Biomolecular characterization of formalin-fixed paraffin-embedded primary renal tumor specimens.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 421-421
Author(s):  
Vanessa Medina ◽  
Guadalupe Aparicio Gallego ◽  
Isabel Santamarina ◽  
Manuel Valladares Ayerbes ◽  
Luis M. Antón Aparicio
Keyword(s):  
Correlation Coefficient ◽  
Positive Association ◽  
Suppressor Gene ◽  
Nonparametric Tests ◽  
Strong Positive Correlation ◽  
Significance Level ◽  
Chromophobe Rcc ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Formalin Fixed Paraffin Embedded

421 Background: Renal cell carcinoma (RCC) is the most common type of kidney cancer. It is required a better understanding of signalling pathways involved in renal cells. Methods: We assessed using immunohistochemistry (IHC) and quantitative real-time PCR (qPCR) with SYBR Green the profile of predictive markers involved in the cascade of events leading to the formation and progression: invasiveness, angiogenesis and antiapoptotic mechanisms. 80 RCC tissues were detected by IHC. RNA of quality only was obtained in 72 (80% clear RCC, 10% papillary RCC and 10% chromophobe RCC) to carry out the study of gene expression through qPCR. A pool of normal kidney-derived RNA samples (N=5) was used as healthy control. GAPDH and YWHAZ were used as reference genes. GenEx software was used for qPCR data processing and analysis. Nonparametric tests (Pearson’s correlation coefficient test and Spearman’s rho test, Kruskal — Wallis and Mann — Whitney) were applied for statistical data analysis (SPSS 19). Results: p53 showed higher expression in those cases with Furhman grade I (p=0.036). Moreover p53 showed a positive association with VEGF, GLUT1, GLUT4, VEGFR-2 and VHL (r=0.241, sig. level 0.05; r=0.291, sig. level 0.01; r=0.456, sig. level 0.01; r=0.187, sig. level 0.097 and Spearman’s rho=0.269, sig. level 0.05 respectively). Hif1- α, Hif1- β, Notch1 and Notch3 were upregulated in chromophobe RCC (p=0.045, p=0.03, p=0.03 and p=0.02 respectively). Hif1- α and Notch3 were upregulated in clear RCC (p=0.034 and p=0.041 respectively). Spearman’s correlation coefficient showed a strong positive correlation between Nocth1-4 members and their receptors and Hif1-α and β genes. Highlight the correlation found between: Notch1 and Hif1-α (Spearman’s rho = 0.740, significance level 0.01) and Hif1-β and Jagged1 (Spearman’s rho = 0.752, significance level 0.01). Conclusions: The pathway involving the tumor suppressor gene p53 could regulate tumor angiogenesis. Co-expression of Notch receptors, their ligands and Hif-1 α and Hif1- β subunits may play a role in human RCC. Notch cascade may represent a novel and therapeutically accessible pathway in chromophobe and clear RCC. More detailed studies of these crossing pathways are in progress.

scholarly journals Pengaruh Dukungan Sosial Terhadap Kecemasan Pada Ibu Hamil di Puskesmas Jetis Kabupaten Ponorogo

2018 ◽  
Vol 5 (1) ◽  
pp. 55-66
Author(s):  
Ambika Kurnia Mustikawati
Keyword(s):  
Social Support ◽  
Pregnant Women ◽  
Correlation Coefficient ◽  
Sampling Technique ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
The Social ◽  
The Face ◽  
Independent Variable

Background: Pregnancy is a valuable thing, but also one of the great stresses for awoman both physically and mentally. Pregnant women with high anxiety will increase therisk of hypertension, difficulty sleeping and stroke, seizures and even death in the motherand fetus. In Puskesmas Ponorogo district the number of pregnant women as much as5903 mothers, while in health centers Jetis the number of pregnant women as many as200 mothers. Interview results, 21 out of 27 mothers said were very anxious during herpregnancy. The purpose of this study was to analyze the factors of social support foranxiety in pregnant women.Subjects and Methods: The type of research is analytical with cross-sectional approach.The location of research at Jetis health center Ponorogo regency. Research conducted onSeptember 1 to October 15, 2016. Sample of 30 pregnant women using proportionalrandom sampling technique. Dependent variable is anxiety, while independent variable issocial support. Data collection techniques using questionnaires. Data analysis usingSpearman's Rho using SPSS 18.0 for windows computer program.Results: The results showed that from 40 respondents, almost half were 13 (32.5%)multiparous had mild anxiety and nearly half were 13 (32.5%) primipara experiencedmoderate anxiety. of the 40 respondents, nearly half (12%) of 3 trimester pregnantwomen had moderate anxiety and a small proportion of 9 (22.5%) of 2 trimester pregnantwomen had mild anxiety. The result of calculation using spearman's rho statistic testobtained p = 0,006 <α 0,05 mean there is influence between parity with anxiety inpregnant woman with correlation coefficient of -0,424 which show intensity of influenceof medium that is if the smaller parity hence more anxiety level. The calculation ofgestational age with spearman's rho p = 0,023 <α 0.05 means that there is an influencebetween parity with anxiety in pregnant women with a correlation coefficient of 0.359which shows the weakness of weak influence.Conclusion: The social support provided by husband and family will affect the level ofanxiety in each pregnant woman. It is hoped for a place of research to provide a solutionfor pregnant women who experience anxiety so that pregnancy can run smoothly andrespondents are expected to have a good coping mechanism in the face of anxiety forhealth and also the fetus.

scholarly journals Precipitation Trends over Time Using Mann-Kendall and Spearman’s rho Tests in Swat River Basin, Pakistan

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Ijaz Ahmad ◽  
Deshan Tang ◽  
TianFang Wang ◽  
Mei Wang ◽  
Bakhtawar Wagan
Keyword(s):  
River Basin ◽  
Statistical Tests ◽  
Annual Precipitation ◽  
Positive Trend ◽  
Monthly Precipitation ◽  
Significance Level ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Swat River ◽  
Precipitation Trends

Accurately predicting precipitation trends is vital in the economic development of a country. This research investigated precipitation variability across 15 stations in the Swat River basin, Pakistan, over a 51-year study period (1961–2011). Nonparametric Mann-Kendall (MK) and Spearman’s rho (SR) statistical tests were used to detect trends in monthly, seasonal, and annual precipitation, and the trend-free prewhitening approach was applied to eliminate serial correlation in the precipitation time series. The results highlighted a mix of positive (increasing) and negative (decreasing) trends in monthly, seasonal, and annual precipitation. One station in particular, the Saidu Sharif station, showed the maximum number of significant monthly precipitation events, followed by Abazai, Khairabad, and Malakand. On the seasonal time scale, precipitation trends changed from the summer to the autumn season. The Saidu Sharif station revealed the highest positive trend (7.48 mm/year) in annual precipitation. In the entire Swat River basin, statistically insignificant trends were found in the subbasins for the annual precipitation series; however, the Lower Swat subbasin showed the maximum quantitative increase in the precipitation at a rate of 2.18 mm/year. The performance of the MK and SR tests was consistent at the verified significance level.

ANALISIS FAKTOR DOMINAN YANG BERHUBUNGAN DENGAN KUALITAS TIDUR PADA MAHASISWA FAKULTAS KEPERAWATAN UNIVERSITAS AIRLANGGA

2019 ◽  
Vol 1 (1) ◽  
pp. 46
Author(s):  
Dhimas Wahyu Wicaksono
Keyword(s):  
Sleep Quality ◽  
Life Style ◽  
Nursing Student ◽  
Sampling Technique ◽  
Significance Level ◽  
Purposive Sampling ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Correlation Factors

Rest and sleep were human base necessary. Sleep quality was human satisfied for sleep, so that human not felt tired, not easier stimulated and nervous, not weak and apathies, no blackness around eyes, no swollen eyelid, no red conjunctiva, no poignant eyes, no difficulties to concentrate, no headache, or often felt sleepy. The aimed of this study was to explain the dominant correlation factors of sleep quality in Faculty of Nursing student Airlangga University.The research was used Descriptive Analyze Design. Population was Faculty of Nursing student Airlangga University stayed in Mulyorejo-Surabaya in Juni 2012. The samples were 50 taken with purposive sampling technique. Data were collected with questionnaire and were analyzed with spearman’s rho with significance level was p<0.05.The result showed that some factors had significance correlation but some were not. The factors were had significance correlation were between stress and sleep quality (p=0.024), tired with sleep quality (p=0.001), illness with sleep quality (p=0.022). Some factors were had no correlation were between environment with sleep quality (p=0.497), diet with sleep quality (p=0,201), drug with sleep quality (p=0.731), and life style with sleep quality (p=0.816). It can be concluded that stress, tired, and illness were dominant factors which were influence sleep quality for Faculty of Nursing student Airlangga University. Further research should occupied larger amount of sample to make more representative population.

scholarly journals Hubungan Pola Asuh Orang Tua Terhadap Kemandirian Anak Di TK Widya Bakti Desa Nongan, Kecamatan Rendang, Kabupaten Karangasem

2021 ◽  
Vol 5 (1) ◽  
pp. 46-56
Author(s):  
Agung Darmawan ◽  
Ni Putu Amelia Puspita
Keyword(s):  
Correlation Coefficient ◽  
P Value ◽  
Cross Sectional ◽  
Probability Sampling ◽  
Spearman's Rho ◽  
Spearman’S Rho

Latar Belakang: Pola asuh orang tua adalah cara atau metode yang ditempuh orang tua dalam mengasuh dan menerapkan kemandirian kepada anaknya dalam membentuk watak, kepribadian, dan memberikan nilai-nilai bagi anak agar dapat menyesuaikan diri dengan lingkungan. Kemandirian anak dibentuk dari lingkungan yang utama yaitu keluarga dan pola asuh orang tua yang akan mempengaruhinya. Apabila kemandirian anak tidak dilatih sejak dini oleh orang tua maka akan mengganggu kehidupan sosial anak dan anak tidak dapat bersosialisasi dengan baik di lingkungannya. Tujuan Penelitian: tujuan dari penelitian ini untuk mengetahui hubungan pola asuh orang tua terhadap kemandirian anak di TK Widya Bakti Desa Nongan, Kecamatan Rendang, Kabupaten Karangasem. Metedologi: Penelitian ini menggunakan metode kuantitatif deskriptif dengan pendekatan Cross Sectional, dengan jumlah sampel sebanyak 38 orang. Teknik sampling dengan cara non probability sampling yaitu total sampling. Instrument pengumpulan data dengan menggunakan kuesioner pola asuh orang tua dan kuesioner kemandirian anak. Data dianalisis dengan menggunakan uji Spearman’s rho. Hasil: Hasil menunjukkan bahwa sebagian besar pola asuh orang tua berada pada kategori cukup baik, yaitu sebanyak 20 responden atau 52,6%. Hasil analisis kemandirian anak menunjukkan sebagian besar anak memiliki tingkat kemandirian yang telah berkembang sesuai harapan, yaitu sebanyak 23 responden (60,5%). Hasil analisis menggunakan uji Spearman’s rho didapatkan hasil nilai p-value = 0,000 yang berarti nilai p≤0,05 dengan nilai Correlation Coefficient (r) sebesar 0,851. Hasil ini mengindikasikan bahwa Ho dalam penelitian ditolak yang artinya ada hubungan yang kuat antara pola asuh orang tua terhadap kemandirian anak di TK Widya Bakti Desa Nongan, Kecamatan Rendang, Kabupaten Karangasem. Kesimpulan: Berdasarkan penelitian tersebut diharapkan para orang tua khususnya yang memiliki anak usia prasekolah agar memperhatikan pola pengasuhan yang diberikan agar tidak mengganggu perkembangan mental anak.

scholarly journals FAMILY SUPPORT AND FAMILY ECONOMIC STATUS WITH DEPRESSION LEVEL ON PATIENTS END STAGE RENAL DISEASE (ESRD) IN GATOEL HOSPITAL MOJOKERTO DISTRICT INDONESIA

2019 ◽  
Vol 3 (2) ◽  
pp. 66-72
Author(s):  
Abdul Muhith Muhith ◽  
Lutfi K ◽  
Tatik Sutarti ◽  
Hannan Mujib4 ◽  
Lantin Sulistyorini ◽  
...  
Keyword(s):  
Family Support ◽  
Economic Status ◽  
Statistical Test ◽  
Cross Sectional ◽  
Significance Level ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
The Family ◽  
Depression Level ◽  
Esrd Patients

Patients with hemodialysis therapy have uncertainty as to how long hemodialysis is required and should accept the fact that therapy is needed throughout life. Because it appears anxiety response, rejection and anger. ESRD patients undergoing hemodialysis therapy, require support from the family. The purpose of this study was to determine the relationship of family support and economic status with depressed ESRD patients who underwent hemodialysis therapy <1 year. The design of this research is descriptive correlation with cross sectional research method, by using simple random sampling technique with the number of samples of 47 ESRD patients who are undergoing hemodialysis at Gatoel Hospital Mojokerto. The Research done in April 2017. The results obtained most of the respondents have economic ability Above the Provincial Minimum Wage of 27 respondents (57.4%). Most of the respondents stated that they received good family support in 30 categories (63,8%) and most of respondents had light depression 24 respondents (51,1%). Based on statistical test of spearman's rho with significance level α 0,05 obtained result (r) = 0,462 meaning bigger than value signifikansi (0,462> 0,05) hence H1 rejected which mean there is no significant relation between economic status with depression level In ESRD patients and Spearman's rho statistical test results obtained significance value 0.000 <0.05 which means there is a significant relationship between family support with depression levels in ESRD patients. The economic level does not affect depression because the cost of hemodialysis therapy all respondents is covered by health insurance, whereas family support has a positive influence where the better the family support the lighter the depression level in ESRD patients undergoing hemodialysis therapy

scholarly journals TINGKAT PENGETAHUAN TB PARU MEMPENGARUHI PENGGUNAAN MASKER PADA PENDERITA TB PARU

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Christina Yuliastuti ◽  
Nur Wachida Novita ◽  
Siti Narsih
Keyword(s):  
Sampling Technique ◽  
Simple Random Sampling ◽  
Cross Sectional ◽  
Significance Level ◽  
Spearman's Rho ◽  
Number Of Patients ◽  
Spearman’S Rho ◽  
Spearman’S Rho Test ◽  
Level Of Knowledge ◽  
Analytic Design

Number of patients with pulmonary TB increased annually in Surabaya, on of the measures to prevent TB infections is by using a mask. In TB care room a lot of visitors (family) who did not wear a mask. The purpose of this study to determine the relationship between the knowledge level of Tuberculose with the masks using among visitors (family). This study used correlational analytic design with cross sectional approach. independent variable in the study is the level of knowledge about Tuberculose and dependent variable is the using of masks. Samples were taken by using simple random sampling technique earned by 28 respondents. Data collection was undertaken using questionnaire about Pulmonary Tuberculose and observation sheet of the using of mask. Data were analyzed with Spearman's Rho test with a significance level Corellation ρ <0.05. Results showed that the level of knowledge about Tuberculose less 14 respondents (50%) and 16 respondents (57.1%) did not wear a mask. Spearman's Rho test showed that there is a relationship between the level of knowledge about Pulmonary Tuberculose with the using of masks in Pulmonary Wards,  Dr. Ramelan Navy Hospital, Surabaya (ρ = 0.000). The implications of this study is the level of knowledge about Tuberculosis associated with using of a mask, which is expected for nurses in the room can provide health education about and prevention of pulmonary Tuberculose transmission by using a mask.

scholarly journals TINGKAT PENGETAHUAN TENTANG TB PARU MEMPENGARUHI PENGGUNAAN MASKER DI RUANG PARU RUMKITAL Dr. RAMELAN SURABAYA

2018 ◽  
Vol 7 (1) ◽  
Author(s):  
Nur Wachida Novita ◽  
Christina Yuliastuti ◽  
Siti Narsih
Keyword(s):  
Sampling Technique ◽  
Cross Sectional ◽  
Significance Level ◽  
Spearman's Rho ◽  
Number Of Patients ◽  
Spearman’S Rho ◽  
Spearman’S Rho Test ◽  
Level Of Knowledge ◽  
Relationship Of ◽  
The Relationship

Number of patients with pulmonary TB increased annually in Surabaya, on of the measures to prevent TB infections is by using a mask. In TB care room a lot of visitors (family) who did not wear a mask. The purpose of this study to determine the relationship of the level of knowledge with the use of masks to visitors (family).This study used correlational analytic designwith cross sectional approach. independent variable in the study is the level of knowledge about Tuberculose anddependent variable is the use of masks. Samples were taken by using purposive sampling technique earned by 28 respondents visitors in Pulmonary Wards,Dr. Ramelan Navy Hospital, Surabaya, date 11 – 20 June 2013. Data collection was undertaken using questionnaire about Pulmonary Tuberculose and observation sheet of the use of mask. Data were analyzed with Spearman's Rho test with a significance level Corellation ρ <0.05.Results showed that the level of knowledge about Tuberculose less 14 respondents (50%) and 16 respondents (57.1%) did not wear a mask. Spearman's Rho test showed that there is a relationship between the level of knowledge about Pulmonary Tuberculosewith the use of masks in in Pulmonary Wards,Dr. Ramelan Navy Hospital, Surabaya (ρ = 0.000).

Correlation between five-year overall survival by PREDICT and 21 gene recurrence score (RS) in a Mexican private institution.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12543-e12543
Author(s):  
Geovani Amador García ◽  
Omar Serrano Villamayor ◽  
Raul Alejandro Andrade Moreno ◽  
Elina Alexandra Rodríguez Meléndez ◽  
José Fabián Martínez-Herrera ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Cancer Patients ◽  
Correlation Coefficient ◽  
Intraclass Correlation Coefficient ◽  
Intraclass Correlation ◽  
Breast Cancer Patients ◽  
Online Tool ◽  
Spearman's Rho ◽  
Spearman’S Rho

e12543 Background: In México the 5-year overall survival of Early Breast Cancer (EBC) reaches to 82-97%. Oncotype Dx evaluates the expression of 21 genes associated with recurrence and classifies patients into risk groups. PREDICT (https://breast.predict.nhs.uk/tool) is an online tool which assesses 5 and 10 year overall survival in breast cancer patients who receive adjuvant chemotherapy, adjuvant hormonal therapy and trastuzumab therapy for HER2(+) patients. Methods: Retrospective review of medical records of early stage breast cancer patients with (HR+) and HER2 (-) treated at our institution. Clinicopathological characteristics and (RS) were collected. 5-year overall survival was calculated with the PREDICT online tool. Both scores were compared and the correlation was estimated with Spearman’s Rho and global agreement with intraclass correlation coefficient (CCI), statistical software: STATA SE ver11.0 (StataCorp LLC Texas,USA). Results: From January 2008 to December 2018, 136 patients with EBC (IA-IIB), HR(+) HER2(-), N0-1 were included. The Median age at diagnosis was 55.03 years (30-80). Stage IA patients accounted for 68.38% of the population. Patients were classified into risks according to the original description of Oncotype. 72 patients (53%) were classified as low risk (LR), 49 (36%) at intermediate risk (IR) and 15 (11%) patients at high risk (HR). When reclassifying the risk categories using the cut-off values in TAILORx trial, the population distribution was modified, with a notable increase in the population in IR with 86 (63.2%) patients in this group, 28 patients in the LR group ( 20.5%) and 22 patients (16.1%) in HR. We decided to use TAILORx cut-off values for the aim of this work. Mean overall survival established by the 21 gene RS was 98% for the overall population. The mean overall survival calculated by PREDICT was 93%. Spearman’s correlation coefficient was 0.16 (Spearman’s Rho = 0.16 p = 0.065) with intraclass correlation coefficient (ICC) = 0.04 (IC 95% -0.15 – 0.22, p = 0.33). Conclusions: The results do not show a clear correlation between the tests. Lack of such correlation may be due to a low number of patients. In our population PREDICT couldn't replace the RS test for therapeutic decision making.

scholarly journals What Traits Should Be Measured for Biomass in Kenaf?

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1394
Author(s):  
Jaeyoung Kim ◽  
Gyung Doeok Han ◽  
Gopi Muthukathan ◽  
Renato Rodrogues ◽  
Do Yoon Hyun ◽  
...  
Keyword(s):  
Breeding Strategy ◽  
Hibiscus Cannabinus ◽  
Stem Diameter ◽  
Strong Positive Correlation ◽  
Spearman's Rho ◽  
Individual Traits ◽  
Spearman’S Rho ◽  
Leaf Volume ◽  
Energy Provider ◽  
Efficient Breeding

Kenaf (Hibiscus cannabinus L.) is widely used as an important industrial crop. It has the potential to act as a sustainable energy provider in the future, and contains beneficial compounds for medical and therapeutic use. However, there are no clear breeding strategies to increase its biomass or leaf volume. Thus, to attain an increase in these parameters, we examined potential key traits such as stem diameter, plant height, and number of nodes to determine the relationship among them. We hypothesized that it would be easier to reduce the amount of time and labor required for breeding if correlations among these parameters are identified. In this study, we found a strong positive correlation between height and number of nodes (Spearman’s Rho = 0.67, p < 0.001) and number of nodes and stem diameter (Spearman’s Rho = 0.65, p < 0.001), but a relatively low correlation (Spearman’s Rho = 0.34, p < 0.01) between height and stem diameter in the later stages of kenaf growth. We suggest that an efficient breeding strategy could be devised according to the breeding purpose, considering the correlations between various individual traits of kenaf.

scholarly journals GAMBARAN PENGETAHUAN IBU DAN POLA ASUH DALAM PEMBERIAN MAKAN DENGAN STATUS GIZI PADA BALITA DI KECAMATAN KERTOSONO, KABUPATEN NGANJUK

2020 ◽  
Vol 8 (2) ◽  
pp. 63-73
Author(s):  
Cintya Della Widyanata ◽  
Yuni Sufyanti Arief ◽  
Iqlima Dwi Kurnia
Keyword(s):  
Nutritional Status ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Poor Nutritional Status ◽  
Nutritional Status Of Children

Pendahuluan: Status gizi kurang saat ini menjadi masalah universal yang dihadapi di seluruh dunia, terutama Indonesia memiliki masalah gizi yang kompleks. Balita merupakan kelompok usia yang rentan terhadap kelainan gizi sebab usia tersebut membutuhkan gizi lebih besar untuk masa pertumbuhan. Tujuan dari penelitian ini adalah untuk menganalisis hubungan pengetahuan dan pola asuh dalam pemberian makan dengan status gizi pada balita. Metode:. Penelitian ini menggunakan desain cross-sectional. Populasi sebesar 1.135 orang dan sampel terdiri dari 114 responden dengan teknik pengambilan sampel menggunakan simple random sampling. Variabel independen dalam penelitian ini adalah pengetahuan dan pola asuh dalam pemberian makan yang diukur menggunakan kuesioner dan variabel dependen penelitian ini yaitu status gizi balita diukur berdasarkan penilaian status gizi dari WHO. Data dianalisis menggunakan uji Spearman’s rho dan Chi- square dengan tingkat kemaknaan ρ = 0,05. Hasil: Hasil penelitian menunjukkan bahwa terdapat hubungan antara pengetahuan ibu dengan status gizi balita (p=0,001) dan tidak terdapat hubungan antara pola asuh dalam pemberian makan dengan status gizi pada balita (p=0,662).   Kesimpulan: Sebagian besar ibu dengan pengetahuan kurang tentang gizi memiliki balita dengan status gizi kurang dan ibu menerapkan pola asuh demokratif dengan status gizi baik pada balita, hal tersebut menunjukkan bahwa perlu dilakukan edukasi mengenai pentingnya gizi untuk meningkatkan kesehatan dan kesejahteraan anak. Kata kunci: pengetahuan, pola asuh dalam pemberian makan, status gizi ABSTRACT Introduction: Poor nutritional status is now a universal problem faced throughout the world, especially Indonesia has complex nutritional problems. Toddler is an age group that was susceptible to nutritional disorders because that age requires greater nutrition for growth period. The purpose of this study was to analyze the relationship between knowledge and parenting in feeding with nutritional status in toddler. Methods: This study used a cross-sectional design. The population of 1,135 people and the sample consisted of 114 respondents with sampling techniques used simple random sampling. The independent variable in this study were the knowledge and parenting style of feeding which was measured used a questionnaire and the dependent variable of this study was the nutritional status of children measured by the assessment of nutritional status of the WHO. Data were analyzed used the Spearman's rho and Chi-square test with significance level ρ = 0.05. Result: The results showed that there was a relationship between knowledge of mothers with nutritional status of children (p = 0.001) and there was no relationship between parenting in feeding and nutritional status in toddler (p = 0.662). Conclusion: Most mothers with insufficient knowledge about nutrition have toddlers with poor nutritional status and mothers applied democratic parenting with good nutritional status for toddlers, this showed that education needs to be done on the importance of nutrition to improve children's health and welfare. Keywords: knowledge, parenting in feeding, nutritional status

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