scholarly journals Antihyperlipidemic activity of Chloroxylon swietenia in triton WR1339 induced hyperlipidemia

2018 ◽  
Vol 7 (3) ◽  
pp. 518
Author(s):  
B. H. M. R. K. Guptha ◽  
S. L. D. V. Ramana Murty Kadali ◽  
Vijay Kumar M. ◽  
Revanasiddappa B. C.
Keyword(s):  
Metabolic Disorders ◽  
Ethanolic Extract ◽  
Life Time ◽  
Tween 80 ◽  
Positive Control ◽  
Albino Rats ◽  
Metabolic Risk ◽  
Antihyperlipidemic Activity ◽  
Ethanolic Extracts ◽  
Chloroxylon Swietenia

Background: Medicinal herbs are beneficial and effective either in the management and prevention of several metabolic disorders, associated with hyperlipidemia, hypertension and insulin resistance which increases the cardio-metabolic risk and demands for the life time therapy. Current allopathic medicines are expensive and reported with several adverse effects and hence, finding of a suitable herbal medicine for hyperlipidemic disorders is very important.Methods: Thirty albino rats weighing 200-230g were randomly divided into 5 groups were rendered hyperlipidemia with a single dose of triton WR 1339. Normal control, positive control, standard, aqueous and ethanolic extract groups were treated with tween-80, tween-80, atorvastatin, aqueous and ethanolic extracts of Chloroxylon swietenia respectively for seven days. At the end of the study, blood was collected for estimation of the lipid profile.Results: Both the aqueous and ethanolic extract groups significantly reduced the TG and VLDL levels.Conclusions: The extracts exhibited remarkable activity on one or either parameter of the lipid profile. It could be due to the presence of alkaloids, steroids, flavonoids, coumarins and phenols in the extracts.

Efek Antiinflamasi dari Ekstrak Kulit Buah Durian (Durio zibethinus murray) terhadap Tikus Putih Jantan

2015 ◽  
Vol 5 (2) ◽  
pp. 74
Author(s):  
Masayu Azizah ◽  
Fitriani Fitriani
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Tween 80 ◽  
Optimal Dose ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Durio Zibethinus ◽  
Anti Inflammatory ◽  
Durian Rind

The observation on anti-inflammatory effects ofextract of durian rind(Durio zibethinus Murray) has been done. Extractof durian rind(Durio zibethinus Murray) dose were: 100 mg/kg, 200 mg/kg and 400 mg/kg. Tween 80 2% was used as negative control and diclofenac sodium 0.9 mg/200g was used as positive control. The parameter was the percentage of inflammation observed in the left foot of male albino rats induced by 1% suspension of carrageen. Measurements of parameter was done every 30 minutes for 360 minutes. The results showed that percentage of anti-inflammatory of diclofenac sodium 0.9 mg/200g, the extract in dose of 400 mg/kg, 200 mg/kg and 100 mg/kg were 64.9%, 61.86%, 52.98% and 48.58%respectively. It can be concluded that ethanolic extract of durian rind(Durio zibethinus Murray) has an anti-inflammatory effects. The optimal dose as an anti-inflammatory agentwas 400mg/kg BW

scholarly journals Comparative evaluation of anti-diabetic action and pancreatic histopathology of rats treated with two alkaloidal plant extracts

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1841-1846
Author(s):  
Bonagiri Sreedevi ◽  
Vijaya Kuchana ◽  
Shobharani S
Keyword(s):  
Blood Glucose ◽  
Ethanolic Extract ◽  
Bark Extract ◽  
Albino Rats ◽  
Histopathological Study ◽  
Standard Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Soxhlet Apparatus ◽  
Ethanolic Extracts

This study aimed to understand Strychnosnuxvomica and Holarrhena pubescens Stem bark extract action towards M3 receptor in controlling blood glucose levels. Strychnos nux vomica  and Holarrhena pubescens are both alkaloidal drugs can help in controlling Hyperglycemic level. This will be useful in the formulation of a new herbal drug molecule for treating diabetes. Chloroform and ethanolic extracts of selected alkaloidal plants were extracted using the soxhlet apparatus and obtained quotes were tested for acute toxicity studies and carried out anti-diabetic action on Wister albino rats for 21 days. Results obtained from Blood glucose levels and histopathological study of test groups are compared with blood glucose levels of standard group, and highly significant action was identified by the chloroform extract of Strychnos nux vomica and Holarrhena pubescens group. Moderate anti-diabetic action was observed remaining two groups of ethanolic extracts. Strychnos nux vomica and Holarrhena pubescens ethanolic extract groups are acting on M3 receptors and controlling Hyperglycemic levels.

scholarly journals Assessment of Nephroprotective Potential of Ethanolic Extract Premna Tomentosa (Ept) in Alcohol Toxicity in Male Albino Rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3099-3103
Author(s):  
Gomathi Priyadharsini T ◽  
Kavimani M ◽  
Sathiya Narayana Murthy S ◽  
Prabhu K ◽  
Arudyuti Chowdhury
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Blood Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Histopathological Changes

The nephroprotective prospective of Premna tomentosa extract against Alcohol induced nephrotoxicity in rats was investigated in the present study. The characterization of ethanol extract of Premna tomentosa (EPT) was performed using standard phytochemical analysis. Male albino wistar rats 36 in numbers were divided into 6 groups including control, negative control, positive control and various doses of EPT Treated groups; Nephrotoxicity was induced by alcohol (1ml/100gm b.wt) in animals. Rats intoxicated with Alcohol were fed with 500, 750 mg/kg dose of EPT and Liv 52 (1ml/100gm b.wt) for 60 days. Results show that EPT (500mg/kg b.wt) had a significant effect against alcohol induced nephrotoxicity in rats than EPT (750mg/kg b.wt) in blood parameters and consonantly good histopathological changes in kidney. The deleterious histopathological alterations in kidney associated with glomerular and tubular changes in alcohol intoxicated rats was evident. This result shows Premna tomentosa may be used as supplementary drug for alcoholics.

scholarly journals ANTIHYPERLIPIDEMIC ACTIVITY OF COMMIPHORA MUKUL AGAINST ATHEROGENIC DIET-INDUCED HYPERLIPIDEMIA IN EXPERIMENTAL RATS

2018 ◽  
Vol 11 (6) ◽  
pp. 386
Author(s):  
Jaffar Shaik ◽  
Zeenath Khan
Keyword(s):  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Positive Control ◽  
Atherogenic Diet ◽  
Normal Diet ◽  
High Density Lipoproteins ◽  
Albino Rats ◽  
Standard Drug ◽  
Antihyperlipidemic Activity ◽  
Commiphora Mukul

Objective: The aim of the present study was to investigate the effect of antihyperlipidemic activity of ethyl acetate extract of Commiphora mukul (EECM) gum resin and compares its efficacy with that of atorvastatin against atherogenic diet-induced hyperlipidemia model using rat as an experimental animal.Methods: Wistar albino rats were divided into five groups. Control animals received normal diet, hyperlipidemic control; rats treated with EECM 100 and 200 mg/kg and positive control, receiving standard drug atorvastatin 2.70 mg/kg.Results: Increase the level of serum cholesterol, phospholipids, high-density lipoproteins, low-density lipoproteins, and triglycerides causing hyperlipidemia further leading to the development of atherosclerosis. On the other hand, oral administration of ethyl acetate extract of C. mukul at dose of 200 mg/kg for 15 days resulted in the prevention of above abnormalities.Conclusion: The results suggest that EECM could be beneficial in the treatment of atherosclerosis, characterized by atherogenic lipoprotein profile and abnormalities in lipid metabolism.

ANTIDANDRUFF POTENTIAL OF Kaempheria galanga ETHANOLIC EXTRACTS FOR HAIR CREAM FORMULATION

2018 ◽  
Vol 80 (3) ◽  
Author(s):  
Nur Bainun Parjo ◽  
Razauden Mohamed Zulkifli ◽  
Madihah Md Salleh ◽  
Tewin Tencomnao
Keyword(s):  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Zinc Pyrithione ◽  
Cinnamomum Zeylanicum ◽  
Cream Formulation ◽  
Oil In Water ◽  
Ethanolic Extracts ◽  
Fungal Oil ◽  
Anti Fungal

The evaluation of Kaempferia galanga, Citrus hystrix and Cinnamomum zeylanicum ethanolic extracts on antifungal activities and zone of inhibition were conducted. The yield for K. galanga, C. hystrix and C. zeylanicum were 0.4, 0.7 and 0.43 % of raw dried samples respectively. All the extracts demonstrated 5 mg/mL MIC with C. zeylanicum, K. galanga and C. hystrix average holozones diameter of 14.5 + 3.8, 12.0 + 1.8 and 12.0 + 0.8 mm after 3 days of incubation respectively with no effect on negative control. On the other hand, Zinc Pyrithione being more potent than imidazaole as a positive control with inhibition of 32.8 + 2.2 and 21.8 + 3.4 respectively. Based on the findings, the anti-fungal hair cream containing K. galanga ethanolic extract was formulated into oil-in-water cream and the physicochemical properties were evaluated. The cream demonstrated desirable characteristic with no separation between oil and water after vigorously shaken at 14,600 rpm for half an hour. Furthermore the viscosity and pH were 543.7 + 19.2 and 5.46 + 0.01 respectively.  In conclusion, K galanga ethanolic extract has a potential to be used as an anti-fungal oil in water cream formulation. 

scholarly journals To Evaluate the Diuretic Activity in Ethanolic Extract of Leaves of Delonix Regia in Wistar Albino Rats

2018 ◽  
Vol 11 (2) ◽  
pp. 959-963
Author(s):  
Jayanthi M K ◽  
Siddamma Amoghimath
Keyword(s):  
Body Weight ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Diuretic Activity ◽  
Delonix Regia ◽  
Group 4 ◽  
Group 2 ◽  
Wistar Albino Rats

To study the diuretic activity in ethanolic extract of leaves of delonix regia in wistar albino rats. After obtaining the permission from the Institutional Ethical Committee (IAEC) Wistar albino rats were randomly selected and divided into 4 groups. The animals were fasted and deprived of food and water 20hrs prior to the experiment. On the day of experimentation, Group 1 negative control received Normal saline (25ml/kg), Group 2 positive control received Furosemide 20mg/kg body weight, and Group 3 received ethanonic extract of delonix regia 100mg/kg and Group 4 received ethanonic extract of delonix regia 200 mg/kg. Delonix regia increase the excretion of sodium and water at the dose of 100mg/kg and 200mg/kg of body weight. The diuretic index is 5.93 and 6.45 at 100mg/kg and 200mg/kg of delonix regia respectively. The diuretic activity if delonix regia 100mg/kg is 0.61 and 0.67 at dose 200mg/kg, which is more than that of negative control but less when compared to positive control. Ethanonic extract of Delonix regia showed significant diuretic activity at both 100mg/kg and 200mg/kg doses.

scholarly journals ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS

2018 ◽  
Author(s):  
Nahed Al-Baoqai ◽  
Hassan Al-Mahbashi ◽  
Adnan Al-Adhal
Keyword(s):  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Low Density ◽  
Experimental Animals ◽  
Socotra Island ◽  
Antihyperlipidemic Activity ◽  
Dracaena Cinnabari

Dracaena Cinnabari balfis a species plant in Abalfurn 1984e de la p pharmaciegavaceae family. It is a tree endemic to the Island of Socotra,Yemen. It was used as a dye and medicine in Socotra  and the Mediterranean basin. Some researches demonstrated both hypoglycemic and hypolipidemic of its resin of Dracaena Cochinchinensis, a traditional Chinese tree. Accordingly, this study aimed to evaluate the antidiabetic potential of the ethanolic extract of dracanea cinnabari balfresin (DCBR), endemic in Socotra Island, in Alloxan induced diabetes, and evaluation of possible antihyperlipidemic activity of the same extract in high-cholesterol diet-induced hyperlipidemia in male albino rats. Experimental diabetes was induced in rats with intraperitoneal injection a single dose of Alloxan (150 mg/kg). Hyperlipidemia was induced in rats by administration of 1% cholesterol in diet and 0.5 % Hydrogen Peroxide in drinking water for 14 days. Fasting blood glucose levels were measured at 1st day, 7th day and 14th day. Pancreas histopathology was done at the end. Estimation of serum lipid profile and liver   histopathology was done at the end of 14 day. The results were expressed as mean ± SD and differences among the groups of animals were compared using one-way ANOVA. Administration of ethanolic extract of resin of two doses (100mg and 300mg\kg) in alloxan induce diabetic rats resulted in a significant decrease in FBG levels with a recovery in destruction of pancreas cell compared with untreated group .Also the same doses of extract showed significant decrease in triglycerides, total cholesterol, low density lipoprotein, very low density lipoprotein and alkaline phospatase in comparing with untreated groups. From the results of present study we can conclude the ethanolic extract of Dracaena Cinnabari Balf. have a hypoglycemic and hypolipidemic activity in experimental animals  , these activity are time and dose dependent.  

scholarly journals Anti-snake Venom Activity of Aqueous and Ethanolic Extracts of Crinum jagus Bulb

2018 ◽  
pp. 1-9
Author(s):  
A. H. Zailani ◽  
P. K. Magaji ◽  
S. Sarkiyayi ◽  
A. U. Wurochekke
Keyword(s):  
Snake Venom ◽  
Column Chromatography ◽  
Ethanolic Extract ◽  
Design Evaluation ◽  
Control Group ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Crude Extracts ◽  
University Of Technology ◽  
Ethanolic Extracts

Aim: To determine the anti-snake venom effect of crude aqueous and ethanolic extracts and separated fractions of Crinum jagus bulb on rats injected with Echis ocellatus venom. Study Design: Evaluation of LD50 of venom, anti-lethal effects of different extract preparations and their effect on neutralising haemorrhage; the hallmark of Echis ocellatus venom toxicity. Place and Duration of Study: Department of Biochemistry laboratory, Modibbo Adama University of Technology, Yola, Nigeria between March and October 2017. Methodology: venom was collected by the milking method. Fractionation of crude extracts was done by column chromatography separately with benzene/methanol, acetic acid/methanol and ethyl acetate/methanol. Thirty rats were used determine LD50 of venom while twenty-four albino rats were used in the anti-venom study; divided into 6 groups of 4 rats each. Group one served as the normal control, group two served as venom untreated control while groups 3, 4, 5 and 6 were injected with 0.2 mg/mL Echis ocellatus venom and treated with 200 mg/kg body weight crude extracts, fractions I, II and III respectively then observed for 24 hours. Results: LD50 of venom was found to be 5 mg/mL; column chromatography of crude extracts gave three fractions each designated I, II and III respectively. Phytochemical analysis of both crude aqueous and ethanolic extract of Crinum jagus bulb revealed the presence of alkaloids, flavonoids, terpenoids, steroids, tannins and phenolics. Only fraction III of both aqueous and ethanolic extract maintained all phytochemicals from the crude. Both extracts and their fractions were all able to neutralise the venom. For the aqueous extract, the crude extract and fraction III gave the best result while for the ethanolic extract, fractions II and III caused the best neutralisation. Conclusion: Crinum jagus bulb has demonstrated significant anti-venom activity, this can be exploited for the development of new anti-snake venom drugs.

scholarly journals Trypanocidal effect of aqueous and ethanolic extracts of Strychnos spinosa on white mice infected with Trypanosoma brucei brucei

2021 ◽  
Vol 11 (6-S) ◽  
pp. 14-20
Author(s):  
Vourchakbé Joël ◽  
Djamila Zouheira ◽  
Nfor Njini Gael
Keyword(s):  
Trypanosoma Brucei ◽  
Ethanolic Extract ◽  
Mortality Rates ◽  
Positive Control ◽  
Negative Control ◽  
Trypanosoma Brucei Brucei ◽  
Pharmacological Studies ◽  
Ethanolic Extracts ◽  
Local Plants ◽  
Strychnos Spinosa

The emergence of trypanocidal resistance has led to a change in the behavior and use of local plants for the treatment of parasites. The trypanocidal activity of Strychnos spinosa aqueous and ethanolic extracts on Trypanosoma brucei brucei was evaluated during ten days of treatment. Thus, the smear was used to monitor the parasitaemia of mice treated with Strychnos spinose aqueous and ethanolic extracts by gavage at doses of 250, 500, 1000 mg/kg (test groups); with 10 ml/kg of distilled water (negative control) and 1mg/kg of isometamidium chloride (positive control). The results of the pharmacological studies on the trypanocidal potential of the plant showed that On day ten (D10)  a mortality rates of 32 %, 39 % and 62 % respectively for the doses 250, 500 and 1000 mg/kg with the ethanolic extract while  the aqueous extract induced a mortality rates of 32 %, 37 % and 56 % respectively. Isometamidium chloride induced the highest mortality rate of 85 %. The lethal doses were 218.07 and 225.79 mg/kg for the aqueous and ethanolic extracts respectively. All these results justify at least in part the use of this plant in traditional medicine for the treatment of trypanosomiasis. Keywords: Ethanolic extracts - Aqueous extracts - Trypanocidal potential - Trypanosomes - Inhibition of parasitaemia.

scholarly journals Effect of phyto-extracts of neem (Azadirachta indica) and garlic (Allium sativum) on leaf spot disease of groundnut (Arachis hypogaea L.)

2020 ◽  
Vol 5 (1) ◽  
pp. 441-449
Author(s):  
Asafor Henry Chotangui ◽  
Modjibaye Betigne ◽  
Marie Solange Mandou ◽  
Nelly Gaëtane Foussom Kamaleu ◽  
Eric Bertrand Kouam
Keyword(s):  
Arachis Hypogaea ◽  
Azadirachta Indica ◽  
Leaf Spot ◽  
Allium Sativum ◽  
Disease Incidence ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Leaf Spot Disease ◽  
Ethanolic Extracts

AbstractA field experiment was conducted to investigate the effect of aqueous and ethanolic extracts of neem (Azadirachta indica A. JUSS) and garlic (Allium sativum L.) against Cercospora leaf spot (CLS) disease of groundnut (Arachis hypogaea L.). A split plot design using two exotic (“fleur” 11 var., 65-13 var.) and one local (village var.) variety of groundnut as the main factor and ten treatments comprising one negative control (sterile distilled water), one positive control (fungicide: spavozeb) and eight phyto-extracts replicated three times was applied. Treatments were applied to plots at 45, 60, 75 and 90 days after planting (DAP). Results showed that CLS disease incidence ranged between 66.67% and 88.89% at 65 DAP for 10% ethanolic extract of garlic and 20% aqueous extract of garlic, respectively. Disease severity was lowest for 20% ethanolic extracts of neem seeds (14.74%) and garlic bulb (14.99%) at 65 DAP. Yield obtained from treatments of ethanolic extracts of garlic (3.62 t ha−1) was significantly higher (p < 0.05) than the control (2.40 t ha−1) but comparable to the spavozeb treatment (3.09 t ha−1). Exotic varieties were more productive (3.13 and 3.43 t ha−1) than the more resistant local variety (2.67 t ha−1).

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