scholarly journals Moms, babies, and bugs in immune development

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2141
Author(s):  
Katie Alexander ◽  
Charles O. Elson
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Immune Cells ◽  
Mucosal Immunity ◽  
The Other ◽  
Primary Role ◽  
Initial Development ◽  
Immune Development ◽  
The One

Bacteria and mammals have co-evolved with one another over millennia, and it has become impossible to interpret mucosal immunity without taking the microbiota into consideration. In fact, the primary role of the mucosal immune system is regulating homeostasis and the host relationship with the microbiota. Bacteria are no longer seen as simply invading pathogens, but rather a necessary component to one’s own immune response. On the one hand, the microbiota is a vital educator of immune cells and initiator of beneficial responses; but, on the other, dysbiosis of microbiota constituents are associated with inflammation and autoimmune disorders. In this review, we will consider recent advances in the understanding of how the microbiota influences host mucosal immunity, particularly the initial development of the immune response and its implications.

scholarly journals The role of the immune system in tendon healing: a systematic review

2020 ◽  
Vol 133 (1) ◽  
pp. 49-64 ◽  
Author(s):  
Emanuele Chisari ◽  
Laura Rehak ◽  
Wasim S Khan ◽  
Nicola Maffulli
Keyword(s):  
Systematic Review ◽  
Immune Response ◽  
Immune System ◽  
Mast Cells ◽  
Immune Cells ◽  
Tendon Healing ◽  
Risk Of Bias ◽  
Cochrane Library ◽  
Healing Response

Abstract Introduction The role of the immune system in tendon healing relies on polymorphonucleocytes, mast cells, macrophages and lymphocytes, the ‘immune cells’ and their cytokine production. This systematic review reports how the immune system affects tendon healing. Sources of data We registered our protocol (registration number: CRD42019141838). After searching PubMed, Embase and Cochrane Library databases, we included studies of any level of evidence published in peer-reviewed journals reporting clinical or preclinical results. The PRISMA guidelines were applied, and risk of bias and the methodological quality of the included studies were assessed. We excluded all the articles with high risk of bias and/or low quality after the assessment. We included 62 articles assessed as medium or high quality. Areas of agreement Macrophages are major actors in the promotion of proper wound healing as well as the resolution of inflammation in response to pathogenic challenge or tissue damage. The immune cells secrete cytokines involving both pro-inflammatory and anti-inflammatory factors which could affect both healing and macrophage polarization. Areas of controversy The role of lymphocytes, mast cells and polymorphonucleocytes is still inconclusive. Growing points The immune system is a major actor in the complex mechanism behind the healing response occurring in tendons after an injury. A dysregulation of the immune response can ultimately lead to a failed healing response. Areas timely for developing research Further studies are needed to shed light on therapeutic targets to improve tendon healing and in managing new way to balance immune response.

scholarly journals Role of the immune response in COVID-19

ANALES RANM ◽  
2020 ◽  
Vol 137 (137(02)) ◽  
pp. 113-116
Author(s):  
Emilio Gómez de la Concha
Keyword(s):  
Immune Response ◽  
Inflammatory Response ◽  
Immune Responses ◽  
Therapeutic Strategies ◽  
The Other ◽  
Current State ◽  
The Times ◽  
The One ◽  
Antiviral Control

Immune response plays a dual role in COVID-19 infection. On the one hand virus activates innate and adaptative immune responses that most of the times achieve antiviral control. On the other hand in a minority of patients uncontrolled inflammatory response may lead to harmful tissue damage. Here we summarize the current state of knowledge of the factors that contribute to disease severity and death and the rationale of the posible therapeutic strategies.

scholarly journals Immunometabolism Modulation in Therapy

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 798
Author(s):  
Ezequiel Monferrer ◽  
Sabina Sanegre ◽  
Isaac Vieco-Martí ◽  
Amparo López-Carrasco ◽  
Fernando Fariñas ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Tumor Cells ◽  
Immune Cells ◽  
Therapeutic Intervention ◽  
Cancer Biology ◽  
Metabolic Regulation ◽  
Tumor Development ◽  
Molecular Bases

The study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer. We also discuss the extraordinary plasticity of the immune response and its implication in immunotherapy efficacy, and highlight different therapeutic intervention possibilities based on controlling the balanced systems of specific metabolites with antagonistic functions.

scholarly journals The role of pro-inflammatory cytokines in the pathogenesis and progression of neoplasms

2018 ◽  
Vol 72 ◽  
pp. 896-905 ◽  
Author(s):  
Kinga Zielińska ◽  
Konrad Kwasniak ◽  
Jacek Tabarkiewicz ◽  
Bożenna Karczmarek-Borowska
Keyword(s):  
Immune Response ◽  
Immune System ◽  
Inflammatory Cytokines ◽  
Immune Cells ◽  
Host Immune System ◽  
Clinical Observations ◽  
Combined Action ◽  
Progressive Disorder ◽  
Pro Inflammatory Cytokines

Cytokines play an important role in the functioning of the immune system. Studies have reported an increased secretion of inflammatory cytokines by the neoplasms. Inflammation plays a role in the pathogenesis of various diseases; it is also a risk factor for the development and progression of a neoplasm, as exemplified by the development of cancer in the region of the head and neck in response to chronic inflammation caused by irritants present, e.g. in cigarette smoke. Cytokines (IL-1 beta, IL-6, TNF, IL-8, IL-17), which take part in the inflammatory response and are, therefore, strongly involved in the development of cancer. The combined action of cytokines produced by the neoplastic cells via multiple mechanisms, modulates cell response of the host immune system. Clinical observations suggest that cancer patients show a progressive disorder of the immune system, resulting in tumor progression. The mechanisms conducive to the weakening or lack of an immune response to neoplastic antigens contribute to the severity of the invasion of cancerous lesions. Although mechanisms that occur between tumor cells, the micro-environment of the tumor and immune cells of the host are not thoroughly known, previous research point to the importance of this interaction in oncogenesis, which may ultimately affect the prognosis.

scholarly journals Mekanisme Escape dan Respon Imun innate terhadap Candida albicans

2020 ◽  
Vol 9 (1) ◽  
pp. 60
Author(s):  
Putu Oky ari Tania
Keyword(s):  
Immune Response ◽  
Candida Albicans ◽  
Immune System ◽  
Immune Responses ◽  
Immune Cells ◽  
Immune Cell ◽  
Clinical Aspect ◽  
Biological Processes ◽  
Transduction Pathway

Candidiasis is an infection caused by fungal Candida albicans. The incidence of candidiasis is pretty high in Indonesia. Candida albicans develop their pathogenicity by several ways so that it can invade and escape from the immune system. The host’s immune system must always be vigilant to recognized antigen through various receptors, activation of the transduction pathway and activation of various immune cells. But as organisms that struggle to survive, Candida also develops mechanisms to escape the immune response. There are so many articles have written the immune response against candidiasis, this review aims to understand more and updating information about the biological processes of pathogenicity of fungi and the mechanism of Candida albicans in escaping immune responses, the role of each innate molecule and immune cell, and clinical aspect to Candida albicans infections. We already facing the big challenges against therapy of fungal infection, so by understanding the escape mechanism of Candida albicans, it is possible to developed antifungal or Candida vaccine in the future, therefore the incidence of candidiasis can be suppressed.

Renegade Rockets & the Darwin Space Base Fiasco: The Relations Between Aborigines, Developers, and Anthropologists in Australia's Northern Territory

1999 ◽  
Vol 21 (1) ◽  
pp. 24-27
Author(s):  
Ian McIntosh
Keyword(s):  
Aboriginal People ◽  
Northern Territory ◽  
The Other ◽  
Dual Function ◽  
Primary Role ◽  
The People ◽  
The One ◽  
The University ◽  
Aboriginal Groups

The most significant employer of anthropologists in Australia's Northern Territory is not the university or museum. It is the Aboriginal land councils. As I detail in this article, the primary role of the land council anthropologist is to mediate between Aboriginal groups and developers. But there is a catch. While anthropologists are usually employed because they have already developed a relationship with particular clans as a result of Masters or Ph.D. studies, in performing the duties as required by a council, one often alienates the people who we owe our careers to. This is because any land council has a dual function. On the one hand it pursues land and sea rights for the Aboriginal people under its jurisdiction. On the other, it is trying to sell the idea of Aboriginal property rights to the rest of Australia, where Aborigines enjoy nowhere near the same level of rights.

The problem of woman’s emansipation in the feuilleton “Amazonia: a very inept story” by Mykola Chirsky

2020 ◽  
pp. 71-76
Author(s):  
Iryna Rusnak
Keyword(s):  
Scientific Understanding ◽  
The Other ◽  
Literary Studies ◽  
Ethical Guidelines ◽  
Compositional Structure ◽  
Urgent Task ◽  
The Subject ◽  
The One ◽  
Artistic Heritage

The author of the article analyses the problem of the female emancipation in the little-known feuilleton “Amazonia: A Very Inept Story” (1924) by Mykola Chirsky. The author determines the genre affiliation of the work and examines its compositional structure. Three parts are distinguished in the architectonics of associative feuilleton: associative conception; deployment of a “small” topic; conclusion. The author of the article clarifies the role of intertextual elements and the method of constantly switching the tone from serious to comic to reveal the thematic direction of the work. Mykola Chirsky’s interest in the problem of female emancipation is corresponded to the general mood of the era. The subject of ridicule in provocative feuilleton is the woman’s radical metamorphoses, since repulsive manifestations of emancipation becomes commonplace. At the same time, the writer shows respect for the woman, appreciates her femininity, internal and external beauty, personality. He associates the positive in women with the functions of a faithful wife, a caring mother, and a skilled housewife. In feuilleton, the writer does not bypass the problem of the modern man role in a family, but analyses the value and moral and ethical guidelines of his character. The husband’s bad habits receive a caricatured interpretation in the strange behaviour of relatives. On the one hand, the writer does not perceive the extremes brought by female emancipation, and on the other, he mercilessly criticises the male “virtues” of contemporaries far from the standard. The artistic heritage of Mykola Chirsky remains little studied. The urgent task of modern literary studies is the introduction of Mykola Chirsky’s unknown works into the scientific circulation and their thorough scientific understanding.

THE PECULIARITIES OF CRIME PREVENTION BY OPERATIONAL UNITS IN PENAL INSTITUTIONS

2020 ◽  
pp. 27-32
Author(s):  
Ксения Ивановна Голубцова
Keyword(s):  
Crime Prevention ◽  
Complete Information ◽  
Current Situation ◽  
The Other ◽  
Correctional Institutions ◽  
Meaningful Information ◽  
Penal Institutions ◽  
The One ◽  
Negative Factors

Статья посвящена рассмотрению проблем профилактики преступлений оперативными подразделениями исправительных учреждений (далее - ИУ). Автор, раскрывая роль оперативных отделов ИУ в общей профилактике правонарушений, указывает на ее двоякость, поскольку, с одной стороны, рассматриваемые подразделения обладают значительным преимуществом перед другими службами учреждения в выявлении негативных факторов (негласный метод получения оперативно значимой информации), с другой стороны - далеко не все условия, которые способствуют совершению преступлений в ИУ, можно устранить оперативным путем. Изучение специальной литературы позволило выявить в деятельности начальников ИУ определенные проблемы, связанные с оценкой состояния оперативной обстановки в ИУ, сложившейся ситуации; с отсутствием прогноза развития криминогенной ситуации в ИУ, а также с профессиональной некомпетентностью руководителей, неумением объективно оценивать результаты деятельности структурных подразделений. Автор особое внимание уделяет анализу статистических данных о совершенных и предотвращенных преступлениях лицами, находящимися в местах лишения свободы. The article is devoted to the consideration of problems of crime prevention by operational units of correctional institutions (hereinafter referred to as IA). The author, revealing the role of the operational departments of the IA in the general prevention of offences, points to its twofold. On the one hand, the units under consideration have significant advantages over other services of the institution in identifying negative factors (these are tacit methods of obtaining promptly meaningful information). On the other hand, not all conditions conducive to the commission of crimes in IA can be eliminated by operational means: For example, shortcomings in the activities of other departments and services (security department, duty shift, etc.). The study of special literature has made it possible to identify problems in the activities of heads of correctional institutions in the sphere of implementation of solutions in case of lack of objective and complete information on the state of the operational situation in IA, the current situation, the results of the activities of structural subdivisions; No forecast of the development of the crime situation in IE; Professional incompetence of managers, inability to objectively assess the results of activities of structural subdivisions. The author pays particular attention to the analysis of statistics on crimes committed and prevented by persons in detention.

JOHN JOHNSONS LETTERS: THE ACCOUNTING ROLE OF TUDOR MERCHANTS' CORRESPONDENCE

1998 ◽  
Vol 25 (1) ◽  
pp. 57-72 ◽  
Author(s):  
David Oldroyd
Keyword(s):  
Time Delays ◽  
The Other ◽  
Business Decisions ◽  
Accounting Systems ◽  
Agency Relationships ◽  
The One

This article examines the role that correspondence played in the accounting systems of Tudor merchants. Merchants relied heavily on letters as a means of controlling their businesses at a distance by making agents accountable. Written accountability, as well as information for business decisions, was encouraged by agency relationships in mercantile enterprises. The system could be undermined by the breakdown of communication through the negligence of a factor or the lack of involvement by the principal. The time delays between the sending and the receipt of letters, on the one hand, and the procurement and conveyance of goods, on the other, were additional problems.

Metaphor, Cognition, Culture

2018 ◽  
Author(s):  
Zoltán Kövecses
Keyword(s):  
Conceptual Metaphor ◽  
The Other ◽  
Conceptual Metaphor Theory ◽  
Conceptual Metaphors ◽  
Culture And Cognition ◽  
Metaphor Theory ◽  
The One ◽  
Cultural Reality ◽  
Metaphor And Metonymy

The chapter reports on work concerned with the issue of how conceptual metaphor theory (CMT) functions as a link between culture and cognition. Three large areas are investigated to this effect. First, work on the interaction between conceptual metaphors, on the one hand, and folk and expert theories of emotion, on the other, is surveyed. Second, the issue of metaphorical universality and variation is addressed, together with that of the function of embodiment in metaphor. Third, a contextualist view of conceptual metaphors is proposed. The discussion of these issues leads to a new and integrated understanding of the role of metaphor and metonymy in creating cultural reality and that of metaphorical variation across and within cultures, as well as individuals.

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