scholarly journals Morphological Neuroimaging Biomarkers for Tinnitus: Evidence Obtained by Applying Machine Learning

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Yawen Liu ◽  
Haijun Niu ◽  
Jianming Zhu ◽  
Pengfei Zhao ◽  
Hongxia Yin ◽  
...  
Keyword(s):  
Machine Learning ◽  
Healthy Subjects ◽  
Morphological Changes ◽  
Gray Matter Volume ◽  
Brain Regions ◽  
Classification Model ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Svm Classifier ◽  
Neuroimaging Biomarkers

According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, the results of these studies have been inconsistent. The objective of this study was to explore the cortical/subcortical morphological neuroimaging biomarkers that may characterize idiopathic tinnitus using machine learning methods. Forty-six patients with idiopathic tinnitus and fifty-six healthy subjects were included in this study. For each subject, the gray matter volume of 61 brain regions was extracted as an original feature pool. From this feature pool, a hybrid feature selection algorithm combining the F-score and sequential forward floating selection (SFFS) methods was performed to select features. Then, the selected features were used to train a support vector machine (SVM) model. The area under the curve (AUC) and accuracy were used to assess the performance of the classification model. As a result, a combination of 13 cortical/subcortical brain regions was found to have the highest classification accuracy for effectively differentiating patients with tinnitus from healthy subjects. These brain regions include the bilateral hypothalamus, right insula, bilateral superior temporal gyrus, left rostral middle frontal gyrus, bilateral inferior temporal gyrus, right inferior parietal lobule, right transverse temporal gyrus, right middle temporal gyrus, right cingulate gyrus, and left superior frontal gyrus. The accuracy in the training and test datasets was 80.49% and 80.00%, respectively, and the AUC was 0.8586. To the best of our knowledge, this is the first study to elucidate brain morphological changes in patients with tinnitus by applying an SVM classifier. This study provides validated cortical/subcortical morphological neuroimaging biomarkers to differentiate patients with tinnitus from healthy subjects and contributes to the understanding of neuroanatomical alterations in patients with tinnitus.

scholarly journals Healthy Fruits Image Label Categorization through Color Shape and Texture Features Based on Machine Learning Algorithm

2020 ◽  
Vol 9 (3) ◽  
pp. 34-40
Keyword(s):  
Machine Learning ◽  
Feature Fusion ◽  
Learning Algorithm ◽  
Texture Features ◽  
Classification Model ◽  
Support Vector ◽  
Svm Classifier ◽  
Paper Machine ◽  
Textual Features ◽  
Occurrence Matrix

The fruit categorization according to their visual quality has recently experienced tremendous growth in the field of agriculture and food products. Due to post-harvest loses during handling and processing, there is an increasing demand for quality products in agro industry which requires accuracy to predict the fruit. Various techniques of machine learning have been successfully applied for classifying the fruit built on binary class. In this paper, machine leaning technique is used to automate the process of categorization and to improve the accuracy of different types of fruits by feature selection. To categorized images domain specific features such as color, shape and textual features are considered. Statistical color features are extracted from the image, bounding box feature for shape features and gray-level co-occurrence matrix (GLCM) is used to extract the textual feature of an image. These features are combined in a single feature fusion. A support vector machine (SVM) classification model is trained using training set features on fruit360 dataset which includes six fruit categories (classes) with two sub category (sub-classes) which builds multiclass classification task. We present one-vs-one coding design of Error correcting output codes (ECOC) and apply to SVM classifier; validation followed a fivefold cross validation strategy. The result shows that the textual features combined with color and shape feature improved fruit classification accuracy.

scholarly journals Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques

2020 ◽  
Author(s):  
Hao Li ◽  
Liqian Cui ◽  
Liping Cao ◽  
Yizhi Zhang ◽  
Yueheng Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bipolar Disorder ◽  
Functional Mri ◽  
Added Value ◽  
Classification Model ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Learning Techniques ◽  
Svm Model

Abstract Background Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BPD. However, most studies have focused on the construction of classifiers based on single-modality MRI. Hence, in this study, we aimed to construct a support vector machine (SVM) model using a combination of structural and functional MRI, which could be used to accurately identify patients with BPD. Methods In total, 44 patients with BPD and 36 healthy controls were enrolled in the study. Clinical evaluation and MRI scans were performed for each subject. Next, image pre-processing, voxel-based morphometry (VBM), and ReHo analyses were performed. The grey matter volumes or ReHo values of the clusters showed significant differences as discriminant features in the SVM classification model. Based on extracted features, the SVM model was established, and discriminant analysis was performed. Results After using the two-sample t-test with multiple comparisons, 12 clusters with significant differences were extracted from the data. Next, we used both VBM and ReHo data to construct the new SVM classifier, which could effectively identify patients with BPD at an accuracy of 90% in the test data (p=0.0014). Limitations The sample size was small, and we were unable to eliminate the potential effects of medications. Conclusions A combination of structural and functional MRI can be of added value in the construction of SVM classifiers to aid in the accurate identification of BPD in the clinic.

Binary Spectrum Feature for Improved Classifier Performance

2020 ◽  
Author(s):  
Nalika Ulapane ◽  
Karthick Thiyagarajan ◽  
sarath kodagoda
Keyword(s):  
Machine Learning ◽  
Classification Performance ◽  
Feature Reduction ◽  
Sensor Data ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Monitoring Task ◽  
Classifier Performance ◽  
Spectrum Feature

<div>Classification has become a vital task in modern machine learning and Artificial Intelligence applications, including smart sensing. Numerous machine learning techniques are available to perform classification. Similarly, numerous practices, such as feature selection (i.e., selection of a subset of descriptor variables that optimally describe the output), are available to improve classifier performance. In this paper, we consider the case of a given supervised learning classification task that has to be performed making use of continuous-valued features. It is assumed that an optimal subset of features has already been selected. Therefore, no further feature reduction, or feature addition, is to be carried out. Then, we attempt to improve the classification performance by passing the given feature set through a transformation that produces a new feature set which we have named the “Binary Spectrum”. Via a case study example done on some Pulsed Eddy Current sensor data captured from an infrastructure monitoring task, we demonstrate how the classification accuracy of a Support Vector Machine (SVM) classifier increases through the use of this Binary Spectrum feature, indicating the feature transformation’s potential for broader usage.</div><div><br></div>

scholarly journals Value of radiomics in differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma

2019 ◽  
Vol 45 (10) ◽  
pp. 3193-3201 ◽  
Author(s):  
Yajuan Li ◽  
Xialing Huang ◽  
Yuwei Xia ◽  
Liling Long
Keyword(s):  
Machine Learning ◽  
Differential Diagnosis ◽  
Cell Carcinoma ◽  
Area Under The Curve ◽  
Image Features ◽  
Renal Tumors ◽  
Support Vector ◽  
Svm Classifier ◽  
Renal Oncocytoma ◽  
Lasso Regression

Abstract Purpose To explore the value of CT-enhanced quantitative features combined with machine learning for differential diagnosis of renal chromophobe cell carcinoma (chRCC) and renal oncocytoma (RO). Methods Sixty-one cases of renal tumors (chRCC = 44; RO = 17) that were pathologically confirmed at our hospital between 2008 and 2018 were retrospectively analyzed. All patients had undergone preoperative enhanced CT scans including the corticomedullary (CMP), nephrographic (NP), and excretory phases (EP) of contrast enhancement. Volumes of interest (VOIs), including lesions on the images, were manually delineated using the RadCloud platform. A LASSO regression algorithm was used to screen the image features extracted from all VOIs. Five machine learning classifications were trained to distinguish chRCC from RO by using a fivefold cross-validation strategy. The performance of the classifier was mainly evaluated by areas under the receiver operating characteristic (ROC) curve and accuracy. Results In total, 1029 features were extracted from CMP, NP, and EP. The LASSO regression algorithm was used to screen out the four, four, and six best features, respectively, and eight features were selected when CMP and NP were combined. All five classifiers had good diagnostic performance, with area under the curve (AUC) values greater than 0.850, and support vector machine (SVM) classifier showed a diagnostic accuracy of 0.945 (AUC 0.964 ± 0.054; sensitivity 0.999; specificity 0.800), showing the best performance. Conclusions Accurate preoperative differential diagnosis of chRCC and RO can be facilitated by a combination of CT-enhanced quantitative features and machine learning.

Distinguishing hypochondriasis and schizophrenia using regional homogeneity: a resting-state fMRI study and support vector machine analysis

2021 ◽  
pp. 1-29
Author(s):  
Kangyu Jin ◽  
Zhe Shen ◽  
Guoxun Feng ◽  
Zhiyong Zhao ◽  
Jing Lu ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Resting State ◽  
Parietal Lobe ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Brain Regions ◽  
Regional Homogeneity ◽  
Middle Temporal Gyrus ◽  
Support Vector ◽  
Fmri Study

Abstract Objective: A few former studies suggested there are partial overlaps in abnormal brain structure and cognitive function between Hypochondriasis (HS) and schizophrenia (SZ). But their differences in brain activity and cognitive function were unclear. Methods: 21 HS patients, 23 SZ patients, and 24 healthy controls (HC) underwent Resting-state functional magnetic resonance imaging (rs-fMRI) with the regional homogeneity analysis (ReHo), subsequently exploring the relationship between ReHo value and cognitive functions. The support vector machines (SVM) were used on effectiveness evaluation of ReHo for differentiating HS from SZ. Results: Compared with HC, HS showed significantly increased ReHo values in right middle temporal gyrus (MTG), left inferior parietal lobe (IPL) and right fusiform gyrus (FG), while SZ showed increased ReHo in left insula, decreased ReHo values in right paracentral lobule. Additionally, HS showed significantly higher ReHo values in FG, MTG and left paracentral lobule but lower in insula than SZ. The higher ReHo values in insula were associated with worse performance in MCCB in HS group. SVM analysis showed a combination of the ReHo values in insula and FG was able to satisfactorily distinguish the HS and SZ patients. Conclusion: our results suggested the altered default mode network (DMN), of which abnormal spontaneous neural activity occurs in multiple brain regions, might play a key role in the pathogenesis of HS, and the resting-state alterations of insula closely related to cognitive dysfunction in HS. Furthermore, the combination of the ReHo in FG and insula was a relatively ideal indicator to distinguish HS from SZ.

Classification of Diffusion Tensor Metrics for the Diagnosis of a Myelopathic Cord Using Machine Learning

2018 ◽  
Vol 28 (02) ◽  
pp. 1750036 ◽  
Author(s):  
Shuqiang Wang ◽  
Yong Hu ◽  
Yanyan Shen ◽  
Hanxiong Li
Keyword(s):  
Machine Learning ◽  
Surgical Planning ◽  
Diffusion Tensor ◽  
Mean Value ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Svm Classifier ◽  
Control Groups ◽  
Diffusion Tensor Imaging Dti

In this study, we propose an automated framework that combines diffusion tensor imaging (DTI) metrics with machine learning algorithms to accurately classify control groups and groups with cervical spondylotic myelopathy (CSM) in the spinal cord. The comparison between selected voxel-based classification and mean value-based classification were performed. A support vector machine (SVM) classifier using a selected voxel-based dataset produced an accuracy of 95.73%, sensitivity of 93.41% and specificity of 98.64%. The efficacy of each index of diffusion for classification was also evaluated. Using the proposed approach, myelopathic areas in CSM are detected to provide an accurate reference to assist spine surgeons in surgical planning in complicated cases.

scholarly journals Improving Machine Learning Identification of Unsafe Driver Behavior by Means of Sensor Fusion

2020 ◽  
Vol 10 (18) ◽  
pp. 6417 ◽  
Author(s):  
Emanuele Lattanzi ◽  
Giacomo Castellucci ◽  
Valerio Freschi
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Driver Behavior ◽  
Ground Truth ◽  
Support Vector ◽  
Svm Classifier ◽  
Learning Technology ◽  
Average Accuracy ◽  
Unsafe Behaviors ◽  
Vehicle Sensors

Most road accidents occur due to human fatigue, inattention, or drowsiness. Recently, machine learning technology has been successfully applied to identifying driving styles and recognizing unsafe behaviors starting from in-vehicle sensors signals such as vehicle and engine speed, throttle position, and engine load. In this work, we investigated the fusion of different external sensors, such as a gyroscope and a magnetometer, with in-vehicle sensors, to increase machine learning identification of unsafe driver behavior. Starting from those signals, we computed a set of features capable to accurately describe the behavior of the driver. A support vector machine and an artificial neural network were then trained and tested using several features calculated over more than 200 km of travel. The ground truth used to evaluate classification performances was obtained by means of an objective methodology based on the relationship between speed, and lateral and longitudinal acceleration of the vehicle. The classification results showed an average accuracy of about 88% using the SVM classifier and of about 90% using the neural network demonstrating the potential capability of the proposed methodology to identify unsafe driver behaviors.

scholarly journals Deep Learning Assisted Neonatal Cry Classification via Support Vector Machine Models

2021 ◽  
Vol 9 ◽  
Author(s):  
Ashwini K ◽  
P. M. Durai Raj Vincent ◽  
Kathiravan Srinivasan ◽  
Chuan-Yu Chang
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Support Vector Machine ◽  
Feature Extraction ◽  
Deep Learning ◽  
Convolutional Neural Network ◽  
Support Vector ◽  
Svm Classifier ◽  
Infant Cry ◽  
Learning Techniques

Neonatal infants communicate with us through cries. The infant cry signals have distinct patterns depending on the purpose of the cries. Preprocessing, feature extraction, and feature selection need expert attention and take much effort in audio signals in recent days. In deep learning techniques, it automatically extracts and selects the most important features. For this, it requires an enormous amount of data for effective classification. This work mainly discriminates the neonatal cries into pain, hunger, and sleepiness. The neonatal cry auditory signals are transformed into a spectrogram image by utilizing the short-time Fourier transform (STFT) technique. The deep convolutional neural network (DCNN) technique takes the spectrogram images for input. The features are obtained from the convolutional neural network and are passed to the support vector machine (SVM) classifier. Machine learning technique classifies neonatal cries. This work combines the advantages of machine learning and deep learning techniques to get the best results even with a moderate number of data samples. The experimental result shows that CNN-based feature extraction and SVM classifier provides promising results. While comparing the SVM-based kernel techniques, namely radial basis function (RBF), linear and polynomial, it is found that SVM-RBF provides the highest accuracy of kernel-based infant cry classification system provides 88.89% accuracy.

scholarly journals Identification of Diagnostic Markers for Major Depressive Disorder Using Machine Learning Methods

2021 ◽  
Vol 15 ◽  
Author(s):  
Shu Zhao ◽  
Zhiwei Bao ◽  
Xinyi Zhao ◽  
Mengxiang Xu ◽  
Ming D. Li ◽  
...  
Keyword(s):  
Machine Learning ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Meta Analysis ◽  
Single Gene ◽  
Support Vector ◽  
Svm Classifier ◽  
Diagnostic Model ◽  
Roc Curve Analysis ◽  
Major Depressive

BackgroundMajor depressive disorder (MDD) is a global health challenge that impacts the quality of patients’ lives severely. The disorder can manifest in many forms with different combinations of symptoms, which makes its clinical diagnosis difficult. Robust biomarkers are greatly needed to improve diagnosis and to understand the etiology of the disease. The main purpose of this study was to create a predictive model for MDD diagnosis based on peripheral blood transcriptomes.Materials and MethodsWe collected nine RNA expression datasets for MDD patients and healthy samples from the Gene Expression Omnibus database. After a series of quality control and heterogeneity tests, 302 samples from six studies were deemed suitable for the study. R package “MetaOmics” was applied for systematic meta-analysis of genome-wide expression data. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic effectiveness of individual genes. To obtain a better diagnostic model, we also adopted the support vector machine (SVM), random forest (RF), k-nearest neighbors (kNN), and naive Bayesian (NB) tools for modeling, with the RF method being used for feature selection.ResultsOur analysis revealed six differentially expressed genes (AKR1C3, ARG1, KLRB1, MAFG, TPST1, and WWC3) with a false discovery rate (FDR) &lt; 0.05 between MDD patients and control subjects. We then evaluated the diagnostic ability of these genes individually. With single gene prediction, we achieved a corresponding area under the curve (AUC) value of 0.63 ± 0.04, 0.67 ± 0.07, 0.70 ± 0.11, 0.64 ± 0.08, 0.68 ± 0.07, and 0.62 ± 0.09, respectively, for these genes. Next, we constructed the classifiers of SVM, RF, kNN, and NB with an AUC of 0.84 ± 0.09, 0.81 ± 0.10, 0.73 ± 0.11, and 0.83 ± 0.09, respectively, in validation datasets, suggesting that the SVM classifier might be superior for constructing an MDD diagnostic model. The final SVM classifier including 70 feature genes was capable of distinguishing MDD samples from healthy controls and yielded an AUC of 0.78 in an independent dataset.ConclusionThis study provides new insights into potential biomarkers through meta-analysis of GEO data. Constructing different machine learning models based on these biomarkers could be a valuable approach for diagnosing MDD in clinical practice.

scholarly journals Analyzing Behavior of Cancer Patients using Machine Learning Techniques

2019 ◽  
Vol 8 (9) ◽  
pp. 1547-1556
Keyword(s):  
Machine Learning ◽  
Natural Language ◽  
Cancer Patients ◽  
Language Processing ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Operating Characteristics ◽  
Decision Tree Classifier ◽  
Tree Classifier

The online discussion forums and blogs are very vibrant platforms for cancer patients to express their views in the form of stories. These stories sometimes become a source of inspiration for some patients who are anxious in searching the similar cases. This paper proposes a method using natural language processing and machine learning to analyze unstructured texts accumulated from patient’s reviews and stories. The proposed methodology aims to identify behavior, emotions, side-effects, decisions and demographics associated with the cancer victims. The pre-processing phase of our work involves extraction of web text followed by text-cleaning where some special characters and symbols are omitted, and finally tagging the texts using NLTK’s (Natural Language Toolkit) POS (Parts of Speech) Tagger. The post-processing phase performs training of seven machine learning classifiers (refer Table 6). The Decision Tree classifier shows the higher precision (0.83) among the other classifiers while, the Area under the operating Characteristics (AUC) for Support Vector Machine (SVM) classifier is highest (0.98).

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