To study the association of high sensitivity C-reactive protein with metabolic syndrome

Background: Metabolic Syndrome is a constellation of dyslipidemia (elevated triglycerides, low high-density lipoproteins (HDL)), elevation of arterial blood pressure (BP), dysregulated glucose homeostasis, and increased abdominal obesity.Methods: We studied the association of high sensitivity C-reactive protein with metabolic syndrome by case-control method in our tertiary care hospital in West U.P.Results: The mean age of cases and controls was 52.6 ± 7.7 and 51.4±7.0 years, respectively. There were 25 (50%) male and 25 (50%) female in case groups, and 27 (54%) males and 23 (46%) females in control group. Our analysis revelaed that there was a significant association between hs-CRP and the central obesity when compared in case-control group (3.57 vs 0.96 mg/L) (p value <0.001). There was no significant association between hs-CRP and high triglycerides, hypertension, diabetes, and reduced high density lipoprotein cholesterol.Conclusions: Raised hsCRP level can be considered as a surrogate marker of chronic inflammation in patients with metabolic syndrome.

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HIGH SENSITIVITY- C REACTIVE PROTEIN AS CARDIOVASCULAR RISK MARKER IN METABOLIC SYNDROME PATIENTS.

10.36106/ijar/1401070 ◽

2021 ◽

pp. 26-28

Author(s):

Sangeeta M Gawali ◽

Mahesh S Karandikar

Keyword(s):

Metabolic Syndrome ◽

High Sensitivity ◽

Abdominal Circumference ◽

Healthy Population ◽

Care Hospital ◽

C Reactive Protein ◽

Reactive Protein ◽

The Metabolic Syndrome ◽

Increased Risk ◽

Hs Crp

Background & Objectives: 20-25% of the world's adult population have metabolic syndrome (MetS); mortality of these people is double, and the morbidity of heart attack or stroke is three times higher than in the healthy population. Recent research has focused on the use of high-sensitivity C-reactive protein (hs-CRP), a marker of inammation, in the detection of patients at increased risk for cardiovascular disease. The study was conducted to evaluate for the evidence of the association between baseline hs-CRP levels and the metabolic syndrome. Methods: It was a cross-sectional study of 200 adults, 18–50 years of age, both the sexes randomly selected from diabetes & obesity OPD at tertiary care hospital & compared with 200 age & sex-matched controls. Diagnosis of Metabolic syndrome was done according to Modied National Cholesterol Education Program ATP III criteria (2004). High Sensitivity -C Reactive Proteins -hs-CRP was done by ELISA method (CAL BIOTECH). Statistical Analysis was done by Pearson correlation coefcient to study the correlation between hs-CRP & various components of metabolic syndrome. Results: We found signicantly increased hs-CRP levels (P<0.001) in metabolic syndrome, 60% of patients with metabolic syndrome belonged to the high-risk group with a mean hs-CRP value >3 mg/L & a positive correlation of hs-CRP with abdominal circumference & triglyceride & HDL levels Conclusion: increased hs- CRP levels in metabolic syndrome may increase the risk of having cardiovascular mortality. These prospective data suggest that measurement of hs-CRP adds clinically important prognostic information to the metabolic syndrome.

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Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

Mediators of Inflammation ◽

10.1155/2007/93573 ◽

2007 ◽

Vol 2007 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Juha Saltevo ◽

Mauno Vanhala ◽

Hannu Kautiainen ◽

Esko Kumpusalo ◽

Markku Laakso

Keyword(s):

Metabolic Syndrome ◽

Receptor Antagonist ◽

Interleukin 1 ◽

High Sensitivity ◽

Population Based ◽

C Reactive Protein ◽

Reactive Protein ◽

Interleukin 1 Receptor Antagonist ◽

The Metabolic Syndrome ◽

Hs Crp

This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.

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High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents.

Acta Endocrinologica ◽

10.1530/eje-08-0212 ◽

2008 ◽

Vol 159 (1) ◽

pp. R1-R4 ◽

Cited By ~ 37

Author(s):

Leandro Soriano-Guillén ◽

Bárbara Hernández-García ◽

Jimena Pita ◽

Nieves Domínguez-Garrido ◽

Genoveva Del Río-Camacho ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Children And Adolescents ◽

Hdl Cholesterol ◽

High Sensitivity ◽

Oral Glucose ◽

Obese Children ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

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Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

Mediators of Inflammation ◽

10.1155/2012/606207 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Ertuğrul Kurtoğlu ◽

Hasan Korkmaz ◽

Erdal Aktürk ◽

Mücahid Yılmaz ◽

Yakup Altaş ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Systemic Inflammation ◽

High Sensitivity ◽

Control Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Artery Disease ◽

The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

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Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2020.9145 ◽

2020 ◽

Vol 17 (7) ◽

pp. 3113-3116

Author(s):

Dyah Anetta Afri Rukmi ◽

Joseph Eko Wahono Rahardjo

Keyword(s):

Executive Function ◽

Elderly Patients ◽

Complete Blood Count ◽

High Sensitivity ◽

High Serum ◽

Control Group ◽

Case Group ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

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Comparison between High-Sensitivity C-Reactive Protein (hs-CRP) and White Blood Cell Count (WBC) as an Inflammatory Component of Metabolic Syndrome in Japanese

Internal Medicine ◽

10.2169/internalmedicine.49.2670 ◽

2010 ◽

Vol 49 (2) ◽

pp. 117-124 ◽

Cited By ~ 35

Author(s):

Eiji Oda ◽

Ryu Kawai

Keyword(s):

Metabolic Syndrome ◽

Blood Cell ◽

Cell Count ◽

White Blood Cell Count ◽

High Sensitivity ◽

C Reactive Protein ◽

Blood Cell Count ◽

Reactive Protein ◽

Hs Crp ◽

Inflammatory Component

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Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

Asian Journal of Medical Sciences ◽

10.3126/ajms.v7i3.13880 ◽

2016 ◽

Vol 7 (3) ◽

pp. 47-53

Author(s):

Muhammed Saleh Najdat ◽

Ahmed M Lutfi

Keyword(s):

Pulmonary Function ◽

Clinical Characteristics ◽

Clinical Symptoms ◽

Pulmonary Function Tests ◽

High Sensitivity ◽

Control Group ◽

Inhaled Corticosteroid ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Aims and Objectives: To evaluate the relevance of high-sensitivity assays for C-reactive protein (hs-CRP), as a sensitive marker of inflammation in asthmatic Iraqi patients. Additionally, correlations of serum levels of hs-CRP with patients’ clinical characteristics and pulmonary function tests (PFTs) will be studied in a cross-sectional design.Materials and Methods: A random sample of 58 individuals were divided into a healthy (control) group (n = 12) and two groups of adult patients with chronic stable asthma; (n = 22) patients had been receiving inhaled corticosteroids (inhaled corticosteroid-positive, or ICS+VE, group) for the past 2–3 months, and (n = 24) steroid-naive patients (inhaled corticosteroid-negative, or ICS-VE, group). The selected individuals were subjected to hs-CRP measurement and PFTs.Results: The forced expiratory volume in one second (FEV1)/forced vital capacity (FVC), was measured in all subjects. In the ICS+VE and the ICS-VE groups, there was a significant correlation between the level of hs-CRP and FEV1/FVC with r: ?0.891 and a p-value of < 0.0005 for both groups. In the ICS-VE group, 78.5% had significant clinical symptoms, whereas only 22.7% of the ICS+VE group had significant clinical symptoms. This difference (for the prevalence of clinical symptoms) was significant with a chi-square value of 19.59, degree of freedom (df) = 1, and p < 0.0005.Conclusion: In the ICS-VE group, the level of hs-CRP was significantly higher than in both the ICS+VE group and the control group. The values of the PFTs were significantly lower in the ICS-VE group. The prevalence of clinical features was significantly higher in the ICS-VE group.Asian Journal of Medical Sciences Vol. 7(3) 2016 47-53

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Pengaruh Pemberian Sari Ubi Ungu (Ipomea batatas L.) Terhadap KadarHigh Sensitivity C-Reactive Protein(hs-CRP) Pada Tikus Sprague Dawley Dengan Pakan Tinggi Lemak

Journal of Nutrition College ◽

10.14710/jnc.v7i4.22274 ◽

2018 ◽

Vol 7 (4) ◽

pp. 155

Author(s):

Irene Nucifera Puspitadewi ◽

Ani Margawati ◽

Hartanti Sandi Wijayanti

Keyword(s):

High Sensitivity ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Sprague Dawley ◽

C Reactive Protein ◽

Control Group Design ◽

Reactive Protein ◽

Ipomea Batatas ◽

Post Test ◽

Hs Crp

Latar Belakang: Komposisi makanan tinggi lemak dapat menjadi faktor terjadinya obesitasyang menyebabkan oksidasi lemak. Oksidasi lemak dapat menyebabkan inflamasi yang dikarakterisasikan dengan tingginya kadar High Sensitivity C-Reactive Protein (hs-CRP). Ubi ungu kaya akan antioksidan terutama antosianin yang mungkin dapat menurunkan kadar hs-CRP. Penelitian ini bertujuan untuk mengetahui pengaruh sari ubi ungu terhadap kadar hs-CRP tikus sprague dawley dengan pakan tinggi lemak.Metode: Jenis penelitian ini adalah true experimental dengan pre-post test control group design. 24 tikus sprague dawley jantan dibagi menjadi 4 kelompok yaitu kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2. Perlakuan 1 dan 2 diberikan sari ubi ungu dengan dosis 2 gram/200grBB dan 3 gram/200grBB berturut-turut selama 6 hari. Sebelum dan sesudah perlakuan, kadar hs-CRP dianalisis dengan menggunakan metode ELISA (Enzyme Linked Immunosorbent Assay).Hasil: Selisih kadar hs-CRP pada keolompok kontrol negatif, kontrol positif, perlakuan 1 dan perlakuan 2 adalah 0.4±0.20, -0.07±4.70, -4.3±0.79 dan -8.1±0.45. Terdapat perbedaan signifikan kadar hs-CRP antar kelompok sesudah intervensi (p=<0.001). Pada kelompok perlakuan 2 terdapat penurunan yang paling tinggi (persen delta 33,33% dengan nilai p=<0.001).Simpulan: Sari ubi ungu dapat menurunkan kadar High Sensitivity C-Reactive Protein (hs-CRP) secara signifikan.

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Elevated high sensitivity C-reactive protein and uric acid levels in coronary artery ectasia.

Acta Biochimica Polonica ◽

10.18388/abp.2014_1831 ◽

2014 ◽

Vol 61 (4) ◽

Cited By ~ 6

Author(s):

Şerafettin Demir ◽

Gulhan Karakoyun ◽

Mehmet Kanadasi

Keyword(s):

Uric Acid ◽

Coronary Artery ◽

High Sensitivity ◽

Control Group ◽

Coronary Artery Ectasia ◽

C Reactive Protein ◽

Reactive Protein ◽

Group I ◽

Significant Difference ◽

Hs Crp

The aim of this study is to examine uric asid (UA) and high sensitive C-Reactive protein (Hs-CRP) levels in patients with coronary artery ectasia (CAE). Ninety-eight patients with isolated CAE (mean age 57.5±10.3), (group-I), 110 patients with CAD but without CAE (mean age 56.3±10.7), (group-II), and 105 patients with normal coronary angiographies (mean age 58.1±10.8), (group-III) were included in the study. Blood samples of all individual were taken after coronary angiography from an antecubital vein, the patients uric acid and Hs-CRP levels were assessed. The severity of ectasia was evaluated and categorized according to Markis. A significant difference was not seen in serum uric acid and Hs-CRP levels between CAE and CAD groups. However, relative to the control group, uric acid and Hs-CRP levels in CAE and CAD groups were higher to a significant degree (p=0.001, p

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High sensitivity C-reactive protein, a predictor of cardiovascular mortality and morbidity, and psoriasis: a case control study

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20190442 ◽

2019 ◽

Vol 5 (2) ◽

pp. 338

Author(s):

Surinder Gupta ◽

Preeti Garg ◽

Nikita Gupta ◽

Nakul Gupta

Keyword(s):

Serum Level ◽

Inflammatory Process ◽

Case Control Study ◽

High Sensitivity ◽

Case Control ◽

C Reactive Protein ◽

Reactive Protein ◽

Pasi Score ◽

Hs Crp ◽

Control Study

Background: Psoriasis, a chronic inflammatory disease, is associated with systemic comorbidities. The blood levels of various inflammatory markers are increased in psoriasis. One of them is high sensitivity C-reactive protein (hs-CRP). The serum level of hs-CRP is increased in many inflammatory diseases like psoriasis, cardio vascular diseases, infections, arthritis and others. The objectives of the study were to determine serum level of hs-CRP in psoriasis in relation to its PASI score, which is a subjective method to determine severity of the disease, whereas hs-CRP is an objective and more reliable method. And to have a better idea of systemic inflammatory process caused by psoriasis, serum level of hs-CRP was evaluated in psoriasis patients.Methods: A case control study was conducted including 38 patients of chronic plaque psoriasis from dermatology outpatient department of Maharaja Agrasen Medical College (MAMC), Agroha, India, and 38 healthy controls.Results: The serum level of hs-CRP was significantly raised in psoriasis patients (p<0.001). The mean hs-CRP level in psoriasis patients was 6.824±8.562 mg/l whereas it was 1.072±0.929 mg/l in controls. Two observations were noticed, one, the increase in hs-CRP level correlated with PASI score and second, it was much higher in psoriatic patients as compared to controls.Conclusions: The much higher hs-CRP levels in psoriasis as compared to controls and its correlation with severity of psoriasis has led us to propose that this much high hs-CRP is a biomarker of systemic inflammatory process of psoriasis as well as inflamed cutaneous lesions.

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