Preparation and Characterization of Agar Based Magnetic Nanocomposite for Potential Biomedical Applications

2019 ◽  
Vol 25 (34) ◽  
pp. 3672-3680 ◽  
Author(s):  
Nasrullah Shah ◽  
Tahir Zaman ◽  
Touseef Rehan ◽  
Salman Khan ◽  
Waliullah Khan ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Nano Particles ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Sem Images ◽  
Stability Range ◽  
Potential Applications

Purpose: The purpose of the present study was to make a biocompatible agar based composite material via incorporation of appropriate additives within the agar matrix for potential applications in drug delivery and biomedical fields. Methodology: Agar based composites were prepared by the incorporation of magnetic iron oxide nano particles, graphite and sodium aluminum as additives in different proportions within the agar matrix by a simple thermophysico- mechanical method. The as prepared agar based composites were then characterized by different techniques i.e. FTIR, SEM, TGA, XRD and EDX analyses. The FTIR peaks confirmed the presence of each component in the agar composite. SEM images showed the uniform distribution of each component in the agar composite. TGA study showed the thermal stability range of different composite sheets. XRD pattern revealed the crystallinity and EDX analysis confirmed the elemental composition of the prepared composites. The prepared agar based composites were evaluated for antimicrobial activities against three pathogenic bacterial strains Escherichia coli, Staphylococcus aureus and Klebsiella pneumonia and the result indicated efficient antimicrobial activities for all composites. Conclusions: From the overall study, it was concluded that due to the non-toxic nature, thermal stability and excellent antibacterial properties, the prepared agar based composites can receive potential biomedical applications.

scholarly journals Antimicrobial Surface Functionality of PEG Coated and AgNPs Immobilized Extracorporeal Biomaterials

2021 ◽  
Vol 12 (1) ◽  
pp. 1039-1052
Keyword(s):  
Surface Modification ◽  
Biomedical Applications ◽  
Antimicrobial Activities ◽  
Klebsiella Pneumonia ◽  
Colloidal Silver ◽  
Sem Images ◽  
Surface Functionality ◽  
Antimicrobial Function ◽  
Peg Coating

Nanotechnology is a promising field for generating new medicine applications like colloidal silver to prevent nosocomial infections. In this study, the objection of the presented manuscript was to test the antimicrobial activity of PEG/silver nanoparticles (AgNPs) coated blood tubing used in hemodialysis. The modification of plastic tubing was first performed by PEG coating, which was followed by immobilization of AgNPs synthesized with a green chemical approach from the leaves of Liquidambar Orientalis Miller. The stabilization of each surface modification stage was assured by methanol fixation. The characterization of AgNPs, surface modification steps, and final tubing surface appearances was performed by spectrophotometric measurements, DLS analysis, FTIR spectrums, and SEM images. The results indicated that the surfaces of hemodialysis tubing were successfully coated with PEG/AgNPs processed sequentially. Antimicrobial activities were evaluated against pathogens (Escherichia coli, Pseudomonas aeruginosa. Klebsiella pneumonia, Staphylococcus aureus, and Candida albicans), which are commonly involved in catheter-related infections. In conclusion, a new AgNPs immobilization method to polymeric catheter surfaces after PEG layering was developed. The antimicrobial function against five nosocomial microorganisms would have potential in biomedical applications.

scholarly journals Graphene Family Nanomaterials: Properties and Potential Applications in Dentistry

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Ziyu Ge ◽  
Luming Yang ◽  
Fang Xiao ◽  
Yani Wu ◽  
Tingting Yu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Current Knowledge ◽  
Antibacterial Properties ◽  
Biological Properties ◽  
New Materials ◽  
Clinical Reality ◽  
Comprehensive Literature Review ◽  
Potential Applications

Graphene family nanomaterials, with superior mechanical, chemical, and biological properties, have grabbed appreciable attention on the path of researches seeking new materials for future biomedical applications. Although potential applications of graphene had been highly reviewed in other fields of medicine, especially for their antibacterial properties and tissue regenerative capacities, in vivo and in vitro studies related to dentistry are very limited. Therefore, based on current knowledge and latest progress, this article aimed to present the recent achievements and provide a comprehensive literature review on potential applications of graphene that could be translated into clinical reality in dentistry.

scholarly journals Efficacy assessment of various natural and organic antimicrobials against Escherichia coli O157:H7, Salmonella enteritidis and Listeria monocytogenes

2020 ◽  
Vol 44 (1) ◽  
Author(s):  
Dina H. Amin ◽  
Assem Abolmaaty
Keyword(s):  
Escherichia Coli ◽  
Listeria Monocytogenes ◽  
Foodborne Pathogens ◽  
Salmonella Enteritidis ◽  
Bactericidal Effect ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
Low Concentrations ◽  
Potential Applications ◽  
Efficacy Assessment

Abstract Background Foodborne illness is a public health alarm with a deleterious effect on human health and the economy all over the world. Searching for possible solutions to beat foodborne pathogens is still a demanding concern. The scope of this study is to evaluate the antimicrobial activity of some natural and organic compounds against important pathogens including Escherichia coli O157:H7 C9490, Listeria monocytogenes Lm2 Scott A 4b, and Salmonella enteritidis 8-9-99. Results The bactericidal effect of eight compounds and their concentrations were evaluated by the tube dilution assay against the tested bacterial strains. Thymol was found to be superior to all tested compounds. Antimicrobial activities found to be highly influenced by varying pH values. Low pH 4.5 found to report higher inhibition when compared with pH 7.1. For instance, minimum inhibitory concentration (MIC) occurred at pH 7.1 with 25 ppm of thymol against Escherichia coli O157:H7 and Salmonella enteritidis, while 200 ppm against Listeria monocytogenes. However, MIC occurred at pH 4.5 with 25 ppm of thymol against all tested bacterial strains. Conclusions Thymol is the most active antimicrobial recorded in our study at low concentrations. Our results indicated thymol, benzoic acid, sodium benzoate, salicylic acid, 3-t-butyl-4-Hydroxyanisole, and acetylsalicylic acid have promising potential applications in controlling tested foodborne pathogens.

scholarly journals In vitro study of antimicrobial activity of some plant seeds against bacterial strains causing food poisoning diseases

2022 ◽  
Vol 82 ◽  
Author(s):  
A. A. Abu-Zaid ◽  
A. Al-Barty ◽  
K. Morsy ◽  
H. Hamdi
Keyword(s):  
Antimicrobial Activity ◽  
Nigella Sativa ◽  
Food Poisoning ◽  
In Vitro Study ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Plant Seeds

Abstract In this research, some plant seeds powder was evaluated to find their potential effect to rule diseases of food poisoning. Antimicrobial effect of five plant seeds was examined contra Bacillus cereus, Staphylococcus aureus, Escherichia coli, Klebsiella. pneumonia and Candida albicans by using well diffusion method. Antimicrobial activity studies revealed high potential activity of plant seeds powder of Nigella sativa L., cucurbita pepo, Sesamum radiatum, Trigonella foenum-graecum, Linum usitatissimum with variable efficiency contra tested microbial strains with concentration of 100 mg/ml, except Sesamum radiatum scored no effect. The T. foenum and N. sativa seed powder showed the largest inhibition zone (24-20 mm) contra K. pneumonia, followed by S. aureus (20-18 mm) and C. albicans (15mm) respectively. The five plant seeds powder exhibited bacteriostatic and bactericidal effects with MIC’s 20 and MBC 40 mg/ml against K. pneumonia, and MIC’s 40 and MBC 60 mg/ml against S. aureus. The results of this study indicated that plants seeds powder have promising antimicrobial activities and their potential applications in food process. It could be utilized as a natural medicinal alternative instead of chemical substance.

scholarly journals Advances on biodegradable zinc-silver-based alloys for biomedical applications

2021 ◽  
Vol 19 ◽  
pp. 228080002110624
Author(s):  
Ximei Xiao ◽  
Enyang Liu ◽  
Jinlong Shao ◽  
Shaohua Ge
Keyword(s):  
Mechanical Properties ◽  
Mechanical Strength ◽  
Human Body ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Research Field ◽  
Medical Applications ◽  
Secondary Surgery ◽  
Biodegradable Metals ◽  
Potential Applications

The biodegradable metals have great potential for the biomedical applications, which could be gradually degraded, absorbed, or excreted in the human body, avoiding the removal though secondary surgery. Zinc-based alloys are novel series of degradable metals for medical applications, and they are gaining lots of attention in the research field of absorbable metals. Zinc-silver (Zn-Ag) alloys show superior mechanical strength, good biodegradability, biocompatibility, and antibacterial properties, which render them to be potential candidates for biomedical applications. In this paper, we reviewed the development of Zn-Ag alloys in terms of mechanical properties, degradabilities, biocompatibilities, antibacterial properties, and potential applications in dentistry.

Gold Nanotubes from Organic Scaffolds for Biomedical Applications

2013 ◽  
Vol 754 ◽  
pp. 109-119
Author(s):  
Mohammad A. Jafar Mazumder
Keyword(s):  
Thermal Stability ◽  
Biomedical Applications ◽  
Volume Ratio ◽  
Atomic Level ◽  
Cutting Edge ◽  
Medical Applications ◽  
Nanoscale Devices ◽  
Recent Advances ◽  
Potential Applications

Nanoparticles are the cutting edge of the rapidly developing field of nanotechnology, which enables visualization and manipulation of matter down to the atomic level. Their unique size to volume ratio, shape and thermal stability make these materials superior, and rapidly usable in various bio-medical applications. This brief review summarize the recent advances in the field of applied nanomaterials with an emphasis in designing nanoscale devices with pre-defined structure, and their potential applications in the field of biology and medicine.

scholarly journals Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy Lavender

Foods ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 132 ◽  
Author(s):  
Chang Ha Park ◽  
Ye Eun Park ◽  
Hyeon Ji Yeo ◽  
Se Won Chun ◽  
Thanislas Bastin Baskar ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Essential Oils ◽  
Antibacterial Properties ◽  
Antimicrobial Activities ◽  
Aeromonas Salmonicida ◽  
Gas Chromatography Mass Spectrometry ◽  
Chemical Compositions ◽  
Significant Activity ◽  
Bacterial Strains

The discovery of a new species exhibiting more effective antibacterial properties is necessary because of the demand on Lavandula species, which continues to increase in a variety of industries. Lavandula pubescens might be a good alternative, as it exhibits strong antibacterial activity. In this study, the chemical composition of the essential oils from different organs (flowers, leaves, stems, and roots) of L. pubescens was identified using gas chromatography-mass spectrometry. Furthermore, the antimicrobial activities of different solvent extracts (methanol, ethanol, diethyl ether, hexane, and ethyl acetate) and different organ (flower, leaf, stem, and root) extracts of L. pubescens were evaluated. Only the ethyl acetate extracts of L. pubescens exhibited antibacterial activity against all bacterial strains tested, including Staphylococcus haemolyticus, Escherichia coli (KF 918342), Aeromonas hydrophila (KCTC 12487), E. coli (ATCC 35150), Cronobacter sakazakii (ATCC 29544), and Aeromonas salmonicida (KACC 15136). In particular, the extracts exhibited significant activity against S. haemolyticus. Ethyl acetate extract of the leaf exhibited the best activity against all bacterial strains. This study provides valuable information on the chemical compositions in essential oils and antimicrobial properties of L. pubescens.

scholarly journals Assessment of Antidiarrheal, Antispasmodic and Antimicrobial Activities of Methanolic Seeds Extract of Peganum harmala L. (Nitrariaceae)

2020 ◽  
pp. 74-82
Author(s):  
Mohd Nazam Ansari
Keyword(s):  
Castor Oil ◽  
Antimicrobial Activities ◽  
Positive Control ◽  
In Vitro Assays ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Peganum Harmala ◽  
Control Drug

Background: Many plants and herbs have been shown to possess antidiarrheal, antispasmodic, and antimicrobial activities. The present study was developed to determine the possible antidiarrheal and antispasmodic effects of methanolic extract of Peganum harmala L. (MEPH) in diarrhea and hyperactive gut. Methodology: The crude MEPH was studied using the in-vivo castor oil-induced diarrhea model in mice, while isolated rat ileum was used in the in-vitro studies. Antimicrobial efficacy of MEPH was tested against different bacterial strains (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia), Yeast (Candida albicans) and Fungus (Aspergillus niger) using in-vitro assays. Results: In the castor oil-induced diarrhea, MEPH at 100 and 200 mg/kg showed 40% and 80% protection in mice while positive control drug, loperamide showed 100% protection. In the in-vitro experiments, MEPH dose-dependently (0.01 to 0.3 mg/mL) inhibited carbachol and high K+-induced contractions at comparable EC50 values similar to papaverine, a phosphodiesterase (PDE) inhibitor. The PDE inhibitory like effect was further confirmed when pre-incubated ileum tissues with MEPH (0.1 and 0.3 mg/mL) shift the isoprenaline-mediated inhibitory CRCs against carbachol to the left, similar to papaverine. In antibacterial assay, MEPH showed efficacy against two Gram positive bacteria (S. aureus, and B. subtilis) and one Gram negative bacteria (E. coli). But extract didn’t show any effect against K. pneumoniae. The MEPH also showed efficacy against fungal strain (A. niger) and yeast strain (C. albicans). Conclusions: MEPH shows antidiarrheal and antispasmodic effects because of its antimotility effect which were possibly due to the inhibition of PDE enzyme. The study has shown an optimal antimicrobial activity of MEPH as all bacteria, yeast and fungal strains were found sensitive except K. pneumoniae. MEPH proved efficacy against both enteric and non-enteric pathogens causing diarrhea, thus confirming its role in both the infectious and non-infectious diarrhea.

Extraction and characterization of sea anemones compound and its Anti bacterial and hemolytic studies

2020 ◽  
Vol 10 (4) ◽  
pp. 93-97
Author(s):  
Anil Kumar A ◽  
Raja Sheker K ◽  
Naveen B ◽  
Abhilash G ◽  
Akila CR
Keyword(s):  
Antibacterial Activity ◽  
Focal Point ◽  
Haemolytic Activity ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
Sea Anemones ◽  
Marine Plants ◽  
Heteractis Magnifica ◽  
Trididemnum Solidum

Seas assets that give us a variety of characteristic items to control bacterial, contagious and viral ailment and mostly utilized for malignancy chemotherapy practically from spineless creatures, for example, bryozoans, wipes, delicate corals, coelenterates, ocean fans, ocean bunnies, molluscs and echinoderms. In the previous 30 - 40 years, marine plants and creatures have been the focal point of overall endeavours to characterize the regular results of the marine condition. Numerous marine characteristic items have been effectively exceptional to the last phases of clinical preliminaries, including dolastatin-10, a group of peptides disengaged from Indian ocean rabbit, Dollabella auricularia. Ecteinascidin-743 from mangrove tunicate Ecteinascidia turbinata, Didemnins was isolated from Caribbean tunicate Trididemnum solidum and Conopeptides from cone snails (Conus sp.), and a developing number of up-and-comers have been chosen as promising leads for expanded pre-clinical appraisals. Sea anemones possess numerous tentacles containing stinging cells or cnidocytes. The stinging cells are equipped with small organelles known as nematocysts. The two species of sea anemones namely, Heteractis magnificaandStichodactyla haddoni, were collected from Mandapam coastal waters of Ramanathapuram district, Tamilnadu, India. The Nematocyst was collected and centrifuged, and the supernatant was lyophilized and stored for further analysis. The amount of protein from Heteractis Magnifica and Stichodactyla haddoni was estimated. The crude extract has shown haemolytic activity on chicken blood and goat blood. In the antibacterial activity of the sea anemone against six bacterial strains Staphylococcus aureus, Salmonella typhii, Salmonella paratyphii, Klebsiella pneumonia, Vibrio cholerae, Pseudomonas aeruginosa. Antibacterial activity of H. Magnifica and S.haddoni was measured as the radius of the zone of inhibition.

scholarly journals Extraordinary thermal behavior of graphene oxide in air for electrode applications

2021 ◽  
Author(s):  
Joong Tark Han ◽  
Joon Young Cho ◽  
Jeong Hoon Kim
Keyword(s):  
Thermal Stability ◽  
Graphene Oxide ◽  
Physical Properties ◽  
Thermal Behavior ◽  
Stability Of Solution ◽  
Exfoliated Graphene ◽  
Potential Applications ◽  
Thermal Stability Of

The thermal stability of solution-exfoliated graphene oxide (GO) in air is one of the most important physical properties influencing its potential applications. To date, majority of the GO prepared by...

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