The relationship between leptin, gonadotropic hormones, and body composition during puberty in a Dutch children cohort

ObjectiveTo investigate the relationship between leptin concentrations, gonadotropic hormone concentrations, and body composition during puberty in a Dutch children cohort.DesignIn a cohort of 98 children, we determined anthropometric measurements, body composition, and concentrations of leptin, FSH, and LH.ResultsSex differences were observed from Tanner stage 1 onwards in weight, body fat percentage, and leptin/fat mass ratio. In boys and girls, the relationship between leptin concentrations and FM was weaker at Tanner stage 2 (R2=0.33 andR2=0.39;P<0.001), 3 (R2=0.27 andR2=0.36;P<0.002), and 4 (R2=0.21 andR2=0.28;P<0.03) than at Tanner stage 1 (R2=0.51 andR2=0.67;P<0.001) and 5 (R2=0.46 andR2=0.78;P<0.01). In girls, a peak in leptin concentrations (8.5±6.0 ng/ml) preceded a peak in LH and FSH concentrations (15.1±3.5 and 5.0±4.5 IU/l). A lead/lag relationship was observed of leptin at Tanner stage 1 to LH and FSH at Tanner stage 2 (R2=0.12,P<0.05 andR2=0.18,P<0.05). In boys, there was no peak in leptin, LH, and FSH; additionally, leptin at Tanner stage 3 was related FSH at Tanner stage 4 (R2=0.17,P<0.04).ConclusionIn boys and girls during puberty, factors independent of fat mass become (transiently) more important in the regulation of plasma leptin concentrations. Moreover, in girls, leptin is suggested to act as a permissive factor for the onset of puberty, while, in boys, leptin has a different timing and possibly different function.

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Assessment of Body Composition and Sport Performance of Brazilian Paralympic Swim Team Athletes

Journal of Sport Rehabilitation ◽

10.1123/jsr.2015-0036 ◽

2016 ◽

Vol 25 (4) ◽

pp. 364-370 ◽

Cited By ~ 3

Author(s):

Radamés M.V. Medeiros ◽

Eduardo S. Alves ◽

Valdir A. Lemos ◽

Paulo A. Schwingel ◽

Andressa da Silva ◽

...

Keyword(s):

Body Composition ◽

Outcome Measures ◽

Fat Mass ◽

High Performance ◽

Swimming Performance ◽

Sport Performance ◽

Fat Percentage ◽

Reduced Fat ◽

And Performance ◽

The Relationship

Context:Body-composition assessments of high-performance athletes are very important for identifying physical performance potential. Although the relationship between the kinanthropometric characteristics and performance abilities of Olympic swimmers is extremely important, this subject is not completely understood for Paralympic swimmers.Objective:To investigate the relationship between body composition and sport performance in Brazilian Paralympic swimmers 6 mo after training.Design:Experimental pre/posttest design.Setting:Research laboratory and field evaluations of swimming were conducted to verify the 50-m freestyle time of each athlete.Participants:17 Brazilian Paralympic swim team athletes (12 men, 5 women).Main Outcome Measures:Body-composition assessments were performed using a BOD POD, and swimming performance was assessed using the 50-m freestyle, which was performed twice: before and after 6 mo of training.Results:Increased lean mass and significantly reduced relative fat mass and swimming time (P < .05) were observed 6 mo after training. Furthermore, a positive correlation between body-fat percentage and performance (r = .66, P < .05) was observed, but there was no significant correlation between body density and performance (r = –.14, P > .05).Conclusions:After a 6-mo training period, Paralympic swimmers presented reduced fat mass and increased lean body mass associated with performance, as measured by 50-m freestyle time. These data suggest that reduced fat-mass percentage was significantly correlated with improved swimming performance in Paralympic athletes.

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Does menarche mark a period of elevated resting metabolic rate?

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00410.2003 ◽

2004 ◽

Vol 286 (3) ◽

pp. E456-E462 ◽

Cited By ~ 3

Author(s):

Jennifer L. Spadano ◽

Linda G. Bandini ◽

Aviva Must ◽

Gerard E. Dallal ◽

William H. Dietz

Keyword(s):

Body Composition ◽

Metabolic Rate ◽

Fat Mass ◽

Resting Metabolic Rate ◽

Tanner Stage ◽

Normal Weight ◽

Fat Free Mass ◽

Time Points ◽

Stage 1

Resting metabolic rate (RMR) and body composition were measured in 44 initially nonoverweight girls at three time points relative to menarche: premenarche (Tanner stage 1 or 2), menarche (±6 mo), and 4 yr after menarche. Mean absolute RMR was 1,167, 1,418, and 1,347 kcal/day, respectively. Absolute RMR was statistically significantly higher at menarche than at 4 yr after menarche despite statistically significantly less fat-free mass (FFM) and fat mass (FM), suggesting an elevation in RMR around the time of menarche. The pattern of change in RMR, adjusted for FFM, log transformed FM, age, race, parental overweight, and two interactions (visit by parental overweight, parental overweight by FFM), was also considered. Adjusted RMR did not differ statistically between the visits for girls with two normal-weight parents. For girls with at least one overweight parent, adjusted RMR was statistically significantly lower 4 yr after menarche than at premenarche or menarche. Thus parental overweight may influence changes that occur in RMR during adolescence in girls.

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Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects

Acta Endocrinologica ◽

10.1530/eje-08-0878 ◽

2009 ◽

Vol 160 (5) ◽

pp. 769-775 ◽

Cited By ~ 36

Author(s):

Claudia Brufani ◽

Alberto Tozzi ◽

Danilo Fintini ◽

Paolo Ciampalini ◽

Armando Grossi ◽

...

Keyword(s):

Body Composition ◽

Insulin Sensitivity ◽

Fat Mass ◽

Pubertal Development ◽

Tanner Stage ◽

Oral Glucose ◽

Fat Percentage ◽

Central Fat ◽

Total Fat ◽

Fat Depot

BackgroundPuberty is a period of rapid growth associated with metabolic, hormonal, and body composition changes that can influence risk factors for chronic diseases such as type 2 diabetes.ObjectiveTo evaluate body composition and insulin sensitivity (IS) modifications throughout puberty in a large group of obese Caucasian subjects.MethodsFive hundred and nineteen obese subjects (4–19 years), grouped according to gender and Tanner stage (T), underwent oral glucose tolerance test. Quantitative insulin check index (QUICKI) and ISI were calculated as indexes of IS. In 309 subjects, body composition by dual-energy X-ray absorptiometry, IGF1, adiponectin, and leptin were also evaluated.ResultsBody composition modifications were sexually dimorphic, with girls not modifying fat and lean percentage and fat distribution (P>0.15), and boys decreasing fat percentage and increasing lean percentage and central fat depot (P<0.001) across Ts. IS decreased during mid-puberty and returned to prepubertal levels by the end of puberty. Girls showed lower IS than boys (P<0.01 and =0.03 for QUICKI and ISI respectively). In multivariate analysis factors that negatively influenced IS, independently from T or age, were total fat mass and central fat depot in girls (P<0.05 and <0.01, respectively), total fat and lean mass in boys (P<0.01). IGF1, adiponectin, and leptin were not related to pubertal IS.ConclusionsIn obese Caucasian subjects, further decrease of IS observed during puberty is a transient phenomenon. Factors that independently from T or age influence IS are central fat depot in girls, lean amount in boys, and total fat mass in both sexes.

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Effect of Puberty on the Relationship between Circulating Leptin and Body Composition1

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.85.7.6689 ◽

2000 ◽

Vol 85 (7) ◽

pp. 2509-2518 ◽

Cited By ~ 4

Author(s):

Mary B. HorlickK ◽

Michael Rosenbaum ◽

Margery Nicholson ◽

Lenore S. Levine ◽

Barbara Fedun ◽

...

Keyword(s):

Body Composition ◽

Sexual Dimorphism ◽

Tanner Stage ◽

Gender Effect ◽

Gonadal Steroids ◽

Stage I ◽

Regression Equations ◽

Regression Analyses ◽

Plasma Leptin ◽

The Relationship

Circulating concentrations of leptin are better correlated with absolute amounts of adipose tissue [fat mass (FM)] than with relative body fatness (body mass index or percent body fat). There is a clear sexual dimorphism in circulating concentrations of leptin (females> males) at birth and in adulthood. However, whether such dimorphism is present in the interval between these periods of development remains controversial. We examined body composition and clinical (Tanner stage) and endocrine (pituitary-gonadal axis hormones) aspects of sexual maturation in relationship to circulating concentrations of leptin in 102 children (53 males and 49 females, 6–19 yr of age) to evaluate the relationship between circulating leptin concentrations and body composition before and during puberty. Pubertal stage was assigned by physical examination (Tanner staging) and also assessed by measurement of plasma estradiol, testosterone, and pituitary gonadotropins. Body composition was determined by dual-energy x-ray absorptiometry and by anthropometry. Circulating concentrations of leptin in the postabsorptive state were determined by a solid-phase sandwich enzyme immunoassay. The effect of gender on the relationship between circulating leptin concentrations and FM was determined by ANOVA at each Tanner stage. Stepwise multiple linear regression analyses, including circulating concentrations of pituitary-gonadal axis hormones, and FM were performed, by gender, to determine whether the relationship between circulating concentrations of leptin and FM changes during puberty. Plasma leptin concentrations were significantly correlated with FM at all Tanner stages in males and females. Plasma leptin concentrations, normalized to FM, were significantly higher in females than males at Tanner stages IV and V but not at earlier stages of pubertal development. Plasma leptin concentrations, normalized to FM, were significantly greater in females at Tanner stage V compared with females at Tanner stage I and significantly lower in males at Tanner stage IV and V compared with males at Tanner stage I. These significant gender and maturational differences were confirmed by demonstrating that the regression equation relating circulating leptin concentrations to FM in females and males at Tanner stages IV and V were significantly different (predicted lower leptin concentrations in males than females with identical body composition) and that the regression equations relating circulating concentrations of leptin to FM in each gender before puberty (Tanner stage I) were significantly different (predicted higher plasma concentrations of leptin in prepubertal males and lower leptin concentrations in prepubertal females) than the same regression equations in later puberty. Circulating concentrations of testosterone were significant negative correlates of circulating concentrations of leptin normalized to FM in males when considered as a group over all pubertal stages. The inclusion in multivariate regression analyses of circulating concentrations of testosterone and estradiol, FM, fat-free mass, and gender did not eliminate a significant gender-effect (P < 0.05) on circulating concentrations of leptin at Tanner stages IV and V. The circulating concentration of leptin, normalized to FM, declines significantly in males and rises significantly in females late in puberty to produce a late-pubertal/adult sexual dimorphism. These studies confirm a potent role for gonadal steroids as mediators of this sexual dimorphism in circulating concentrations of leptin. The persistence of a significant gender-effect on circulating leptin concentrations at Tanner stages IV and V, even when the regression equation includes body composition and circulating concentrations of gonadal steroids, however, suggests that this sexual dimorphism also reflects the direct or interactive effects of either other sex-related metabolic variables (such as insulin, GH, or body fat distribution) or additional X or Y- chromosome-linked gene effects that produce an increasing sexual dimorphism of circulating leptin concentrations later in puberty.

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Comparison of the Effect of Soy protein and Whey protein on Body Composition: A Meta-Analysis of Randomized Clinical Trials

British Journal Of Nutrition ◽

10.1017/s0007114521001550 ◽

2021 ◽

pp. 1-27

Author(s):

Masoome Piri Damaghi ◽

Atieh Mirzababaei ◽

Sajjad Moradi ◽

Elnaz Daneshzad ◽

Atefeh Tavakoli ◽

...

Keyword(s):

Body Composition ◽

Whey Protein ◽

Lean Body Mass ◽

Body Mass ◽

Body Fat ◽

Fat Mass ◽

Soy Protein ◽

Protein Supplementation ◽

Body Fat Percentage ◽

Fat Percentage

Abstract Background: Essential amino acids (EAAs) promote the process of regulating muscle synthesis. Thus, whey protein that contains higher amounts of EAA can have a considerable effect on modifying muscle synthesis. However, there is insufficient evidence regarding the effect of soy and whey protein supplementation on body composition. Thus, we sought to perform a meta-analysis of published Randomized Clinical Trials that examined the effect of whey protein supplementation and soy protein supplementation on body composition (lean body mass, fat mass, body mass and body fat percentage) in adults. Methods: We searched PubMed, Scopus, and Google Scholar, up to August 2020, for all relevant published articles assessing soy protein supplementation and whey protein supplementation on body composition parameters. We included all Randomized Clinical Trials that investigated the effect of whey protein supplementation and soy protein supplementation on body composition in adults. Pooled means and standard deviations (SD) were calculated using random-effects models. Subgroup analysis was applied to discern possible sources of heterogeneity. Results: After excluding non-relevant articles, 10 studies, with 596 participants, remained in this study. We found a significant increase in lean body mass after whey protein supplementation weighted mean difference (WMD: 0.91; 95% CI: 0.15, 1.67. P= 0.019). Subgroup analysis, for whey protein, indicated that there was a significant increase in lean body mass in individuals concomitant to exercise (WMD: 1.24; 95% CI: 0.47, 2.00; P= 0.001). There was a significant increase in lean body mass in individuals who received 12 or less weeks of whey protein (WMD: 1.91; 95% CI: 1.18, 2.63; P<0.0001). We observed no significant change between whey protein supplementation and body mass, fat mass, and body fat percentage. We found no significant change between soy protein supplementation and lean body mass, body mass, fat mass, and body fat percentage. Subgroup analysis for soy protein indicated there was a significant increase in lean body mass in individuals who supplemented for 12 or less weeks with soy protein (WMD: 1.48; 95% CI: 1.07, 1.89; P< 0.0001). Conclusion: Whey protein supplementation significantly improved body composition via increases in lean body mass, without influencing fat mass, body mass, and body fat percentage.

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Uric acid is associated with adiposity factors, especially with fat mass reduction during weight loss in obese children and adolescents

Nutrition & Metabolism ◽

10.1186/s12986-020-00500-9 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Yang Niu ◽

Xue-lin Zhao ◽

Hui-juan Ruan ◽

Xiao-meng Mao ◽

Qing-ya Tang

Keyword(s):

Weight Loss ◽

Body Composition ◽

Uric Acid ◽

Children And Adolescents ◽

Body Fat ◽

Fat Mass ◽

Dietary Control ◽

Obese Children ◽

Fat Percentage ◽

Before And After

Abstract Background Current adult studies suggest that uric acid (UA) is associated with body fat, but the relationship in obese children is unclear. Thus, we aim to evaluate the association between uric acid and body composition of obese children. Methods A total of 79 obese children were included in this study, and 52 children (34 boys and 18 girls) underwent a 6-week weight loss camp, including 34 boys and 18 girls. Six-week weight-loss interventions were performed on all participants through aerobic exercise and appropriate dietary control. Laboratory tests and body composition were collected before and after the intervention. Results Before the intervention, correlation analysis demonstrated that uric acid was positively correlated with height, weight, body mass index (BMI), waist circumference, hip circumference, fat mass (FM), and free fat mass (FFM) with adjusting for age and gender (P < 0.05). After 6 weeks of intervention, the participants gained 3.12 ± 0.85 cm in height, body fat percentage decreased by 7.23 ± 1.97%, and lost 10.30 ± 2.83 kg in weight. Univariate and multivariate analysis indicated that uric acid at baseline was associated with FM reduction during weight loss (P < 0.05). Conclusions This study is the first report that uric acid is associated with BMI and FM, and may play an important role in the reduction of FM during weight loss in obese children and adolescents. The interaction between UA and adiposity factors and its underlying mechanisms need to be further explored. Trial registration This study was registered in Clinical Trials.gov (NCT03490448) and approved by the Ethics Committee of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine.

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Examining the Relationship Between Physical Activity Intensity and Adiposity in Young Women

Journal of Physical Activity and Health ◽

10.1123/jpah.2013-0441 ◽

2015 ◽

Vol 12 (6) ◽

pp. 764-769 ◽

Cited By ~ 3

Author(s):

Bruce W. Bailey ◽

Pamela Borup ◽

James D. LeCheminant ◽

Larry A. Tucker ◽

Jacob Bromley

Keyword(s):

Physical Activity ◽

Body Composition ◽

Body Fat ◽

Young Women ◽

Physical Activity Intensity ◽

Fat Percentage ◽

Bod Pod ◽

Activity Intensity ◽

Objectively Measured ◽

The Relationship

Background:The purpose of this study was to assess the relationship between intensity of physical activity (PA) and body composition in 343 young women.Methods:Physical activity was objectively measured using accelerometers worn for 7 days in women 17 to 25 years. Body composition was assessed using the BOD POD.Results:Young women who spent less than 30 minutes a week performing vigorous PA had significantly higher body fat percentages than women who performed more than 30 minutes of vigorous PA per week (F = 4.54, P = .0113). Young women who spent less than 30 minutes per day in moderate to vigorous PA (MVPA) had significantly higher body fat percentages than those who obtained more than 30 minutes per day of MVPA (F = 7.47, P = .0066). Accumulating more than 90 minutes of MVPA per day was associated with the lowest percent body fat. For every 10 minutes spent in MVPA per day, the odds of having a body fat percentage above 32% decreased by 29% (P = .0002).Conclusion:Vigorous PA and MVPA are associated with lower adiposity. Young women should be encouraged to accumulate at least 30 minutes of MVPA per day, however getting more than 90 minutes a day is predictive of even lower levels of adiposity.

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The relationship between second-to-fourth digit ratio (2D:4D), muscle strength and body composition to bone mineral density in young women

Kinesiology ◽

10.26582/k.51.2.8 ◽

2019 ◽

Vol 51 (2) ◽

pp. 238-245

Author(s):

Hamid Arazi ◽

Ehsan Eghbali

Keyword(s):

Body Composition ◽

Muscle Strength ◽

Young Women ◽

Upper Body ◽

Lower Body ◽

Fat Percentage ◽

Mineral Density ◽

Body Strength ◽

Lower Body Strength ◽

The Relationship

2D:4D ratio is determined by balance between androgens and estrogens. Low level estrogen reduces bone mineral density (BMD) and incurs negative changes to bone microarchitecture, increasing the risk of osteoporosis and, as a consequence, fracture risk in women. The purpose of this study was to investigate the relationship between 2D:4D, muscle strength and body composition to BMD in young women. One hundred twenty-seven young women (age range 24-36 years) voluntarily participated in this study. Lengths of the second (index) and fourth (ring) fingers, upper and lower body strength and body composition (body mass index, BMI; waist to hip ratio, WHR) and body fat percentage were estimated. Also, blood levels of calcium and 25-hydroxyvitamin D (25OHD) were evaluated and dual-energy X-ray absorptiometry device was used to measure BMD in the lumbar spine (LS) and femoral neck (FN). The results showed that digit ratios, upper body and lower body muscle strength, BMI and fat percentage had a positive relationship with LS and FN BMD (LS BMD: r=.47, r=.56, r=.46, r=.34, r=.28, p≤.001, respectively; FN BMD: r=.34, r=.49, r=.51, r=.45, r=.27, p≤.001, respectively). In addition, there was no significant relationship between WHR and BMD of LS and FN (p˃.05). Multiple linear regression analysis showed the upper body strength was a stronger determinant of LS BMD and the lower body strength was a stronger determinant of FN BMD. Based on the results, the researchers concluded that upper and lower body strength, 2D:4D ratios and BMI were important determinants of young women’s BMD. Also, it seemed that some of these factors may be able to help predicting the osteoporosis potential in young women

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The experience of life events and body composition in middle childhood: a population-based study

International Journal of Behavioral Nutrition and Physical Activity ◽

10.1186/s12966-021-01188-7 ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Ivonne P. M. Derks ◽

Sara Hannani ◽

Florianne O. L. Vehmeijer ◽

Henning Tiemeier ◽

Pauline W. Jansen

Keyword(s):

Body Composition ◽

Life Events ◽

Middle Childhood ◽

Population Based ◽

Fat Free Mass ◽

Structured Interviews ◽

Population Based Study ◽

Wide Range ◽

The Relationship ◽

Dutch Children

AbstractWhile studies suggest potential influences of childhood adversities on obesity development in adulthood, less is known about the short-term association in children. We examined the association between a wide range of life events experienced in the first ten years of life (including maltreatment and milder adversities) and body composition in 5333 ten-year old Dutch children. In structured interviews, mothers retrospectively reported on their children’s experience of 24 events. BMI was calculated, and fat mass index and fat free mass index were determined by dual-x-ray absorptiometry scanning. Linear regressions showed that, unadjusted, a higher number of life events was associated with higher BMI and body composition. However, associations attenuated to non-significance after adjustment for covariates. Similar findings were observed for maltreatment and milder life events. Thus, the number of experienced life events was not associated with body composition in middle childhood. Rather, other factors, like socioeconomic conditions, accounted for the relationship between life events and weight development in children.

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Composición corporal y rendimiento físico de jugadores de fútbol soccer universitario por posición de juego (Body composition and physical performance of college soccer by player´s position)

Retos ◽

10.47197/retos.v0i39.75075 ◽

2020 ◽

pp. 52-57

Author(s):

Oswaldo Ceballos-Gurrola ◽

Fernando Bernal-Reyes ◽

Marquelia Jardón-Rosas ◽

María Cristina Enríquez-Reyna ◽

Jesús Durazo- Quiroz ◽

...

Keyword(s):

Body Composition ◽

Physical Performance ◽

Body Mass ◽

Fat Mass ◽

Physical Characteristics ◽

Soccer Players ◽

Hip Circumference ◽

Soccer Teams ◽

Physical Abilities ◽

The Relationship

Se propuso determinar la relación que existe entre la composición corporal y el rendimiento físico de jugadores de fútbol soccer universitario. Participaron 26 jugadores de sexo masculino con edad promedio de 20.7 años (DT = 1.7), pertenecientes a los equipos representativos de fútbol soccer de dos universidades mexicanas. Se midieron características morfológicas, de composición corporal y físicas para las posiciones de defensa, mediocampo y delantero. Se determinó el nivel de asociación entre las variables. Los resultados muestran que los defensas presentan mayor masa corporal, diámetro de húmero y circunferencia de cadera que los delanteros (p < .05), no así respecto a los jugadores de mediocampo. No se presenta diferencia en la expresión de las capacidades físicas y del porcentaje de masa grasa de los jugadores por posición de juego (p > .05). La masa grasa se asoció de manera directa con la velocidad (.427*, p < .05). Se encontraron diferencias en la masa ósea y corporal por posición de juego entre defensas, mediocampistas y delanteros. Los hallazgos sugieren la influencia de la composición corporal en el rendimiento físico de los participantes. Abstract. The aim of the study was to determine the relationship between body composition and physical performance in college soccer players. Twenty-six male players with an average age of 20.7 years (SD = 1.7), belonging to the representative soccer teams of two Mexican universities participated in the research. Morphological, body composition, and physical characteristics were measured for the defense, midfield, and forward positions. The level of association between variables was determined. The results show that defenders have greater body mass, humerus diameter, and hip circumference than forwards (p <. 05), whereas no differences were found in comparison to midfielders. There is no difference in players’ expression of physical abilities and percentage of fat mass by playing position (p > .05). Fat mass was directly associated with speed (.427 *, p < .05). Differences were found in bone and body mass by playing position between defenders, midfielders, and forwards. The findings hint at an influence of body composition on participants’ physical performance.

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