PD-L1 expression in soft tissue sarcomas and its prognostic implication.

e14261 Background: The expression rate of PD-L1 in human malignant tumors paid a lot of attention and has been reported to vary from 19% to 92%, and the expression of PD-L1 was associated with poor prognosis of various human and may predicted the response to immune checkpoint inhibitors. The purpose of this study to investigate the expression of PD-L1 and its clinic-pathological feature in soft tissue sarcomas (STS). Methods: We collected Paraffin embedded tissue of 50 Patients with STS retrospectively from the archives of Pathology and oncology Department, Ain Shams University Hospitals from 2011-2017.then we correlated between PD-L1 expression and the clinico-pathological features. For PD-L1 expression we followed the Cologne 6-step proportional scoring system, using the rabbit monoclonal antibody (E1L3N 13684) and Tumors with > /10% membranous stained cells were considered to be positive for expression. The differences among variables were calculated by chi-square test. Results: PD-L1 expression was found in 12 (24%) of cases. Of all sarcoma subtypes , desmoid tumors had the highest prevalence of PD-L1 expression noted in 2/3 (66%) of samples followed by GIST 2/4(50%), then liposarcoma 3/11(27%). In addition, there were 2 rhabdomyosarcoma cases with tumor positivity for PD-L1 expression. We found that STS patients with PD-L1 expression have shorter survival with a median OS 11 vs 19 months (p-value = 0.1) as well as a mean PFS 6 vs 11 months (p-value = 0.1) in PD-L1 positive and negative respectively; this finding considered as clinically significant, but not reached to statistical significant . Conclusions: We report here that PD-L1 expression is as prognostic factor for poorer outcome. This finding may be clinically significant but does not reach the statistically significant levels due to small number of samples included. Its role beyond that of a prognostic biomarker remains to be established in the context of larger clinical trials. Clinical trial information: 31/2017.

Download Full-text

Pattern of Malignant Tumors in Najran, Saudi Arabia: A 5-year Retrospective Study

International Journal of Biomedicine ◽

10.21103/article11(4)_oa15 ◽

2021 ◽

Vol 11 (4) ◽

pp. 498-504

Author(s):

Saad Al-Qahtani ◽

Muhammad Zafar ◽

Abdullah Assiri ◽

Galal Bashanfer ◽

Mohammed Alwaily ◽

...

Keyword(s):

Saudi Arabia ◽

Risk Factor ◽

Retrospective Study ◽

Soft Tissue ◽

Relative Frequency ◽

Malignant Tumors ◽

Histopathological Diagnosis ◽

Body System ◽

Chi Square ◽

Chi Square Test

Background: The relative frequency of malignant tumors has been reported to have an association with age, gender, and location. The current study is a retrospective study to assess the pattern and relative frequency of different malignant tumors in Najran, Saudi Arabia. Methods and Results: All patients from both genders were included in the study from June 2014 to May 2019, and data were retrieved from the records of confirmed cancer cases at the departments of pathology. For 5 years, a total of 763 cases [325(42.6%) men and 438(57.4%) women] and 37 types of malignant tumors were diagnosed in Najran. According to the histopathological diagnosis, carcinomas were the most frequent tumors (n=564, 73.9%). According to the affected organ/body system, tumors of the gastrointestinal system were the commonest malignancy, observed in 156 (20.4%) of the patients (91 men and 65 women). Finally, the chi-square test revealed that the frequency of malignant tumors climbed as age increased (P=0.0005). Conclusion: The relative frequency of several cancers in Najran showed that the most common cancers in both genders are in the following order: gastrointestinal, thyroid, breast, skin and soft tissue cancers, and lymphoma. In addition, women are more affected than men, and increasing age is a risk factor to develop a malignancy.

Download Full-text

Prevalence and Prognostic Implications of PD-L1 Expression in Soft Tissue Sarcomas

Pathology & Oncology Research ◽

10.3389/pore.2021.1609804 ◽

2021 ◽

Vol 27 ◽

Author(s):

Mohamed Kelany ◽

Thomas FE. Barth ◽

Dina Salem ◽

Marwa M. Shakweer

Keyword(s):

Soft Tissue ◽

Statistical Significance ◽

Soft Tissue Sarcomas ◽

Predictive Marker ◽

University Hospital ◽

Chi Square ◽

Tissue Samples ◽

Cancer Subtypes ◽

Chi Square Test ◽

Prognostic Implications

Background: PD-L1 expression differs from 19 to 92% in various cancer subtypes. Its expression carries a worse prognostic value in various malignancies and could also be used as a predictive marker for immune checkpoint inhibitor response. This study aimed to explore the prevalence of PD-L1 expression in soft tissue sarcomas and the correlation of PD-L1 expression with clinicopathological features.Patients and Methods: The tissue samples of 50 patients with STS were tested for PD-L1 expression using immunohistochemistry (IHC). We followed a 6-step proportional scoring system. The patients were treated at Ain Shams University Hospital from 2011 to 2017. We also explored the correlation of PD-L1 expression with different clinical features of the patients. The chi-square test was used to calculate the differences among variables.Results: Twelve cases (24%) showed positive PD-L1 expression with the highest prevalence in rhabdomyosarcoma and desmoid tumors (2/2 and 2/3 cases, respectively), followed by GIST in 2/4 cases and liposarcoma in 3/11 cases. Patients with positive PD-L1 expression showed a trend for worse survival, with a median overall survival of 11 months vs. 19 months for patients with negative PD-L1 expression (p-value = 0.1) and a mean PFS of 6 months vs. 11 months for patients with negative PD-L1 expression (p-value = 0.1). However, these findings did not reach statistical significance.Conclusion: Although the results did not reach statistical significance due to the small number of cases, PD-L1 expression could represent a prognostic factor for poor outcome. Larger clinical trials are recommended for the validation of PD-L1 as a poor prognostic biomarker.

Download Full-text

Analisis Faktor Determinan Pelaksanaan Inisiasi Menyusu Dini Oleh Bidan Di Rumah Sakit Umum Anutapura Palu

Jurnal Bidan Cerdas (JBC) ◽

10.33860/jbc.v1i1.87 ◽

2018 ◽

Vol 1 (1) ◽

pp. 34

Author(s):

Ni Nyoman Novita ◽

Gusman Arsyad

Keyword(s):

Emergency Room ◽

Peer Support ◽

Statistical Tests ◽

Bivariate Analysis ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Implementation Processes ◽

Chi Square Test ◽

The Government

Implementation of IMD in hospitals has decreased from the previous year and has not reached the target set by the government. Some IMD implementation processes have not been carried out according to applicable standards. So that babies do not get an IMD in accordance with existing SOPs. The purpose of this study was to determine the determinant factors associated with the implementation of the IMD by midwives in the Midwifery and Maternity Room Emergency Room (IGD) at the Anutapura General Hospital in Palu. This research method is analytical with cross sectional approach. The population of this study was that all midwives in the obstetrics emergency room and maternity room at Anutapura Palu Hospital were 37 respondents. The sample in this study is total sampling. The analysis used was univariate, and bivariate analysis using the chi square test with a confidence level of 95% (α = 0.05). The results of statistical tests on variable knowledge of midwives with the implementation of IMD p value: 0.018 (p value <0.05). APN training with the implementation of IMD p value: 0.697 (p value> 0.05). length of work with the implementation of IMD p value: 0.029 (p value <0.05). and peer support with the implementation of IMD p value: 0.007 (p value <0.05). Conclusions there is a relationship between knowledge, length of work, peer support with the implementation of the IMD, and training factors that have nothing to do with IMD implementation. The strongest factor in the relationship is peer support. It is recommended that the Anutarapura Palu Hospital be able to motivate midwives so that they can further enhance their role in the implementation and provide support to their colleagues so that the implementation of the IMD can be carried out in accordance with applicable standards.Keywords: Knowledge, APN Training, Duration of work, Implementation of IMD

Download Full-text

HUBUNGAN ANTARA UMUR IBU DAN JARAK KEHAMILAN DENGAN KEJADIAN PERDARAHAN POSTPARTUM DI RUANG KEBIDANAN RSUD KOTA PRABUMULIH TAHUN 2016

Jurnal Kebidanan : Jurnal Medical Science Ilmu Kesehatan Akademi Kebidanan Budi Mulia Palembang ◽

10.35325/kebidanan.v7i2.115 ◽

2019 ◽

Vol 7 (2) ◽

Author(s):

Desti Widya Astuti Desti Widya Astuti

Keyword(s):

General Hospital ◽

Post Partum ◽

District General Hospital ◽

Study Data ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Significance Level ◽

Chi Square Test ◽

Post Partum Bleeding

ABSTRAK Berdasarkan data di RSUD Kota Prabumulih bahwa terdapat peningkatan jumlah kejadian perdarahan post partum, tahun 2014 sebanyak 178 orang, tahun 2015 sebanyak 246 orang dan tahun 2016 sebanyak 151 orang. Penelitian ini bertujuan untuk mengetahui hubungan umur ibu dan jarak kehamilan terhadap kejadian perdarahan post partum di RSUD Kota Prabumulih Tahun 2016. Penelitian ini merupakan penelitian analitik dengan rancangan cross sectional. Populasi yang digunakan adalah semua ibu bersalin di RSUD Kota Prabumulih, sebanyak 1.296 ibu bersalin dan 306 sampel. Pengambilan sampel dengan mengunakan random sampling, analisa data menggunakan analisa univariat dan bivariat dengan menggunakan uji statistik chi-square dengan derajat kemaknaan 0,05. Hasil penelitian ini menunjukan bahwa dari 288 ibu bersalin terdapat 151 yang mengalami perdarahan post partum sebagian besar adalah ibu dengan umur resiko tinggi sebanyak 43 orang (40,9%) dan ibu dengan jarak kehamilan resiko tinggi sebanyak 21 orang (17,3%). Hasil uju chi-square umur didapatkan p.value 0,000 < α 0,05 dan uji chi-square untuk jarak kehamilan didapatkan p.value 0,000 < α 0,05. Maka ada hubungan umur ibu dan jarak kehamilan terhadap kejadian perdarahan post partum di RSUD Kota Prabumulih Tahun 2016. ABSTRACK Based on the data at District General Hospital (RSUD) Prabumulih, there was increasing of post-partum bleeding, in 2014, there were 178 people. In 2015, there were 246 people. And in 2016, there were 151 people. The purpose of the study was to know relationship between maternal mother and the distance and old post-partum bleedingat District General Hospital (RSUD) Prabumulih in 2013. The study was analytic researchwith cross sectional design. Population thas was used in the study was all maternal mother ar District General Hospital (RSUD) Prabumulih. It was about 1.296 maternal mother and from 306. Random sampilng was done in the study, data analyses used univariate and bivariate analyses by using chi-square statistic test with significance level 0,05. The study result showed that from 306 maternal mother, there were 151 mother who experienced old post-partum bleeding, the large of that was high maternal mother 43 people (40,9%) and mother age high distance 21 people (17,3%). The result of chi-square test was p value 0,000 < α 0,05 and chi-square test for age was p value 0,000 < α 0,05. It meant that there was relationship between maternal mother and the distance and of post-partum bleeding at District General Hospital (RSUD) Prabumulih in 2016.

Download Full-text

HUBUNGAN UMUR DAN PARITAS IBU DENGAN KEJADIAN HIPEREMESIS GRAVIDARUM DI RUMAH SAKIT UMUM PUSAT Dr. MOHAMMAD HOESIN PALEMBANG TAHUN 2011

Jurnal Kebidanan : Jurnal Medical Science Ilmu Kesehatan Akademi Kebidanan Budi Mulia Palembang ◽

10.35325/kebidanan.v2i1.23 ◽

2019 ◽

Vol 2 (1) ◽

Author(s):

Wahyu Ida Muliana Wahyu Ida Muliana

Keyword(s):

Pregnant Women ◽

Medical Record ◽

Random Sampling ◽

Hyperemesis Gravidarum ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Systematic Random Sampling ◽

Pregnancy And Childbirth ◽

Chi Square Test

ABSTRACT Hyperemesis Gravidarum marked excessive nausea and vomiting in pregnant women at a young age. WHO estimates that 536,000 women died from direct complications of pregnancy and childbirth. One complication of pregnancy is Hyperemesis Gravidarum. Hyperemesis Gravidarum in the world has been estimated to occur in 1-2% of pregnant. According to data from the Medical Record of Dr. Mohammad Hoesin Palembang Hospital, the incidence of Hyperemesis Gravidarum in 2011 there were 72 people of 661 pregnant women. The purpose of this reseach was to determine the relationship between maternal age and parity with Hyperemesis Gravidarum in Dr. Mohammad Hoesin Palembang Hospital 2011. The Design of this reseach used Cross Sectional by analytic approach survey. The population of this reseach are all of mother who gestational ≤ 16 weeks (four months) in the Installation of Obstetrics and Gynecology, Dr. Mohammad Hoesin Palembang Hospital in January to December of 2011 with the sample of 661 people which taken by systematic random sampling and the reseach was conducted from 17 April to 24 April 2012. Each variable that was observed in tests using Chi-Square test with a (0.05). The results of this study showed that 5.9% of mothers with hyperemesis gravidarum, 21.8% of mothers with high risk age, and 30.0% primigravida. Chi-Square test showed no significant relationship between age (p value = 0.000) and parity (p value = 0.000) with the incidence of hyperemesis gravidarum. Expected to the Hospital to be implemented properly instructed how to provide counseling to pregnant women about pregnancy and childbirth, as well as provide confidence that the nausea and vomiting is a symptom of physiology in pregnancy. ABSTRAK Hiperemesis Gravidarum ditandai mual dan muntah yang berlebihan terjadi pada ibu hamil di usia muda. WHO memperkirakan 536.000 perempuan meninggal dunia akibat langsung dari komplikasi kehamilan dan persalinan. Salah satu komplikasi kehamilan adalah Hiperemesis Gravidarum. Insiden Hiperemesis Gravidarum di dunia telah diperkirakan terjadi pada 1-2% wanita hamil. Menurut data dari Medical Record Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang, angka kejadian Hiperemesis Gravidarum pada tahun 2011 terdapat 72 orang dari 661 ibu hamil. Tujuan penelitian ini adalah untuk mengetahui hubungan antara umur dan paritas ibu dengan kejadian Hiperemesis Gravidarum pada ibu di Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang tahun 2011. Desain Penelitian ini menggunakan survei analitik dengan pendekatan Cross Sectional. Populasi penelitian ini adalah dengan umur kehamilan ≤ 16 minggu (4 bulan) yang pernah dirawat inap di Instalasi Kebidanan dan Penyakit Kandungan Rumah Sakit Umum Pusat Dr. Mohammad Hoesin Palembang pada bulan Januari-Desember tahun 2011 dengan jumlah sample 661 orang yang diambil secara systematic Random Sampling (secara acak sistematis) dan penelitian ini dilakukan dari tanggal 17 April sampai dengan 24 April 2012. Masing-masing variabel yang diteliti di uji dengan menggunakan uji Chi-Square dengan a (0,05). Hasil penelitian ini menunjukkan bahwa 5,9% ibu mengalami hiperemesis gravidarum, 21,8% ibu dengan umur resiko tinggi, dan 30,0% ibu primigravida. Uji Chi-Square menunjukkan ada hubungan yang bermakna antara umur (p value = 0,000) dan paritas (p value = 0,000) dengan kejadian hiperemesis gravidarum. Diharapkan dapat menjadi masukan bagi pihak Rumah Sakit agar dilaksanakan penyuluhan dengan cara memberikan konseling terhadap ibu hamil tentang kehamilan dan persalinan, serta memberikan keyakinan bahwa mual muntah merupakan gejala fisiologi pada kehamilan.

Download Full-text

Hubungan Pola Asuh Orang Tua Terhadap Perkembangan Sosial Anak Usia 4-6 Tahun Di Tk Dharma Wanita Gumukmas Tahun 2011

Jurnal Ilmiah Kesehatan ◽

10.35952/jik.v1i2.79 ◽

2012 ◽

Vol 1 (2) ◽

Author(s):

Wahyu Widayati

Keyword(s):

P Value ◽

Chi Square ◽

Chi Square Test

Pola asuh orang tua adalah pola perilaku yang diterapkan pada anak dan bersifat relative konsisten dari waktu ke waktu. Dimana salah satu faktor yang mempengaruhi perkembangan sosial anak adalah cara mendidik anak dalam keluarga (pola asuh). Penelitian ini bertujuan untuk mengetahui hubungan pola asuh orang tua terhadap perkembangan sosial anak usia 4-6 tahun di TK Dharma wanita Gumukmas Tahun 2011. Desain penelitian yang digunakan adalah penelitian deskriptif korelasi dengan populasi orang tua murid di TK Dharma wanita Gumukmas. Pengambilan sampel dengan total sampling sebanyak 95 responden. Pengumpulan data untuk mengetahui pola asuh oang tua dan perkembangan sosial anak dengan menggunakan koesioner. Analisanya yaitu univariat dan bivariat. Uji statistik yang digunakan chi square test dengan derajat kemaknaan p>0,05. Hasil penelitian menunjukkan bahwa tidak ada hubungan yang bermakna antara pola asuh orang tua dengan perkembangan sosial anak usia 4-6 tahun di TK Dharma wanita Gumukmas dengan p value 0,008. Berdasarkan hasil penelitian tersebut, diharapkan perlunya pemahaman tentang metode pemberian pola asuh yang efektif bagi anak karena ini sangat penting untuk perkembangan sosial anak

Download Full-text

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

Jurnal Kesehatan Panrita Husada ◽

10.37362/jkph.v2i1.147 ◽

2017 ◽

Vol 2 (1) ◽

pp. 20-28

Author(s):

Fitriani ◽

Tenriwati

Keyword(s):

Wound Healing ◽

Nutritional Status ◽

Healing Process ◽

Data Retrieval ◽

Observational Research ◽

Wound Healing Process ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Download Full-text

Relationship of Workload and Double Role With Work Fatigue on Batik Craftsmen

Jurnal Endurance ◽

10.22216/jen.v4i2.4013 ◽

2019 ◽

Vol 4 (2) ◽

pp. 293

Author(s):

Herdianti Herdianti ◽

Tatik Maryana

Keyword(s):

Data Analysis ◽

Quantitative Research ◽

Sampling Technique ◽

Work Load ◽

Dual Role ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Chi Square Test ◽

Almost All

Background: In Batik Mawar, almost all work is done manually using the hands and upper arms on a continuous basis combined with the rigor of work and the use of traditional tools. The work has a heavy workload because all the work process is done by the same craftsman causing fatigue besides that the worker also have double role. The purpose of this study is to determine the relationship between workload and dual role with feelings of fatigue on craftsmen batik roses.Method: This research is Quantitative research with Cross Sectional research design. The population in this study are all artisans in Batik Mawar. Sampling in this study using total sampling technique with the number of research samples as many as 40 respondents. Data analysis used by Univariat and Bivariat.Result: Result of data analysis using Chi-Square test for work load got value p-Value = 0,001. The result of data analysis using Chi-square test for double role got p-value = 0,031. Thus it is concluded that there is a meaningful relationship between workload and dual role with feeling tired. We recommend that craftsmen wash clothes 2 times a day, cook ready meals, other than together in completing the work at home Di Batik Mawar, hampir semua pekerjaan dikerjakan secara manual menggunakan tangan dan lengan atas secara berkesinambungan yang dikombinasi dengan ketelitian kerja dan penggunaan alat-alat tradisional. Pekerjaan mempunyai beban kerja yang berat dikarenakan semua proses kerja dilakukan oleh pengrajin yang sama sehingga menimbulkan kelelahan disamping itu pekerjanya juga memiliki peran ganda. Tujuan penelitian ini adalah untuk mengetahui hubungan beban kerja dan peran ganda dengan perasaan lelah pada pengrajin batik mawar.Metode: Penelitian ini merupakan penelitian Kuantitatif dengan desain penelitian Cross Sectional. Populasi dalam penelitian ini adalah semua pengrajin di Batik Mawar. Pengambilan sampel pada penelitian ini menggunakan teknik total sampling dengan jumlah sampel penelitian sebanyak 40 responden. Analisis data yang digunakan Univariat dan Bivariat.Hasil: Hasil analisis data yang menggunakan uji Chi-Square untuk beban kerja didapatkan nilai p-Value = 0,001. Hasil analisis data yang menggunakan uji Chi-square untuk peran ganda didapatkan nilai p-value= 0,031. Dengan demikian disimpulkan bahwa ada hubungan yang bermakna antara beban kerja dan peran ganda dengan perasaan lelah.Sebaiknya pengrajin mencuci pakaian 2 kali sehari, memasak makanan siap saji, selain itu dengan cara bersama-sama dalam menyelesaikan pekerjaan dirumah.

Download Full-text

The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy

Cancers ◽

10.3390/cancers13153865 ◽

2021 ◽

Vol 13 (15) ◽

pp. 3865

Author(s):

Tânia Fortes-Andrade ◽

Jani Sofia Almeida ◽

Luana Madalena Sousa ◽

Manuel Santos-Rosa ◽

Paulo Freitas-Tavares ◽

...

Keyword(s):

Clinical Trials ◽

Soft Tissue ◽

Nk Cells ◽

Nk Cell ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

Good Prognosis ◽

Regulatory Pathways ◽

Immunological Profile ◽

Study Support

Soft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in cytogenetic and genetic sequence alterations, which further increases the diversity of sarcomas. This variety is one of the main challenges for the classification and understanding of STS patterns, as well as for their respective treatments, which further decreases patient survival (<5 years). Despite some studies, little is known about the immunological profile of STS. As for the immunological profile of STS in relation to NK cells, there is also a shortage of studies. Observations made in solid tumors show that the infiltration of NK cells in tumors is associated with a good prognosis of the disease. Notwithstanding the scarcity of studies to characterize NK cells, their receptors, and ligands in STS, it is noteworthy that the progression of these malignancies is associated with altered NK phenotypes. Despite the scarcity of information on the function of NK cells, their phenotypes and their regulatory pathways in STS, the findings of this study support the additional need to explore NK cell-based immunotherapy in STS further. Some clinical trials, very tentatively, are already underway. STS clinical trials are still the basis for adoptive NK-cell and cytokine-based therapy.

Download Full-text

Molecular Determinants of Soft Tissue Sarcoma Immunity: Targets for Immune Intervention

International Journal of Molecular Sciences ◽

10.3390/ijms22147518 ◽

2021 ◽

Vol 22 (14) ◽

pp. 7518

Author(s):

Marcella Tazzari ◽

Laura Bergamaschi ◽

Alessandro De Vita ◽

Paola Collini ◽

Marta Barisella ◽

...

Keyword(s):

Soft Tissue ◽

Malignant Tumors ◽

Soft Tissue Sarcomas ◽

Point Of View ◽

Molecular Features ◽

Molecular Determinants ◽

Genetic Landscape ◽

Current Therapies ◽

Cumulative Evidence

Soft tissue sarcomas (STSs) are a family of rare malignant tumors encompassing more than 80 histologies. Current therapies for metastatic STS, a condition that affects roughly half of patients, have limited efficacy, making innovative therapeutic strategies urgently needed. From a molecular point of view, STSs can be classified as translocation-related and those with a heavily rearranged genotype. Although only the latter display an increased mutational burden, molecular profiles suggestive of an “immune hot” tumor microenvironment are observed across STS histologies, and response to immunotherapy has been reported in both translocation-related and genetic complex STSs. These data reinforce the notion that immunity in STSs is multifaceted and influenced by both genetic and epigenetic determinants. Cumulative evidence indicates that a fine characterization of STSs at different levels is required to identify biomarkers predictive of immunotherapy response and to discover targetable pathways to switch on the immune sensitivity of “immune cold” tumors. In this review, we will summarize recent findings on the interplay between genetic landscape, molecular profiling and immunity in STSs. Immunological and molecular features will be discussed for their prognostic value in selected STS histologies. Finally, the local and systemic immunomodulatory effects of the targeted drugs imatinib and sunitinib will be discussed.

Download Full-text