred by the panellists because of its sticky texture. Inversely to red meat products, the solution containing phosphate caused weight loss during marination. The results indicate that the solution containing 0.2% carrageenan LM (low methoxyl) was the best solution in the marination process. Dipping into this solution caused weight gains of 4.69, 2.98, 4.04 and 2.78% in the big squids, the mussels, the small squids and the diced squids, respectively (P < 0.01). The organoleptic properties (mouth feel, flavour and softness) of mussels and squids were also improved by carrageenan LM addition.

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