scholarly journals Preventative effects of aripiprazole and quetiapine on seizure and lethality in a mice cocaine toxicity model: an experimental study

2019 ◽  
Vol 47 (8) ◽  
pp. 3831-3840
Author(s):  
Atakan Yilmaz ◽  
Bulent Erdur ◽  
Mert Ozen ◽  
Ramazan Sabirli ◽  
Ibrahim Turkcuer ◽  
...  
Keyword(s):  
Experimental Study ◽  
Saline Solution ◽  
Seizure Activity ◽  
Study Groups ◽  
Control Group ◽  
Significant Difference ◽  
Cocaine Hydrochloride ◽  
The Mean ◽  
Pre Treatment ◽  
Cocaine Toxicity

Objective To assess the effectiveness of pre-treatment with aripiprazole and quetiapine to prevent acute cocaine toxicity in a mouse model of cocaine toxicity. Methods This experimental study included three groups ( n = 25 per group) of mice that were intraperitoneally injected with normal saline solution, 10 mg/kg quetiapine or 10 mg/kg aripiprazole 15 min before 105 mg/kg cocaine hydrochloride. When the cocaine administration was completed, researchers blinded to the study groups observed the mice in terms of seizures and death for a further 30 min. Results In the cocaine + quetiapine group, the mean ± SE time to the first seizure was 10.80 ± 2.27 min and seizure activity was detected in 18 mice (72%) by the end of the 30 min. In the cocaine + aripiprazole group, the mean ± SE time to the first seizure was 18.10 ± 1.94 min and seizure activity was detected in 15 mice (60%) by the end of the 30 min. When compared with the control group, there was a significant difference between the cocaine + quetiapine and cocaine + aripiprazole groups in terms of seizure activity. Survival time was increased in the cocaine + aripiprazole group compared with the control and cocaine + quetiapine groups. Conclusion Quetiapine and aripiprazole pre-treatment reduced seizure activity and delayed the onset of seizures compared with the control group.

scholarly journals Effects of eye cover among high risk neonates at night shift on their distress levels

2019 ◽  
Vol 9 (7) ◽  
pp. 9
Author(s):  
Eman Ali Moselhi Mater ◽  
Huda Shawky Mahamud ◽  
Mohamed Farouk Mohamed
Keyword(s):  
High Risk ◽  
Night Shift ◽  
Newborn Infants ◽  
Study Groups ◽  
University Hospital ◽  
Control Group ◽  
Stressful Environment ◽  
Distress Level ◽  
Significant Difference ◽  
The Mean

Background and aim: The Neonatal Intensive Care Unit (NICU) is a stressful environment for high risk neonates. Persistent bright light is one of the main environmental stressors that are distressed newborn infants in NICU. Cycled lighting may decrease distress level of newborn infants by enhancing calming status. This study aimed to investigate effects of eye cover among high risk neonates at night shift on their distress levels.Methods: Quasi experimental research design was carried out on a randomized sample of 60 newborn infants attending the NICU of El Manial University Hospital (Kasr Al Ainy), (30 control group and 30 study group). Neonatal assessment tool and COMFORTneoNRS scale were utilized for data collection.Results: There was a statistically significant difference between control and study groups regarding the distress levels (p < .00). The mean score of distress levels were 6.80 ± 1.80 and 0.80 ± 1.15 respectively and the mean score of comfort levels in the newborn infants in the control and study groups were 23.22 ± 5.50 and 6.60 ± 1.06 respectively. Eye coved enhanced quite sleep (66.7%), relaxed muscle (73.3%), decrease movement (66.7%) and no crying (85.7%).Conclusions: The use of eye cover among high risk neonates at night shift is effective to decrease their distress level and improve their comfort state in the morning shift by promoting quite sleep and relaxation. Recommendations: The educational program is needed to raise awareness among neonatal nurses about the effect of light reduction methods such as eye patches on the distress level and comfort state that enhances the growth and development of newborn infants.

scholarly journals Investigating the Impact of Foot Reflexology on Postpartum Energy in Primiparous Women

2020 ◽  
Vol 10 (2) ◽  
pp. 184-195
Author(s):  
Maryam Moddares ◽  
◽  
Shekoufeh Maleki ◽  
Shima Haghanni ◽  
◽  
...  
Keyword(s):  
Energy Level ◽  
Low Cost ◽  
Study Groups ◽  
Routine Care ◽  
Control Group ◽  
Visual Fatigue ◽  
Informed Consent Form ◽  
Significant Difference ◽  
The Mean ◽  
The Impact

Objective: The postpartum period is a critical stage that exposes the mother to unpleasant experiences, including changes in energy level. Implementing reflexology during this period, as a branch of complementary medicine, may be helpful in promoting healthcare, especially in the areas of maternal and child health. Methods: In total, 70 eligible women who referred to health centers in the south of Tehran City, Iran, affiliated to Tehran University of Medical Sciences participated in this quasi-experimental study. A written informed consent form was obtained from them before initiating the study. The mothers of the postpartum routine care control group and the reflexology group received a massage for 3 consecutive days for 30 minutes (15 minutes per leg). Both study groups completed energy-related items in the Visual Fatigue Questionnaire before as well as immediately and one week after the completion of the intervention. The collected data were analyzed by SPSS. Results: Demographic characteristics and the energy level before intervention were homogenous in both research groups. Immediately after the intervention, the Mean±SD energy scores in the control and reflexology groups were 34.55±2.84 and 33.7±4.33, respectively; thus the obtained data revealed no statistically significant difference between the study groups (P=0.02). One week after the intervention, the Mean±SD energy scores in the reflexology and control groups were 35.87±2.71 and 35.5±3.43), respectively; thus, there was no significant difference between the study groups in this regard (P=0.64). Conclusion: The presented massage intervention was not as effective as a non-invasive low-cost method on the postpartum energy level of the study participants.

scholarly journals Effectivity comparison between aspirin, propolis, and bee pollen as an antiplatelet based on bleeding time taken on mice

2018 ◽  
Vol 197 ◽  
pp. 07008
Author(s):  
Sake Juli Martina ◽  
Muhammad Luthfi ◽  
Pradeepa Govindan ◽  
Arlinda Sari Wahyuni
Keyword(s):  
Cardiovascular Disease ◽  
Experimental Study ◽  
Bleeding Time ◽  
Control Group ◽  
Placebo Administration ◽  
Control Group Design ◽  
Bee Pollen ◽  
Group Design ◽  
Significant Difference ◽  
The Mean

The use of standard antiplatelet therapy for cardiovascular disease patients has many side effects. This study aims to determine the effectiveness of Propolis and Bee Pollen, two bee products, as antiplatelet and in comparison with Aspirin. This is an experimental study with posttest only control group design. The samples were 32 mice, divided into 4 groups: placebo, administration of aspirin (10.4 mg/kg-bw/day), Propolis (65 mg/kg-bw/day), and Bee Pollen (68 mg/kg-bw/day). The study was conducted for 12 days and the suspensions were given orally. The bleeding time was then measured using tail-bleeding technique. The data collected was bleeding time in seconds. All samples completed the study. The mean bleeding time for placebo, Aspirin, Propolis and Bee Pollen groups were 106.1, 442.9, 310.1, and 203 in seconds respectively. ANOVA and Bonferroni tests showed a significant difference between Propolis and placebo groups (p=0.003), no difference between Propolis and Aspirin groups (p=0.100), no difference between Bee Pollen and placebo groups (p=0.442), and a significant difference between Bee Pollen and Aspirin groups (p=0.000). Administration of Propolis in mice showed prolongation of bleeding time while Bee Pollen did not prove to have antiplatelet effects.

Impact of poetry-based ethics education on the moral sensitivity of nurses: A semi-experimental study

2021 ◽  
pp. 096973302110417
Author(s):  
Kobra Rashidi ◽  
Tahereh Ashktorab ◽  
Mehdi Birjandi
Keyword(s):  
Experimental Study ◽  
Ethics Education ◽  
Control Group ◽  
Moral Sensitivity ◽  
Post Intervention ◽  
Lasting Effect ◽  
Significant Difference ◽  
The Mean ◽  
Design And Methods ◽  
The Impact

Background: The nurses’ moral sensitivity is the first step to make right decisions in difficult moral situations. Therefore, its education and promotion is highly important. Research objectives: The aim of this study was to examine the impact of poetry-based ethics education on the nurses’ moral sensitivity. Research design and methods: This was a semi-experimental study. The sample consisted of 108 nurses who were selected by convenience sampling method and randomly assigned to three groups: intervention with poetry (G1), who read a booklet about values and principles of professional ethics as well as poems related to these subjects for 1 month; intervention without poetry (G2), who only read the booklet without any poetry; and control group (G3), who did not receive any intervention. Data were collected by Moral Sensitivity Questionnaire that was completed by the participants prior to the intervention (T1), 1-month post-intervention (T2), and 2-month post-intervention (T3). Data were analyzed by SPSS 16 software. Ethical considerations: This study was conducted in accord with the principles of research ethics and regulations relating to informed consent. Findings: Changes in the mean score of total moral sensitivity were significantly higher in G1 than in G2, which was in turn significantly higher than in G3. This increase was significant from T1 to T2 and T2 to T3 (P < 0.001). In all subscales, there was a significant difference between the mean changes in the three groups, so that in these subscales, the mean changes in G1 were significantly higher than those in other groups. Discussion: In line with previous studies, our results showed the effectiveness of poetry-based education on the transfer of educational concepts and increase moral sensitivity scores with greater lasting effect. Conclusion: The use of interdisciplinary subjects such as poetry, due to its entertaining, fun, and lasting effect on minds; level of awareness; and actions of nurses, can help raise nursing moral sensitivity.

scholarly journals The Effectiveness of Using Video in Teaching Listening To The Eleventh Grade Students of Senior High School

2018 ◽  
Vol 6 (2) ◽  
pp. 247
Author(s):  
Safarina Rachmaningdias ◽  
Martono Martono ◽  
Dwi Elyono
Keyword(s):  
High School ◽  
Experimental Study ◽  
Senior High School ◽  
Control Group ◽  
Significant Difference ◽  
Post Test ◽  
The Mean ◽  
Experimental Group

<p><em>This research is an experimental study of using video in teaching listening to the eleventh grade students of SMA N 1 Slawi. The objective of the research is to find out whether the use of video in teaching listening to the eleventh grade students of SMA N 1 Slawi is effective. The data were obtained from the students’ scores. The findings of the research are: (1) There is a significant difference between the listening achievement of the students taught using video and the listening achievement of the students taught using audio (t<sub>o</sub> is higher than t<sub>t</sub> or 2.605 &gt; 2.000); (2) The post-test mean score of the experimental group taught using video is higher than the post-test mean score of the control group taught using audio. The mean score of the experimental group is 75.80 while the mean score of the control group is 68.87. Therefore, it can be  concluded that using video in teaching listening is effective.</em></p>

scholarly journals The Effect of Hope Therapy-based Training on the Happiness of Women with Breast Cancer: A Quasi-experimental Study

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Niloofar Kondori Fard ◽  
Asadollah Keikhaei ◽  
Maliheh Rahdar ◽  
Nasrin Rezaee
Keyword(s):  
Breast Cancer ◽  
Experimental Study ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
Paired Samples ◽  
Significant Difference ◽  
Quasi Experimental ◽  
The Mean ◽  
Hope Therapy

Background: The prevalence of cancer and its psychological consequences has increased steadily in recent decades. Hence, parallel to providing medical interventions, psychological therapies should be provided to cancer patients. Objectives: The present study aimed to determine the effect of hope therapy-based training on the happiness of women with breast cancer. Methods: In this quasi-experimental study, 100 female patients with breast cancer admitted to the chemotherapy wards of two hospitals affiliated to the Zahedan University of Medical Sciences (Iran) in 2020 are studied. Participants were selected using the convenience sampling technique and randomly divided into two groups of intervention and control (each with 50 subjects). The intervention group received eight sessions of group-based hope therapy training. Data were collected using a demographic information form and the Oxford Happiness questionnaire. Data were analyzed using SPSS version 16 by chi-square, independent samples t-test, and paired samples t-test, at a significant level of P < 0.05. Results: There was no significant difference between the two groups concerning demographic characteristics. The independent samples t-test showed no significant difference in the mean scores of happiness between the two groups before the intervention (P = 0.55). However, the mean score of happiness for the participants in the intervention group showed a significant increase after providing the intervention compared to the control group (P = 0.001). Besides, the paired samples t-test indicated a significant increase in the mean score of happiness after providing the intervention compared to before intervention (P = 0.001), while the mean score of happiness for the participants in the control group showed a statistically significant decrease (P = 0.004). Conclusions: This study demonstrated that hope therapy-based training is effective for the happiness of women with breast cancer. Since physical and psychological problems caused by cancer lead to sadness and reduced happiness, hope therapy can be added to the care programs for women with cancer undergoing chemotherapy.

scholarly journals Effect of submucosal injection of ketorolac versus dexamethasone on postoperative pain after third molar surgery: a randomized clinical trial

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Dariush Hasheminia ◽  
Reyhaneh Faghihian ◽  
Farhad Mardani
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Third Molar ◽  
Study Groups ◽  
Third Molar Surgery ◽  
Control Group ◽  
Impacted Third Molar ◽  
Significant Difference ◽  
The Mean ◽  
The Difference

Abstract Background One of the most common dentoalveolar surgeries is the removal of impacted third molars. Moderate to severe pain is predictable after these surgeries, usually leaving the patient in need of an effective analgesic for at least 24 h. Corticosteroids and NSAIDs are well-known medications used to reduce pain. This prospective, randomized clinical trial aimed to assess the effectiveness of two types of analgesics, ketorolac and dexamethasone, on pain experienced after unilateral impacted third molar surgery. The analgesics were injected sublingually after profound anesthesia was confirmed in 60 healthy adult patients. During this study, the patients were divided into three groups. The patients in group K received 1 mL of ketorolac (30 mg), while the patients in group D received 1 mL of dexamethasone (4 mg) sublingually. The patients in group C (the control group) received 1 mL of normal saline solution as a placebo. Results The mean pain scores reported by the patients in groups K and D were significantly lower than group C (P = 0.002 and P < 0.001, respectively). However, the difference between groups D and K was not significant (P = 0.158). The mean number of analgesics taken by patients in groups K and D 24 h after surgery was significantly lower than the control group (P < 0.05). At 48 and 72 h postoperatively, however, the difference was not significant between the study groups (P > 0.05). The mean time of the first analgesic taken by the patients in groups K and D was 200.94 and 214.74 min after surgery, respectively. Exhibiting a significant difference, it was 132.65 min for the patients in group C (P = 0.003). Conclusions Under this study’s limitations, preoperative sublingual injection of ketorolac and dexamethasone were similarly effective in pain control after impacted third molar surgery.

Determination some Immunological Aspects in Pulmonary Tuberculosis Patients in Qadisiyah Province

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Syoof Khowman Alramahy ◽  
Akram Hadi Hamza
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Statistical Difference ◽  
Positive Culture ◽  
Control Group ◽  
Tuberculosis Patients ◽  
Significant Difference ◽  
Lowenstein Jensen ◽  
The Mean ◽  
Igg Level

This study was carried out to study of some immunological aspects among the pulmonary Tuberculosis patients infected with causative agent, Mycobacterium tuberculosis. A Total of 200 sputum samples were collected from patients attending the consultant Clinic for Chest and Respiratory disease center, Diwaniya. Control group (No=15) also included. According to acid fast stain of sputum, the patients were classified as positive (No=91,45.5%) and negative (No=109,54.5, Lowenstein Jensen medium used for the cultivation of samples, on which 70% of sputum samples where positive culture for this microorganism. The grown microorganism were identified as M. tuberculosis, based on positive A.F.B, Niacin producers ,negative for catlase at 68c. The mean IgG level was l184.053±76.684 mg/100 ml in tuberculosis group compared with 1016.533 ± 44.882 mg/100ml in control group, rendering the statistical difference significant. For IgA and IgM levels, they were at mean of 315.880±38.552 mg/100 ml and 119.527±8.464 mg/100 ml in control group compared with 396.358±38.776 mg/100 ml and 134.207±11.696 mg/100 ml in patients group respectively with significant difference

Success Rate of Obturation of Root Canals by Different Techniques in Primary Molars: A Comparative Clinical Study

2020 ◽  
Vol 2 (1) ◽  
pp. 36-44
Author(s):  
Satyawan G. Damle ◽  
Ritika Bansal ◽  
Dhanashree D. Sakhare
Keyword(s):  
Success Rate ◽  
Study Groups ◽  
Primary Molars ◽  
Control Group ◽  
Second Primary ◽  
Chi Square ◽  
Exact Test ◽  
Root Canals ◽  
Significant Difference ◽  
Comparative Clinical Study

Objective: To compare the success rate of different obturation procedures in primary mandibular second molars clinically and also by digital radiovisiography. Methods: A total of 40 children aged between 4-8 years with deeply carious mandibular second primary molars indicated for single session pulpectomy were selected. Canals were obturated with Metapex. The 3 study groups (Endodontic plugger, Handheld lentulospiral, Navi Tip syringe) were compared with the control group (reamer) both clinically and radiovisiographically. The data collected were statistically analyzed using Pearson’s Chi-square and Fisher’s exact test. Results: The use of Navi tip syringe led to the least number of voids followed by Endodontic plugger and Reamer and the highest number of voids was reported with Lentulospiral. Navitip presented maximum number of optimally filled cases followed by Endodontic plugger and Lentulospiral and least number of optimally filled cases with reamer. However, there was no statistically significant difference (p>0.05) in any of the groups with clinical (pain and tenderness to percussion) and radiographic parameters (presence or absence of voids and length of obturation). Conclusion: Within the limitations of the present study, though the clinical outcome was statistically insignificant, Navitip syringe exhibited encouraging results and is a promising option for obturation in primary teeth.

scholarly journals The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1569
Author(s):  
Tomislav Šušnjar ◽  
Ivana Kuzmić Prusac ◽  
Ivan Švagelj ◽  
Anđela Jurišić ◽  
Tomislav Šušnjar ◽  
...  
Keyword(s):  
Sperm Count ◽  
Semen Analysis ◽  
Study Groups ◽  
Testicular Biopsy ◽  
Male Rats ◽  
Lower Percentage ◽  
Control Group ◽  
Sprague Dawley ◽  
Left Testis ◽  
Significant Difference

Background: The aim of this study was to compare consequences in single and triple testicular biopsy by biopty gun in pubertal rats using histological and immunohistochemical analysis. Methods: Thirty-two Sprague-Dawley male rats were used as the experimental model. The rats were randomly divided into three study groups. The rats from the first group (n = 12) received a single-biopsy of upper pole of the left testis, while the rats from the second group (n = 10) received triple-biopsy of upper and lower poles and lateral surface of left testis. The third group (n = 10) was a control group. On the eightieth day after the biopsy in all rats bilateral orchiectomy and funiculectomy were performed to obtain testicular tissue and sperm for analysis. The consequences of the puncture were observed by pathohistology, immunohistochemistry and semen analysis. Results: The results of the study showed lower percentage of sperm count (14.5 mill/mL vs. 16 mill/mL, p = 0.130), sperm motility (24.6% vs. 32.7%, p > 0.05), abnormal sperm (30% vs. 27%, p > 0.05), atrophic tubules (21% vs. 6%, p < 0.001), volume (1.7 mL vs. 2.28 mL, p < 0.01) and apoptotic index (1.56 vs. 1.19, p = 0.650) in the testes with a triple-biopsy compared to the testes with a single-biopsy. Semen analysis showed a borderline significant difference between the group with triple-biopsy where sperm count was lower than it in the control group (14.5 mill/mL vs. 17.5 mill/mL, p = 0.05). A single-biopsy has little effect on the testis, especially on overall fertility. A triple-biopsy showed higher degree of the testicular damage but without a significant impact on overall fertility. Semen analysis showed that single- and triple-biopsies did not have a significant effect on sperm count, motility and morphology. Conclusion: Biopty gun procedure is a cheap, simple and reliable method for testicular biopsy in rats without a significant effect on sperm count, motility and morphology.

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