scholarly journals Efficacy of nano silver dressings over conventional dressings in chronic wounds

2018 ◽  
Vol 5 (12) ◽  
pp. 3995
Author(s):  
K. Suhas ◽  
P. Manvi Naga Manvi
Keyword(s):  
Chronic Wounds ◽  
Fungal Infections ◽  
Wide Spectrum ◽  
Cost Effective ◽  
Biological Properties ◽  
Nano Particles ◽  
Wound Management ◽  
Control Group ◽  
Study Group ◽  
Nano Silver

Background: Chronic wounds give rise to serious health problems, accompanied by a decrease in quality of life. Silver has been an effective agent with documented efficacy against wide spectrum of bacterial, viral, and fungal infections. Recently, many silver-based preparations are available for effective management of wounds. Among them silver nano particles, exhibit significantly novel and distinct physical, chemical, and biological properties. Due to their nano scale size, they have been elicited much interest in wound management. This study aims to compare the efficacy of nano silver dressing in chronic wounds with that of conventional dressings.Methods: This was a prospective study conducted in the Department of General Surgery, Alluri Sita Rama Raju Academy of Medical Sciences from August 2017 to August 2018. A total of 100 patients with chronic wounds were included in the study and were equally divided into-Study group and Control group randomly. Swab cultures were sent in all the patients. The study group received nano silver dressings while the controls received daily dressings with normal saline soaked gauges, betadine and hydrogen peroxide. Data regarding the time required for healing, number of days required for healing and percentage of healing are noted.Results: Nano silver dressings in the treatment of chronic wounds are found to be safe, effective, promoter of wound healing, promotes epithelization, accelerates healing, eliminates anaerobes and breaks microbial synergy more effectively than conventional dressing. Hence Nano silver spray prove to be more effective in the management of chronic wounds. In study group, 50% of patients stay for 3-4 weeks whereas in control group, 70% of patients stay for 5-6 weeks. 91-99% reduction in size of ulcer is seen in 43 out of 50 patients in study group whereas in control group only 8 out of 50 shows 91-99% reduction in size.Conclusions: Nano silver dressings is a cost effective option in ulcer management. It decreases the period of hospitalization and reduces the burden on the health care system.

scholarly journals Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Mechanical Performance ◽  
Healing Process ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Wound Management ◽  
Wound Healing Process ◽  
Treatment Of Wounds

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

scholarly journals Telemedicine for wound management

2012 ◽  
Vol 45 (02) ◽  
pp. 412-417 ◽  
Author(s):  
Ravi K. Chittoria
Keyword(s):  
Health Care ◽  
Chronic Wounds ◽  
Wound Care ◽  
Cost Effective ◽  
Skin Lesions ◽  
Wound Management ◽  
Care Practice ◽  
Telemedicine Technology ◽  
Store And Forward ◽  
Financial Burdens

ABSTRACTThe escalating physiological, psychological, social and financial burdens of wounds and wound care on patients, families and society demand the immediate attention of the health care sector. Many forces are affecting the changes in health care provision for patients with chronic wounds, including managed care, the limited number of wound care therapists, an increasingly ageing and disabled population, regulatory and malpractice issues, and compromised care. The physician is also faced with a number of difficult issues when caring for chronic wound patients because their conditions are time consuming and high risk, represent an unprofitable part of care practice and raise issues of liability. Telemedicine enhances communication with the surgical wound care specialist. Digital image for skin lesions is a safe, accurate and cost-effective referral pathway. The two basic modes of telemedicine applications, store and forward (asynchronous transfer) and real-time transmission (synchronous transfer, e.g. video conference), are utilized in the wound care setting. Telemedicine technology in the hands of an experienced physician can streamline management of a problem wound. Although there is always an element of anxiety related to technical change, the evolution of wound care telemedicine technology has demonstrated a predictable maturation process.

scholarly journals An observational study to evaluate improved graft acceptance and viability after single dressing on 15th postoperative day in cases of split thickness skin graft (STSG)

2018 ◽  
Vol 5 (12) ◽  
pp. 3935
Author(s):  
Narendra G. Naik ◽  
Sangram Karandikar
Keyword(s):  
Cost Effectiveness ◽  
Skin Graft ◽  
Cost Effective ◽  
Control Group ◽  
Split Thickness Skin Graft ◽  
Routine Practice ◽  
Study Group ◽  
Traditional Practice ◽  
Recipient Site ◽  
Thickness Skin

Background: After split thickness skin graft (STSG), it’s a routine practice to change recipient site dressing on 5th post-operative day and frequent dressing thereafter. The repeated change of recipient site dressing may interfere in graft acceptance. It’s also an effort to evaluate cost-effectiveness and graft acceptance after single dressing of recipient site at the end of 2 weeks.Methods: In the study group, 120 patients were operated for STSG. The recipient site dressing was done on 15th post-operative day. Observations were made regarding presence of residual ulcer at the recipient site. The results were compared with rate of residual ulcers at the recipient site in control group. The control group was comprised of 134 patients of STSG operated by the same surgeon in the previous year. Their dressing of recipient site was first changed on 5th post-operative day and multiple times thereafter. The results in both the groups were correlated with co-morbidities affecting wound healing.Results: The rate of residual ulcer at recipient site in both the groups was comparable with better cosmetic result and cost-effectiveness associated with the study group. In both the groups, common co-morbid factors were observed to be responsible for residual ulcers at the recipient site.Conclusions: After appropriate preparation of recipient site and in absence of co-morbid factors, the single 1st dressing of recipient site on 15th post-operative day gives better cosmetic outcome. This is also cost-effective as compared to the traditional practice of frequent multiple change of recipient site dressing.

scholarly journals Influence of dietary glycemic index and glycemic load on the occurrence of ischemic heart disease

2009 ◽  
Vol 66 (3) ◽  
pp. 212-217
Author(s):  
Maja Nikolic ◽  
Dragana Nikic ◽  
Branislav Petrovic ◽  
Natasa Rancic ◽  
Mirjana Arandjelovic
Keyword(s):  
Risk Factors ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Dietary Intake ◽  
Glycemic Index ◽  
Wide Spectrum ◽  
Glycemic Load ◽  
Ischemic Heart ◽  
Control Group ◽  
Study Group

Background/Aim. There are no recommendations for the dietary intake of carbohydrates compared with the dietary intake of lipids in patients with ischemic heart disease (IHD). The aim of the study was to assess the influence of high dietary glycemic load (GL) on the occurrence of IHD. Methods. The case-control study was carried out between 2003 and 2004. The study group consisted of 290 patients with IHD hospitalized in the Clinical Center in the town of Nis. There were 290 controls admitted to the same medical institution as cases for a wide spectrum of acute conditions unrelated to known or potential risk factors for IHD. The data about risk factors for IHD were collected by the epidemiological questionnaire. The data about nutrition were collected by administered food frequency questionnaire. A total GL for each patient was calculated by the international tables and the standard for the glycemic index (GI) was used. Standard anthropometric measurements were applied. A total level of lipids and cholesterol was determined, too. Multivariate odds ratios (OR) and 95% confidence intervals were obtained by multiple logistic regression models. Statistical analysis was performed with Epi Info Programme (Version 6.04) and with the SPSS for Windows (Release 8.0). Results. The patients with IHD had statistically significantly different intake of carbohydrate compared with the patients of the control group but the risk of IHD occurrence was not associated with the total intake of carbohydrate. The total average GL in the patients of the study group was statistically significantly higher compared with the patients of the control group (p < 0.05) and a high GL was independent risk factor for IHD (OR = 1.99). Conclusions. In prevention of IHD it is recommended to intake food with lower GI, for example vegetables and fruit.

scholarly journals Phyto Mediated Silver Nanoparticle Synthesis Coated Fabrics Towards Antibacterial Potential

2021 ◽  
Author(s):  
Nivedhitha Kabeerdass ◽  
Karthikeyan Murugesan ◽  
Srinivasan Ramasamy ◽  
Maghimaa Mathanmohun
Keyword(s):  
Management Strategies ◽  
Nanoparticle Synthesis ◽  
Cost Effective ◽  
Nano Particles ◽  
Wound Management ◽  
Biochemical Tests ◽  
E Coli ◽  
Gram Staining ◽  
Synthetic Chemicals ◽  
Coated Fabrics

Abstract Sore repairing since occurrence up to dry skin formation (scar) is a precious process gifted by nature. Immunology takes a predominant part in healing. A sore which is sustained just now, within minutes/hours is usually ignored till its uninterrupted scar formation. When is delayed that persists for many days, many weeks, more months, even for years is keenly noticed and is seeking secondary healing which is donated by medical men. Uninterrupted natural healing is usually processed by the immune system of the host when healing is delayed then comes interruption of the medical experts with the inclusive of medicines such as synthetic chemicals, phytotherapy, micro nano particles mingled medicines, botanical flora yield Phyto metal micro therapies which going for updated management like 3D bioprinting is in practice. An array of twenty exudates of nasal, pus, urine, stool, and blood are collected from the diverse age group of sex in various wards of SOTS (such as ICU, CCU, maternity, and casualty) from the Hospitals of Madurai. After isolating from other commensals its phenotypic character is studied through gram staining and biochemical tests. To get rid of their pathogenicity a cheap, cost-effective, eco-friendly potential medicinal ingredients possessed Amaranthaceae family yielded Alternanthera sessilis mediated fabrics coated silver nanoparticles were synthesized. In the case of MIC of AS-AgNPs against isolates zone of inhibition of the E. coli is 16mm > S. aureus is 15mm at 60µg. But in the case of MIC of fabrics against isolates the E. coli and K. oxytoca show susceptibility of 19 mm in mixed cotton. In a confirmation study of AS-AgNPs in FTIR, a sharp band is observed between 1500-500cm-1, in SEM with EDAX a graph was observed between 2.6–3.9 and black white crystals measured at 200nm in HR-TEM. Nanotechnology conjoined with herbal therapeutics provides a promising solution for wound management strategies.

scholarly journals A comparative study between aloe vera gel dressing and conventional dressing in chronic wounds

2017 ◽  
Vol 4 (10) ◽  
pp. 3427
Author(s):  
Virendra S. Athavale ◽  
Shivmurti N. Khandalkar ◽  
Megha Mahawar ◽  
Iresh Shetty ◽  
Aditya Lad
Keyword(s):  
Wound Healing ◽  
Surface Area ◽  
Chronic Wounds ◽  
Average Rate ◽  
Aloe Vera ◽  
Cost Effective ◽  
Control Group ◽  
Percentage Reduction ◽  
Aloe Vera Gel ◽  
Group A

Background: The aim of this study was to evaluate the effectiveness and rate of healing of Aloe vera gel in treatment of chronic wounds, to compare the effectiveness of Aloe vera gel with conventional dressing (normal saline and povidone iodine) and to assess the percentage reduction of wound healing with Aloe vera gel dressing.Methods: The study was conducted at Dr. D. Y. Patil Medical College and Hospital, DPU University, for a period of 2 months (from January 2017 to March 2017) and is a prospective and comparative randomized type of study using 50 cases (Group A and Group B, 25 each). The study was approved by the Institute’s Ethics Committee.Results: Data analysis showed that at the end of 4 weeks, mean surface area in Group A is reduced to 4.58 cm2 from 9.79 cm2 which is higher than that in the control group. Also, the average rate of healing in Aloe vera gel is more than control group. Percentage reduction in ulcer surface area was calculated to be much more in Group A as compared to Group B.Conclusions: The study concluded that Aloe vera gel is highly effective in treatment of chronic ulcers and stimulates the growth of wound healing. Thus, reducing the hospital stay. Apart from being efficacious in wound healing, Aloe vera gel is safe product. No allergic reactions/infections were associated with Aloe vera gel. Aloe vera gel not only heals faster but is also cost effective.

scholarly journals Oral cavity fungal flora among HIV-positive people

2020 ◽  
pp. 33-42
Keyword(s):  
Oral Cavity ◽  
Fungal Infections ◽  
Hiv Positive ◽  
Control Group ◽  
Study Group ◽  
Healthy Controls ◽  
Fungal Flora ◽  
Immunological Status ◽  
Immunosuppressed Patients ◽  
Species Isolation

BACKGROUND. Immunosuppressed patients, also those who are HIV-positive patients, are susceptible to oral cavity fungal infections. AIM OF STUDY. In this study, we aimed to show differences in qualitative composition of oral cavity flora between HIV-positive people and healthy controls and identify factors which affect fungal oral cavity flora. MATERIALS AND METHODS. The study group contained HIV-positive people and a control group of healthy people. All cultured species were analysed using MALDI-TOF MS. RESULTS. More HIV-positive people had two or more fungus species present than controls (p=0.008). Seven species were cultured in the study group compared to three in the control group. Smoking was associated with higher prevalence of C. albicans (p=0.03), C. glabrata (p=0.026), C. tropicalis (p=0.01). Dental prosthesis or braces was also associated with presence of more species (p=0.04).The lower level of lymphocytes CD4+ was not associated with fungus presence in oral cavity. CONCLUSIONS. HIV infection is associated with changes to oral cavity fungal flora. Given the higher number of non-albicans species among HIV-positive patients it is important to individually choose a treatment for such patients’ fungal infections. Proper oral hygene and not smoking can reduce prevalence of fungi in oral cavity. Patients’ immunological status did not have an impact on the frequency of Candida species isolation from the oral cavity.

scholarly journals A comparative study of safety and efficacy of vaginal isosorbide mononitrate (40mg) with dinoprostone gel (0.5mg)

2018 ◽  
Vol 7 (10) ◽  
pp. 4197
Author(s):  
Malathi T. M. ◽  
Kanchanamalai K.
Keyword(s):  
Side Effects ◽  
Cost Effective ◽  
Labor Induction ◽  
Cervical Ripening ◽  
Labour Induction ◽  
Controlled Study ◽  
Isosorbide Mononitrate ◽  
Control Group ◽  
Study Group ◽  
Safety And Efficacy

Background: It is essential to intervene pregnancy for safety of mother, fetus or both. Successful labor induction is clearly related to the state of the cervix. Women with an unfavorable cervix who have not experienced cervical ripening phase before labor present the greatest challenge with regard to labor induction. Therefore, it is necessary to use optimal technique for cervical ripening and safe confinement. One of the common methods includes use of PGE2 gel for cervical ripening. The rationale of this study is to compare the safety and efficacy of Iso-sorbide mononitrate as pre-induction cervical ripening with PGE2 gel induction.Methods: After attaining ethics approval [PSG IHEC], a prospective randomised, case-controlled study was conducted on 182 women undergoing elective induction of labour. They were allocated to either Study or Control group by computer generated random number table method. ISMN was used vaginally prior to labour induction in the study group whereas PGE2 gel induction was used in the control group. Change in bishop score and Induction to delivery interval was assessed in both the groups.Results: There was a significant reduction in induction to delivery interval in the study group (ISMN) 15.2 hours when compared to 23.2 hours in the control group (PGE2 gel) with p=0.000. Need for augmentation of labour was reduced in the study group significantly with p=0.003. Cost of induction was less when compared to the control group. ISMN had less side effects hence can be used as OP basis.Conclusions: Vaginal Isosorbide mononitrate when used as a cervical ripening agent significantly reduces induction to delivery interval. Use of Isosorbide mononitrate was associated with very less side effects and it is a cost-effective drug. Thus, ISMN can be used safely and effectively in term patients for pre-induction cervical ripening when compared to PGE2 gel.

scholarly journals Effect of a Carbohydrate-Rich Diet on Rat Detrusor Smooth Muscle Contractility: An Experimental Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Mustafa Suat Bolat ◽  
Sırrı S. Bilge ◽  
Ekrem Akdeniz ◽  
Onder Cinar ◽  
Fatih Firat ◽  
...  
Keyword(s):  
Contractile Response ◽  
National Policy ◽  
Cost Effective ◽  
Study Groups ◽  
Control Group ◽  
Study Group ◽  
Detrusor Muscle ◽  
Sprague Dawley ◽  
Smooth Muscle Contractility ◽  
Detrusor Contractility

Objectives. We aimed to investigate the effect of a carbohydrate-rich diet on detrusor contractility in rats. Materials and Methods. Sprague-Dawley rats were randomized into two groups. The control group received regular food and water. The study group received carbohydrate-rich diet for six weeks. The rats’ detrusor muscle was isolated for pharmacological and histopathological examinations. Results. In the control and study groups, mean body weights were 431.5 ± 27.6 g and 528.0 ± 36.2 g, respectively (p < 0.001). Electrical stimulation of the detrusor strips of the control group resulted in gradual contraction. A decreased contractile response was shown in the study group. Acetylcholine in 10-7-10-3 molar concentration produced a decreased contractile response in the study group, compared to the control group (p < 0.01). The study group showed marked subepithelial and intermuscular fibrosis in the bladder. Conclusion. Carbohydrate-rich diet causes marked subepithelial and extracellular fibrosis and changes in contractility in the detrusor within a six-week period. Changes have higher costs in therapeutic choices and correction of these changes remains difficult. Putting an end to carbohydrate-rich diet would seem to be more cost-effective than dealing with the effects of consuming it in high proportions which should be the national policy worldwide.

scholarly journals Caesarean Myomectomy is No Longer a Dreaded Job: a Case Control Study in Multiple Specialized Centre

2013 ◽  
Vol 8 (1) ◽  
pp. 07-10
Author(s):  
Dilruba Zeba ◽  
Shila Rani Das ◽  
Nusrat Fatima ◽  
Nazrul Islam ◽  
Julhash Uddin ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Blood Loss ◽  
Post Partum ◽  
Operation Time ◽  
Cost Effective ◽  
Control Group ◽  
Study Group ◽  
Safe Procedure ◽  
Severe Haemorrhage ◽  
A Prospective Study

Removal of uterine myoma during caesarean section (CS) is not commonly done due to fear of severe haemorrhage which may lead to hysterectomy. Contradicting the previous belief many studies have been showing that myomectomy during caesarean section is a safe procedure without significant increase of risk. The objective of this study is to analyze the safety and clinical outcome of caesarean myomectomy. This is a prospective study carried out in different hospitals of Faridpur district, Bangladesh from 01.01.10 up to 31.12.12. Total 16 (study group) patients had undergone caesarean myomectomy. Operation time, peroperative blood loss, post operative complications and length of hospital staying was compared with that of 32 women (control group) with caesarean section alone. The result shows that peroperative blood loss was average 350±100 ml in study group which is 50 ml more than control group. Operation time was 20 minutes more and length of hospital staying was 1 day more than control group. There was no post partum haemorrhage, no hysterectomy was done at the time of CS and there was no maternal or perinatal mortality. So, caesarean myomectomy is safe and convenient to patient and cost effective without increasing any extra risk. DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16889 Faridpur Med. Coll. J. 2013;8(1): 07-10

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