scholarly journals Household Clusters of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Suzhou, China

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Lin Yao ◽  
Peijun Tang ◽  
Hui Jiang ◽  
Binbin Gu ◽  
Ping Xu ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Secondary Infection ◽  
High Rate ◽  
Cross Sectional ◽  
Emerging Virus ◽  
Transmission Capability ◽  
Index Cases ◽  
Substantial Morbidity ◽  
Close Contacts

Objectives. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus causing substantial morbidity and mortality worldwide. We performed a cross-sectional investigation of SARS-CoV-2 clusters in Suzhou to determine the transmissibility of the virus among close contacts and to assess the demographic and clinical characteristics between index and secondary cases. Methods. We review the clustered patients with SARS-CoV-2 infections in Suzhou between 22 January and 29 February 2020. The demographic and clinical characteristics were compared between index and secondary cases. We calculated the basic reproduction number ( R 0 ) among close contacts with SLI model. Results. By 22 February, 87 patients with SARS-CoV-2 infection were reported, including 50 sporadic and 37 clustered cases, who were generated from 13 clusters. On admission, 5 (20.8%) out of 24 secondary cases were asymptomatic. The male ratio of index cases was significantly higher than that of secondary cases. Additionally, the index cases were more likely to have fever and increased CRP levels than the secondary cases. The R 0 values of clusters displayed a significantly declining trend over time for all clusters. The relative risk of infection in blood-related contacts of cases versus unrelated contacts was 1.60 for SARS-CoV-2 (95% CI: 0.42-2.95). Conclusions. In conclusion, SARS-CoV-2 has great person-to-person transmission capability among close contacts. The secondary cases are more prone to have mild symptoms than index cases. There is no increased RR of secondary infection in blood relatives versus unrelated contacts. The high rate of asymptomatic SARS-CoV-2 infections highlights the urgent need to enhance active case finding strategy for early detection of infectious patients.

scholarly journals Candida Coinfection among Patients with Pulmonary tuberculosis in the World; A Systematic Review and Meta-analysis of Cross-Sectional Studies

2019 ◽  
Author(s):  
Mehran Ghazalibina ◽  
Ali Shakerimoghaddam ◽  
Azad Khaledi
Keyword(s):  
Systematic Review ◽  
Pulmonary Tuberculosis ◽  
Fungal Infections ◽  
Secondary Infection ◽  
Meta Analysis ◽  
High Rate ◽  
Candida Spp ◽  
Cross Sectional ◽  
Cross Sectional Studies ◽  
Early Diagnose

Abstract Background Diagnosis of fungal co-infections in patients with pulmonary tuberculosis has critical importance. In this review, we aimed to determine the prevalence of candida coinfection in patients with pulmonary tuberculosis.Methods The present systematic review of cross-sectional studies was conducted based on the Preferred Reporting Items for Systematic reviews and Meta-analysis (PRISMA) Protocol. Studies published online in English from January 2001 to March 2019 were assessed. Literature search was performed in Web of Science, MEDLINE/PubMed, and Scopus databases using keywords combinations of “pulmonary fungal”, “pulmonary coinfection”, OR “pulmonary mycosis”, “pulmonary fungal infections/agents”, OR “polymicrobial infection”, OR “secondary infection”, OR “mixed infections”, “pulmonary candidiasis”, “fungi coinfection”, “fungal co-colonization”, AND “pulmonary tuberculosis”, OR “pulmonary TB”. Data was analyzed using Comprehensive Meta-Analysis software. Heterogeneity between studies was evaluated by Cochran's Q, and I 2 tests.Results The pooled global prevalence of candida coinfection among patients with pulmonary tuberculosis was 25.7% (95% CI: 23.7-27.9). C. albicans was the most prevalent Candida spp. with a pooled prevalence of 65.8% (95% CI: 54.3-75.7). Risk factors of candida coinfection included smoking, diabetes, advanced age, and low body mass index.Conclusion The present review showed the high rate of candida coinfection among patients suffering from pulmonary tuberculosis. Adequate measures are necessary to early diagnose and treat these infections.

scholarly journals Demographic and Clinical Characteristics of Epilepsy in Childhood: A Prospective Cross Sectional Study from Sudan

2021 ◽  
pp. 6
Author(s):  
Keyword(s):  
Low Socioeconomic Status ◽  
Clinical Characteristics ◽  
Genetic Disorders ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
High Rate ◽  
Idiopathic Epilepsy ◽  
Cns Infection ◽  
Sectional Study ◽  
Cross Sectional

Background: Epilepsy is a common neurological disorder affecting around 1% of children. The incidence in Sudan is likely to be higher given the high rate of genetic disorders related to consanguity and acquired disorders caused by CNS infection and birth injury. Epilepsy can be idiopathic or non-idiopathic, symptomatic epilepsy indicates a known cause while cryptogenic epilepsy implies a presumed unknown cause. Objective: To understand the demographic and clinical characteristics of epilepsy in children in the setting of a tertiary epilepsy clinic in Khartoum, Sudan. Methods: This is a hospital-based cross sectional study recruiting patients with epilepsy attending a tertiary pediatric neurology clinic. All patients attending the clinic in the 6 month period were included. Data was collected by medical students and was analyzed on IBM SPSS Version 20.0 in a descriptive fashion. Results: 284 Children were recruited. The mean age for children with epilepsy was 5.74 (range 0-12 Years). Females constituted 59.9%; while 94.7% of patients were of low socioeconomic status. The most common type of seizures found were generalized tonic clinic at 51.8% (147/284), followed by focal seizures at 21.1% (60/284). 71% of our patients (201/284) had no identifiable cause (idiopathic), while 29% were non-idiopathic. Of the non-idiopathic group; 41% were due to congenital anomalies, followed by HIE at 24.1%, infections at 16.9% trauma at 10.8% and tumors at 7.2%. Only 18.3% (52/284) had a positive family history of epilepsy. Conclusions: There appears to be a higher incidence of epilepsy in Children with low socio – economic status with a slight female predominance. The incidence of idiopathic epilepsy appears to be similar to inter-national figures. We recommend broader community based and long-term studies for better understanding of epilepsy in Sudan.

scholarly journals A New Features of SARS-CoV-2 Infection in Wenzhou, China

2020 ◽  
Author(s):  
Zhao Hongjun ◽  
Xiaoxiao Lu ◽  
Tiegang Li ◽  
Boqi Rao ◽  
Dedong Wang ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Wuhan City ◽  
Intimate Contact ◽  
Cross Sectional ◽  
Epidemic Area ◽  
History Of ◽  
Epidemiological Characteristics

Abstract BACKGROUND: An outbreak of pneumonia associated with the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) was initially emerged in Wuhan city, and subsequently spread throughout China. Then the epidemic is rapidly circulating in a few other countries at present. So it is very urgent to delineate the clinical characteristics of these affected patients. METHODS: To investigate the epidemiological characteristics of this new Coronavirus Disease 2019 (COVID-19), a cross-sectional study was executed with 459 patients with confirmed COVID-19 in Wenzhou, China, from January 27 to February 12, 2020. RESULTS: The median age of all patients was 48.0 years, and 46.8% were females. 37.5% of patients had a history of residence in Wuhan. Fever (72.1%) and cough (43.6%) were the most frequent symptoms. We also found that there were three kinds of unconventional patients including 4.4% of total confirmed patients who were asymptomatic, 7.8% patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 10.7% who had no link to Wuhan city nor a history of intimate contact with patients or individuals from Wuhan without any symptoms, respectively. CONCLUSIONS: Our findings presented the possibility of asymptomatic carriers affected with SARS-CoV-2, and this phenomenon suggested that chances of uncontrollable transmission in the larger population might be higher than formerly estimated, and transmission by these three kinds of unconventional patients in Wenzhou may be one of the characteristics of infection in other Chinese cities outside the Wuhan epidemic area.

scholarly journals High Rate of SARS-CoV-2 Transmission due to Choir Practice in France at the Beginning of the COVID-19 Pandemic

2020 ◽  
Author(s):  
Nathalie CHARLOTTE
Keyword(s):  
Attack Rate ◽  
Transmission Rate ◽  
High Rate ◽  
Individual Risk ◽  
High Transmission ◽  
The Mean ◽  
The Individual ◽  
Practice Methods ◽  
Index Cases ◽  
Close Contacts

Background: There has been little focus on the individual risk of acquiring COVID-19 related to choir practice. Methods: We report the case of a high transmission rate of SARS-CoV-2 linked to an indoor choir rehearsal in France in March 2020 at the beginning of the COVID-19 pandemic. Results: A total of 27 participants, including 25 male singers, a conductor and an accompanist attended a choir practice on March 12, 2020. The practice was indoor and took place in a non-ventilated space of 45 m2. No choir member reported having been symptomatic for COVID-19 between March 2 and March 12.The mean age of the participants was 66.9 (range 35-86) years. 70% of the participants (19 of 27) were diagnosed with COVID-19 from 1 to 12 days after the rehearsal with a median of 5.1 days. 36% of the cases needed a hospitalization (7/19), and 21% (4/19) were admitted to an ICU. The index cases were possibly multiple. Discussion: The choir practice was planned in March 2020 at a period when the number of new cases of COVID-19 began to grow exponentially in France because SARS-CoV-2 was actively circulating. The secondary attack rate (70%) was much higher than it is described within households (10-20%) and among close contacts made outside households (0-5%). Singing might have contributed to enhance SARS-CoV-2 person-to-person transmission through emission of droplets and aerosolization in a closed non ventilated space with a relative high number of people including multiple pre-symptomatic suspected index cases. Conclusion: Indoor choir practice should be suspended during SARS-CoV-2 outbreaks. Further studies are necessary to test the spread of the virus by the act of singing. As the benefits of the barrier measures and social distancing are known to be effective in terms of a reduction in the incidence of the COVID-19, experts recommendations concerning the resuming of choir practice are necessary.

scholarly journals Clinical Characteristics in a Sample of Transsexual People

2017 ◽  
Vol 39 (10) ◽  
pp. 545-551 ◽  
Author(s):  
Maria Lerri ◽  
Adriana Romão ◽  
Manoel Santos ◽  
Alain Giami ◽  
Rui Ferriani ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
High Rate ◽  
Anxiety And Depression ◽  
Cross Sectional ◽  
Trans Men ◽  
Life Habits ◽  
Trans Women ◽  
The Relationship

Purpose To assess the clinical characteristics of subjects with gender dysphoria (GD). Method A cross-sectional study of adults with GD. Symptoms of anxiety and depression were measured using the Hospital Anxiety and Depression Scale (HADS). Sociodemographic data, clinical data and life habits were recorded. Results Total of 44 subjects participated in the study: 36 (82%) trans women and 8 (18%) trans men. Forty-three (98%) of the GD patients had anxiety (36 [100%] trans women and 7 [87.5%] trans men), and 36 (82%) had depression (29 [80.5%] trans women and 7 [87.5%] trans men). Suicide had been attempted by 32 (73%) subjects. The rates of depression were lower among the subjects living with partners, parents, or other people than among those living alone (p = 0.03), and it was also lower among the subjects who were married compared to those who were dating or single (p = 0.03). Conclusion Improving the relationship status may reduce the prevalence of depressive symptoms in GD patients. There was a high rate of attempted suicide in this sample.

scholarly journals LEVEL OF SATISFACTION WITH COVID-19 VACCINE AFTER GETTING JABS AMONG THE GENERALPOPULATION IN GURGAON, HARYANA

2021 ◽  
Vol 9 (10) ◽  
pp. 750-756
Author(s):  
Gyan Jyoti ◽  
◽  
Arun Kumar Yadav ◽  
Ritu Kumari ◽  
Ruma Coudhary Bhattacharjee ◽  
...  
Keyword(s):  
Infectious Disease ◽  
General Population ◽  
Severe Acute Respiratory Syndrome ◽  
Sample Size ◽  
High Rate ◽  
Large Sample Size ◽  
Cross Sectional ◽  
High Burden ◽  
Effective Interventions ◽  
Level Of Satisfaction

Coronavirus disease (COVID-19) is an infectious disease caused Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).To bring this pandemic to an end, only Vaccines are effective interventions that can reduce the high burden of this diseases globally.The purpose of the study to assess the level of satisfaction among the general population after getting the jab of covid -19 vaccine and regarding the vaccination services. A quantitative approach, cross sectional e- survey was conducted on 332 general population through snow ball sampling among general population of Gurgaonaged 18 years and above from 25th May 2021 to 30th July 2021. The result showed that 70.8% of general populationwere dissatisfied after getting the jab of COVID 19 vaccine. The results indicate a high rate of dissatisfaction after getting jab of the COVID-19 vaccine among general population. This result may vary with large sample size.

scholarly journals Epidemiology, clinical characteristics, household transmission, and lethality of severe acute respiratory syndrome coronavirus-2 infection among healthcare workers in Ontario, Canada

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244477
Author(s):  
Kevin L. Schwartz ◽  
Camille Achonu ◽  
Sarah A. Buchan ◽  
Kevin A. Brown ◽  
Brenda Lee ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Language Processing ◽  
Healthcare Workers ◽  
Clinical Characteristics ◽  
Care Home ◽  
Multivariable Logistic Regression Model ◽  
Cross Sectional ◽  
Term Care ◽  
Personal Support ◽  
Risk Of Death

Introduction Protecting healthcare workers (HCWs) from Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a priority to maintain a safe and functioning healthcare system. Our objective was to describe and compare the epidemiology, clinical characteristics, and lethality of SARS-CoV-2 infections among HCWs compared to non-HCWs. Methods Using reportable disease data at Public Health Ontario, we conducted a population-based cross-sectional study comparing demographic, exposure, and clinical variables between HCWs and non-HCWs with SARS-CoV-2 infections as of 30 September 2020. We calculated rates of infections over time and determined the frequency of within household transmissions using natural language processing based on residential address. We evaluated the risk of death using a multivariable logistic regression model adjusting for age, sex, comorbidities, symptoms, and long-term care home exposure. Results There were 7,050 (12.5%) HCW SARS-CoV-2 infections in Ontario, Canada, of whom 24.9% were nurses, 2.3% were physicians, and the remaining 72.8% other specialties, including personal support workers. Overall HCWs had an infection rate of 1,276 per 100,000 compared to non-HCWs of 346 per 100,000 (3.7 times higher). This difference decreased from a 7 times higher rate in April to no difference in September 2020. Twenty-six percent of HCWs had a household member with SARS-CoV-2 infection; 6.8% were probable acquisitions, 12.3% secondary transmissions, and 6.9% unknown direction of transmission. Death among HCWs was 0.2% compared to 6.1% of non-HCWs. The risk of death in HCWs remained significantly lower than non-HCWs after adjustment (adjusted odds ratio 0.09; 95%CI 0.05–0.17). Conclusion HCWs represent a disproportionate number of diagnosed SARS-CoV-2 infections in Ontario, however this discrepancy is at least partially explained by limitations in testing earlier in the pandemic for non-HCWs. We observed a low risk of death in HCWs which could not be completely explained by other factors.

scholarly journals New approach for tuberculosis contact tracing implemented in the two regions of Kyrgyz Republic during 2017-2018

2020 ◽  
Vol 14 (11.1) ◽  
pp. 109S-115S
Author(s):  
Bakyt Dzhangaziev ◽  
Aizat Kulzhabaeva ◽  
Nune Truzyan ◽  
Abdykadyr Zhoroev ◽  
Dinagul Otorbaeva ◽  
...  
Keyword(s):  
Contact Tracing ◽  
Kyrgyz Republic ◽  
National Guidelines ◽  
Cross Sectional ◽  
New Approach ◽  
Tb Control ◽  
Contact Investigation ◽  
The Mean ◽  
Index Cases ◽  
Close Contacts

Introduction: Tuberculosis (TB) contact investigation as a proved approach for finding new TB cases, is not fully performed in Kyrgyzstan. In 2018, the country started aligning the National Guidelines for tracking contacts with the WHO recommendations by expanding the definition for TB index cases to all close contacts, regardless of their TB risk status. Methodology: This cross-sectional census aimed to determine the active case detection changes among TB contacts after implementation of a new TB tracing strategy using the National Surveillance data. We compared populations in Chui and Issyk-Kul regions of Kyrgyzstan who had contacts with TB index cases before (2017) and after (2018) strategic changes for the rates of indexes, contacts, screened contacts, and detected TB among screened contacts. Results: New TB tracing strategy resulted in increased numbers of indexes (21%) and contacts (36%). Though the smaller number of contacts (1730 vs. 1590) have been screened in 2018, the proportion of TB diagnosed was substantially higher (95% CI: 0.024-0.005; p = 0.002) in 2018 vs. 2017. The mean numbers of TB contacts per-one-index-case also has increased dramatically by 117% (1.8 vs. 3.9) in Chui and by 43% (3.0 vs. 4.3) in Issyk-Kul regions (95% CI: 3.20-3.37; p < 0.001 and 95% CI: 2.97-3.09; p < 0.001, respectively) between 2018 and 2017. Conclusion: Extending new tracing approach to other regions of Kyrgyzstan will increase the number of identified contacts, leading to better TB control in the country and prevention of more severe TB development among the unidentified contacts.

scholarly journals High rate of clinically unrecognized SARS-CoV-2 infections in pediatric palliative care patients

2021 ◽  
Author(s):  
Benedikt Bötticher ◽  
Lars Dinkelbach ◽  
Martina Hillebrecht ◽  
Ortwin Adams ◽  
Oliver Dechert ◽  
...  
Keyword(s):  
Palliative Care ◽  
Pediatric Patients ◽  
Severe Disease ◽  
High Rate ◽  
Pediatric Palliative Care ◽  
Cross Sectional ◽  
Significant Difference ◽  
High Prevalence ◽  
Symptom Load ◽  
Close Contacts

AbstractLittle is known about the frequency and clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients with severe comorbidities. In this prospective cross-sectional trial, the seroprevalence of SARS-CoV-2-IgG in patients with life-limiting conditions being treated by a large specialized pediatric palliative home-care team was determined. In order to gain insight into the infection chain, close contacts of seropositive patients were also included in the study. We analyzed the sera of 39 patients and found a 25.6% seroprevalence for SARS-CoV-2. No SARS-CoV-2 infections were known prior to the study. No significant difference was found in the symptom load between seropositive and seronegative patients during the risk period for SARS-CoV-2 infections. Of the 20 close contacts tested, only one was seropositive for SARS-CoV-2.Conclusions: Our results indicate a substantially high prevalence of silent SARS-CoV-2 infections in pediatric palliative care patients. Surprisingly, no severe outcomes were seen in this fragile patient collective with severe comorbidities. The chain of infection and thus the reason for the high frequency of SARS-CoV-2 infections in pediatric palliative care patients remain unclear. What is Known:•Even though severe disease courses of COVID-19 have been reported in children, there are yet no established risk factors for SARS-CoV-2 in pediatric patients. What is New:•In this cross-sectional seroprevalence study of palliative pediatric patients with severe life-limiting conditions, a high rate of seropositive patients (25.6%) was found.•Surprisingly, all seropositive patients were previously unrecognized, despite the severe comorbidities of our collective.

scholarly journals Clinical characteristics of Severe Acute Respiratory Syndrome by COVID-19 in Indigenous of Brazil

2020 ◽  
Author(s):  
Daniele Melo Sardinha ◽  
Karla Valéria Batista Lima ◽  
Ana Lúcia da Silva Ferreira ◽  
Juliana Conceição Dias Garcez ◽  
Thalyta Mariany Rêgo Lopes Ueno ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Clinical Characteristics ◽  
Signs And Symptoms ◽  
Access To Health Services ◽  
Cross Sectional ◽  
The Public ◽  
Respiratory Discomfort ◽  
The Impact

AbstractBackgroundThe indigenous people of Brazil present several cases and deaths, affecting 158 peoples, with high vulnerability and limited access to health services.ObjectiveInvestigate the clinical characteristics of severe acute respiratory syndrome by COVID-19 in indigenous peoples of Brazil.MethodThe epidemiological, cross-sectional, and analytical study, from the data of the platform opendataSUS referring to the SIVEP-GRIPE in the period of 01/01/2020 until 31/08/2020. Profile variables, signs and symptoms, and risk factors/comorbidities. The data were analyzed by Bioestat 5.3.Results1,207 cases and 470 deaths. Profile: male gender (59.48%) mean age 53. Signs and symptoms: fever (74.23%), cough (77.71%), sore throat (35.62%), dyspnea (69.34%), respiratory discomfort (62.80%), O2 saturation <95% (56.42%); and associated with mortality: dyspnea (80.0%) and O2 saturation <95% (69.36%). Risk factors and comorbidities (45.89%) were associated with deaths (54.04%). Comorbidities: Chronic Cardiovascular Disease (18.97%) and Diabetes Mellitus (18.97%), and associated with deaths: Chronic Cardiovascular Disease (24.46%). There was significance in the survivors vaccinated for influenza (26.18%).ConclusionThe public and health policies of Brazil should be directed to control the dissemination of COVID-19 in this population, that COVID-19 evolves in the same intensity, however, the indigenous have vulnerabilities that can enhance the impact of the pandemic in this population.

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