scholarly journals Terapi Hiperkolesterol pada Mencit (Mus musculus) strain Balb/C Betina Umur 2 Bulan Menggunakan Sari Bawang Putih

Jurnal Biota ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 71
Author(s):  
Muhammad Sungging Pradana ◽  
Imam Suryanto
Keyword(s):  
Cardiovascular Disease ◽  
Active Agent ◽  
The Body ◽  
Blood Cholesterol ◽  
High Cholesterol ◽  
Synthetic Drugs ◽  
Cholesterol Levels ◽  
Increase Risk ◽  
Group 3 ◽  
Strip Test

Cholesterol is a waxy substance which is mainly made in the body. Cholesterol can provide benefits. However, having too much cholesterol in the blood can increase risk of cardiovascular disease. Prevention and treatment of cardiovascular disease can be done by taking synthetic drugs such as statin. Due to side effects of synthetic drugs, it is necessary to substitute synthetic drugs with herbal plant and some natural component in these plants. The important ones is garlic. Garlic contain organosulphur compounds such as diallyldisulphide (DADS), dipropyldisulphide (DPDS), diallytrisulphide (DATS) and dipropyltrisulphide (DPTS) which have anti artherogenic effects. Garlic also have active agent allicin, can reduce the levels of cholesterol. This research was conducted at the Experimental Animal Enclosure Installation, Center for Veterinary Farma Surabaya with 3 experimental groups. Animals used in this research were female mice 2 months old were feeding with high cholesterol feed such as fried offal of chicken twice a day as much 0,5 cc/ day every 3 days. On the 3rd day, the levels of cholesterol in each group was examined. On the 4th day, mice in group 3 were given 1cc of garlic juice. 1 hour later mice was examined blood cholesterol using Strip Test Easy Touch GCU. The results through T-paired test on SPSS stated that (p < 0,05), it means there is influence between the 3 treatment of mice. This results it can be concluded that the provision of garlic juice can reduced blood cholesterol levels in mice after fed with high cholesterol.

scholarly journals Cholesterol in pregnancy: a review of knowns and unknowns

2011 ◽  
Vol 4 (4) ◽  
pp. 147-151 ◽  
Author(s):  
Änne Bartels ◽  
Keelin O'Donoghue
Keyword(s):  
Cardiovascular Disease ◽  
Vitamin D ◽  
Fetal Development ◽  
Plasma Cholesterol ◽  
Adult Population ◽  
The Body ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Growing Body ◽  
In Pregnancy

Cholesterol forms part of every cell in the human body, and also helps make and metabolize hormones, bile acids and vitamin D. Human plasma cholesterol levels are determined by production in the liver and by dietary intake. Lipoproteins carry cholesterol around the body, and facilitate it crossing the placenta. Cholesterol is carefully monitored in the non-pregnant adult population, where its association with atherosclerosis and cardiovascular disease is well understood. Although it is known that cholesterol rises in pregnancy, at present it is not routinely measured or treated. The effects of maternal high cholesterol on pregnancy and on fetal development are not yet fully understood. However, a growing body of evidence from animal and human studies suggests adverse consequences of high cholesterol levels in pregnancy.

Targeting the Cholesterol Paradigm in the Risk Reduction for Atherosclerotic Cardiovascular Disease: Does the Mechanism of Action of Pharmacotherapy Matter for Clinical Outcomes?

2021 ◽  
pp. 107424842110236
Author(s):  
Ruihai Zhou ◽  
George A. Stouffer ◽  
Sidney C. Smith
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Outcomes ◽  
Mechanism Of Action ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Blood Cholesterol ◽  
Atherosclerotic Cardiovascular Disease ◽  
Pcsk9 Inhibitors ◽  
Cholesterol Lowering ◽  
Cholesterol Levels

Hypercholesterolemia is a well-established risk factor for atherosclerotic cardiovascular disease (ASCVD). Low-density lipoprotein cholesterol (LDL-C) has been labeled as “bad” cholesterol and high-density lipoprotein cholesterol (HDL-C) as “good” cholesterol. The prevailing hypothesis is that lowering blood cholesterol levels, especially LDL-C, reduces vascular deposition and retention of cholesterol or apolipoprotein B (apoB)-containing lipoproteins which are atherogenic. We review herein the clinical trial data on different pharmacological approaches to lowering blood cholesterol and propose that the mechanism of action of cholesterol lowering, as well as the amplitude of cholesterol reduction, are critically important in leading to improved clinical outcomes in ASCVD. The effects of bile acid sequestrants, fibrates, niacin, cholesteryl ester transfer protein (CETP) inhibitors, apolipoprotein A-I and HDL mimetics, apoB regulators, acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitors, cholesterol absorption inhibitors, statins, and proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors, among other strategies are reviewed. Clinical evidence supports that different classes of cholesterol lowering or lipoprotein regulating approaches yielded variable effects on ASCVD outcomes, especially in cardiovascular and all-cause mortality. Statins are the most widely used cholesterol lowering agents and have the best proven cardiovascular event and survival benefits. Manipulating cholesterol levels by specific targeting of apoproteins or lipoproteins has not yielded clinical benefit. Understanding why lowering LDL-C by different approaches varies in clinical outcomes of ASCVD, especially in survival benefit, may shed further light on our evolving understanding of how cholesterol and its carrier lipoproteins are involved in ASCVD and aid in developing effective pharmacological strategies to improve the clinical outcomes of ASCVD.

scholarly journals THE STATE OF CHOLESTEROL LEVEL IN HYPERTENSION IN SADANANYA HEALTH CENTER

2021 ◽  
Vol 4 (2) ◽  
pp. 80-85
Author(s):  
Irpan Ali Rahman ◽  
Endrian Mulyadi Justitia Waluyo ◽  
Shafira Aisyah Darmawan
Keyword(s):  
Blood Pressure ◽  
Total Cholesterol ◽  
Health Center ◽  
Cholesterol Level ◽  
Blood Cholesterol ◽  
High Total Cholesterol ◽  
High Cholesterol ◽  
Hypertensive Patients ◽  
Cholesterol Levels ◽  
Quantitative Descriptive

Hypertension is an increase in systolic blood pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The number of hypertension sufferers has increased each year, in 2015 it reached 19,552, in 2016 it reached 24,750 and in 2017 it reached 38,057. In 2017 there were 115 hypertensive patients recorded in the report book that checked their health at the Sadananya Health Center. One of the causes of the high incidence of hypertension is cholesterol caused by the consumption of inappropriate food. One of the laboratory examinations to support hypertension diagnosis is blood cholesterol examination which can show excess cholesterol which makes hypertension difficult to control. To know the description of total cholesterol levels in hypertensive patients at the Sadananya Health Center. Quantitative descriptive, the population in this study were people with hypertension at the Sadananya Health Center. Sampling with accidental sampling, as many as 30 respondents. The cholesterol examination method used is CHOD-PAP. The results showed that blood pressure in respondents all had high blood pressure, namely >140/90 mmHg (100%), a high cholesterol level of 24 respondents (80%), blood pressure 140-150 who had high cholesterol as many 13 respondents, blood pressure 160-170 who had high cholesterol as much 6 respondents, blood pressure >180 who had high cholesterol as much 5 respondents. This study concludes that hypertensive clients have more high total cholesterol levels, which is as much as 80% and normal 20%. More hypertensive patients have high total cholesterol levels, which are 80% and 20% normal.

scholarly journals Pengaruh Pemberian Alpukat Terhadap Kadar Kolesterol Total Darah Pada Mahasiswa/i Obesitas Di Fakultas Kedokteran Universitas HKBP Nommensen Medan Tahun 2019

2021 ◽  
Vol 6 (2) ◽  
pp. 40-43
Author(s):  
Syupiarni Putri Waruwu ◽  
Joseph Partogi Sibarani ◽  
Saharnauli Janna Verawaty Simorangkir
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Density Lipoprotein ◽  
The Body ◽  
Blood Cholesterol ◽  
Ldl Oxidation ◽  
Blood Cholesterol Level ◽  
Total Blood ◽  
Cholesterol Levels ◽  
Total Blood Cholesterol

Background: Cholesterol is a fat that does not dissolve easily in the blood. Most of the cholesterol in the blood is attached to specific protein carriers in the plasma in the form of lipoprotein complexes, which are soluble in water. Lipoprotein which carries cholesterol throughout the body. namely LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein). An increase in LDL in the body tends to form atherosclerosis. In contrast HDL cholesterol inhibits LDL oxidation so that atherosclerotic plaque formation does not occur. Obesity is one of the risk factors for atherosclerosis with manifestations of coronary heart disease. Handling of obesity has been done by many researchers and implemented. One ingredient from nature that serves as an alternative ingredient to lower blood cholesterol levels is avocado. Objective: To determine the effect of avocado administration on total blood cholesterol levels in the obese college students at the Medical Faculty of Nommensen HKBP University in 2019. Methods :This research is a pre-experimental study with a pre-post test design in one group. The sample was selected by purposive sampling method and obtained 20 obese students. Subjects consumed avocado juice every day for 14 days. Total cholesterol levels were measured before (day 0) and after (day 14) treatment. Results: The mean total cholesterol level of the subject's blood on the pretest examination was 188.10 mg / dL and the posttest examination was 180.05 mg / dL. There was a decrease in the average total blood cholesterol level of 8.05 mg / dl. Paired T-test showed that there was a non-significant decrease in mean total blood cholesterol level with a value of p = 0.068 (p <0.05). Conclusion: In this study there was no effect of avocado administration on total blood cholesterol levels in obese students.

Treatment with Simvastatin and Low-dose Aspirin Depresses Thrombin Generation in Patients with Coronary Heart Disease and Borderline-high Cholesterol Levels

2001 ◽  
Vol 85 (02) ◽  
pp. 221-225 ◽  
Author(s):  
Anetta Undas ◽  
Robert Undas ◽  
Jan Brożek ◽  
Andrzej Szczeklik ◽  
Jacek Musiał
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Thrombin Generation ◽  
Low Dose ◽  
Ex Vivo ◽  
Blood Cholesterol ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Dose Aspirin ◽  
Low Dose Aspirin

SummaryAspirin and statins are beneficial in coronary heart disease across a broad range of cholesterol levels. We assessed the effects of low-dose aspirin (75 mg daily) on thrombin generation in patients with coronary heart disease and average blood cholesterol levels. We also investigated whether in patients with borderline-high cholesterol level who have been already taking aspirin, additional treatment with simvastatin would affect thrombin generation.Seven-day treatment with low-dose aspirin decreased thrombin generation ex vivo only in patients with total cholesterol 5.2 mmol/L. In patients with higher cholesterol levels aspirin had no effect. In these patients, already taking low-dose aspirin, additional three-month simvastatin treatment resulted in a reduction of thrombin generation. This demonstrates that low-dose aspirin depresses thrombin generation only in subjects with desirable blood cholesterol levels, while in others, with borderline-high cholesterol, thrombin formation is being reduced following the addition of simvastatin.

scholarly journals The Correlation of Weight and Blood Cholesterol Levels of White Rat (Rattus Norvegicus) with High-Fat Diet

2016 ◽  
Vol 3 (3) ◽  
pp. 202-206
Author(s):  
Thatit Nurmawati
Keyword(s):  
Body Weight ◽  
Rattus Norvegicus ◽  
High Fat Diet ◽  
Egg Yolk ◽  
The Body ◽  
Blood Cholesterol ◽  
High Fat ◽  
Data Measurement ◽  
Cholesterol Levels

Cholesterol is an essential substance for the body. The role of cholesterol as material hormones,cell membranare needed by the body. This conditionchanges into a distrubtion if the cholesterollevels in the blood increase. Weight becomes one of this trigger. The consumption of high-fat foodsincrease weight which resulting in the increase of cholesterol cases. The purpose of this study was todetermine the level of correlations between weight and cholesterol levels after being given a high-fatdiet.The study used rats (Rattus norvegicus) sex male, 16 rats with age between 1-2 months. Rats weightrange between 100-150 gr and in healthy conditions. The giving of high-fat diet were in the form ofchicken feed, duck eggs, goat oil, lard and flour for 8 weeks. The data measurement done by scales andmeasuringcholesterol levels through the end of the tail by means of easy touch. The data analysis weredone to understand level of correlation between variables. The presentation of the data used tables. Theresults showed body weight of rats did not change after administration of a high-fat diet. The cholesterolslevels of the subjects were high. Theadministration of high-fat diet from egg yolk dan goat oilcouldincrease the level of cholesterol. There was a correlation between weight and cholesterol levels afterbeing given a high-fat diet (p <0.5). It was needed to repeatthe measurements to determine changes incholesterol levels and other factors that affect thigh blood to cholesterol levels.

scholarly journals The Description of Lipid Profile on Injectable DMPA Contraception Acceptors in Public Health Center Banjarsengon, Jember District

2021 ◽  
Vol 8 (1) ◽  
pp. 043-048
Author(s):  
Ririn Handayani ◽  
Rizki Fitrianingtyas
Keyword(s):  
Lipid Profile ◽  
Cholesterol Oxidase ◽  
Lipoprotein Metabolism ◽  
The Body ◽  
High Cholesterol ◽  
Exclusion Criteria ◽  
Cholesterol Levels ◽  
Very High ◽  
High Triglyceride

Injectable DMPA contraception can cause changes in lipoprotein metabolism. Changes in fat metabolism occur because of the hormonal influence of progesterone, causing disruption of the balance of lipid profiles in the body. The change in serum lipid profile (trgliseride, total cholesterol, HDL and LDL) in long-term use of DMPA is a risk factor for atherosclerosis and cardiovascular disease. The purpose of this study was to look at the description of the lipid profile at 3 months injection acceptors. The design of the study was descriptive. The population in this study was 76, the number of samples that met the inclusion and exclusion criteria in this study was 30. Examination of the lipid profile was carried out with an enzymatic colorimetric (cholesterol oxidase method / CHOD PAP). The results of lipid profile examination showed that 13.33% had high cholesterol levels, 3.33% had high triglyceride levels, 13.33% had high HDL levels, 20% had high LDL levels and 3.33% have very high LDL levels. The conclusion of this study was long term use of DMPA injection contraception could cause changes in the lipid profile, so it is recommended for acceptors who want to use contraception in the long term to use MKJP as an option so as not to affect the fat profile in the body.

scholarly journals Kandungan Antioksidan Pada Daun Kelor (Moringa Oleifera) dan Potensi Sebagai Penurun Kadar Kolesterol Darah

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Angelyn Tjong ◽  
Youla A. Assa ◽  
Diana S. Purwanto
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Moringa Oleifera ◽  
Google Scholar ◽  
Blood Cholesterol ◽  
Exclusion Criteria ◽  
Traditional Medicines ◽  
Cholesterol Levels ◽  
Antioxidant Content ◽  
Moringa Oleifera Leaves

Abstract: One of the biggest risk factors for cardiovascular disease is hypercholesterolemia. Cholesterol is an important fat, however if it is excessive in the blood it can cause various diseases, one of which is cardiovascular disease. One of the traditional medicines used to reduce blood cholesterol levels is Moringa Oleifera leaves, which contain flavonoids and play an important role in lowering blood cholesterol levels. This study aimed to determine the antioxidant content of Moringa Oleifera leaves, the benefits of lowering blood cholesterol levels, and the dosage of administration. This study was conducted by using three databases, namely PubMed, ClinicalKey and Google Scholar to find articles which met the inclusion and exclusion criteria, then the assessment was carried out. There was a significant reduction in blood cholesterol levels when given Moringa leaves, as well as the dose given. In conclusion, antioxidants in Moringa leaves can reduce cholesterol levels in the blood.Keywords: antioxidants, moringa leaves, cholesterol, cardiovascular  Abstrak: Salah satu faktor risiko terbesar penyakit kardiovaskular adalah hiperkolesterolemia. Kolesterol merupakan lemak yang penting, namun jika berlebihan dalam darah dapat menyebabkan berbagai penyakit, salah satunya kardiovaskular. Salah satu obat tradisional yang digunakan untuk menurunkan kadar kolesterol darah adalah daun kelor (Moringa Oleifera), yang mengandung flavonoid dan berperan penting dalam menurunkan kadar kolesterol darah. Tujuan penelitian ini untuk mengetahui kandungan antioksidan daun kelor, manfaat sebagai penurun kadar kolesterol darah, dan dosis pemberian. Pencarian artikel menggunakan tiga database yaitu PubMed, ClinicalKey, dan Google Scholar untuk menemukan artikel sesuai dengan kriteria inklusi dan eksklusi, kemudian dilakukan penilaian. Terdapat penurunan kadar kolesterol darah yang signifikan ketika diberikan daun kelor dalam menurunkan kadar kolesterol darah, serta dosis yang diberikan. Sebagi simpulan, antioksidan pada daun kelor dapat menurunkan kadar kolesterol dalam darah. Kata Kunci: antioksidan, daun kelor, kolesterol, kardiovaskular

scholarly journals ANALISIS PENYAKIT KARDIOVASKULAR MENGGUNAKAN METODE KORELASI PEARSON, SPEARMAN DAN KENDALL

2020 ◽  
Vol 10 (2) ◽  
pp. 119
Author(s):  
Yudi Eko Windarto
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Strong Relationship ◽  
High Cholesterol ◽  
Cholesterol Levels ◽  
Kendall Correlation ◽  
Analyze Data

Cardiovascular disease is a disease that is affected by the heart and blood vessels. There are several main risk factors that cause cardiovascular disease. Risk factors for cardiovascular disease include: high blood pressure, high cholesterol, diabetes, being overweight or obese, age, sex, smoking, and alcohol. The more risk factors you have, the greater the chance of causing cardiovascular disease. In this research, it was developed using the Spearman, Pearson and Kendall correlation methods to analyze data on cardiovascular disease patients. The results showed there was correlation between blood pressure (ap_hi and ap_lo), age, and cholesterol had a strong relationship with cardiovascular disease. Glucose and cholesterol levels also have a strong relationship between one another.

scholarly journals Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Manoj Kumar ◽  
Ravinder Nagpal ◽  
Rajesh Kumar ◽  
R. Hemalatha ◽  
Vinod Verma ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Serum Cholesterol ◽  
Dairy Products ◽  
Health Benefits ◽  
Natural Resistance ◽  
Blood Cholesterol ◽  
Low Fat ◽  
Cholesterol Removal ◽  
Cholesterol Levels ◽  
Fat Diets

Cardiovascular diseases are one of the major causes of deaths in adults in the western world. Elevated levels of certain blood lipids have been reported to be the principal cause of cardiovascular disease and other disabilities in developed countries. Several animal and clinical trials have shown a positive association between cholesterol levels and the risks of coronary heart disease. Current dietary strategies for the prevention of cardiovascular disease advocate adherence to low-fat/low-saturated-fat diets. Although there is no doubt that, in experimental conditions, low-fat diets offer an effective means of reducing blood cholesterol concentrations on a population basis, these appear to be less effective, largely due to poor compliance, attributed to low palatability and acceptability of these diets to the consumers. Due to the low consumer compliance, attempts have been made to identify other dietary components that can reduce blood cholesterol levels. Supplementation of diet with fermented dairy products or lactic acid bacteria containing dairy products has shown the potential to reduce serum cholesterol levels. Various approaches have been used to alleviate this issue, including the use of probiotics, especiallyBifidobacteriumspp. andLactobacillusspp.. Probiotics, the living microorganisms that confer health benefits on the host when administered in adequate amounts, have received much attention on their proclaimed health benefits which include improvement in lactose intolerance, increase in natural resistance to infectious disease in gastrointestinal tract, suppression of cancer, antidiabetic, reduction in serum cholesterol level, and improved digestion. In addition, there are numerous reports on cholesterol removal ability of probiotics and their hypocholesterolemic effects. Several possible mechanisms for cholesterol removal by probiotics are assimilation of cholesterol by growing cells, binding of cholesterol to cellular surface, incorporation of cholesterol into the cellular membrane, deconjugation of bile via bile salt hydrolase, coprecipitation of cholesterol with deconjugated bile, binding action of bile by fibre, and production of short-chain fatty acids by oligosaccharides. The present paper reviews the mechanisms of action of anti-cholesterolemic potential of probiotic microorganisms and probiotic food products, with the aim of lowering the risks of cardiovascular and coronary heart diseases.

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