Efek Antiinflamasi dari Ekstrak Kulit Buah Durian (Durio zibethinus murray) terhadap Tikus Putih Jantan

2015 ◽  
Vol 5 (2) ◽  
pp. 74
Author(s):  
Masayu Azizah ◽  
Fitriani Fitriani
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Tween 80 ◽  
Optimal Dose ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Durio Zibethinus ◽  
Anti Inflammatory ◽  
Durian Rind

The observation on anti-inflammatory effects ofextract of durian rind(Durio zibethinus Murray) has been done. Extractof durian rind(Durio zibethinus Murray) dose were: 100 mg/kg, 200 mg/kg and 400 mg/kg. Tween 80 2% was used as negative control and diclofenac sodium 0.9 mg/200g was used as positive control. The parameter was the percentage of inflammation observed in the left foot of male albino rats induced by 1% suspension of carrageen. Measurements of parameter was done every 30 minutes for 360 minutes. The results showed that percentage of anti-inflammatory of diclofenac sodium 0.9 mg/200g, the extract in dose of 400 mg/kg, 200 mg/kg and 100 mg/kg were 64.9%, 61.86%, 52.98% and 48.58%respectively. It can be concluded that ethanolic extract of durian rind(Durio zibethinus Murray) has an anti-inflammatory effects. The optimal dose as an anti-inflammatory agentwas 400mg/kg BW

scholarly journals UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK KULIT TERONG BELANDA (Solanum betaceum, Cav.) PADA MENCIT JANTAN YANG DIINDUKSI KARAGENIN

2020 ◽  
Vol 16 (02) ◽  
pp. 86
Author(s):  
Margareta Retno Priamsari ◽  
Rina Ayu Krismonikawati
Keyword(s):  
Diclofenac Sodium ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Test Material ◽  
Edema Formation ◽  
Flavonoid Compounds ◽  
The One ◽  
Post Hoc ◽  
Solanum Betaceum

ABSTRACT Inflammation is a normal response to injury due to release of chemical mediators such as prostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to determine the antiinflammatory power and the effect of variations in the dose of ethanolic extract of the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic extract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol solvent. Antiinflammatory power test using edema formation method with induction of caragenin 1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 mice records which were divided into 5 groups namely negative control (0.5% CMC Na suspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) and given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 mg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness measured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of antiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test and continued by the Post Hoc Test with a 95% confidence level. The results showed that the ethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has antiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, the greater the anti-inflammatory power. Keywords: Solanum betaceum Cav., antinflammation, caragenin

scholarly journals ASSESSMENT OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF ASAM KANDIS (GARCINIA XANTHOCHYMUS HOOK. F. EX T. ANDERSON) FRUIT

2018 ◽  
Vol 11 (4) ◽  
pp. 81
Author(s):  
Hanafis Sastra Winata ◽  
Rosidah Rosidah ◽  
Panal Sitorus
Keyword(s):  
Ethanolic Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Control Group ◽  
Phytochemical Screening ◽  
Fruit Extract ◽  
Garcinia Xanthochymus ◽  
Anti Inflammatory

 Objective: The objective of this study was to evaluate the anti-inflammatory activity in acute and subacute models of inflammation from ethanolic fruit extract of Asam kandis (Garcinia xanthochymus Hook. f. ex T. Anderson) in animal (rats) models.Methods: Pleliminary phytochemical screening was carried out by using standard procedures.. Assessment of acute and subacute models of inflammation was using carrageenan-induced paw edema method and cotton pellet granuloma method using three dosage treatments; 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW along with a negative control group (0.5% Na CMC) and positive control (Na diclofenac 2.25 mg/kg BW). The inhibition period was observed at 30, 60, 90, 120, 150, and 180 min time intervals.Result: The phytochemical screening showed that the ethanolic fruit extract from Asam kandis contain contains flavonoids, glycosides, steroids, and triterpenoids. The anti-inflammatory result showed that the strongest inhibition produced by ethanolic fruit extract of Asam kandis occurred on the dosage of 800 mg/kg BW compared to the other doses (200 and 400 mg/kg BW) throughout the observation period.Conclusion: This finding indicated that ethanolic fruit extract of Asam kandis (G. xanthochymus Hook. f. ex T. Anderson) might become an interesting candidate for treatment of inflammation.

scholarly journals Effect extract of Ipomoea pes-caprae leaf as anti-inflammatory non immunological in rat Rattus norvegicus

2019 ◽  
Vol 4 (1) ◽  
pp. 11-17
Author(s):  
Safrida Safrida ◽  
Hasanuddin Hasanuddin ◽  
Nurul A. Agusdinianti
Keyword(s):  
Diclofenac Sodium ◽  
Control Variable ◽  
Positive Control ◽  
Negative Control ◽  
Test Results ◽  
Anova Test ◽  
Drug Candidates ◽  
Randomized Design ◽  
Anti Inflammatory ◽  
One Way Anova

Ipomoea pes-caprae is one of the plants in Indonesia that has the potential as a traditional herbal medicine to treat inflammation. Hence, the objective of this study was to evaluate the effect of I. pes-capraeleaf extract as anti-inflammatory in edema rats induced by 5% egg white solution. The experimental design used was a Completely Randomized Design (CRD) consisted of 5 treatments, each consisted of 5 rats.The treatment consisted of KN = negative control, KP = positive control, giving  of 25 mg diclofenac sodium, K 100 = giving 100 mg kg-1body weight (BW) of I. pes-capraeleaf extract , K300 = 300 mg kg-1BW of I. pes-capraeleaf extract, and K500 = 500 mg kg-1BW of I. pes-capraeleaf extract. The anti-inflammatory data obtained were tested statistically with a one-way ANOVA test at  99% confidence level and followed by Duncan's test. The ANOVA test results showed that the giving ofI. pes-capraeleaf extract had a very significant effect (p 0.01) on the percentage of inflammatory, obtained Fcount Ftable, 21.46 4.79 at the level of α = 0.01. The treatment of I. pes-capraeleaf extract of 500 mg kg-1BW had the effect of decreasing the volume of edema with the positive control variable using diclofenac sodium 25 mg. It is concluded that I. pes-capraeleaf extract can be used as an anti-inflammatory by decreasing rat feet edema volume. I. pes-capraeleaf extract has a prospect for non-immunological inflammatory natural drug candidates.

scholarly journals Assessment of Nephroprotective Potential of Ethanolic Extract Premna Tomentosa (Ept) in Alcohol Toxicity in Male Albino Rats

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 3099-3103
Author(s):  
Gomathi Priyadharsini T ◽  
Kavimani M ◽  
Sathiya Narayana Murthy S ◽  
Prabhu K ◽  
Arudyuti Chowdhury
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Blood Parameters ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Phytochemical Analysis ◽  
Histopathological Changes

The nephroprotective prospective of Premna tomentosa extract against Alcohol induced nephrotoxicity in rats was investigated in the present study. The characterization of ethanol extract of Premna tomentosa (EPT) was performed using standard phytochemical analysis. Male albino wistar rats 36 in numbers were divided into 6 groups including control, negative control, positive control and various doses of EPT Treated groups; Nephrotoxicity was induced by alcohol (1ml/100gm b.wt) in animals. Rats intoxicated with Alcohol were fed with 500, 750 mg/kg dose of EPT and Liv 52 (1ml/100gm b.wt) for 60 days. Results show that EPT (500mg/kg b.wt) had a significant effect against alcohol induced nephrotoxicity in rats than EPT (750mg/kg b.wt) in blood parameters and consonantly good histopathological changes in kidney. The deleterious histopathological alterations in kidney associated with glomerular and tubular changes in alcohol intoxicated rats was evident. This result shows Premna tomentosa may be used as supplementary drug for alcoholics.

scholarly journals Evaluation of Antiinflammatory Activity of Marine Omega-3 in Rats

2020 ◽  
Vol 2 (2) ◽  
pp. 1-5
Author(s):  
Ana Khusnul Faizah ◽  
Angelica Kresnamurti
Keyword(s):  
Tween 80 ◽  
Positive Control ◽  
Negative Control ◽  
Dependent Manner ◽  
Omega 3 ◽  
Paw Edema ◽  
Control Groups ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Inflammatory Effect

Marine omega-3 from fish contains high EPA dan DHA which may have an analgesic and anti-inflammatory effects. The objective of study is to analyze the anti-inflammatory effect of marine omega-3 in rats. The method of this study is pre-post control experimental. The acute anti-inflammatory effect of marine omega-3 were investigated through carrageenan induced paw edema in rats. Thirty minutes before the procedure, the experimental groups were treated with fish oil 40 and 60 mg/kg; sodium diclofenac (5 mg/kg) as positive control groups and span 80-tween 80 as negative control groups. The degree of paw edema was measured by caliper. The marine omega-3 showed anti-inflammatory effect in a dose-dependent manner. The results of 60 mg/kg of marine omega-3 was significantly different compared with the negative. Overall, the marine omega-3 has acute anti-inflammatory activity in rats.

scholarly journals ANTIINFLAMMATION ACTIVITY ETHANOL EXTRACT OF MARBOSI-BOSI LEAVES (Tarenna polycarpa (Miq.) Koord.Ex Valeton) ON WHITE RAT IN CARRAGEENAN INDUCED PAW INFLAMMATION

2018 ◽  
Vol 6 (3) ◽  
pp. 1-4
Author(s):  
Haris Munandarnst ◽  
Marline N
Keyword(s):  
Diclofenac Sodium ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Group Iii ◽  
Rat Paw Edema ◽  
Group I ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Traditionally, (Tarenna polycarpa (Miq.) Koord Ex Valeton as known as marbosi-bosi which commonly found in Sibolga, North Sumatera, Indonesia has been used as antidiabetes, cholesterol, anti-inflammatory and antibacterial. Tarenna species has been found its activities as antimicrobial, anti-oxidant and anti-inflammatory activity. The aim of this study was to investigate the anti inflammatory effect ethanol extract of marbosi-bosi leaves (Tarenna polycarpa (Miq.) Koord Ex Valeton in terms of decreased edema volume of male white rat in 1% carrageenan-induced and also to determine the effective dose of extract to decrease the volume of rat paw edema Ethanol extract of marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton was obtained by maceration. The antiinflammatory activity test was divided into 5 groups. The Group I (negative control) was given CMC 0.5%, Group II (positive control) was given diclofenac sodium 2,25 mg / kg BW, while Group III, IV and V were  given marbosi-bosi leaf extract at a dose of 50, 100 and 200 mg/kgBW respectively.  Each rat was induced by 1% carrageenan subplantar injection. Examination of antiinflammatory effect was measured by using digital plethysmometer at minute of 30 to minute of 360. The data were analyzed statistically using ANOVA (analysis of variance).The results showed that negative control did not show anti-inflammatory effect had significant differences with other treatment groups. In conclusion, ethanol extract marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton has an effective anti-inflammatory activity at a dose of 100 mg / kgBW.

scholarly journals To Evaluate the Diuretic Activity in Ethanolic Extract of Leaves of Delonix Regia in Wistar Albino Rats

2018 ◽  
Vol 11 (2) ◽  
pp. 959-963
Author(s):  
Jayanthi M K ◽  
Siddamma Amoghimath
Keyword(s):  
Body Weight ◽  
Ethanolic Extract ◽  
Positive Control ◽  
Negative Control ◽  
Albino Rats ◽  
Diuretic Activity ◽  
Delonix Regia ◽  
Group 4 ◽  
Group 2 ◽  
Wistar Albino Rats

To study the diuretic activity in ethanolic extract of leaves of delonix regia in wistar albino rats. After obtaining the permission from the Institutional Ethical Committee (IAEC) Wistar albino rats were randomly selected and divided into 4 groups. The animals were fasted and deprived of food and water 20hrs prior to the experiment. On the day of experimentation, Group 1 negative control received Normal saline (25ml/kg), Group 2 positive control received Furosemide 20mg/kg body weight, and Group 3 received ethanonic extract of delonix regia 100mg/kg and Group 4 received ethanonic extract of delonix regia 200 mg/kg. Delonix regia increase the excretion of sodium and water at the dose of 100mg/kg and 200mg/kg of body weight. The diuretic index is 5.93 and 6.45 at 100mg/kg and 200mg/kg of delonix regia respectively. The diuretic activity if delonix regia 100mg/kg is 0.61 and 0.67 at dose 200mg/kg, which is more than that of negative control but less when compared to positive control. Ethanonic extract of Delonix regia showed significant diuretic activity at both 100mg/kg and 200mg/kg doses.

scholarly journals Ethanolic Extract of The Graptophyllum Pictum Griff Leaves as Antipyretic agent to Male White Rat

2018 ◽  
Vol 1 (1) ◽  
pp. 59
Author(s):  
Setya Enti Rikomah ◽  
Gina Lestari ◽  
Juwita Winanti
Keyword(s):  
Rural Areas ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Induction Method ◽  
Antipyretic Effect ◽  
Anti Inflammatory ◽  
Statistic Result ◽  
Dpt Vaccine

<p><em>Utilization of plants as traditional medicinal are still always be  used by people in Indonesian. Especially in rural areas that  still rich with variety of plants. Plants  of black pudding leaves (Graptophyllum pictum Griff) are one that efficacious for treating various of diseases. The content of  flavonoid  in the black pudding leaves have  antipyretic effect, analgesic and anti-inflammatory. This research aims to find  out  whether the black pudding leaves have  antipyretic effect or not. This research  used the induction method  of vaccineDPT-Hb 0.022 / 20 gr a white rat as stimulant fever. Positive control with paracetamol 1.3 mg / 20 gram a white rat, negative control with Na CMC 0.5 ml / 20 grams a white rat, first extract test of black pudding leaves  0.8 mg / 20 gram a white rat, second extract test of  black pudding leaves 1.6 / 20 gram a white rat, and third extract test  of black pudding leaves 3.2 / 20 gram a white rat. The results of research showed that ethanol extract of black pudding leaves if it’s looked from  statistic result of SPSS 16 program , it doesn’t  show out of any effect as antipyretic effect because  the significant value  is P&gt; 0.05.</em><em></em></p><strong><em>Keywords: Antipyretic, DPT vaccine Hb, (Graptophyllum pictum)</em></strong>

scholarly journals Uji Efektifitas Ekstrak Kulit Petai (Parkia speciosa Hassk) Terhadap Mencit (Mus musculus) Sebagai Anti Inflamasi

2020 ◽  
Vol 1 (2) ◽  
pp. 80
Author(s):  
Ilham Maulana ◽  
Ajeng Kurniati Roddu ◽  
Suriani Suriani
Keyword(s):  
Diclofenac Sodium ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Group V ◽  
Group I ◽  
Anti Inflammatory ◽  
Group 5

ABSTRAKTelah dilakukan penelitian uji efektifitas ekstrak etanol kulit petai dengan tujuan untuk mengetahui efek anti inflamasi dari ekstrak etanol kulit petai (Parkia speciosa Hassk).Pengujian dilakukan terhadap hewan uji mencit dengan melihat volume udem telapak kaki dari mencit, yang sebelumnya di induksi oleh putih telur 1%. Perhitungan hasil pengujian menggunakan uji analisis varians dan uji newman - keuls. Pengujian dilakukan dengan membagi 5 kelompok penguian, kelompok I dengan pemberian Na.CMC 1 % sebagai kelompok kontrol negatif   kelompok II dengan pemberian suspensi ekstrak etanol kulit petai dengan konsentrasi 1 %, kelompok III dengan konsentrasi 3%, kelompok IV dengan konsentrasi 5% dan kelompok V dengan pemberian suspensi natrium diklofenak 0,195%b/v sebagai kelompok kontrol positif. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit petai dengan konsentrasi 1%, 3%, dan 5% memiliki efek sebagai anti inflamsi.Kata Kunci: Ekstrak Etanol; Kulit Petai; Anti Inflamasi; Mencit.ABSTRACTHas conducted research Study On Effectiveness of Petai (Parkia speciosa Hassk) Extract, with the aim to determine the anti -inflammatory effect of the ethanol petai extract (Parkia speciosa Hassk). Testing forum mice to test animals by looking at the volume of foot edema of mice , which previously induced by egg white 1 %. Calculations results of testing using analysis of variance test and test newman – keuls. Testing is done by dividing the testing group 5, group I with giving Na. CMC 1% as a negative control, group II and group administration of ethanol extract of petai suspension with a concentration of 1%, group III with a concentration 3%, group IV with a concentration 5% and the group V with the provison of 0,195% diclofenac sodium suspension as the positive control group. The result showed that the ethanol extract of petai with concentration of 1%, 3%, and 5% have anti – Inflamamatory effect.Keywords: Extract Ethanol; Petai; Anti Inflammatory; Mice.

scholarly journals Spirulina platensis Extract Reduces Serum TNF-a, Neutrophils, and Increases Macrophage Count in Skin Incisional Mice Model

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Riski Dwi Utami ◽  
Tri Nur Kristina ◽  
Renni Yuniati
Keyword(s):  
Spirulina Platensis ◽  
Diclofenac Sodium ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
M2 Macrophages ◽  
Therapeutic Group ◽  
Mice Model ◽  
Anti Inflammatory

Spirulinasp.is an alga that has antioxidant and anti-inflammatory potential.Phycocyanin contained in Spirulina platensis can reduce tumor necrosis factor-? levels, neutrophils, and M2 macrophages in inflammation. This research aims to investigate the anti-inflammatory activity of S. platensisin a mice wound model. Thirty-two male Wistar rats were incised and divided into 4 groups. The first therapeutic group (X1) received S. platensisextract at a dose of 500 mg/kgBW/day, and the second therapeutic group received S. platensisextract at a dose of 750 mg/kgBW/day. The negative control group (C1) received a saline solution and the positive control group (C2) received diclofenac sodium 20mg/kgBW/day. Serum TNF-? levels examined by the Enzyme-Linked Immunosorbent Assaymethod. Neutrophils and M2 macrophages were calculated by tissue biopsy and hematoxylin-eosin (HE) staining. Data analysis was performed with ANOVA test and LSD Post-Hoc Test. The average levels of serum TNF-? on the 14-day were 394.50; 180.33; 2,980.33; and 607.42 pg/ml for X1, X2, C1 and C2, respectively. The average neutrophils number on the 14-day were 8.00; 6.83; 14.67; and 11.17 for X1, X2, C1 and C2, respectively. The average macrophage number in the 14-day was 15.50; 19.17; 6.33; and 11.17 for X1, X2, C1 and C2, respectively. We found significant differences between TNF-? levels, the number of neutrophils, and the number of M2 macrophages. The administration of S. platensisextract at a dose of 750 mg/ kgBW/day reduces serum TNF-? levels, neutrophil count, and increases M2 macrophages in skin incisional mice model.

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