Change in regulation of serum cholesterol induced by homologous and heterologous desoxyribonucleic acid

1959 ◽  
Vol 197 (6) ◽  
pp. 1359-1363 ◽  
Author(s):  
J. Philip Savitsky
Keyword(s):  
Normal Control ◽  
Serum Cholesterol ◽  
Active Material ◽  
Desoxyribonucleic Acid ◽  
Beef Liver ◽  
Cholesterol Levels ◽  
Regulatory Systems ◽  
Change In The Mean ◽  
The Mean ◽  
Induced Changes

Desoxyribonucleic acid (DNA) was carefully prepared in a highly purified, undenatured form from beef brain, beef liver and rabbit liver. One milligram of DNA was injected into each rabbit. Over a period of 2–6 months the mean serum cholesterol declined significantly below normal control levels. This change in the mean largely reflected the decline in cholesterol levels of those animals with high normal values. Concomitantly, the standard deviation and coefficient of variation of the serum cholesterol levels decreased to one-third the normal control values. The serum phospholipids and neutral fat showed similar lower mean levels and decreasing variation. Evidence is presented that the injected DNA is the active material producing these changes. Homologous and heterologous DNA were equally effective. An hypothesis is suggested relating the DNA-induced changes in the serum lipids to polygenic regulatory systems.

Prolonged alteration of serum cholesterol induced by deoxyribonucleic acid in rabbits

1961 ◽  
Vol 200 (3) ◽  
pp. 541-544 ◽  
Author(s):  
J. Philip Savitsky
Keyword(s):  
Serum Cholesterol ◽  
Deoxyribonucleic Acid ◽  
Normal Values ◽  
Single Injection ◽  
Desoxyribonucleic Acid ◽  
Beef Liver ◽  
Cholesterol Levels ◽  
Change In The Mean ◽  
The Mean ◽  
Time Required

Desoxyribonucleic acid (DNA) was carefully prepared in a highly purified, undenatured form from beef liver. Each rabbit of a group of 20 rabbits received a single injection of 1 mg of this heterologous DNA. The mean serum cholesterol declined significantly within 4 months and was maintained at the new lower level with no return to control values for at least 2 years. This change in the mean reflected the decline in cholesterol levels of those animals with high normal values. The serum phospholipids responded similarly but no changes were observed in the serum neutral fat concentrations. Injection with varying quantities of DNA showed that the time required for changes to appear depended upon the amount of DNA injected.

An Assessment of Serum Cholesterol level and BMI in Women: Study in Several Private Chambers in Mymensingh

2019 ◽  
Vol 8 (2) ◽  
pp. 4-9
Author(s):  
Nahid Bintay Ansary ◽  
Arup Ratan Paul ◽  
Md Mahamudur Rahman ◽  
Maria Hussain ◽  
Rubiat Naznin
Keyword(s):  
Cardiovascular Disease ◽  
Health Status ◽  
Cholesterol Level ◽  
Serum Cholesterol ◽  
Serum Cholesterol Level ◽  
Normal Weight ◽  
Cholesterol Levels ◽  
Increased Risk ◽  
The Mean ◽  
Study Participants

The increased risk of cardiovascular disease associated with higher serum cholesterol levels in middle-aged persons has been established, but there have been few studies conducted regarding the issues in Mymensingh. For evaluation of serum cholesterol and BMI in women of Mymensingh, across-sectional studywas conducted in several private chambers in the districts of Mymensingh, Bangladesh during the period from January 2017 to December 2017. A total of 48 Female patients participated in the study. In the study, participants were aged between 18 to 29 years of age. The study suggested that the serum cholesterol was below 4.99 were 15(31.25%), 5.00 to 6.49 were 13(26.08%) and above 6.50 were 20 (41.67%), the Mean ± SD was 4.45 (0.76). The health status according to BMI showed that 12.50% (n=6) of the participants were underweight <18.49, majority 50.00% (n=24) of the population were from normal weight range (18.5-24.9), 16.67% (n=8) of the participants were overweight and 20.83 %( n=10) of the participants were obese >30. The Mean ± SD was 18.93± (3.68). Measurement of BMI and Serum Cholesterol levels can help doctors to treat patients properly for reducing the burden of death in our country. CBMJ 2019 July: Vol. 08 No. 02 P: 4-9

scholarly journals The effect of coffee consumption on serum total cholesterol in the Sami and Norwegian populations

2010 ◽  
Vol 13 (11) ◽  
pp. 1818-1825 ◽  
Author(s):  
Tove Nystad ◽  
Marita Melhus ◽  
Magritt Brustad ◽  
Eiliv Lund
Keyword(s):  
Total Cholesterol ◽  
Serum Cholesterol ◽  
Coffee Consumption ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
The Mean ◽  
The Impact

AbstractObjectiveTo assess coffee consumption in the Sami and Norwegian populations and to investigate the impact of unfiltered boiled coffee consumption on serum cholesterol concentrations.DesignA cross-sectional study. Information was collected by self-administrated questionnaires and total serum cholesterol was analysed. Participants were divided into three ethnic groups: Sami I (Sami used as home language in the last three generations), Sami II (at least one Sami identity marker) and Norwegian.SettingIn an area with Sami, Kven/Finnish and Norwegian populations, the SAMINOR study, 2003–2004.SubjectsA total of 5647 men and 6347 women aged 36–79 years.ResultsMore than 90 % of the study populations were coffee drinkers. Only 22 % were unfiltered coffee consumers. Sami I had the highest proportion of participants who consumed nine or more cups of unfiltered coffee per day, although the number of participants was limited. Total coffee consumption was associated with increased total cholesterol for men (P < 0·01) and women (P < 0·0001). For those who drank only unfiltered coffee, a significant association was found only in Norwegian men, adjusted for physical activity in leisure time, BMI and smoking habits (P < 0·001). From the lowest (less than five cups) to the highest (nine or more cups) unfiltered coffee consumption category, the mean total cholesterol levels increased by 0·29 mmol/l in Norwegian men.ConclusionsUnfiltered coffee consumption was lower in the present study compared to previous reports. In general, total coffee consumption was positively associated with total cholesterol levels. However, for unfiltered coffee consumption, an association was found only in Norwegian men.

Serum cholesterol levels of inbred rats

1964 ◽  
Vol 207 (3) ◽  
pp. 631-633 ◽  
Author(s):  
David Kritchevsky ◽  
Shirley A. Tepper
Keyword(s):  
Body Weight ◽  
Serum Cholesterol ◽  
Inbred Strains ◽  
Female Rats ◽  
Male Rats ◽  
Liver Cholesterol ◽  
Cholesterol Levels ◽  
Male And Female Rats ◽  
Males And Females ◽  
The Mean

Changes in serum cholesterol levels with age have been studied in male and female rats of three inbred strains (BN, DA, and Lewis) and one random-bred strain (Wistar). The mean serum cholesterol levels at each age differed among strains. Serum cholesterol levels (mg/100 ml) for male rats at 30, 60, and 90 days were: BN-65, 46, and 47; DA-105, 85, and 101; Lewis-79, 76, and 57; and Wistar-64, 63, and 73. For female rats the values were: BN-56, 45, and 47; DA-86, 74, and 91; Lewis-77, 83, and 67; and Wistar-59, 71, and 83. The variation of serum cholesterol with age was different between strains, but similar for males and females within each strain. There was no correlation between body weight and serum cholesterol. Liver cholesterol levels (mg/100 g) determined at 90 days were, for the males, BN-187, DA-233, Lewis-247, and Wistar-300, and for the females, BN-188, DA-244, Lewis-216, and Wistar-249. No correlation with body weight or serum cholesterol was observed.

scholarly journals Metabolic Effects of Two Different Doses of Venlafaxine Therapy on Rats

2015 ◽  
Vol 61 (3) ◽  
pp. 196-199
Author(s):  
Imre Annamária ◽  
Kolcsár Melinda ◽  
Groşan Alexandra ◽  
M Imre ◽  
Dogaru Maria Titica
Keyword(s):  
Serum Cholesterol ◽  
Serum Triglyceride ◽  
Metabolic Effects ◽  
Control Group ◽  
Glucose Levels ◽  
Cholesterol Levels ◽  
Norepinephrine Reuptake Inhibitor ◽  
The Mean ◽  
Access To Food ◽  
Different Doses

AbstractObjectives: Venlafaxine is an antidepressant, categorized as a serotonin-norepinephrine reuptake inhibitor (SNRI) with suspected metabolic side effects. The aim of our study was to assess these metabolic effects in rats, using two different doses of venlafaxine.Materials: Three groups of Wistar rats have been treated with venlafaxine during seven weeks. The rats have received a daily dose of 10mg/kg (D1) and 40 mg/kg (D2) while the control group (Dc) has received no treatment. Rats were given “ad libitum” access to food and water. The rats were weighted at treatment day 0, 7, 14, 21, 28, 35, 42 and 49. After completion of venlafaxine treatment, the rats were sacrificed, blood was harvested and the following biochemical parameters have been determined from the centrifuged plasma: triglycerides, glucose and total cholesterol levels.Results: Both the 10 mg/kg and the 40 mg/kg dose venlafaxine therapy resulted in a highly significant increase of rat’s weight. Compared with the control group the mean weight of D1 group has increased with 130.5 ±21.79 g (<0.01) while the mean weight of the second group increased with 94±24.16 g (p<0.01). In addition weight gain of D1 group was significantly higher than that of D2 group (p<0.01). Venlafaxine therapy induced significant increase in serum triglyceride levels (140.04±55.46 mg/dL p<0.01, 83.59±52.85 mg/dL p=0.05). This metabolic effect has been shown to be more evident in case of 10mg/kg dose therapy (p=0.03). Simultaneously, serum cholesterol levels have been reduced, however this decrease proved to be significant only in case of group D2 (p=0.03). Despite of increased triglyceride values, glucose levels were significantly decreased in both treated groups (133.33±36.18mg/dL p=0.05, 118.10±51.98 mg/dL p=0.02).Conclusions: Our results suggest that venlafaxine administrated to rats has unwished dose related metabolic effects such as significant increase in weight and hypertriglyceridemia, however serum cholesterol and plasma glucose levels appears to be decreased by this medication.

scholarly journals Anthropometric measurements and amounts of body fat and serum cholesterol in samples of three Nigerian populations

1975 ◽  
Vol 33 (2) ◽  
pp. 141-148 ◽  
Author(s):  
R. S. Watson ◽  
K. M. Etta
Keyword(s):  
Body Weight ◽  
University Students ◽  
Body Fat ◽  
Serum Cholesterol ◽  
Skinfold Thickness ◽  
Mean Values ◽  
Cholesterol Levels ◽  
The Mean ◽  
Male Subjects ◽  
Triceps Skinfold Thickness

1. Skinfold thicknesses, arm circumferences, heights, weights and serum cholesterol levels were determined in ninety-one university students, 207 soldiers and 102 out-patients, all male subjects. Some of these measurements were used to determine the amount of body fat, Quetelet's index and mid-arm muscle circumference2. Quetelet's indices and body-fat values obtained were similar to previously reported values for lean or moderately built males3. Serum cholesterol levels were generally low, with means ranging from 3·98 mmol/1 for 18- to 29-year-old students to 5·19 mmol/l for 40- to 69-year-old out-patients4. The mean values for triceps skinfold thickness, the amount of body fat and serum cholesterol levels for healthy adults obtained in this study are probably normal for northern Nigerian populations5. There was a significant correlation between the amount of body fat and values for triceps and subscapular skinfold thicknesses, Quetelet's index and body-weight for all adults. The correlation between muscle circumference and the amount of body fat was significant for all subjects except adult soldiers.

scholarly journals Serum Cholesterol Level Comparison: Control Subjects, Anxiety Disorder Patients, and Obsessive-Compulsive Disorder Patients

2002 ◽  
Vol 47 (6) ◽  
pp. 557-561 ◽  
Author(s):  
Helmut Peter ◽  
Iver Hand ◽  
Fritz Hohagen ◽  
Anne Koenig ◽  
Olaf Mindermann ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Panic Disorder ◽  
Anxiety Disorders ◽  
Cholesterol Level ◽  
Normal Control ◽  
Serum Cholesterol ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Control Subjects ◽  
Cholesterol Levels

Objective: To determine whether panic disorder is associated with elevated serum cholesterol levels. Serum cholesterol levels of panic disorder patients are reported to be elevated. This could explain the higher-than-expected cardiovascular mortality in this population. Some evidence exists wherein cholesterol levels are also increased in patients with general anxiety disorder and phobias. To date, there are only 2 reports on cholesterol levels of obsessive-compulsive disorder (OCD) patients, giving controversial results. Method: We compared serum cholesterol levels of anxiety disorder patients, OCD patients, and normal control subjects with each other ( n = 60 in each group). Serum cholesterol was measured in each subject before treatment. Subjects of the 3 groups were matched by age and sex. Results: Patients with anxiety disorders and OCD had elevated cholesterol levels, compared with normal control subjects. Cholesterol levels in OCD patients were comparable with those in patients with phobia. Conclusions: Our data support the assumption that elevation in cholesterol level is not a specific feature of panic disorder (as most assumed), but more generally associated with anxiety disorders. Increased cholesterol levels in patients with anxiety disorders and OCD may be of clinical relevance.

Vitamin B3 (Niacin) in Diet Act as Protective Negotiator for Development of Myocardial Infarction

2021 ◽  
Vol 15 (5) ◽  
pp. 1127-1129
Author(s):  
A. R. Memon ◽  
M. Akram ◽  
U. Bhatti ◽  
A. S. Khan ◽  
K. Rani ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Statin Therapy ◽  
Serum Cholesterol ◽  
Hdl Cholesterol ◽  
Vitamin B3 ◽  
Mean Values ◽  
Cholesterol Levels ◽  
Group I ◽  
The Mean ◽  
Group Ii

Background: Vitamin B3 (Niacin) is known to decrease LDL‐cholesterol, and triglycerides, and increase HDL‐cholesterol levels. The evidence of benefits with niacin monotherapy or add‐on to statin‐based therapy is controversial. Aim: To determine the effects of vitamin B3 with statins on lipid profile of patients of angina pectoris with dyslpidemia. Study Design: Randomized control trial study. Place and Duration of Study: Department of Biochemistry, Shaikha Fatima Institute of Nursing & Health Sciences (SFINHS), Lahore with collaboration of Cardiology OPD of Shaikh Zayed Hospital Lahore from 1st November 2019 to 31st January 2020. Methodology: Seventy four diagnosed cases of angina pectoris with dyslipidemia were recruited with age range from 30 to 50 years. They were divided into two groups; Group I contained 36 patients as controlled group which was given treatment of angina with Tab. Rovista (statin) 10mg at dinner for treatment of dyslipidemia and Group II contained 38 patients as case study group which was given treatment of angina with Tab. Rovista (statin) 10 mg at dinner and tablet Vitamin B3 500 mg with single OD dose at day time for treatment of dyslipidemia for 8 weeks. Results: The mean serum cholesterol levels at zero level (before the start of treatment) of group I was 244 mg/dl and group II was 246 mg/dl, LDL of group I was 169 mg/dl while group II was 170 mg/dl and HDL of group I was 20 mg/dl while group II was 19 mg/dl . After the treatment group I which taken only statins for treatment of dyslipidemia the mean serum cholesterol levels was 210 mg/dl, LDL was 144 mg/dl and HDL was 26 mg/dl while the mean values of group II (taken statin as well as vitamin B3) serum cholesterol level was 192 mg/dl, LDL was 122 mg/dl and HDL was 44 mg/dl. The results shown there were significant effects of statin therapy along with vitamin B3 on serum LDL and serum HDL levels. Conclusion: There were significant effects of statin therapy along with vitamin B3 on serum LDL and Serum HDL levels. Key Words: Vitamin B3, Serum Cholesterol, Serum LDL &HDL

scholarly journals Effect of green tea on serum cholesterol level in cholesterol fed rabbits

2016 ◽  
Vol 7 (2) ◽  
pp. 91
Author(s):  
Mohammad Aftabuddin ◽  
Mohammed Irfan ◽  
Omar Sadeque Khan ◽  
Khan Mohammad Amanur Rahman ◽  
Md. Rezwanul Hoque ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Green Tea ◽  
Serum Cholesterol ◽  
Serum Cholesterol Level ◽  
Plain Water ◽  
Normal Range ◽  
Cholesterol Levels ◽  
The Mean ◽  
Medical University

<p><strong>Background:</strong> Since the development of atherosclerosis involves dyslipidemia, we postulated that green tea may exert lowering of serum cholesterol levels. Objectives: To investigate the effects of green tea on serum cholesterol level. Methods: Total 45 rabbits (15 were fed on 1% cholesterol and green tea for 16 weeks, another 15 were fed on 1% cholesterol and plain water for 16 weeks, last batch of 15 rabbits received normal rabbit diet for 16 weeks) in the department of Cardiac Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka from April 2011 to September 2012.They were evaluated for lipid profile and presence of atherosclerosis. Results: The mean total cholesterol in cholesterol fed rabbits with green tea after 16 weeks was 21.06 ± 5.55, LDL-C was 20.80 ± 6.16, Serum TG was 153.67 ± 33.59, HDL-C neither increased nor decreased. The mean total cholesterol in cholesterol fed rabbits with plain water after 16 weeks was 27 .53 ± 5.15, LDL-C was 32.40 ± 8.24 and TG was 290.13 ± 44.31, no effect were seen on HDL-C. These rabbits were fed on green tea for 8 weeks, cholesterol levels returned to levels at commencement of experiment. Rabbits fed on normal rabbit diet for 16 weeks had TC l9.20 ± 4.85, LDL-C was 19.20 ± 2.04 and TG was 155.06 ± 32.03 mg/dl. HDL-C remained in normal range. But there was no atheroschlerotic change in any group. Conclusion: Green tea significantly reduces serum cholesterol levels in cholesterol fed rabbits. There was no effect of green tea on HDL-C in any group.</p>

scholarly journals Influence of light on serum cholesterol levels in complete (by birth) blind people

2018 ◽  
Vol 6 (10) ◽  
pp. 3309
Author(s):  
J. Sudha Rani ◽  
D. S. S. K. Raju
Keyword(s):  
Diabetes Mellitus ◽  
Serum Cholesterol ◽  
Liver Diseases ◽  
Dietary Habits ◽  
Kidney Diseases ◽  
Cholesterol Levels ◽  
Upper Limit ◽  
The Mean ◽  
Alcoholic Liver Diseases ◽  
Stimulation Of

Background: With blindness normal stimulation of the hypothalamic pituitary axis is reduced. The serum cholesterol is frequently increased the upper limit of normal it is unclear whether the effect is due to complete absence of light, HPA axis function reduction or diurnal variation of melatonin levels.Methods: A self-administered questionnaire ascertained lifestyle characteristics, including alcohol consumption, cigarette smoking, diabetes mellitus and dietary habits. Inclusion criteria: 50 complete blindness persons (by birth), healthy adults, Age group between 30-50 years. Exclusion area: age <30, Age >50, alcoholic, liver diseases, kidney diseases, diabetes mellitus, thyroid diseases.Results: A total No of 100 cases were studied by dividing them into two groups controls 50 and cases 50. The results so obtain were compared with 50 healthy controls (excluded consumed alcoholic, liver diseases, kidney diseases, diabetes mellitus, thyroid diseases.). Statistical evaluation was carried out to confirm any deviation from the normal values. The mean serum cholesterol of Cases (298.28±26.82) is having higher level as compared to the mean value of controls (153.38±11.79). This increase is statistically highly significant (<0.0001).Conclusions: It has been shown from this study with blindness normal stimulation of the HPA is reduced consequently the serum cholesterol is frequently increased the concentration may exceed the upper limit of normal. On this basis we observed increases the upper limit of the cholesterol levels in blind healthy people than subjects with normal healthy light perception.

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