scholarly journals Evaluation of Acoustic Reflex Thresholds in COVID-19 Patients With Taste Disorders

2021 ◽  
pp. 014556132110398
Author(s):  
Ali Seyed Resuli ◽  
Mehdi Salviz ◽  
Fatih Oktem
Keyword(s):  
Pure Tone Audiometry ◽  
Control Group ◽  
Study Group ◽  
Speech Discrimination ◽  
Acoustic Reflex ◽  
Taste Test ◽  
Men 2 ◽  
History Of ◽  
Taste Disorders ◽  
Acoustic Reflex Threshold

Objective: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, can result in persistent loss of taste and smell. This study was performed to assess acoustic reflex threshold (ART) in patients with taste disorders caused by SARS-CoV-2. Material and Methods: This retrospective study enrolled 11 patients (9 men, 2 women; average age = 22.3 years) with a history of COVID-19 and had complaints of taste disorder and sensitivity to loud sounds. The control group consisted of 13 healthy participants (10 men, 3 women; average age = 23.4 years). Anamnesis, neuro-otological, ear, nose and throat, and eye examinations, as well as a taste test, pure tone audiometry, speech discrimination test, and impedance audiometry were performed in all participants. Results: All participants in the study group had a negative taste test result. In addition, ART values were significantly higher in the study group than the control group at all frequencies. Conclusions: SARS-CoV-2 could be a neurotropic virus that can cause facial nerve neuropathy.

CARDIOVASCULAR RISK FACTORS PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND CHRONIC INFLAMMATORY LUNG DISEASES

2020 ◽  
pp. 21-25
Author(s):  
Tupitsyn V.V. ◽  
Bataev Kh.M. ◽  
Men’shikova A.N. ◽  
Godina Z.N.
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Digestive System ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Internal Organs ◽  
History Of

Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.

scholarly journals Frequency-Following Response (FFR) in Military Pilots

2020 ◽  
Author(s):  
Graziela Maria Martins-Moreira ◽  
Alessandra Spada Durante
Keyword(s):  
Pure Tone Audiometry ◽  
Control Group ◽  
Study Group ◽  
Aircraft Accidents ◽  
Frequency Following Response ◽  
Significant Difference ◽  
Qualitative Variables ◽  
Chi Squared ◽  
The Right ◽  
Military Pilots

Abstract Introduction Good hearing in pilots, including central auditory skills, is critical for flight safety and the prevention of aircraft accidents. Pure tone audiometry alone may not be enough to assess hearing in the members of this population who, in addition to high noise levels, routinely face speech recognition tasks in non-ideal conditions. Objective To characterize the frequency-following response (FFR) of a group of military pilots compared with a control group. Methods Twenty military pilots in the Study Group and 20 non-pilot military personnel, not exposed to noise in their work, in the Control Group, all with normal hearing, aged between 30 and 40 years old, completed a questionnaire to assess their hearing habits, and their FFRs were measured with a /da/ syllable (duration 40 milliseconds, speed 10.9/s), at 80 dB NA in the right ear. All procedures were approved by the ethical committee of the institution. Statistical analysis was performed using the t-Student or Mann-Whitney tests for quantitative variables, and the Fisher or chi-squared tests for qualitative variables, and a value of p < 0.05 was considered to be statistically significant. Results There was no significant difference between the groups regarding auditory habits. In the FFR, wave amplitudes A (p = 0.01) and C (p = 0.04) were significantly lower in the Study Group. Conclusion Working as a military pilot can be a crucial factor in determining an individual's typical FFR pattern, demonstrated in the present study by statistically significant reductions in the amplitudes of the A and C waves.

scholarly journals Case-control study of oral disease indexes in individuals with head and neck cancer after antineoplastic therapy

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Reyna Aguilar Quispe ◽  
Adrielle Lindolpho Cremonesi ◽  
Jeanne Kelly Gonçalves ◽  
Cassia Maria Fischer Rubira ◽  
Paulo Sérgio da Silva Santos
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Permanent Teeth ◽  
Control Group ◽  
Study Group ◽  
Periodontal Index ◽  
Community Periodontal Index ◽  
History Of ◽  
Antineoplastic Treatment

ABSTRACT Objective To evaluate the oral health of patients with head and neck cancer after antineoplastic treatment, and to compare them with patients with no history of cancer. Methods A total of 75 patients, divided into Study Group, composed of individuals after antineoplastic treatment (n=30), and Control Group, with individuals with no history of cancer (n=45), aged 37 to 79 years. The oral health status was evaluated through the index of decayed, missing or filled permanent teeth (DMFT), community periodontal index and evaluation of the use and need of prosthesis. All of these items were evaluated according to the criteria recommended by the World Health Organization. The statistical analysis was descriptive and used the Pearson’s χ2 test. Results The community periodontal index was higher in the Study Group when compared to the Control Group (p<0.0001). The need for an upper (p<0.001) and lower (p<0.0001) prostheses was higher in the Study Group. Also, the use of upper prosthesis was higher in the Study Group (p<0.002). The missing or filled permanent teeth index between the two groups (p>0.0506) and the use of lower prosthesis (p>0.214) did not present a relevant statistical difference. Conclusion Periodontal disease and edentulism are the most significant changes in individuals who received antineoplastic therapy for head and neck cancer as well as greater need for oral rehabilitation.

Auditory Brainstem Response and Audiologic Findings in Adrenoleukodystrophy: Its Variant and Carrier

1988 ◽  
Vol 98 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Hiroshi Shimizu ◽  
Hugo W. Moser ◽  
Sakkubai Naidu
Keyword(s):  
High Sensitivity ◽  
Auditory Brainstem ◽  
Speech Discrimination ◽  
Acoustic Reflex ◽  
Auditory Brain Stem Response ◽  
Auditory Brain Stem ◽  
Profound Deafness ◽  
Brainstem Response ◽  
Reflex Threshold ◽  
Acoustic Reflex Threshold

Auditory brain stem response, auditory sensitivity, speech discrimination function, acoustic reflex threshold, and reflex decay were studied in seven children with adrenoleukodystrophy (ALD), nine adults with adrenomyeloneuropathy (AMN), one child with neonatal ALD, and two carriers of ALD. Significant auditory dysfunctions were found in only two patients; a retrocochlear type auditory disorder in one child with ALD, and a profound deafness in a child with neonatal ALD. None of the patients showed significant abnormality in acoustic reflex threshold and reflex decay except for one patient with ALD who showed a slightly elevated reflex threshold. All but two ALD patients showed significantly prolonged wave latencies and interwave intervals. The latency values revealed the highest incidence of abnormality in the I to III interval; this was followed by the III to V interval, then by wave I. Significantly, one child with asymptomatic ALD and both heterozygous female relatives showed abnormal ABRs, demonstrating the high sensitivity of ABR in detection of the existence of pathophysiological condition in subclinical or presymptomatic ALD.

Serum testosterone level and its relation to aggressive behavior in schizophrenia

2017 ◽  
Vol 41 (S1) ◽  
pp. s845-s846
Author(s):  
M. Zholob ◽  
S. Godinova ◽  
M. Zelman
Keyword(s):  
Aggressive Behavior ◽  
Testosterone Level ◽  
Laboratory Evaluation ◽  
Serum Testosterone Level ◽  
Control Group ◽  
Study Group ◽  
Average Value ◽  
Intergroup Comparison ◽  
History Of ◽  
Male Patients

This work is presenting partial preliminary outcomes of our study focused on evaluating the levels of testosterone in psychotic patients and its relationship to aggressive behavior.Our study group included 10 male patients (from planned 20), with history of aggressive behavior at baseline and 24 male patients (from planned 40), without history of aggressive behavior. Non-aggressive patients were considered as control group. All included patients were hospitalized in psychiatric hospital Hronovce with diagnose of psychotic disorder. Levels of testosterone were measured by laboratory evaluation. Aggressive behavior was assessed by HCR scale, which was linked with every TSH evaluation. The level of testosterone was measured in all subjects at the baseline and in the group of aggressive patients was realized next measurement after 14 days of hospitalization.According to our preliminary findings, the average level of TSH in our whole study group was 478.66 ng/dl (range from 158.06 to 767.81). The control group showed average value of TSH 486,84 ng/dl (range from 158.06 to 767.81). The group of patients with history of aggressive behavior showed average value of TSH 459.04 ng/dl (range from 191.81 to 638.02) and after 14 days of cure the levels were of average value 452.55 ng/dl (range from 253.53 to 657.92).These preliminary findings don’t show significant intergroup differences, but there are some clear casuistic declines in TSH. After collecting the envisaged group of patients we plan to correlate values of testosterone level with the score of HCR, intergroup comparison and detailed analysis (including demography, pharmacology).Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Long latency auditory evokedpotentials in malnourished children

CoDAS ◽  
2013 ◽  
Vol 25 (5) ◽  
pp. 407-412 ◽  
Author(s):  
Renata Parente de Almeida ◽  
Carla Gentile Matas
Keyword(s):  
Evoked Potentials ◽  
Auditory Evoked Potentials ◽  
Impedance Measurement ◽  
Pure Tone Audiometry ◽  
Control Group ◽  
Study Group ◽  
Malnourished Children ◽  
Long Latency ◽  
Significant Difference ◽  
The Right

PURPOSE: To characterize the findings obtained in the long latency auditory evoked potentials in malnourished children, as well as to compare them to the results obtained for children at the same age who present typical development. METHODS: Sixty-five children aged between 7 and 12 years old, of both genders, were evaluated. The control group consisted of 34 children with normal development and the study group consisted of 31 children diagnosed with malnutrition. All children underwent conventional pure tone audiometry, acoustic impedance measurement, dichotic digit test and long latency auditory evoked potentials. RESULTS: The study group presented a statistically significant difference for latencies of the components P1, N1 and P300. The latencies of these components were higher than those of the control group. Concerning the types of alterations found in the study group, increased latency for P1 and P300 and the absence of response in N1 were predominant. The control group showed a statistically significant difference in the amplitude of P300 when compared to the right and left ears. CONCLUSION: Malnourished children present with changes in the long latency auditory evoked potentials, suggesting a deficit in central auditory pathways and alterations in the processing of acoustic information.

scholarly journals Polymorphism of MTHFR gene (677 and 1298) in females with spontaneous abortions in Bihor County

2015 ◽  
Vol 62 (2) ◽  
pp. 195-199
Author(s):  
Kinga Kozma ◽  
◽  
Claudia Jurca ◽  
Marius Bembea ◽  
◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Protective Role ◽  
Mthfr Gene ◽  
Control Group ◽  
Study Group ◽  
Spontaneous Abortions ◽  
Wild Type ◽  
Genotype Combination ◽  
Mthfr Gene Polymorphism ◽  
History Of

Introduction. The MTHFR gene polymorphism is cited as a possible cause of spontaneous abortion. Aim. The genotype profile determination for the MTHFR (677 and 1298) gene and its correlations with spontaneous abortion in a female study group from Bihor County, Romania. Material and methods. This is a comparative research type conducted on a study group (SG) consisting of 46 female patients with a history of spontaneous abortions and a control group (CG) consisting of 50 females with no spontaneous abortions, no familial or personal history of thromboembolic events and who have had at least two previous live births. All women in both groups were genotyped for the MTHFR gene in positions 677 and 1298 by the Real-Time PCR method. Results. The proportion and the statistic significance of MTHFR 677/1298 genotype combinations found by us in the SG compared with the CG was, as follow: C677C/A1298A 2,17%, vs. 22% (p=0,01), C677T/A1298A 23,91%, vs. 20% (p=0,81), C677C/A1298C 21,73%, vs. 16% (p=0,61), C677C/C1298C 17,39%, vs. 4% (p=0,09), T677T/A1298A 13,04%, vs. 8% (p=0,51), C677T/A1298C 19,56%, vs. 28% (p=0,49), C677T/C1298C 2,17%, vs. 2% (p=1) and T677T/A1298C 0%, vs. 0% (p=1). Conclusion. The C677C/A1298A genotype combination (wild type/wild type) is in a significant higher percentage (p<0.05) in the control group compared to the study group, suggesting its protective role in producing spontaneous abortion. No other polymorphism of this gene has been statistically associated with spontaneous abortion.

scholarly journals Family history of disease and risk of glioma occurrence: Results of the case-control study

2020 ◽  
Vol 77 (4) ◽  
pp. 413-417
Author(s):  
Ana Azanjac-Arsic ◽  
Gordana Toncev ◽  
Svetlana Miletic-Drakulic ◽  
Katarina Vesic ◽  
Dejan Aleksic ◽  
...  
Keyword(s):  
Family History ◽  
Cardiovascular Diseases ◽  
Case Control Study ◽  
Malignant Gliomas ◽  
Case Control ◽  
Control Group ◽  
Study Group ◽  
Malignant Diseases ◽  
History Of ◽  
Control Study

Background/Aim. Malignant gliomas represent a heterogenaus group of tumors. They occur in all age groups, predominatly in males in older age. The purpose of this case-control study was to examine the association between risk for developing glioma and family history of diseases. Methods. The case-control study included 100 pathologically confirmed cases of glioma at the Clinical Centre Kragujevac, Serbia, between 2015 and 2016, and 200 ageand sex-matched controls without glioma and other malignant diseases in personal and family history at the same institution. After signing the informed consent all the patients filled out an epidemiological questionnaire. Multivariate logistic regression analysies was used in statistical data processing. Results. Malignant diseases in family history were more common in the study group than in the control group [odds ratio (OR) = 1.821, 95% confidence interval (CI) 1.004?3.305; p = 0.049]. The most common malignant tumor in the study group were cancer of the uterus (7%) and colon cancer (6%), while in the control group the most common cancer were lung cancer (6%) and cancer of the uterus (7%). Diabetes mellitus in family history was more common among control individuals than among glioma patients (OR = 0.520, 95% CI = 0.271? 0.995; p = 0.048). Also, our results showed that cardiovascular diseases in family history were more common in the control group than among patients of the study group (OR = 0.557, 95% CI = 0.325?0.953; p = 0.033). Conclusion. In this case-control study, we observed a statistically significant relation between family history of malignant diseases and glioma. Also, we found statistically significant inverse relation between family history of cardiovascular diseases and diabetes and glioma.

scholarly journals Current and past adherence to the World Cancer Research Fund/American Institute for Cancer Research recommendations in survivors of breast cancer

2019 ◽  
pp. 295-305
Author(s):  
Emilia Kałędkiewicz ◽  
Dorota Szostak-Węgierek
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Cancer Research ◽  
Dietary Habits ◽  
Control Group ◽  
Study Group ◽  
Research Fund ◽  
American Institute ◽  
The World ◽  
History Of

Background. Breast cancer is the first in the structure of the incidence of neoplastic diseases in women, with the number of affected individuals becoming higher every year. The risk of breast cancer is influenced not only by genetic factors, but also by the lifestyle. Proper dietary habits, a high level of physical activity and normal body weight not only reduce the risk of developing a primary neoplastic lesion, but also a recurrence. In 2007 the World Cancer Research Fund (WCRF) and American Institute for Cancer Research (AICR) published their recommendations concerning lifestyle in the prophylaxis of neoplasms. Objective. The aim of the study was to assess whether the adherence to WCRF/AICR recommendations influenced the risk of developing breast cancer in women. Materials and methods. A case control study included 108 women aged over 50 with a history of breast cancer. The study group was divided into two subgroups: women who completed oncological treatment and experienced no recurrences for at least 5 years (group I, n=82) and women who had a recurrence (group II, n=26). The control group included women with no history of breast cancer (n=74). The adherence of lifestyle was assessed by assigning points for 8 WCRF/AICR recommendations. The results were compared in the study and control groups, both in all participants and separately in those who declared no changes in dietary habits after being diagnosed with breast cancer. Results. The adherence of lifestyle to WCRF/AICR recommendations was significantly lower in the group of women with a history of cancer compared to the control group. It was reported both in the study group as a whole (5.5 ± 1.34 vs 6.4 ± 1.48 points) and in those who declared no changes in dietary habits after being diagnosed with breast cancer (5.3 ± 1.24 vs 6.6 ± 1.38 points). The differences in the lifestyles of the participants with breast cancer and those in the control group were associated predominantly with the adherence to recommendations concerning appropriate physical activity, avoiding the consumption of sweetened drinks and limiting the consumption of processed and red meat. Conclusions. The results of the study confirmed the benefits of complying with WCRF/AICR recommendations in the prevention of breast cancer.

P-746 Obstetric outcomes of singleton birth after hysteroscopic division of septate uterus

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
O Abuzeid ◽  
C Heiselman ◽  
A Fuchs ◽  
J La Chance ◽  
K Herrera ◽  
...  
Keyword(s):  
Lower Incidence ◽  
Surgical Correction ◽  
Obstetric Outcomes ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Septate Uterus ◽  
Significant Difference ◽  
Singleton Birth ◽  
History Of

Abstract Study question The aim of this study is to determine the obstetric outcomes in patients with a singleton birth after hysteroscopic division of septate uterus. Summary answer The data suggest excellent obstetric outcomes for singleton gestation after hysteroscopic division of a septate uterus reaching either the internal or the external cervical os. What is known already Septate uterus is a rare Müllerian anomaly with major impact on reproductive outcomes, particularly with a septum over 10mm. Controversy still exists over the need for surgical correction of the septum due to conflicting data on outcomes, particularly in women with histories of good obstetric outcomes and incidental septum findings. Placental location in relation to the septum may account for such conflicting reports. Most data on reproductive outcomes after hysteroscopic surgical correction combine both septate and subseptate uteri. There is limited published data on obstetric outcomes after hysteroscopic surgical correction of septate uteri, especially septate uteri reaching the external os. Study design, size, duration This retrospective cohort study included 107 patients with infertility and/or recurrent pregnancy loss (RPL) who received treatment between 2002 -2019. The study group included 24 patients with a singleton birth after hysteroscopic correction of septate uterus (Class Va; ASRM classification) that was diagnosed on trans-vaginal 3D ultrasound. The control group included 83 patients with a singleton birth who had normal endometrial cavity on hysteroscopy during the same period of time, before starting treatment. Participants/materials, setting, methods This study was conducted at an infertility clinic affiliated with a teaching hospital. In the study group the septum reached the internal or the external cervical os in 14 and 10 patients respectively. After hysteroscopic correction, all patients were offered various infertility treatments depending on the underlying etiology. The inclusion criterion in this study was to have a singleton birth after hysteroscopy. Demographic and clinical data and obstetric outcomes were compared between the two groups. Main results and the role of chance There was no significant difference in mean age, infertility duration, infertility type and incidence of male infertility or ovulatory disorders between the two groups. There was a significantly higher BMI (0.048), and a higher incidence of history of miscarriage (P=0.002) and history of RPL (P=0.017) in the study group. There was significant lower incidence of tubal factors infertility (P=0.005) and endometriosis (P=0.03) in the study group, therefore there was higher incidence of spontaneous conception (70.8% vs 19.3%; P=0.000) and lower incidence of conception with IVF-ET (20.8% vs 66.3%; P=0.000) in the study group compared to the control group respectively. There was significantly higher incidence of prophylactic cervical cerclage (17.4% vs 0%; P=0.000), and delivery by CS (69.6% vs 41.2%; P=0.019) and lower incidence of vaginal delivery (30.4% vs 58.8%; P=0.019), in the study group compared to the control group. There was no significant difference in gestational age in weeks (38.3 + 1.8 vs 38.6 + 2.0), newborn birth weight in grams (3173.9 + 630.0 vs 3202.1 + 555.6), incidence of premature birth (12.5% vs 12.2%), or other obstetric complications (25% vs 17.6%) between the study and the control groups respectively. For premature births, mean gestational age was 34.3 + 0.47 and 34.6 + 1.2 weeks in the study and control groups respectively. Limitations, reasons for caution A retrospective study has its own inherent bias. Furthermore, the small sample size is explained by the fact that a septate uterus is a rare anomaly leading to difficulties finding cases and organizing a prospective study to achieve a larger sample size. A multicenter prospective study is needed. Wider implications of the findings Regardless of whether the septum reached the internal or external os, there were excellent obstetric outcomes in singleton gestations after hysteroscopic correction of septate uteri. There was no increased risk with septate uteri involving the cervix. Hysteroscopic surgical correction should be the treatment of choice for patients with septate uteri. Trial registration number Not Applicable

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