scholarly journals Lubricin Structural and Functional Characteristics, Its Participation in Maintaining Articular Cartilage Tribological Parameters

2020 ◽  
pp. 22-28
Author(s):  
Tatyana Lyzo ◽  
Pavel Krylov

Articular cartilage is constantly exposed to high loads. Wearing out of joints due to aging, as well as their poor functioning, is a common problem leading to a significant decline in the quality of human life. Lubricin is one of the main components of the biological lubrication system, it is a surface-active mucinous glycoprotein, which plays an important role in cartilage integrity. Its main function is to protect the cartilage surfaces from excessive friction – a necessary condition for maintaining the health of mammal joints. Moreover, lubricin has growth-regulating properties, it participates in the maturation of the subchondral bone and prevents cell adhesion. Although the molecule of lubricin was discovered almost half a century ago, there is still not much data available. The molecule has a great potential in medical applications. Studying lubricin can help solve problems caused by joint diseases, such as osteoarthritis. This review presents up-to-date information about structural and functional features of lubricin, its role in maintaining the integrity of articular cartilage, which can serve as a basis for the development of chondroprotectors or as a material to improve existing joint prostheses.

2018 ◽  
Vol 1 ◽  
pp. 198
Author(s):  
Lusy Tunik Muharlisiani ◽  
Henny Sukrisno ◽  
Emmy Wahyuningtyas ◽  
Shofiya Syidada ◽  
Dina Chamidah

Service at the “Kelurahan” is a very important part in determining the success of development, especially in public service. The problem faced is the lack of skill level of the “Kelurahan” apparatus with the more dynamic demands of the community and the archive management system is still conventional and manual that is writing the identity of the archive into the book agenda, expedition, control card, and borrowed archive card, so it takes a more practical electronic system, effective and efficient so required to develop themselves in order to improve public services. Conventional administration and archive management must be transformed into cloud-based computing (digital), for which archiving managers should always be responsive and follow these developments and wherever possible in order to utilize for archival activities, with greater access expected archives are evidence at once able to talk about historical facts and events and be able to give meaning and benefit to human life, so archives that were only visible and readable at archival centers can now be accessed online, and even their services have led to automated service systems. Using Microsoft Access which its main function is to handle the process of data manipulation and manufacture of a system, this system is built so that the bias runs on Cloud which means Cloud itself is a paradigm in which information is permanently stored on servers on the internet and stored. The purpose of this program is the implementation of administrative management that has been based cloud computing (digital) and is expected to be a solution in managing the archive so that if it has been designed and programmed, it can be stored in the computer and benefi- cial to the “Kelurahan” apparatus and add in the field of management archives in the form of improving the quality of service to the community, can facilitate and scientific publications.


2021 ◽  
Vol 10 (4) ◽  
pp. 196
Author(s):  
Julio Manuel de Luis-Ruiz ◽  
Benito Ramiro Salas-Menocal ◽  
Gema Fernández-Maroto ◽  
Rubén Pérez-Álvarez ◽  
Raúl Pereda-García

The quality of human life is linked to the exploitation of mining resources. The Exploitability Index (EI) assesses the actual possibilities to enable a mine according to several factors. The environment is one of the most constraining ones, but its analysis is made in a shallow way. This research is focused on its determination, according to a new preliminary methodology that sets the main components of the environmental impact related to the development of an exploitation of industrial minerals and its weighting according to the Analytic Hierarchy Process (AHP). It is applied to the case of the ophitic outcrops in Cantabria (Spain). Twelve components are proposed and weighted with the AHP and an algorithm that allows for assigning a normalized value for the environmental factor to each deposit. Geographic Information Systems (GISs) are applied, allowing us to map a large number of components of the environmental factors. This provides a much more accurate estimation of the environmental factor, with respect to reality, and improves the traditional methodology in a substantial way. It can be established as a methodology for mining spaces planning, but it is suitable for other contexts, and it raises developing the environmental analysis before selecting the outcrop to be exploited.


2009 ◽  
Vol 2009 ◽  
pp. 219-219
Author(s):  
S D Sharifi ◽  
S Khorsandi ◽  
A A Khadem ◽  
A Salehi

Antibiotics have been used for 50 years to enhance growth performance and to prevent disease in poultry production. Recently, most of the antibacterial growth promoters have been banned because the feeding of antibiotics is risky due not only cross-resistance but also to multiple resistances. Plants (especially herbs) have been used as food and medicinal purposes and some of them have played a significant role in maintaining human health and improving the quality of human life for thousands of years. Herbs or products containing plant extracts, essential oils or main components of the essential oil are among the alternative growth promoters that are already being used in practice. (Acamovic and Brooker, 2005; Ocak et al., 2008). There is evidence suggesting that herbs, spices, and various plant extracts have appetizing, digestion-stimulating and antimicrobial properties. But, there is only limited evidence about whether the inclusion as a solid herb material would have the growth promoting effects in live birds. The aim of this study was to evaluate the antibacterial effects of dietary dry peppermint (Mentha piperita L.), Cumin (Cuminum L.), Milfoil (Achellia millefolium L.) and poley (Teucrium Polium L.) on the performance of broiler.


2017 ◽  
Author(s):  
Lusy Tunik Muharlisiani ◽  
M. Pd Dr Heni Sukrisno ◽  
Emmy Wahyuningtyas ◽  
Shofiya Syidada

Service at the “Kelurahan” is a very important part in determining the success of development, especially in public service. The problem faced is the lack of skill level of the “Kelurahan” appa-ratus with the more dynamic demands of the community and the archive management system is still conventional and manual that is writing the identity of the archive into the book agenda, expedition, control card, and borrowed archive card, so it takes a more practical electronic system, effective and efficient so required to develop themselves in order to improve public services. Conventional administration and archive management must be transformed into cloud-based computing (digital), for which archiving managers should always be responsive and follow these developments and wherever possible in order to utilize for archival activities, with greater access expected archives are evidence at once able to talk about historical facts and events and be able to give meaning and benefit to human life, so archives that were only visible and readable at archival centers can now be accessed online, and even their services have led to automated service systems. Using Microsoft Access which its main function is to handle the process of data manipulation and manufacture of a system, this system is built so that the bias runs on Cloud which means Cloud itself is a paradigm in which information is permanently stored on servers on the internet and stored. The purpose of this program is the implementation of administrative management that has been based cloud computing (digital) and is expected to be a solution in managing the archive so that if it has been designed and programmed, it can be stored in the computer and beneficial to the “Kelurahan” apparatus and add in the field of management archives in the form of improving the quality of service to the community, can facilitate and scientific publications


2020 ◽  
Vol 9 (3) ◽  
pp. 476
Author(s):  
Viktoriia Druzhynina ◽  
Ganna Likhonosova ◽  
Galyna Lutsenko ◽  
Galyna Lutsenko

The potential of using information technology for socio-economic development of the country and the life quality of every citizen is quite significant now in Ukraine. The aim of the article is to study the modern possibilities of using information technologies, namely, adaptations of accounting and analytical support in the conditions of diffusion of socio-economic values to increase the welfare of the population. The methods of divergence and convergence, rationality and irrationality were used in the work - to search for effective tools for regulating national and international financial relations in Ukraine in the context of the challenges of globalization; methods of analysis of cognitive data – to determine the forms and directions of digital hygiene in Ukrainian society; conceptualization of consequences and the duality of assessing results - to illustrate the reflection of the current state of development of the analytical basis and levelling Ukraine’s dependence on financial hedonism, which currently prevails in the world. Specific areas of application of innovative technologies are proposed, such as tourism services and hotel and restaurant business. Ensuring the competitiveness of national industries as a result of their use of innovative behaviour and the development of new technologies and the accumulation by economically active subjects of innovative knowledge and empirical skills ensures the introduction of new information technologies in various spheres of human life, with no exception of tourism and restaurant industry. The modern industry of restaurant and tourism business has been actively using specialized software and global computer networks in recent years to increase the efficiency of the placement and search of information, the activation of promotion and services marketing, and the improvement of the quality of customer service, as this is an important condition for the quality of such services. Thus, integration aspirations in the global socio-economic system should be supplemented by facilitating access to advanced information technologies within the country itself. This is a necessary condition for the process of diffusion of socio-economic development and innovative knowledge that should be accumulated in the country. Keywords: innovation, technology transfer, welfare, socio-economic development, accounting and analytical support


2020 ◽  
Vol 17 (6) ◽  
pp. 76-91
Author(s):  
E. D. Solozhentsev

The scientific problem of economics “Managing the quality of human life” is formulated on the basis of artificial intelligence, algebra of logic and logical-probabilistic calculus. Managing the quality of human life is represented by managing the processes of his treatment, training and decision making. Events in these processes and the corresponding logical variables relate to the behavior of a person, other persons and infrastructure. The processes of the quality of human life are modeled, analyzed and managed with the participation of the person himself. Scenarios and structural, logical and probabilistic models of managing the quality of human life are given. Special software for quality management is described. The relationship of human quality of life and the digital economy is examined. We consider the role of public opinion in the management of the “bottom” based on the synthesis of many studies on the management of the economics and the state. The bottom management is also feedback from the top management.


1970 ◽  
Vol 11 (3) ◽  
pp. 408-421
Author(s):  
Fauzi Fauzi

As typical Indonesian education institute, pesantren with all its component, tradition, culture, and uniqueness have drawn attention many expert and researchers. Pesantren existence has given great contribution to enhancement of the quality of human life. Many role have been played by pesantren; in social, political, economics, cultural aspect; and of course religious aspect which its basic study. These realities in turn have invited the attention of many circles to continuously examine, checking, or studying dynamics, growth, and also existence of pesantren. Among the study result is Mastuhu’s research: Dynamics of System of Education Pesantren, a Study about Element and Value of Pesantren Educational System. With this masterpiece, Mastuhu trying to promote the form of study pesantren which do not merely touching manifest (visible) aspect, but trying to find the values which is consisted inside that manifest; so can found positive, negative, and plus-minus items from pesantren’s education which need and needn’t to be developed in national’s education system. Through this article, the writer will express the work content from a perspective of its study approach.


2020 ◽  
Vol 19 (11) ◽  
pp. 2116-2135
Author(s):  
G.V. Savin

Subject. The article considers functioning and development of process flows of transportation and logistics system of a smart city. Objectives. The study identifies factors and dependencies of the quality of human life on the organization and management of stream processes. Methods. I perform a comparative analysis of previous studies, taking into account the uniquely designed results, and the econometric analysis. Results. The study builds multiple regression models that are associated with stream processes, highlights interdependent indicators of temporary traffic and pollution that affect the indicator of life quality. However, the identified congestion indicator enables to predict the time spent in traffic jams per year for all participants of stream processes. Conclusions. The introduction of modern intelligent transportation systems as a component of the transportation and logistics system of a smart city does not fully solve the problems of congestion in cities at the current rate of urbanization and motorization. A viable solution is to develop cooperative and autonomous intelligent transportation systems based on the logistics approach. This will ensure control over congestion, the reduction of which will contribute to improving the life quality of people in urban areas.


2014 ◽  
Vol 9 (2) ◽  
pp. 141-151
Author(s):  
Jolanta Wiśniewska

The purpose of this article is to present the correlation between management of an economic entity and the development of ethical accounting dilemmas in the era of high-risk business. In the globalisation era and recurring economic crises, realisation of the objectives of a company takes place under high risk conditions. It is therefore necessary to use a proper management system. The necessary condition for making all decisions is to have relevant information. The value and relevance of these decisions depend on the quality of information which they have been based on. Lack of ethics in accounting has a direct impact on the company's management, which is based on information generated by the accounting system of the company. Ethical dilemmas arising in accounting are also ethical dilemmas arising in the process of business management. 


2016 ◽  
pp. 120-127
Author(s):  
Dinh Toan Nguyen

Background: Dementia after stroke, particularly subacute period is often overlooked. Today the quality of human life is increasingly high, finding scales that have high value for detection of dementia in patients with stroke is increasingly interested. MoCA test is high sensitivity with mild dementia and identify more abnormalities of awareness caused by vascular, but MoCA have not been studied much in Vietnam. Objective: Assessing MoCA test in subacute stroke patients and compare MoCA versus MMSE in these patients. Subjects: 90 patients with subacute stroke period, these people are being treated at Department of cardiovascular internal medicine at Hue Central Hospital, from 7/2014 - 7/2015. Methods: cross-sectional description and analysis. Results: The mean age is 65.57 ± 13.38, accounting for 54.4% male and 45.6% female. Age, duration of illness has weak correlation with MoCA. The risk factors: hypertension, stroke ischemic transient, alcoholism, smoking, heart disease, diabetes, dyslipidemia related no statistical significance with MoCA. The proportion of dementia in subacute stroke according MoCA is 82.2%. The concordance between MoCA and MMSE was good (kappa = 0.684). Using DSM-IV criteria as the gold standard we found MoCA more valuable in the dementia diagnosis than MMSE (AUC 0.864 versus 0.774, p <0.05). Conclusion: The rate of dementia in stroke subacute period according MoCA is quite high. MoCA is valuable than MMSE in detecting dementia in patients with stroke subacute period, this scale is short, easy to implement so should put into using widely in clinical practice. Key words: MoCA test, subacute stroke, dementia


Sign in / Sign up

Export Citation Format

Share Document