scholarly journals AtDAT1 is a key enzyme of D-amino acid stimulated ethylene production in Arabidopsis thaliana

2019 ◽  
Author(s):  
Juan Suarez ◽  
Claudia Hener ◽  
Vivien-Alisa Lehnhardt ◽  
Sabine Hummel ◽  
Mark Stahl ◽  
...  
Keyword(s):  
Ethylene Production ◽  
Biochemical Characterization ◽  
Reciprocal Relation ◽  
Loss Of Function ◽  
Working Models ◽  
Specific Effects ◽  
Starting Point ◽  
Natural Variants ◽  
Key Enzyme ◽  
The Impact

AbstractD-enantiomers of proteinogenic amino acids (D-AAs) are found ubiquitously, but the knowledge about their metabolism and functions in plants is scarce. A long forgotten phenomenon in this regard is the D-AA-stimulated ethylene production in plants. As a starting point to investigate this effect the Arabidopsis accession Landsberg erecta (Ler) got into focus as it was found defective in metabolizing D-AAs. Combining genetics and molecular biology of T-DNA lines and natural variants together with biochemical and physiological approaches we could identify AtDAT1 as a major D-AA transaminase in Arabidopsis. Atdat1 loss-of-function mutants and Arabidopsis accessions with defective AtDAT1 alleles were not able to produce D-Ala, D-Glu and L-Met, the metabolites of D-Met, anymore. This result corroborates the biochemical characterization of AtDAT1, which showed highest activity using D-Met as substrate. Germination of seedlings in light and dark led to enhanced growth inhibition of atdat1 mutants on D-Met. Ethylene measurements revealed an enhanced D-AA stimulated ethylene production in these mutants. According to initial working models of this phenomenon D-Met is preferentially malonylated instead of the ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC). This decrease of ACC degradation should then lead to the increase of ethylene production. We could observe in our studies a reciprocal relation of malonylated methionine and ACC upon D-Met application and even significantly more malonyl-methionine in atdat1 mutants. Unexpectedly, the malonyl-ACC levels did not differ between mutants and wild type in these experiments. With AtDAT1, the first central enzyme of plant D-AA metabolism was characterized biochemically and physiologically. The specific effects of D-Met on ACC metabolization, ethylene production and plant development of dat1 mutants unraveled the impact of AtDAT1 on these processes, but they are not in full accordance to previous working models. Instead, our results imply the influence of additional candidate factors or processes on D-AA-stimulated ethylene production which await to be uncovered.

The Impact of Visual Stereotypes on Judgments about Rape

2016 ◽  
Vol 75 (3) ◽  
pp. 133-140
Author(s):  
Robert Busching ◽  
Johannes Lutz
Keyword(s):  
Mental Representations ◽  
Irrelevant Information ◽  
Clear Distinction ◽  
Rape Myth ◽  
Facial Features ◽  
Reverse Correlation ◽  
Correlation Technique ◽  
Specific Effects ◽  
Legal Judgments ◽  
The Impact

Abstract. Legally irrelevant information like facial features is used to form judgments about rape cases. Using a reverse-correlation technique, it is possible to visualize criminal stereotypes and test whether these representations influence judgments. In the first step, images of the stereotypical faces of a rapist, a thief, and a lifesaver were generated. These images showed a clear distinction between the lifesaver and the two criminal representations, but the criminal representations were rather similar. In the next step, the images were presented together with rape scenarios, and participants (N = 153) indicated the defendant’s level of liability. Participants with high rape myth acceptance scores attributed a lower level of liability to a defendant who resembled a stereotypical lifesaver. However, no specific effects of the image of the stereotypical rapist compared to the stereotypical thief were found. We discuss the findings with respect to the influence of visual stereotypes on legal judgments and the nature of these mental representations.

Liszt at the Piano: The Impact of Iconography on mid-Nineteenth Century Musicology

2014 ◽  
Vol 55 (1-2) ◽  
pp. 131-144
Author(s):  
Suzanne Marie Francis
Keyword(s):  
Nineteenth Century ◽  
Music History ◽  
Collective Identities ◽  
Cultural Contexts ◽  
Maximum Benefit ◽  
Starting Point ◽  
The Social ◽  
Iconic Status ◽  
The Impact

By the time of his death in 1827, the image of Beethoven as we recognise him today was firmly fixed in the minds of his contemporaries, and the career of Liszt was beginning to flower into that of the virtuosic performer he would be recognised as by the end of the 1830s. By analysing the seminal artwork Liszt at the Piano of 1840 by Josef Danhauser, we can see how a seemingly unremarkable head-and-shoulders bust of Beethoven in fact holds the key to unlocking the layers of commentary on both Liszt and Beethoven beneath the surface of the image. Taking the analysis by Alessandra Comini as a starting point, this paper will look deeper into the subtle connections discernible between the protagonists of the picture. These reveal how the collective identities of the artist and his painted assembly contribute directly to Beethoven’s already iconic status within music history around 1840 and reflect the reception of Liszt at this time. Set against the background of Romanticism predominant in the social and cultural contexts of the mid 1800s, it becomes apparent that it is no longer enough to look at a picture of a composer or performer in isolation to understand its impact on the construction of an overall identity. Each image must be viewed in relation to those that preceded and came after it to gain the maximum benefit from what it can tell us.

Nachhaltigkeit im Wald – vor und hinter der Welle der Globalisierung | Sustainable Forest Management – In Front and Behind the Wave of Globalization

2000 ◽  
Vol 151 (12) ◽  
pp. 502-507
Author(s):  
Christian Küchli
Keyword(s):  
Forest Management ◽  
Cultural Landscape ◽  
Sustainable Forest Management ◽  
Essential Element ◽  
Specific Situation ◽  
The South ◽  
The North ◽  
Time Space ◽  
Starting Point ◽  
The Impact

Are there any common patterns in the transition processes from traditional and more or less sustainable forest management to exploitative use, which can regularly be observed both in central Europe and in the countries of the South (e.g. India or Indonesia)? Attempts were made with a time-space-model to typify those force fields, in which traditional sustainable forest management is undermined and is then transformed into a modern type of sustainable forest management. Although it is unlikely that the history of the North will become the future of the South, the glimpse into the northern past offers a useful starting point for the understanding of the current situation in the South, which in turn could stimulate the debate on development. For instance, the patterns which stand behind the conflicts on forest use in the Himalayas are very similar to the conflicts in the Alps. In the same way, the impact of socio-economic changes on the environment – key word ‹globalisation› – is often much the same. To recognize comparable patterns can be very valuable because it can act as a stimulant for the search of political, legal and technical solutions adapted to a specific situation. For the global community the realization of the way political-economic alliances work at the head of the ‹globalisationwave›can only signify to carry on trying to find a common language and understanding at the negotiation tables. On the lee side of the destructive breaker it is necessary to conserve and care for what survived. As it was the case in Switzerland these forest islands could once become the germination points for the genesis of a cultural landscape, where close-to-nature managed forests will constitute an essential element.

The Opera-Telephone in Munich

2018 ◽  
Author(s):  
Sonja Neumann
Keyword(s):  
Social Economic ◽  
Historical Analysis ◽  
Technical Innovation ◽  
Reciprocal Relation ◽  
Special Means ◽  
Private And Public ◽  
Listening Experience ◽  
Visual Element ◽  
The Impact ◽  
Technical Products

Through a cultural-historical analysis, the chapter portrays the Opera-Telephone in Munich as a special means of listening and explores its technical, social, economic, and psychological aspects. These aspects strongly reflect the reciprocal relation of technical innovation and listening to music, for example, by emphasizing the meaning of live broadcasting for listening habits and by highlighting the impact of headphone use on aural perception. The latter practice enables the transfer of the multidimensional opera event into a pure listening experience as the visual element is eliminated. The Opera-Telephone also serves to illustrate matters of social status in regard to private and public listening. In this way, opera was incorporated into the marketing of modern technical products.

Law and Economics

2020 ◽  
pp. 84-102
Author(s):  
Daniel B. Kelly
Keyword(s):  
Economic Analysis ◽  
First Generation ◽  
Law And Economics ◽  
Private Law ◽  
Foreseeable Future ◽  
Business Associations ◽  
The Third ◽  
Starting Point ◽  
The Law ◽  
The Impact

This chapter analyzes how law and economics influences private law and how (new) private law is influencing law and economics. It focuses on three generation or “waves” within law and economics and how they approach private law. In the first generation, many scholars took the law as a starting point and attempted to use economic insights to explain, justify, or reform legal doctrines, institutions, and structures. In the second generation, the “law” at times became secondary, with more focus on theory and less focus on doctrines, institutions, and structures. But this generation also relied increasingly on empirical analysis. In the third generation, which includes scholars in the New Private Law (NPL), there has been a resurgence of interest in the law and legal institutions. To be sure, NPL scholars analyze the law using various approaches, with some more and some less predisposed to economic analysis. However, economic analysis will continue to be a major force on private law, including the New Private Law, for the foreseeable future. The chapter considers three foundational private law areas: property, contracts, and torts. For each area, it discusses the major ideas that economic analysis has contributed to private law, and surveys contributions of the NPL. The chapter also looks at the impact of law and economics on advanced private law areas, such as business associations, trusts and estates, and intellectual property.

scholarly journals ATP13A2 Regulates Cellular α-Synuclein Multimerization, Membrane Association, and Externalization

2021 ◽  
Vol 22 (5) ◽  
pp. 2689
Author(s):  
Jianmin Si ◽  
Chris Van den Haute ◽  
Evy Lobbestael ◽  
Shaun Martin ◽  
Sarah van Veen ◽  
...  
Keyword(s):  
Membrane Integrity ◽  
Ubiquitin Proteasome System ◽  
Regulatory Function ◽  
Membrane Association ◽  
Loss Of Function ◽  
Atypical Form ◽  
Polyamine Transport ◽  
Independent Functions ◽  
Ubiquitin Proteasome ◽  
The Impact

ATP13A2, a late endo-/lysosomal polyamine transporter, is implicated in a variety of neurodegenerative diseases, including Parkinson’s disease and Kufor–Rakeb syndrome, an early-onset atypical form of parkinsonism. Loss-of-function mutations in ATP13A2 result in lysosomal deficiency as a consequence of impaired lysosomal export of the polyamines spermine/spermidine. Furthermore, accumulating evidence suggests the involvement of ATP13A2 in regulating the fate of α-synuclein, such as cytoplasmic accumulation and external release. However, no consensus has yet been reached on the mechanisms underlying these effects. Here, we aimed to gain more insight into how ATP13A2 is linked to α-synuclein biology in cell models with modified ATP13A2 activity. We found that loss of ATP13A2 impairs lysosomal membrane integrity and induces α-synuclein multimerization at the membrane, which is enhanced in conditions of oxidative stress or exposure to spermine. In contrast, overexpression of ATP13A2 wildtype (WT) had a protective effect on α-synuclein multimerization, which corresponded with reduced αsyn membrane association and stimulation of the ubiquitin-proteasome system. We also found that ATP13A2 promoted the secretion of α-synuclein through nanovesicles. Interestingly, the catalytically inactive ATP13A2 D508N mutant also affected polyubiquitination and externalization of α-synuclein multimers, suggesting a regulatory function independent of the ATPase and transport activity. In conclusion, our study demonstrates the impact of ATP13A2 on α-synuclein multimerization via polyamine transport dependent and independent functions.

Engels on women, the family, class and gender

2021 ◽  
pp. 194277862110000
Author(s):  
Sheila Margaret McGregor
Keyword(s):  
Historical Materialism ◽  
Human Society ◽  
Human Beings ◽  
True Nature ◽  
Starting Point ◽  
Women's Oppression ◽  
1960S And 1970S ◽  
Socialist Movement ◽  
The Impact ◽  
The Way

This article looks at Engels’s writings to show that his ideas about the role of labour in the evolution of human beings in a dialectical relationship between human beings and nature is a crucial starting point for understanding human society and is correct in its essentials. It is important for understanding that we developed as a species on the basis of social cooperation. The way human beings produce and reproduce themselves, the method of historical materialism, provides the basis for understanding how class and women’s oppression arose and how that can explain LGBTQ oppression. Although Engels’s analysis was once widely accepted by the socialist movement, it has mainly been ignored or opposed by academic researchers and others, including geographers, and more recently by Marxist feminists. However, anthropological research from the 1960s and 1970s as well as more recent anthropological and archaeological research provide overwhelming evidence for the validity of Engels’s argument that there were egalitarian, pre-class societies without women’s oppression. However, much remains to be explained about the transition to class societies. Engels’s analysis of the impact of industrial capitalism on gender roles shows how society shapes our behaviour. Engels’s method needs to be constantly reasserted against those who would argue that we are a competitive, aggressive species who require rules to suppress our true nature, and that social development is driven by ideas, not by changes in the way we produce and reproduce ourselves.

scholarly journals On Present Value Evaluation under the Impact of Behavioural Factors Using Oriented Fuzzy Numbers

Symmetry ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 468
Author(s):  
Krzysztof Piasecki ◽  
Anna Łyczkowska-Hanćkowiak
Keyword(s):  
Fuzzy Numbers ◽  
Asset Price ◽  
Financial Knowledge ◽  
Present Value ◽  
Market Knowledge ◽  
Value Evaluation ◽  
Starting Point ◽  
Behavioural Factors ◽  
Objective Financial Knowledge ◽  
The Impact

In general, the present value (PV) concept is ambiguous. Therefore, behavioural factors may influence on the PV evaluation. The main aim of our paper is to propose some method of soft computing PV evaluated under the impact of behavioural factors. The starting point for our discussion is the notion of the Behavioural PV (BPV) defined as an imprecisely real-valued function of distinguished variables which can be evaluated using objective financial knowledge or subjective behavioural premises. In our paper, a BPV is supplemented with a forecast of the asset price closest to changes. Such BPV is called the oriented BPV (O-BPV). We propose to evaluate an O-BPV by oriented fuzzy numbers which are more useful for portfolio analysis than fuzzy numbers. This fact determines the significance of the research described in this article. O-BPV may be applied as input signal for systems supporting invest-making. We consider here six cases of O-BPV: overvalued asset with the prediction of a rise in its price, overvalued asset with the prediction of a fall in its price, undervalued asset with the prediction of a rise in its price, undervalued asset with the prediction of a fall in its price, fully valued asset with the prediction of a rise in its rice and fully valued asset with the prediction of a fall in its rice. All our considerations are illustrated by numerical examples. Presented examples show the way in which we transform superposition of objective market knowledge and subjective investment opinion into simple return rate.

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

2021 ◽  
pp. 1-10
Author(s):  
Varvara Kanti ◽  
Lia Puder ◽  
Irina Jahnke ◽  
Philipp Maximilian Krabusch ◽  
Jan Kottner ◽  
...  
Keyword(s):  
Leptin Receptor ◽  
Skin Pigmentation ◽  
Gene Mutations ◽  
Continuous Treatment ◽  
Whole Body ◽  
Hair Color ◽  
Phase 2 ◽  
Loss Of Function ◽  
The Impact ◽  
Over Time

<b><i>Background and Objectives:</i></b> Gene mutations within the leptin-melanocortin signaling pathway lead to severe early-onset obesity. Recently, a phase 2 trial evaluated new pharmacological treatment options with the MC4R agonist <i>setmelanotide</i> in patients with mutations in the genes encoding proopiomelanocortin (POMC) and leptin receptor (LEPR). During treatment with <i>setmelanotide,</i> changes in skin pigmentation were observed, probably due to off-target effects on the closely related melanocortin 1 receptor (MC1R). Here, we describe in detail the findings of dermatological examinations and measurements of skin pigmentation during this treatment over time and discuss the impact of these changes on patient safety. <b><i>Methods:</i></b> In an investigator-initiated, phase 2, open-label pilot study, 2 patients with loss-of-function POMC gene mutations and 3 patients with loss-of-function variants in LEPR were treated with the MC4R agonist <i>setmelanotide</i>. Dermatological examination, dermoscopy, whole body photographic documentation, and spectrophotometric measurements were performed at screening visit and approximately every 3 months during the course of the study. <b><i>Results:</i></b> We report the results of a maximum treatment duration of 46 months. Skin pigmentation increased in all treated patients, as confirmed by spectrophotometry. During continuous treatment, the current results indicate that elevated tanning intensity levels may stabilize over time. Lips and nevi also darkened. In red-haired study participants, hair color changed to brown after initiation of <i>setmelanotide</i> treatment. <b><i>Discussion:</i></b> <i>Setmelanotide</i> treatment leads to skin tanning and occasionally hair color darkening in both POMC- and LEPR-deficient patients. No malignant skin changes were observed in the patients of this study. However, the results highlight the importance of regular skin examinations before and during MC4R agonist treatment.

Analysis of the journal impact factor and related bibliometric indicators in education and educational research category

2021 ◽  
pp. 1-22
Author(s):  
Metin Orbay ◽  
Orhan Karamustafaoğlu ◽  
Ruben Miranda
Keyword(s):  
Impact Factor ◽  
Educational Research ◽  
Journal Impact Factor ◽  
Impact Factors ◽  
Bibliometric Indicators ◽  
Strongly Correlated ◽  
Starting Point ◽  
Consistent Assessment ◽  
The Impact ◽  
Journal Impact

This study analyzes the journal impact factor and related bibliometric indicators in Education and Educational Research (E&ER) category, highlighting the main differences among journal quartiles, using Web of Science (Social Sciences Citation Index, SSCI) as the data source. High impact journals (Q1) publish only slightly more papers than expected, which is different to other areas. The papers published in Q1 journal have greater average citations and lower uncitedness rates compared to other quartiles, although the differences among quartiles are lower than in other areas. The impact factor is only weakly negative correlated (r=-0.184) with the journal self-citation but strongly correlated with the citedness of the median journal paper (r= 0.864). Although this strong correlation exists, the impact factor is still far to be the perfect indicator for expected citations of a paper due to the high skewness of the citations distribution. This skewness was moderately correlated with the citations received by the most cited paper of the journal (r= 0.649) and the number of papers published by the journal (r= 0.484), but no important differences by journal quartiles were observed. In the period 2013–2018, the average journal impact factor in the E&ER has increased largely from 0.908 to 1.638, which is justified by the field growth but also by the increase in international collaboration and the share of papers published in open access. Despite their inherent limitations, the use of impact factors and related indicators is a starting point for introducing the use of bibliometric tools for objective and consistent assessment of researcher.

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